Search | Preprints.org

Preprint ARTICLE | doi:10.20944/preprints202001.0077.v1

The Role of Immune and Oxidative Pathways in Menstrual-Cycle Associated Depressive, Physio-Somatic, Breast and Anxiety Symptoms: Modulation by Sex Hormones

Chutima Roomruangwong, Andressa Keiko Matsumoto, Ana Paula Michelin, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania G. Moreira, Sunee Sirivichayakul, Andre Carvalho, Decio S. Barbosa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: premenstrual syndrome; depression; anxiety; antioxidants; neuro-immune; inflammation; oxidative stress

Online: 9 January 2020 (08:17:43 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202202.0179.v2

Research on 4-UPUS Parallel Mechanism Ankle Joint Rehabilitation Training Robot

Ao Hu, Qiang Yin, Chengcai He, Xiaohong Dun, Jia Ai

Subject: Engineering, Mechanical Engineering Keywords: Ankle joint rehabilitation robot; Parallel mechanism; Statics analysis; Kinematics analysis; Workspace

Online: 18 February 2022 (13:06:23 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201907.0147.v1

Schizophrenia Phenomenology Revisited: Positive and Negative Symptoms are Strongly Related Reflective Manifestations of an Underlying Single Trait Indicating Overall Severity of Schizophrenia

Abbas Almulla, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: deficit schizophrenia, positive symptoms, negative symptoms, inflammation, neuro-immune

Online: 10 July 2019 (11:02:41 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202011.0540.v1

The Effectiveness of Therapeutic Physical Exercise in Patients with Amyotrophic Lateral Sclerosis in Relation to the Alsfrs-R Functionality Scale: A Systematic Review

Laura Ortega-Hombrados, Guadalupe Molina Torres, Alejandro Galán-Mercant, Eduardo Sánchez-Guerrero, Manuel Gonzalez-Sanchez, María Ruiz-Muñoz

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Amyotrophic lateral sclerosis; physical therapy; rehabilitation; exercise

Online: 20 November 2020 (11:53:01 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202205.0164.v1

A Comprehensive Review of Pain Interference on Postural Control: From Experimental to Chronic Pain

Frédéric JF Viseux, Martin Simoneau, Maxime Billot

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: pain; postural control; rehabilitation

Online: 12 May 2022 (08:52:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202107.0281.v1

Clinical Application of Next Generation Sequencing in Recurrent Glioblastoma

Daniel Zeitouni, Michael Catalino, Jordan Wise, Sean McCabe, Kathryn Pietrosimone, Naim Rashid, Simon Khagi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Glioblastoma; Precision Medicine; Targeted Therapy; Genomics; Neuro-Oncology

Online: 13 July 2021 (09:28:35 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202106.0558.v1

High Vegetables Intake and Response to COPD Rehabilitation. The Role of Oxidative Stress, Inflammation and Dna Damage.

Sara Ilari, Laura Vitiello, Patrizia Russo, Stefania Proietti, Mirta Milic, Carolina Muscoli, Vittorio Cardaci, Carlo Tomino, Gaia Bonassi, Stefano Bonassi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Chronic obstructive pulmonary disease (COPD); Pulmonary Rehabilitation; Vegetables; DNA damage; Genomic Instability; Oxidative stress; Inflammation.

Online: 23 June 2021 (10:08:20 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201912.0012.v1

Biomarker Validation of a New Case Definition of Menstrual Cycle-Associated Syndrome (MCAS)

Chutima Roomruangwong, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: premenstrual; depression; inflammation; neuro-immune; oxidative stress; antioxidants

Online: 2 December 2019 (14:12:33 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0397.v1

Group A Rotavirus Gastroenteritis in Orphaned Leopardus Tigrinus and Leopardus Pardalis (CARNIVORA: FELIDAE) in the Eastern Amazon

Áurea M. Gabriel, Washington L.A. Pereira, Klena S. Silva, Lorena Souza, Akim F.S. Nobre, Joana D’Arc Mascarenhas, Alexandre da C. Linhares

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: group A rotavirus gastroenteritis; emerging zoonotic viral diseases; leopardus tigrinus and leopardus pardalis; endangered neotropical rain forest felids; rehabilitation of injured or orphaned native wild cats

Online: 19 August 2020 (08:06:31 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202104.0479.v1

Increased Neurotoxicity Due to Activated Immune-Inflammatory and Nitro-Oxidative Stress Pathways in Patients with Suicide Attempts: A Systematic Review and Meta-Analysis

Asara Vasupanrajit, Ketsupar Jirakran, Chavit Tunvirachaisakul, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: suicide; neuro-immune; inflammation; oxidative and nitrosative stress; depression; mood disorders; schizophrenia; psychiatry

Online: 19 April 2021 (12:46:06 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202111.0368.v1

Assessing the Acceptability of a Co-produced Long COVID Intervention in an Underserved Community in the UK

Sally Fowler-Davis, Rachel Young, Tom Maden-Wilkinson, Waqas Hameed, Elizabeth Dracas, Eleanor Hurrell, Romila Bahl, Elisabeth Kilcourse, Rebecca Robinson, Robert Copeland

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Long Covid; rehabilitation; virtual methods; multi-disciplinary team

Online: 19 November 2021 (15:00:47 CET)

Show abstract| Download PDF| Share

Background: The COVID-19 pandemic has disproportionately affected people from more deprived communities. The experience of Long Covid is similarly distributed but very few investigations have concentrated on the needs of this population. The aim of this project was to co-produce an acceptable intervention for people with Long Covid, living in communities recognised as more deprived. Methods: The intervention was based on a multi-disciplinary team using approaches from sport and exercise medicine and functional rehabilitation. The co-production process was undertaken with a stakeholder advisory group and patient public involvement representation. This study identified participants by postcode and the indices of multiple deprivation (IMD); recruitment and engagement were supported by an existing health and wellbeing service. A virtual ‘clinic’ was offered with a team of professional practitioners who met participants three times each; to directly consider their needs and offer structured advice. The acceptability of the intervention was based on the individual’s participation and their completion of the intervention. Results: Ten participants were recruited with eight completing the intervention. The partnership with an existing community health and wellbeing service was deemed to be an important way of reaching participants. Two men and six women ages ranging from 38 to 73 were involved and their needs were commonly associated with fatigue, anxiety and depression with overall de-conditioning. None reported serious hardship associated with the pandemic although most were in self-employment/part-time employment or were not working due to retirement or ill-health. Two older participants lived alone, and others were single parents and had considerable challenges associated with managing a household alongside their Long Covid difficulties. Conclusions: This paper presents the needs and perspectives of eight individuals involved in the process and discusses the needs and preferences of the group in relation to their support for self- managed recovery from Long Covid.

