Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease Progression

Version 1 : Received: 10 September 2023 / Approved: 11 September 2023 / Online: 12 September 2023 (03:15:45 CEST)

A peer-reviewed article of this Preprint also exists.

Quintero, J.C.; Díaz, N.F.; Rodríguez-Dorantes, M.; Camacho-Arroyo, I. Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease Progression. Int. J. Mol. Sci. 2023, 24, 15085. Quintero, J.C.; Díaz, N.F.; Rodríguez-Dorantes, M.; Camacho-Arroyo, I. Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease Progression. Int. J. Mol. Sci. 2023, 24, 15085.

Abstract

The cancer stem cell hypothesis suggests that neoplastic cells with stem characteristics hierarchically regulate tumor generation and its high cellular heterogeneity. These cells have been detected in all cancer types, and specific signaling pathways give the regulation of self-renewal and differentiation. In prostate cancer, androgen receptor signaling has been extensively studied, and in non-stem cells, it promotes cell proliferation and tumor progression, but in the cancer stem cell population, it negatively regulates processes such as self-renewal. However, in other types of cancer, such as breast and glioblastoma, the androgen receptor seems to favor the maintenance of cancer stem cells, suggesting that androgen signaling has different effects depending on the tumor context. This review discusses the role of androgen receptor in maintaining cancer stem cells by regulating proliferation, self-renewal, and differentiation, as well as the possible signaling pathways involved in these processes.

Keywords

Cancer Stem Cell; Androgen Receptor; Prostate Cancer; Breast Cancer; Glioblastoma

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

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