Working Paper Review Version 1 This version is not peer-reviewed

Micronutrients and Breast Cancer Progression: A systematic Review

Version 1 : Received: 1 November 2020 / Approved: 2 November 2020 / Online: 2 November 2020 (13:50:43 CET)

A peer-reviewed article of this Preprint also exists.

Cuenca-Micó, O.; Aceves, C. Micronutrients and Breast Cancer Progression: A Systematic Review. Nutrients 2020, 12, 3613. Cuenca-Micó, O.; Aceves, C. Micronutrients and Breast Cancer Progression: A Systematic Review. Nutrients 2020, 12, 3613.

Journal reference: Nutrients 2020, 12, 3613
DOI: 10.3390/nu12123613

Abstract

Epidemiological studies on micronutrient consumption have reported protective associations in the incidence and/or progression of various cancer types. Supplementation with some of these micronutrients has been analyzed, showing chemoprotection, low toxicity, antiproliferation, and the ability to modify epigenetic signatures in various cancer models. The following review inves-tigates the reported effects of micronutrient intake or supplementation in breast cancer progres-sion. A PubMed search was conducted with the keywords “micronutrients breast cancer progres-sion,” and the results were analyzed. The selected micronutrients were: Vitamins (A, C, D, and E), Folic Acid, metals (Cu, Fe, Se, and Zn), fatty acids, polyphenols, and iodine. The majority of in vitro models showed antiproliferative, cell cycle arrest, and antimetastatic effects for almost all the micronutrients analyzed, but these effects do not reflect animal or human studies. Only one clinical trial with Vitamin D and one pilot study with molecular iodine showed favorable overall survival and disease-free interval.

Keywords

breast cancer; micronutrients; cancer

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.