Preprint ARTICLE | doi:10.20944/preprints202202.0080.v1

The Turmell-Meter: A Device for Ankle Joint Axis Estimation Appliyng Product of Exponentials

Óscar Agudelo, Ángel Valera, Julio Vargas-Riaño

Subject: Engineering, Bioengineering Keywords: anthropometry; biomechanics; coordinate measuring machines; in vivo; kinematics; mechanical sensors; sensor arrays; human ankle model, operational amplifiers; pose estimation; position measurement; rehabilitation robotics; biomedical informatics; product of exponentials formula; Riemmanian manifolds

Online: 7 February 2022 (11:50:24 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202106.0112.v1

High Vegetables Intake and Response to COPD Rehabilitation Treatment. The Role of Oxidative Stress, Inflammation and DNA Damage

Sara Ilari, Laura Vitiello, Patrizia Russo, Stefania Proietti, Mirta Milic, Carolina Muscoli, Vittorio Cardaci, Carlo Tomino, Gaia Bonassi, Stefano Bonassi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic obstructive pulmonary disease (COPD); Pulmonary Rehabilitation; Diet; DNA damage; Genomic Instability; Oxidative stress; Inflammation

Online: 3 June 2021 (12:21:13 CEST)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202203.0370.v1

A Narrative of a Certified Nurse in Dementia Care in Japan How to Compensate the Gap Caused by Visitation Restrictions Due to Coronavirus Disease

Yuki Ohashi, Yumiko Furukubo, Diane Bunn

Subject: Public Health And Healthcare, Nursing Keywords: COVID-19; visitation restrictions; psychological distress; cognitive disfunction; long-term care; rehabilitation ward

Online: 28 March 2022 (15:13:31 CEST)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202204.0276.v1

Don’t Bury Functional Electrical Stimulation Too Fast! An Introspection Based on Gait Improvement after an Ecological 6-Month Training Program at Home for a Stroke Survivor

Romain David, Maxime Billot, Etienne Ojardias, Bernard Parratte, Manuel Roulaud, Amine Ounajim, Frédéric Louis, Hachemi Meklat, Philippe Foucault, Christophe Lombard, Anne Jossart, Laura Mainini, Martin Lavalliere, Lisa Goudman, Maarten Moens, Davy Laroche, Marjorie Salga, François Genet, Jean Christophe Daviet, Anaick Perrochon, Maxence Compagnat, Philippe Rigoard

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: foot drop; walking; rehabilitation; ankle-foot orthosis; mobility; Functional Electrical Stimulation

Online: 28 April 2022 (08:45:35 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202012.0314.v1

Histo-Neuro-Behavioral Effects of a Single, Very Mild Trauma on Senescent Rodent Brains: A Systematic Review

Eduard Drima, Camelia Vrabie

Subject: Social Sciences, Psychology Keywords: Very mild Traumatic Brain Injury; Animal models (rodents); Post-concussion syndrome; neuro-behavioral changes; “inflammaging”; brain apoptosis

Online: 14 December 2020 (09:33:51 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202111.0065.v1

Upper Limb Robotic Rehabilitation for Patients With Cervical Spinal Cord Injury: A Comprehensive Review

Giovanni Morone, Alessandro De Sire, Alex Martino Cinnera, Matteo Paci, Luca Perrero, Marco Invernizzi, Lorenzo Lippi, Marialuisa Gandolfi, Michela Agostini, Irene Aprile, Emanuela Casanova, Dario Marino, Giuseppe La Rosa, Federica Bressi, Silvia Sterzi, Daniele Giansanti, Alberto Battistini, Sandra Miccinilli, Serena Filoni, Monica Sicari, Salvatore Petrozzino, Claudio Marcello Solaro, Stefano Gargano, Paolo Benanti, Paolo Boldrini, Donatella Bonaiuti, Enrico Castelli, Francesco Draicchio, Vincenzo Falabella, Silvia Galeri, Francesca Gimigliano, Mauro Grigioni, Stefano Mazzoleni, Stefano Mazzon, Franco Molteni, Maurizio Petrarca, Alessandro Picelli, Federico Posteraro, Michele Senatore, Giuseppe Turchetti, Sofia Straudi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Cervical spinal cord injury; Arm function; Exoskeleton; Robot-assisted therapy; Robotic therapy; Rehabilitation.

Online: 3 November 2021 (08:35:46 CET)

Show abstract| Download PDF| Share

The upper extremities limitation represents one of the essential functional impairments in patients with cervical spinal cord injury. Electromechanics assisted devices and robots are increasingly used in neurorehabilitation to help functional improvement in patients with neurological diseases. This review aimed to systematically report the evidence-based, state-of-art on clinical applications and robotic-assisted arm training (RAT) in motor and functional recovery in subjects affected by cervical spinal cord injury. The present study has been carried out within the framework of the Italian Consensus Conference on "Rehabilitation assisted by robotic and electromechanical devices for persons with disability of neurological origin" (CICERONE). PubMed/MEDLINE, Cochrane Library, and Physiotherapy Evidence Database (PEDro) databases were systematically searched from inception to September 2021. The 10-item PEDro scale assessed the study quality for the RCT and the AMSTAR-2 for the systematic review. Two different authors rated the studies included in this review. If consensus was not achieved after discussion, a third reviewer was interrogated. The 5-item Oxford CEBM scale was used to rate the level of evidence. A total of 11 studies were included. The selected studies were: two systematic reviews, two RCTs, one parallel-group controlled trial, one longitudinal intervention study and five case series. One RCT was scored as a high-quality study, while the systematic review was of low quality. RAT was reported as feasible and safe. Initial positive effects of RAT were found for arm function and quality of movement in addition to conventional therapy. The high clinical heterogeneity of treatment programs and the variety of robot devices could severely affect the generalizability of the study results; therefore, future studies are warranted to standardize the type of intervention and evaluate the role of robotic-assisted training in subjects affected by cervical spinal cord injury.

Preprint ARTICLE | doi:10.20944/preprints202006.0160.v1

Methodology for the Design of Rehabilitation Robots: Application in an Exoskeleton for Upper Limb Rehabilitation

Giorgio Mackenzie Cruz Martinez, Luis Adrian Zuñiga Aviles

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: methodology; exoskeleton; upper limb rehabilitation; design; digital twin

Online: 14 June 2020 (03:27:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202012.0457.v1

Inflammatory and Oxidative Pathways are New Drug Targets in Multiple Episode Schizophrenia and Leaky Gut, Klebsiella pneumoniae, and C1q Immune Complexes are Additional Drug Targets in First Episode Schizophrenia

Michael Maes, Aristo Vojdani, Sunee Sirivichayakul, Decio Barbosa, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: deficit schizophrenia; neuro-immune; inflammation; oxidative and nitrosative stress; antioxidants; biomarkers; IgM; autoimmune

Online: 18 December 2020 (11:50:42 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201811.0533.v1

Improvement of the Classification Algorithms of Postures for Non-Marker Systems of Human Motion Capture

Tatiana Klishkovskaia, Andrey Aksenov

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: exercise classification; motion capture; virtual rehabilitation

Online: 22 November 2018 (04:33:58 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201810.0677.v1

RabbitRun: An Immersive Virtual Reality Game for Promoting Physical Activities Among People with Low Back Pain ^†

Amal Alazba, Hend Al-Khalifa, Hana AlSobayel

Subject: Computer Science And Mathematics, Software Keywords: low back pain; virtual reality; virtual rehabilitation; serious game; gamification

Online: 29 October 2018 (11:38:57 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202104.0500.v1

