Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Effectiveness of Adjunctive Hyaluronic Acid Application in Surgical Treatment of Gingival Recession Sites: A Systematic Scoping Review

Mattia Manfredini
ORCID logo ,
Mario Beretta
,
Carlo Maiorana
,
Marco Tandurella
,
Federica Euegnia Salina
* ORCID logo ,
Pier Paolo Poli
Version 1 : Received: 26 May 2023 / Approved: 30 May 2023 / Online: 30 May 2023 (08:02:03 CEST)

A peer-reviewed article of this Preprint also exists.

Manfredini, M.; Beretta, M.; Maiorana, C.; Tandurella, M.; Salina, F.E.; Poli, P.P. Effectiveness of Adjunctive Hyaluronic Acid Application in Surgical Treatment of Gingival Recession Sites. Prosthesis 2023, 5, 635-646. Manfredini, M.; Beretta, M.; Maiorana, C.; Tandurella, M.; Salina, F.E.; Poli, P.P. Effectiveness of Adjunctive Hyaluronic Acid Application in Surgical Treatment of Gingival Recession Sites. Prosthesis 2023, 5, 635-646.

Abstract

The aim of this systematic scoping review was to provide scientific evidence on the efficacy and methods of application of hyaluronic acid in the coverage of gingival recessions in terms of recession depth (RD) reduction, clinical attachment level (CAL) gain, probing depth (PD). An electronic search of the literature on the main databases was conducted. Initially, 405 articles were identified. Finally, 4 studies were included after the review process. It was not possible to perform a meta-analysis of the articles selected because of the differences among the surgical treatments and commercial formulations and compositions of hyaluronic acid. Both randomized controlled trials in this research examined Recession Type 1 gingival treated with coronally advanced flap. Recessions were treated with either modified coronally advanced tunnel or laterally closed tunnel combined with subepithelial connective tissue graft and hyaluronic acid (HA) in all case series. The studies analyzed no significant variation was found in PD variable. The results of RD reduction are in accordance with the literature. Modifications of CAL are connected to variations of RD. HA seems to improve the clinical outcomes of the described surgical treatment.

Keywords

gingival recession; linear hyaluronic acid; cross-linked hyaluronic acid; root coverage procedure; surgical treatment of recession

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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