The Influence of Microbiome on Urological Malignancies: A Systematic Review

Porto, J.G.; Arbelaez, M.C.S.; Pena, B.; Khandekar, A.; Malpani, A.; Nahar, B.; Punnen, S.; Ritch, C.R.; Gonzalgo, M.L.; Parekh, D.J.; Marcovich, R.; Shah, H.N. The Influence of the Microbiome on Urological Malignancies: A Systematic Review. Cancers 2023, 15, 4984. Porto, J.G.; Arbelaez, M.C.S.; Pena, B.; Khandekar, A.; Malpani, A.; Nahar, B.; Punnen, S.; Ritch, C.R.; Gonzalgo, M.L.; Parekh, D.J.; Marcovich, R.; Shah, H.N. The Influence of the Microbiome on Urological Malignancies: A Systematic Review. Cancers 2023, 15, 4984.

Abstract

The microbiome, once considered peripheral, is emerging as a relevant player in the intricate web of factors contributing to cancer development and progression. These often overlooked microorganisms, in the context of urological malignancies, have been investigated primarily focusing on the gut microbiome, while exploration of urogenital microorganisms remains limited. In light of this, our systematic review delves into the complex role of these understudied actors in various neoplastic conditions, including prostate, bladder, kidney, penile, and testicular cancers. Our analysis found a total of 37 studies, with prostate cancer-12, bladder cancer-20, kidney cancer-4, penile/testicular cancer-1, which reveals distinct associations specific to each condition, hinting at potential therapeutic avenues and future biomarker discoveries. It becomes evident that further research is imperative to unravel the complexities of this domain and provide a more comprehensive understanding.

Keywords

microbiome; prostate cancer; bladder cancer; kidney cancer; testicular cancer; penile cancer

Subject

Medicine and Pharmacology, Urology and Nephrology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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