Cell Proliferation in the Piriform Cortex of Rats with Motor Cortex Ablation Treated with Growth Hormone and Rehabilitation

Margarita Heredia, Virginia Sánchez-Robledo, Inés Gómez, José María Criado, Antonio de la Fuente, Jesús Devesa, Pablo Devesa, Adelaida Sánchez Riolobos

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: motor ablation; growth hormone; rehabilitation; cell proliferation; piriform cortex; brain injury

Online: 19 April 2021 (14:46:46 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202105.0509.v1

Intersections between Copper, β-Arrestin-1, Calcium, FBXW7, CD17, Insulin Resistance and Atherogenicity Mediate Depression and Anxiety Due to Type 2 Diabetes Mellitus: A Nomothetic Network Approach

Hussein Al-Hakeim, Hadi Hadi, Ghoufran Jawad, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: depression; mood disorders; inflammation; oxidative stress; nitrosative stress; neuro-immune; antioxidants; psychoneuroimmunology

Online: 21 May 2021 (09:36:47 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201910.0239.v1

Construction of a Neuro-Immune-Cognitive Pathway-Phenotype Underpinning the Phenome of Deficit Schizophrenia

Hussein Kadhem Al-Hakeim, Abbas F. Almulla, Arafat Hussein Al-Dujaili, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: deficit schizophrenia; machine learning; cytokines; cognition; inflammation; neuro-immune

Online: 20 October 2019 (17:21:05 CEST)

Show abstract| Download PDF| Share

In Schizophrenia, pathway-genotypes may be constructed by combining interrelated immune biomarkers with changes in specific neurocognitive functions that represent aberrations in brain neuronal circuits. These constructs provide insight on the phenome of schizophrenia and show how pathway-phenotypes mediate the effects of genome X environmentome interactions on the symptomatology/phenomenology of schizophrenia. Nevertheless, there is a lack of knowledge how to construct pathway-phenotypes using Partial Least Squares (PLS) path modeling and Soft Independent Modeling of Class Analogy (SIMCA). This paper aims to provide a step-by-step utilization guide for the construction of pathway-phenotypes that reflect aberrations in the neuroimmune - brain circuit axis (NIBCA) in deficit schizophrenia. This NIBCA index is constructed using immune biomarkers (CCL-2, CCL-11, IL-1β, sIL-1RA, TNF-α, sTNFR1, sTNFR2) and neurocognitive tests (Brief Assessment of Cognition in Schizophrenia) predicting overall severity of schizophrenia (OSOS) in 120 deficit SCZ and 54 healthy participants. Using SmartPLS path analysis, a latent vector is extracted from those biomarkers and cognitive tests, which shows a good construct reliability (Cronbach alpha and composite reliability) and replicability and which is reflectively measured through its NIBCA manifestations. This NIBCA pathway-phenotype explains 75.0% of the variance in PHEMN (psychotic, hostility, excitation, mannerism and negative) symptoms. Using SIMCA, we constructed a NIBCA pathway-class that defines deficit schizophrenia as a qualitatively distinct nosological entity and which allows patients with deficit schizophrenia to be authenticated as belonging to the deficit schizophrenia class. In conclusion, our nomothetic approach to develop a nomological network combining neuro-immune and neurocognitive phenome markers to predict OSOS and cross-validate a diagnostic class generated replicable models reflecting the key phenome of the illness, which may mediate the effects of genome X environmentome interactions on the final outcome phenome features, namely symptomatology and phenomenology.

Preprint ARTICLE | doi:10.20944/preprints202005.0145.v1

Lowered Antioxidant Defenses and Increased Oxidative Toxicity Are Hallmarks of Deficit Schizophrenia: Neurocognitive and Symptom Correlates

Michael Maes, Sunee Sirivichayakul, Andressa Keiko Matsumoto, Anna Paula Michelin, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania G. Moreira, Decio S. Barbosa, Andre F. Carvalho, Marco Solmi, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: oxidative stress; antioxidants; biomarkers; deficit schizophrenia; inflammation; cytokines; neuro-immune

Online: 9 May 2020 (03:29:18 CEST)

Show abstract| Download PDF| Share

Background: There is now evidence that schizophrenia and deficit schizophrenia are neuro-immune conditions and that oxidative stress toxicity (OSTOX) may play a pathophysiological role. Aims of the study: To compare OSTOX biomarkers and antioxidant (ANTIOX) defenses in deficit versus non-deficit schizophrenia. Methods: We examined lipid hydroperoxides (LOOH), malondialdehyde (MDA), advanced oxidation protein products (AOPP), sulfhydryl (-SH) groups, paraoxonase 1 (PON1) activity and PON1 Q192R genotypes, total radical-trapping antioxidant parameter (TRAP) as well as immune biomarkers in patients with deficit (n=40) and non-deficit (n=40) schizophrenia and healthy controls (n=40). Results: Deficit schizophrenia is characterized by significantly increased levels of AOPP and lowered -SH, and PON1 activity, while no changes in the OSTOX/ANTIOX biomarkers were found in non-deficit schizophrenia. An increased OSTOX/ANTIOX ratio was significantly associated with deficit versus non-deficit schizophrenia (Odds ratio=3.15, p<0.001). Partial least squares analysis showed that 47.6% of the variance in a latent vector extracted from psychosis, excitation, hostility, mannerism, negative symptoms, psychomotor retardation, formal thought disorders, and neurocognitive test scores was explained by LOOH+AOPP, PON1 genotype + activity, CCL11, tumor necrosis factor (TNF)-α, IgA responses to neurotoxic tryptophan catabolites (TRYCATs), whereas -SH groups and IgM responses to MDA showed indirect effects mediated by OSTOX and neuro-immune biomarkers. Discussion: Our findings indicate that with increasing overall severity of schizophrenia, neuro-immune and neuro-oxidative (especially protein oxidation indicating chlorinative stress) toxicities become more prominent and together with lowered antioxidant defenses and impairments in innate immunity-associated resilience against neurotoxic processes shape a distinct nosological entity, namely deficit schizophrenia.

Preprint ARTICLE | doi:10.20944/preprints202012.0783.v1

In Schizophrenia, Depression and Anxiety Symptoms Are Driven by Immune-Inflammatory Pathways.

