Preprint Review Version 1 This version is not peer-reviewed

A New and Integral Approach to the Etiopathogenesis and Treatment of Breast Cancer based upon its Hydrogen Ion Dynamics

Version 1 : Received: 26 November 2019 / Approved: 27 November 2019 / Online: 27 November 2019 (04:57:00 CET)

How to cite: Harguindey, S.; Alfarouk, K.; Polo Orozco, J.; Hardonniere, K.; Stanciu, D.; Fais, S.; Devesa, J. A New and Integral Approach to the Etiopathogenesis and Treatment of Breast Cancer based upon its Hydrogen Ion Dynamics. Preprints 2019, 2019110331 (doi: 10.20944/preprints201911.0331.v1). Harguindey, S.; Alfarouk, K.; Polo Orozco, J.; Hardonniere, K.; Stanciu, D.; Fais, S.; Devesa, J. A New and Integral Approach to the Etiopathogenesis and Treatment of Breast Cancer based upon its Hydrogen Ion Dynamics. Preprints 2019, 2019110331 (doi: 10.20944/preprints201911.0331.v1).

Abstract

Despite all efforts, the treatment of breast cancer (BC) cannot be considered to be a success story. The advances in surgery, chemotherapy and radiotherapy have not been sufficient. Indeed, the accumulated experience clearly indicates that new perspectives and non-main stream approaches are needed to better characterize the etiopathogenesis and treatment of this disease. This contibution deals with how the new pH-centric anticancer paradigm plays a fundamental role in reaching a more integral understanding of the etiology, etiopathogenesis and treatment of this multifactorial disease. For the first time the armamentarium available for the treatment of the different types and phases of BC is approached here from a Unitarian perspective based upon the hydrogen ion dynamics of cancer. The wide-ranged pH-related molecular, biochemical and metabolic model is able to embrace most the fields and subfields of breast cancer pathology. This single and integrated approach allows to advance a unidirectional program to treatment. Further efforts in this line are likely to first improve the therapeutics of each subtype of this tumor, then every phase of the disease and finally every individual patient.

Subject Areas

pH and breast cancer; breast cancer etiology; breast cancer etiopathogenesis; breast cancer treatment; pH-centric anticancer paradigm; hydrogen ion dynamics of cancer; cancer proton reversal; MDR integral approach

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