Working Paper Review Version 1 This version is not peer-reviewed

Micronutrients and Breast Cancer Progression: A systematic Review

Version 1 : Received: 1 November 2020 / Approved: 2 November 2020 / Online: 2 November 2020 (13:50:43 CET)

How to cite: Cuenca, O.; Aceves, C. Micronutrients and Breast Cancer Progression: A systematic Review. Preprints 2020, 2020110045 Cuenca, O.; Aceves, C. Micronutrients and Breast Cancer Progression: A systematic Review. Preprints 2020, 2020110045

Abstract

Epidemiological studies on micronutrient consumption have reported protective associations in the incidence and/or progression of various cancer types. Supplementation with some of these micronutrients has been analyzed, showing chemoprotection, low toxicity, antiproliferation, and the ability to modify epigenetic signatures in various cancer models. The following review inves-tigates the reported effects of micronutrient intake or supplementation in breast cancer progres-sion. A PubMed search was conducted with the keywords “micronutrients breast cancer progres-sion,” and the results were analyzed. The selected micronutrients were: Vitamins (A, C, D, and E), Folic Acid, metals (Cu, Fe, Se, and Zn), fatty acids, polyphenols, and iodine. The majority of in vitro models showed antiproliferative, cell cycle arrest, and antimetastatic effects for almost all the micronutrients analyzed, but these effects do not reflect animal or human studies. Only one clinical trial with Vitamin D and one pilot study with molecular iodine showed favorable overall survival and disease-free interval.

Subject Areas

breast cancer; micronutrients; cancer

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