Abbas Almulla, Khalid Al-Rawi, Michael Maes, Hussein Kadhem Al-Hakeim

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: depression; anxiety; melancholia; inflammation; neuro-immune; physiosomatic; biomarkers; schizophrenia

Online: 31 December 2020 (09:42:35 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202203.0186.v1

Regional Brain Volume Prior to Treatment Is Linked to Outcome after Cognitive Rehabilitation in Traumatic Brain Injury

Alexander Olsen, Emily L. Dennis, Jan Egil Stubberud, Elisabeth S. Hovenden, Anne-Kristin Solbakk, Tor Endestad, Per Kristian Hol, Anne-Kristine Schanke, Marianne Løvstad, Sveinung Tornås

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: rehabilitation medicine; magnetic resonance imaging; brain injury; executive function; personalized treatment

Online: 14 March 2022 (11:27:15 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202305.0645.v1

Exercise-Based Rehabilitation in and with Nature. A Scoping Review Mapping Available Interventions

Henriette Busk, Jonas Ahler, Alessio Bricca, Pætur Mikal Holm, Dorthe Varning Poulsen, Søren T Skou, Lars Tang

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Exercise; Rehabilitation; Nature incidental or intentional interaction; Scoping review

Online: 9 May 2023 (11:53:03 CEST)

Show abstract| Download PDF| Share

Abstract Introduction Exercise is an effective component in rehabilitation of a range of chronic conditions. There is a growing interest in the use of exercise-based nature interacted rehabilitation (EBNIR), but an overview of current evidence is missing. To provide an informed base for future work within this field of EBNIR, the objective of this scoping review was to map existing exercise-based rehabilitation interventions conducted with incidental or intentional nature interaction focusing on its populations, types of outcomes, and theoretical rationale for people with physical and mental disabilities. Methods This scoping review identified peer-reviewed publications, registered upcoming trials and grey literature. To map all available knowledge, we performed a comprehensive search of selected databases (MEDLINE; EMBASE; CINAHL; Cochrane; Web of Science; Pedro) from inception to October 2022. Data was synthesised in a thematic presentation guided by TIDieR, supplemented by a checklist developed for this study accounting nature incidental or intentional interaction by measuring all nature elements implemented in the intervention. Results Twelve studies including 856 participants met the inclusion criteria. 11 were completed trials and 1 was registered in clinicaltrials.gov to be run in 2023. A total of 856 patients were enrolled in the 12 studies (range 18-262, median 50). The included studies were different in terms of design (observational n=4, qualitative n=1, RCT=7), intervention dosage and frequency, control intervention, diagnosis, number of patients, and outcomes included. The used exercise-based interventions consisted of outdoor walks, neck exercises and surfing interventions in patients with physical or mental health conditions. The interventions were incidental or intentional interacted with nature to a varying degree. Conclusion This scoping review presents an overview of limited and diverse evidence within the field of exercise-based rehabilitation incidental or intentional interacting with nature, in patients with physical or mental health conditions. Our review provides an overview that will be helpful in the design of future EBNIR trials.

Preprint ARTICLE | doi:10.20944/preprints202009.0053.v1

A Nomothetic Network Model Disclosing the Comorbidity of Depression and Unstable Angina: Effects of Atherogenicity, Insulin Resistance, Immune Activation, Antioxidants, the Endogenous Opioid System, Trace Elements, and Macrominerals

Rana Mousa, Hasan Smesam, Hasan Qazmooz, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: unstable angina, inflammation, neuro-immune, major depression, oxidative stress, antioxidants, atherogenicity

Online: 3 September 2020 (04:40:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202010.0509.v1

Research on the International Roughness Index Threshold of Road Rehabilitation in Metropolitan Areas: A Case Study in Taipei City

Shong-Loong Chen, Chih-Hsien Lin, Chao-Wei Tang, Liang-Pin Chu, and Chiu-Kuei Cheng

Subject: Engineering, Automotive Engineering Keywords: pavement smoothness; international roughness index; urban road; road rehabilitation

Online: 26 October 2020 (10:19:41 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202012.0331.v1

Rapid Prototyping of Virtual Reality Cognitive Exercises in a Tele–Rehabilitation Context

Damiano Perri, Martina Fortunelli, Marco Simonetti, Riccardo Magni, Jessica Carloni, Osvaldo Gervasi

Subject: Computer Science And Mathematics, Computer Science Keywords: Blender; Cognitive exercises; Nu!Reha; Tele–Rehabilitation; Unity3D; Virtual Reality

Online: 14 December 2020 (13:03:01 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0181.v1

Evaluation of Electrical Efficiency of Photovoltaic Thermal Solar Collector

Mohammad Hossein Ahmadi, Alireza Baghban, Milad Sadeghzadeh, Mohammad Zamen, Amir Mosavi, Shahaboddin Shamshirband, Ravinder Kumar, Mohammad Mohammadi-Khanaposhtani

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: renewable energy; neural networks (NNs); adaptive neuro-fuzzy inference system (ANFIS); least square support vector machine (LSSVM); photovoltaic-thermal (PV/T); hybrid machine learning model

Online: 14 February 2020 (02:53:47 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201911.0342.v1

The Influence of Soft Tissue Therapy on Respiratory Efficiency and Chest Mobility of Women Suffering from Breast Cancer

Katarzyna Domaszewka

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: spirometry; VAS Pain; oncology rehabilitation

Online: 27 November 2019 (09:53:58 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202109.0455.v1

Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

Hasan Smesam, Hasan Qazmooz, Sinan Khayoon, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: inflammation; neuro-immune; cytokines; major depression; chronic fatigue syndrome; affective disorders

Online: 27 September 2021 (16:30:00 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201911.0135.v1

Increased Levels of Plasma Tumor Necrosis Factor-α Mediate Schizophrenia Symptom Dimensions and Neurocognitive Impairments and Are Inversely Associated with Natural IgM and Paraoxonase 1 Activity

Michael Maes, Sunee Sirivichayakul, Andressa Keiko Matsumoto, Annabel Maes, Ana Paula Michelin, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania G. Moreira, Decio S. Barbosa, Michel Geffard, Andre F. Carvalho, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: cytokines, neuro-immune, inflammation, antioxidants, oxidative stress, paraoxonase 1

Online: 12 November 2019 (17:02:22 CET)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints202106.0263.v1

Discharge Plan to Promote Patient Safety and Shared Decision by a Multidisciplinary Team of Healthcare Professionals in a Respiratory Unit

Daniel A. Nnate, David Barber, Ukachukwu O. Abaraogu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic obstructive pulmonary disease; discharge plan; leadership; multidisciplinary team; respiratory medicine; patient safety; pulmonary rehabilitation.

Online: 9 June 2021 (11:43:00 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0258.v1

Increased Nitro-Oxidative Stress Toxicity as a Major Determinant of Increased Blood Pressure in Mood Disorders

Kamila Landucci Bonifacio, Décio Sabbatini Barbosa, Estefânia Gastaldello Moreira, Carine Farias Coneglian, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes, Juliana Brum Moraes, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depression; oxidative and nitrosative stress; antioxidants; inflammation; neuro-immune; biomarkers

Online: 15 May 2020 (16:52:52 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202012.0180.v1

Management of Anemia of Chronic Disease: Beyond Iron-Only Supplementation.

