Quintero, J.C.; Díaz, N.F.; Rodríguez-Dorantes, M.; Camacho-Arroyo, I. Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease Progression. Int. J. Mol. Sci.2023, 24, 15085.
Quintero, J.C.; Díaz, N.F.; Rodríguez-Dorantes, M.; Camacho-Arroyo, I. Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease Progression. Int. J. Mol. Sci. 2023, 24, 15085.
Quintero, J.C.; Díaz, N.F.; Rodríguez-Dorantes, M.; Camacho-Arroyo, I. Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease Progression. Int. J. Mol. Sci.2023, 24, 15085.
Quintero, J.C.; Díaz, N.F.; Rodríguez-Dorantes, M.; Camacho-Arroyo, I. Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease Progression. Int. J. Mol. Sci. 2023, 24, 15085.
Abstract
The cancer stem cell hypothesis suggests that neoplastic cells with stem characteristics hierarchically regulate tumor generation and its high cellular heterogeneity. These cells have been detected in all cancer types, and specific signaling pathways give the regulation of self-renewal and differentiation. In prostate cancer, androgen receptor signaling has been extensively studied, and in non-stem cells, it promotes cell proliferation and tumor progression, but in the cancer stem cell population, it negatively regulates processes such as self-renewal. However, in other types of cancer, such as breast and glioblastoma, the androgen receptor seems to favor the maintenance of cancer stem cells, suggesting that androgen signaling has different effects depending on the tumor context. This review discusses the role of androgen receptor in maintaining cancer stem cells by regulating proliferation, self-renewal, and differentiation, as well as the possible signaling pathways involved in these processes.
Keywords
Cancer Stem Cell; Androgen Receptor; Prostate Cancer; Breast Cancer; Glioblastoma
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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