Preprint Article Version 2 This version is not peer-reviewed

Impact of Genetic Polymorphism of Sulpha Transferase Genes (SULT1A) Genes on the Risk of Females with Breast Cancer in Jordan

Version 1 : Received: 9 October 2017 / Approved: 9 October 2017 / Online: 9 October 2017 (12:34:55 UTC)
Version 2 : Received: 8 November 2018 / Approved: 9 November 2018 / Online: 9 November 2018 (04:28:29 UTC)

How to cite: Bustami, M.; Al-Shudifat, A.; Hussein, N.; Yacoub, M.; Atwa, E.; Sabri, I.; Abu-Hamdah, R.; Abu-Rayyan, W.; Arafat, T.; Badran, A.; Abu-Qatouseh, L. Impact of Genetic Polymorphism of Sulpha Transferase Genes (SULT1A) Genes on the Risk of Females with Breast Cancer in Jordan. Preprints 2017, 2017100050 (doi: 10.20944/preprints201710.0050.v2). Bustami, M.; Al-Shudifat, A.; Hussein, N.; Yacoub, M.; Atwa, E.; Sabri, I.; Abu-Hamdah, R.; Abu-Rayyan, W.; Arafat, T.; Badran, A.; Abu-Qatouseh, L. Impact of Genetic Polymorphism of Sulpha Transferase Genes (SULT1A) Genes on the Risk of Females with Breast Cancer in Jordan. Preprints 2017, 2017100050 (doi: 10.20944/preprints201710.0050.v2).

Abstract

Sulfotransferases (SULTs) family plays a significant role in the biotransformation of a variety of xenobiotics and endogenous compounds by which carcinogenesis and mutagenicity of different malignancies are increasingly affected. Recent data identified various genetically polymorphic SULTs enzymes with significant variations in the enzyme activity. This study aimed to investigate the impact of SULT1A1 gene polymorphism and and its potential risk on females with breast cancer in Jordan using a PCR-RFLP and Sanger Sequencing methods. The analysis showed that 24.7% of the patients and 25.3% of the controls were homozygous for the SULT1A1*1 allele (SULT1A1*1/SULT1A1*1) compared to 8.8% and 5.7% homozygous for the SULT1A1*2 allele (SULT1A1*2/SULT1A1*2) for patients and controls respectively. Most of the patients and controls were heterozygous for SULT1A1*1 allele (SULT1A1*1/SULT1A1*2) with rates of 66.5% and 69.0% in patients and controls respectively. In addition, the frequencies of the mutant SULT1A1*2 allele were 0.42 and 0.4 in the patient and control groups respectively. No significant difference in genotype and allele distribution was noted between the breast cancer and control groups. The risk of breast cancer in individuals carrying the SULT1A1*2 allele was determined by combining the SULT1A1*1/SULT1A1*2 and ULT1A1*2/SULT1A1*2 genotypes. No association was observed between SULT1A1 polymorphism and breast cancer incidence (P = 0.63; OR, 0.93; 95% CI, 0.68–1.26). However, SULT1A1*2 allele was found to increase the risk of breast cancer by 1.26-fold.

Subject Areas

polymorphism; risk for breast cancer; SULT1A allele

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