Evasio Pasini, Giovanni Corsetti, Claudia Romano, Roberto Aquilani, Tiziano Scarabelli, Carol Chen-Scarabelli, Francesco S. Dioguardi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic diseases; iron deficiency; haemoglobin; anaemia; aminoacids; rehabilitation

Online: 8 December 2020 (06:58:25 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202007.0041.v1

Multiple Myeloma Associated Bone Disease

Stine Rasch, Thomas Lund, Jon Thor Asmussen, Anne Lerberg Nielsen, Rikke Faebo Larsen, Mikkel Østerheden Andersen, Niels Abildgaard

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Multiple myeloma; myeloma bone disease; pathophysiology; osteolysis; imaging; zoledronic acid; denosumab; vertebral augmentation; rehabilitation; exercise

Online: 5 July 2020 (04:19:18 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202205.0299.v1

Development of a Medium Care Unit Using an Inexperienced Respiratory Staff: Lessons Learned During the COVID-19 Pandemic

Olivier Van Hove, Alexis Gillet, Jérôme Tack, Gregory Reychler, Magda Guaterri, Asuncion Allarin, Justine Thomas, Rolando Espinoza Laimito, Frédéric Bonnier, Michelle Norrenberg, Pauline Daniel, Michel Toussaint, Dimitri Leduc, Bruno Bonnechère, Olivier Taton

Subject: Public Health And Healthcare, Nursing Keywords: Intermediate care unit; Middle care; Education; CPAP; Noninvasive ventilation; rehabilitation

Online: 23 May 2022 (10:41:43 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202009.0610.v1

Towards A New Model and Classification of Mood Disorders based on Risk Resilience, Neuro-Affective Toxicity, Staging, and Phenome Features Using the Nomothetic Network Psychiatry Approach

Michael Maes, Juliana Brum, Kamila Bonifacio, Decio Barbosa, Heber Vargas, Ana Paula Michelin, Sandra Nunes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: mood disorders; major depression; inflammation; neuro-immune; oxidative stress; nitrosative stress; biomarkers

Online: 25 September 2020 (11:48:43 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202110.0181.v2

Constructability of Road Pavement Layers Using New-Age (Nano) Modified Emulsion (NME) Stabilisation of Naturally Available Granular Materials in Roads Varying from Highways to Local Access Roads

Gerrit J Jordaan, Wynand J vdM Steyn

Subject: Engineering, Civil Engineering Keywords: Constructability using nanotechnology applications; nano-silane stabilisation of granular materials; highway construction; central plant mixing; recycling; rehabilitation using nano-silane technologies; materials compatibility; nanotechnology construction related problems; maintenance advantages of nanotechnology solutions

Online: 19 October 2021 (14:07:49 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1286.v1

The Facilitators and Barriers to Home-based Robotic Rehabilitation in India: A pilot feasibility study

Aravind Nehrujee, AT Prabhakar, Sathish Balaraman, Rasika Bombatkar, Henry Prakash, S SamuelKamaleshKumar, Sanjith Aaron, Suranjan Bhattacharya, Sujatha Srinivasan, Sivakumar Balasubramanian

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: stroke rehabilitation; home therapy; telerehabilitation; rehabilitation robotics

Online: 19 July 2023 (04:52:24 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202011.0170.v1

Functional Disability in Adolescents with Chronic Pain: Comparing an Interdisciplinary Exposure Program to Usual Care

Carolien Dekker, Mariëlle Goossens, Bjorn Winkens, Silvia Remerie, Caroline Bastiaenen, Jeanine Verbunt

Subject: Social Sciences, Psychology Keywords: Chronic musculoskeletal pain; Adolescents; functional disability; multidisciplinary rehabilitation.

Online: 3 November 2020 (15:41:07 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202009.0347.v1

Increased Autoimmune Responses to Oxidative Specific Epitopes in Bipolar Disorder Type 1 and Major Depression: Towards A Data-Driven, Mechanistic Model of Mood Disorders

Drozdstoy Stoyanov, Jean–Claude Leunis, Marianna Murdjeva, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mood disorders; depression; nitrosative and oxidative stress; IgM autoimmunity; neuro-immune; inflammation

Online: 16 September 2020 (04:17:25 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202110.0238.v1

Development of a Feedback Training Protocol and Clinical Force Measuring Walker for Older Patients with Restricted Upper Extremity Weight Bearing

Ansel LaPier

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Median sternotomy; Ossification; Cardiac surgery; Rehabilitation; Functional mobility; Bone fracture; Assistive device; Feedback training; Sternal precautions; Instrumented walker

Online: 18 October 2021 (10:43:01 CEST)

Show abstract| Download PDF| Share

Patients recovering from bone disruption due to trauma or surgery need to limit movement to minimize shear force, thereby protecting callus formation and osteogenesis. Patients often use their arms to assist with functional activities, but pushing is frequently limited to <10 lb (4.5 kg). With only verbal instructions, patients’ ability to accurately limit weight-bearing (WB) force is poor. A therapeutic intervention to improve patient adherence with upper extremity (UE) WB guidelines during functional mobility using an instrumented walker could be beneficial. Therefore, the purpose of this article is to describe a feedback training protocol to improve the ability to modulate weight-bearing force in older adults and then provide an overview of the efficacy of this protocol and subsequent development of a Clinical Force Measuring Walker. An instrumented walker was used to measure UE WB during functional mobility in older healthy subjects (n = 30) before, during, and after (immediately and 2 hours) a visual and auditory concurrent feedback training session. During feedback training, force was significantly reduced with all 3 sessions as compared to baseline. When using the front wheeled walker, UE WB force during the second and third feedback training trials went down compared to the first trial. During the third feedback training trial, force was greater than the two previous trials while transferring sit-to-stand and stand-to-sit. After completion of practice with feedback, UE WB force was significantly reduced and remained so 2 hours later. These findings suggest that feedback training is effective for helping patients to modulate UE WB. Use of an instrumented walker and feedback training would be beneficial in clinical practice, especially with older patients. A more intensive feedback training with additional trials and or simultaneous visual and auditory cues during whole-practice may be needed to get UE WB below a 10 lb threshold.

Preprint ARTICLE | doi:10.20944/preprints202205.0402.v1

Incorporation of Torsion Springs in a Knee Exoskeleton for Stance Phase Correction of Crouch Gait

Katy Bumbard, Harold Herrington, Chung-Hyun Goh, Alwathiqbellah Ibrahim

Subject: Engineering, Mechanical Engineering Keywords: crouch gait; torsion springs; knee exoskeleton; stance phase; gait rehabilitation

Online: 30 May 2022 (11:41:03 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Living the Full Catastrophe: A Mindfulness-Based Program to Support Recovery from Stroke

Lori A. Gray

Subject: Social Sciences, Psychology Keywords: mindfulness; mindfulness-based stress reduction; mindfulness-based stroke recovery; stroke recovery; social support for stroke survivors; medical education; stroke rehabilitation

Online: 12 September 2020 (11:29:22 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202206.0047.v1

Current Technology Developments Can Improve the Quality of Research and Level of Evidence for Rehabilitation Interventions

Bruno Bonnechère, Annick Timmermans, Sarah Michiels

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Rehabilitation; new technology; validation; study design; methods

Online: 3 June 2022 (11:12:44 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202303.0527.v1

High-Intensity Interval Training for Knee Osteoarthritis: A Narrative Review

Domiziano Tarantino, Tine Theysmans, Rosita Mottola, Jonas Verbrugghe

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: high intensity interval training; knee osteoarthritis; exercise therapy; rehabilitation; exercise rehabilitation

Online: 30 March 2023 (12:26:11 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0337.v1

Comparative Analysis of Single and Hybrid Neuro-Fuzzy-Based Models for an Industrial Heating Ventilation and Air Conditioning Control System

