Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad

Paule Bénit
,
Judith Goncalves
,
Riyad El Khoury
ORCID logo ,
Malgorzata Rak
ORCID logo ,
Judith Favier
ORCID logo ,
Anne-Paule Gimenez-Roqueplo
ORCID logo ,
Pierre Rustin
* ORCID logo
Version 1 : Received: 29 June 2022 / Approved: 30 June 2022 / Online: 30 June 2022 (08:31:22 CEST)

A peer-reviewed article of this Preprint also exists.

Bénit, P.; Goncalves, J.; El Khoury, R.; Rak, M.; Favier, J.; Gimenez-Roqueplo, A.-P.; Rustin, P. Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad. Biomedicines 2022, 10, 1788. Bénit, P.; Goncalves, J.; El Khoury, R.; Rak, M.; Favier, J.; Gimenez-Roqueplo, A.-P.; Rustin, P. Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad. Biomedicines 2022, 10, 1788.

Abstract

Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 50’s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism. This allowed to uncover the implication of the SDH in both the mitochondrial respiratory chain and the Krebs cycle. Nowadays this theme is experiencing a real revival following the discovery of the role of SDH and succinate in a subset of tumors and cancers in human. The aim of this review is to enlighten the many questions yet unanswered, ranging from fundamental to clinically oriented aspects, up to the danger of the current use of SDH as a target for a sub class of pesticides.

Keywords

Mitochondria; Respiratory chain; Krebs cycle; Succinate; Cancer; Encephalopathy; SDH, SDHI; pesticides

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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