Sina Ardabili, Bertalan Beszedes, Laszlo Nadai, Karoly Szell, Amir Mosavi, Felde Imre

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: adaptive neuro-fuzzy inference system; ANFIS-PSO; ANFIS-GA; HVAC; hybrid machine learning

Online: 24 February 2020 (01:55:59 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202111.0116.v1

Glial-Neuronal Interactions in Pathogenesis and Treatment of Spinal Cord Injury

Nadezda Lukacova, Alexandra Kisucka, Katarina Kiss Bimbova, Maria Bacova, Maria Ileninova, Tomas Kuruc, Jan Galik

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: microglia and astrocytes phenotypes; intercellular crosstalk; lesion microenvironment; neuroinflammation; in vivo glia-to neuron reprogramming; subpial delivery; gut dysbiosis; electrostimulation; rehabilitation; neuroprotective strategies

Online: 5 November 2021 (11:14:51 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202001.0100.v1

Modeling Climate Change Impact on Wind Power Resources Using Adaptive Neuro-Fuzzy Inference System

Narjes Nabipour, Amir Mosavi, Eva Hajnal, Laszlo Nadai, Shahab Shamshirband, Kwok-Wing Chau

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: wind turbine; adaptive neuro-fuzzy inference system (ANFIS); dynamical downscaling; regional climate change model; renewable energy; machine learning

Online: 11 January 2020 (10:15:40 CET)

Show abstract| Download PDF| Share

Climate change impacts and adaptations is subject to ongoing issues that attract the attention of many researchers. Insight into the wind power potential in an area and its probable variation due to climate change impacts can provide useful information for energy policymakers and strategists for sustainable development and management of the energy. In this study, spatial variation of wind power density at the turbine hub-height and its variability under future climatic scenarios are taken under consideration. An ANFIS based post-processing technique was employed to match the power outputs of the regional climate model with those obtained from the reference data. The near-surface wind data obtained from a regional climate model are employed to investigate climate change impacts on the wind power resources in the Caspian Sea. Subsequent to converting near-surface wind speed to turbine hub-height speed and computation of wind power density, the results have been investigated to reveal mean annual power, seasonal, and monthly variability for a 20-year period in the present (1981-2000) and in the future (2081-2100). The results of this study revealed that climate change does not affect the wind climate over the study area, remarkably. However, a small decrease was projected for future simulation revealing a slightly decrease in mean annual wind power in the future compared to historical simulations. Moreover, the results demonstrated strong variation in wind power in terms of temporal and spatial distribution when winter and summer have the highest values of power. The findings of this study indicated that the middle and northern parts of the Caspian Sea are placed with the highest values of wind power. However, the results of the post-processing technique using adaptive neuro-fuzzy inference system (ANFIS) model showed that the real potential of the wind power in the area is lower than those of projected from the regional climate model.

Preprint ARTICLE | doi:10.20944/preprints202208.0243.v2

Design of Virtual Reality-Based Hippotherapy Simulator Exergaming Software and Its Controller for Rehabilitation of Children with Cerebral Palsy in Indonesia: An Engineering Concept

Ardianto Satriawan, Wildan Trusaji, Muhammad Ogin Hasanuddin, Septia Susanti Rahadini, Mayang Cendikia Selekta, Ellyana Sungkar

Subject: Engineering, Electrical And Electronic Engineering Keywords: Hippotherapy; Cerebral palsy rehabilitation; Virtual Reality; Inertial Sensors; Exergaming

Online: 29 August 2022 (12:30:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202006.0202.v1

Construction of an Exposure-Pathway-Phenotype in Children with Depression due to Transfusion-Dependent Thalassemia: Results of (Un)supervised Machine Learning

Hussein Al-Hakeim, Asawer Najm, Shatha Moustafa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: transfusion-dependent thalassemia; depression; neuro-immune; inflammation; biomarkers; oxidative stress

Online: 16 June 2020 (08:51:33 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202306.1596.v1

Hemianopia Rehabilitation: From Lab to Life, The Missing Piece

Mohammad Ahsan Khodami, Eric Altieri, Luca Battaglini

Subject: Social Sciences, Psychology Keywords: Hemianopia; Real-world conditions; Visual rehabilitation; Visual field defects

Online: 22 June 2023 (10:57:30 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Visual Biofeedback Tool for Quantitative Pressure Monitoring in Lower-Limb Prosthetic Sockets

Shruti Turner, Shivali Jain, Akhil Patel, Matthew O Hopkins, Alison H McGregor

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: prosthetics; prosthetic socket; prosthetic socket fitting; biofeedback; rehabilitation; amputation

Online: 6 October 2021 (12:58:45 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202305.1667.v1

Liphedema Rehabilitation after Breast Cancer Surgery Using Combined Physiotherapy Techniques

Maria Baltag Oana, Mihaela Apostu, Kristo Xhardo, Daniel Andrei Iordan, Ilie Onu, Mariana Cordun

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; lymphedema management; manual lymph drainage; liphedema rehabilitation after mastectomy

Online: 24 May 2023 (02:11:14 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0421.v1

How to Construct a Bottom-up Nomothetic Network Model and Disclose Novel Nosological Classes by Integrating Risk Resilience and Adverse Outcome Pathways with the Phenome of Schizophrenia

Michael Maes, Aristo Vodjani, Piotr Galecki, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: deficit schizophrenia; cytokines; inflammation; neuro-immune; oxidative stress; leaky gut

Online: 20 August 2020 (03:24:47 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202112.0196.v1

Assessment of Speech Quality during Speech Rehabilitation Based on the Solution of the Classification Problem

Evgeny Kostyuchenko, Ivan Rakhmanenko, Alexander Shelupanov, Lidiya Balatskaya, Ivan Sidorov

Subject: Computer Science And Mathematics, Information Systems Keywords: Speech Rehabilitation; Speech Quality Assessment; LSTM

Online: 13 December 2021 (10:10:36 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202010.0108.v1

Morphological Integration in Human Skull and Its Possible Role in Etiogenesis of Neuropsychiatric Disorders: Deciphering the Link between Evolution, Development and Disease

Ashutosh Kumar, Sada N. Pandey, Muneeb A. Faiq, Vikas Pareek, Ravi K. Narayan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Morphological integration; dysmorphogenesis; skull; etiogenesis; neuro-psychiatric disorders

Online: 6 October 2020 (08:29:01 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202208.0301.v1

Simultaneous Motor and Visual Intraoperative Neuromonitoring in Asleep Parietal Lobe Surgery: Dual Strip Technique

Devika Rajashekar, José Pedro Lavrador, Prajwal Ghimire, Hannah Keeble, Lauren Harris, Noemia Pereira, Sabina Patel, Ahmad Beyh, Richard Gullan, Keyoumars Ashkan, Ranjeev Bhangoo, Francesco Vergani

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: corticospinal tract; optic radiations; tractography; transcranial magnetic stimulation; subdural strip electrodes; intra-operative neuro-monitoring; parietal lobe

Online: 17 August 2022 (05:08:09 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Background: The role played by the non-dominant parietal lobe in motor cognition, attention and spatial awareness networks has potentiated the use of awake surgery. When this is not feasible, asleep monitoring and mapping techniques should be used to achieve an onco-functional balance. Objective: This study aims to assess the feasibility of a dual-strip method to obtain direct cortical stimulation for continuous real-time cortical monitoring and subcortical mapping of motor and visual pathways simultaneously in parietal lobe tumour surgery. Methods: Single-centre prospective study between May’19-November’20 of patients with intrinsic non-dominant parietal-lobe tumours. Two subdural strips were used to simultaneously map and monitor motor and visual pathways. Results: Fifteen patients were included. With regards to motor function, a large proportion of patients had abnormal interhemispheric resting motor threshold ratio (iRMTr) (71.4%), abnormal Cortical Excitability Score (CES) (85.7%), close distance to the corticospinal tract – Lesion-To-Tract Distance (LTD) – 4.2mm, Cavity-To-Tract Distance (CTD) – 7mm and intraoperative subcortical distance - 6.4mm. Concerning visual function, the LTD and CTD for optic radiations (OR) were 0.5mm and 3.4mm, respectively; the mean intensity for positive subcortical stimulation of OR was 12mA±2.3mA and 5/6 patients with deterioration of VEPs>50% had persistent hemianopia and transgression of ORs. 12 patients remained stable, one patient had a de-novo transitory hemiparesis, and two showed improvements in motor symptoms. A higher iRMTr for lower limbs was related with a worse motor outcome (p=0.013) and a longer CTD to OR was directly related with a better visual outcome (p=0.041). At 2 weeks after hospital discharge, all patients were ambulatory at home and all proceeded to have oncological treatment. Conclusion: We propose motor and visual function boundaries for asleep surgery of intrinsic non-dominant parietal tumours. Pre-operative abnormal cortical excitability of the motor cortex, deterioration of the VEP recordings and CTD<2mm from the OR were related to poorer outcomes.

Preprint REVIEW | doi:10.20944/preprints202112.0014.v1

Lower Body Positive Pressure Treadmill Training for Pediatric Gait Disorders: A Scoping Review

Yosra Cherni, Léandre Gagné-Pelletier, Laurent Bouyer, Catherine Mercier

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Pediatrics; Gait; Rehabilitation; Anti-gravity; Treadmill

Online: 1 December 2021 (12:57:48 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202208.0246.v1

Resuming Swallowing and Oral Feeding in Tracheostomized COVID-19 Patients: Experience of a Swiss COVID-Center and Narrative Literature Review

Ruben Forni, Etienne Jacot, Giovanni Ruoppolo, Antonio Amitrano, Adam Ogna

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: swallowing; tracheostomy; dysphagia; TLI; COVID-19; ARDS; rehabilitation; physiotherapy

Online: 15 August 2022 (03:50:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202111.0432.v1

Oxidative Stress and Antioxidant Defenses in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Gallayaporn Nantachai, Asara Vasupanrajit, Chavit Tunvirachaisakul, Marco Solmi, Michael Maes Michael Maes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Oxidative and nitrosative stress; antioxidants; biomarkers; neuro-immune; neurocognition

Online: 23 November 2021 (15:05:47 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1038.v1

Design and validation of a low-cost mobile EEG-based Brain-Computer Interface

Alexander R Craik, Juan Jose Gonzalez-Espana, Ayman Alamir, David Edquilang, Sarah Wong, Lianne Sanchez Rodriguez, Jeff Feng, Gerard E Francisco, Jose L Contreras-Vidal

Subject: Engineering, Electrical And Electronic Engineering Keywords: Brain Computer Interfaces; Electroencephalography; Mobile EEG; Rehabilitation; Neurodiagnostics; Motor Intent Detection

Online: 15 May 2023 (11:50:40 CEST)

Show abstract| Download PDF| Share

Objective: Design and validate a wireless, low-cost, easy-to-use, mobile, dry-electrode headset for scalp electroencephalography (EEG) recordings for closed-loop brain-computer (BCI) interface and internet-of-things (IoT) applications. Approach: The EEG-based BCI headset was designed from commercial off-the-shelf (COTS) components using a multi-pronged approach that balanced interoperability, cost, portability, usability, form factor, reliability, and closed-loop operation. Main Results: The adjustable headset was designed to accommodate 90\% of the population. A patent-pending self-positioning dry electrode bracket allowed for vertical self-positioning while parting the user's hair to ensure contact of the electrode with the scalp. In the current prototype, five EEG electrodes were incorporated in the electrode bracket spanning the sensorimotor cortices bilaterally, and three skin sensors were included to measure eye movement and blinks. An accelerometer provides monitoring of head movements. The EEG amplifier operates with 24 bits resolution up to 500 Hz sampling frequency, and can communicate with other devices using 802.11 {b/g/n/WiFi}. It has high SNR and CMRR (121 dB and 110 dB, respectively), and low input noise. In closed-loop BCI mode, the system can operate at 40 Hz, including real-time adaptive noise cancellation and 512 MB of processor memory. It supports LabVIEW as backend coding language and JS, CSS, HTML as front-end coding languages, and includes training and optimization of Support Vector Machine (SVM) neural classifiers. Extensive bench testing supports the technical specifications and human subject pilot testing of a closed-loop BCI application to support upper-limb rehabilitation provides proof-of-concept validation for device use at both the clinic and at home. Significance: The low-cost, accessibility, usability, interoperability, and programmability of the proposed closed-loop BCI system provides a low-cost solution for BCI and neurorehabilitation research and IoT applications.

Preprint ARTICLE | doi:10.20944/preprints202110.0316.v2

Engineering a Clinical Force Measuring Walker for Patients Recovering from Median Sternotomy

Ansel LaPier

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: cardiac surgery; bone fracture; median sternotomy; rehabilitation; ossicication; functional mobility; assistanve device; feedback

Online: 7 December 2021 (23:36:05 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202310.1169.v1

Movement Asymmetries: from their Molecular Origin to the Analysis of Movement Asymmetries in Sportsmen

Alexander Egoyan, Giorgi Parulava, Melinda Gilhen-Baker, Steven Baker, Giovanni N. Roviello

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: myosin; athletes; movement asymmetry; sports; physical rehabilitation; genetics; Functional Movement Screen; exercise genomics

Online: 18 October 2023 (11:48:20 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202306.0887.v1

A Semi – Three Dimensional (3D) Bioprinted Neurocardiac System for Tissue Engineering of a Cardiac Autonomic Nervous System (CANS) Model

Ivana Hernandez, Salma P. Ramirez, Wendy V. Salazar, Sarahi Mendivil, Andrea Guevara, Akshay Patel, Carla D Loyola, Zayra N. Dorado, Binata Joddar

Subject: Engineering, Bioengineering Keywords: 3D Bioprinting; neuro-cardiac junctions; 3D tissue model; Cardiomyocytes; Neuroblastoma cells

Online: 13 June 2023 (08:33:59 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0333.v1

Com@Rehab: An Interactive and Personalised Rehabilitation Activity Based on Virtual Reality

Carolina Silva, Cláudia Quaresma, Raquel Silva, Sara Carvalho, Rute Costa, Miguel Fernández, Andreia Pinto de Sousa, Ana Londral, Micaela Fonseca

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: virtual reality (VR); COVID-19; motor rehabilitation; multidisciplinary; virtual reality activity; serious games; game design; health communication

Online: 5 June 2023 (14:26:52 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.1950.v1

Overactivity of the Less Affected Side as a Possible Pattern of Asymmetry in Sitting in Persons Suffered from First-Time Ischemic Stroke – an Observative Study

Agata Zdrowowicz-Doroz, Jakub Stolarski, Karolina Krzysztoń, Izabela Domitrz, Jan Kochanowski

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: stroke, rehabilitation, sitting position

Online: 30 October 2023 (14:56:59 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202309.1953.v1

Restoration of Over-Ground Walking via Non-invasive Neuromodulation Therapy

Monzurul Alam, Yan To Ling, Md Akhlasur Rahman, Arnold Yu Lok Wong, Hui Zhong, V. Reggie Edgerton, Yong-Ping Zheng

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: chronic spinal cord injury; sensorimotor rehabilitation; transcutaneous electrical stimulation; neuromodulation; over-ground walking

Online: 28 September 2023 (06:28:20 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202306.1161.v1

Remote Sensing-Based Revegetation Assessment at Post-Closure Mine Sites in Canada

Sam Gordon, Xiaoyong Xu, Yanyu Wang

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Mine site; Revegetation; Reclamation; Rehabilitation; Land cover; Sustainable mining; Remote sensing; Landsat image

Online: 16 June 2023 (03:26:15 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202208.0184.v1

A New Architecture for Customizable Exergames: User Evaluation for Different Neuromuscular Disorders

Martina Eckert, Alicia Aglio, María Luisa Martín-Ruiz, Victor Osma-Ruiz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Exergames; Kinect; neuromuscular disesase; physical disability; rehabilitation; serious games; Virtual reality rehabilitation

Online: 10 August 2022 (03:24:24 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202302.0322.v1

Strain Gauge Integration in the Assessment and Rehabilitation of Knee Osteoarthritis

Jessica Lane, Michael Rumpf, Mark Pryer, John Cronin

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: isometric exercise; knee osteoarthritis rehabilitation; strain gauge device; physiotherapeutic practice; exercise quantification

Online: 20 February 2023 (06:18:18 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202009.0377.v1

Adaptive Neuro-Fuzzy Inference System and a Multilayer Perceptron Model Trained with Grey Wolf Optimizer for Predicting Solar Diffuse Fraction

Randall Claywell, Nadai Laszlo, Felde Imre, Amir Mosavi

Subject: Computer Science And Mathematics, Information Systems Keywords: machine learning; prediction; adaptive neuro-fuzzy inference system; adaptive network-based fuzzy inference system; diffuse fraction; multilayer perceptron

Online: 17 September 2020 (05:46:25 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0686.v1

Comparison Between Low-Level and High-Intensity Laser Therapy as An Adjunctive Treatment for Knee Osteoarthritis: A Randomized, Double-Blinded Clinical Trial

Mohd Azzuan Ahmad, Mageswari Moganan, Mohamad Shariff A Hamid, Norhuda Sulaiman, Ushantini Moorthy, Nazirah Hasnan, Ashril Yusof

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: high-intensity laser; knee osteoarthritis; low-level laser; pain; photobiomodulation; rehabilitation

Online: 10 May 2023 (04:42:48 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202112.0301.v1

The Tryptophan Catabolite or Kynurenine Pathway in Schizophrenia: Meta-Analysis Reveals Dissociations Between Central, Serum and Plasma Compartments

Abbas F. Almulla, Asara Vasupanrajit, Chavit Tunvirachaisakul, Hussein K. Al-Hakeim, Marco Solmi, Robert Verkerk, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; indoleamine-dioxygenase; inflammation; neuro-immune; oxidative and nitrosative stress; biomarkers

Online: 20 December 2021 (09:56:45 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint CASE REPORT | doi:10.20944/preprints202308.0650.v1

Effect of Physiotherapy and Treadmill Exercise in a Dog with Delayed Rehabilitation Following TPLO: A Case Report

Shin Ho Lee, Jae-Hyeon Cho, Chung-Hui Kim, Dongbin Lee

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: dog; physical therapy; treadmill exercise; rehabilitation; TPLO

Online: 9 August 2023 (03:07:00 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.1150.v1

Finite Element Analysis (FEA) Of a Premaxillary Device: A New Type of Subperiosteal Implant to Treat Severe Atrophy of the Maxilla

Alessandro Cipollina, Mario Ceddia, Natalia Di Pietro, Francesco Inchingolo, Margherita Tumedei, Tea Romasco, Adriano Piattelli, Alessandro Specchiulli, Bartolomeo Trentadue

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: maxilla atrophy; axillary rehabilitation; sinus augmentation; pterygoid implants; zygomatic implants

Online: 15 June 2023 (13:17:24 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202210.0396.v1

Feasibility Study of Cable Routing for Bi-Planar Trajectory Tracking in Cable Driven Lower Limb Exoskeleton

Rajan Prasad, Marwan El-Rich, Mohammad I. Awad, Sunil K. Agrawal, Kinda Khalaf

Subject: Engineering, Mechanical Engineering Keywords: cable driven; exoskeleton; lower limb rehabilitation; hip adduction; bi-planar trajectory; optimized routing.

Online: 26 October 2022 (03:54:13 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202312.1509.v1

Tailoring MAPK Pathways: New Therapeutics Avenues for Managing Alzheimer’s Diseases

Apoorv Sharma, Vandana Mehra, Vijay Kumar, Hridayesh Prakash

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimers Diseases; MAPK; Neuro-Immunological interaction; Neuronal Fibroblast; Microglia; Th1/17 responses

Online: 20 December 2023 (10:17:06 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1441.v1

The Effects of Incarceration on Youths’ Sense of Identity and Music-Based Rehabilitation: An Exploratory Pilot Study

Stephanie Barsoum

Subject: Arts And Humanities, Music Keywords: identity; music program; self-esteem; juvenile detention; incarceration; rehabilitation

Online: 22 August 2023 (03:40:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202209.0490.v1

Shoulder Musculoskeletal Disorder Rehabilitation Using a Robotic Device Based on Emg Biofeedback: A Retrospective Cohort Study

Martin Lavallière, Mathieu Tremblay, Etienne Ojardias, Maxime Turpin, Anaick Perrochon, Philippe Rigoard, Lisa Goudman, Maarten Moens, Romain David, Maxime Billot

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: rehabilitation; shoulder; electromyography feedback; visual biofeedback; assistive robot; musculoskeletal disorder

Online: 30 September 2022 (15:04:05 CEST)

Show abstract| Download PDF| Share

While shoulder injuries represent the musculoskeletal disorders (MSDs) most encountered in physical therapy, there is no consensus on their management. As attempts to provide standardized and personalized treatment, a robot-ic-assisted device combined with EMG biofeedback specifically dedicated to shoulder MSDs has been developed. The aim of this study was to determine the efficacy of an 8-week rehabilitation program (≈3 sessions a week) using a ro-botic-assisted device combined with EMG biofeedback (RA-EMG group) in comparison with a conventional program (CONV group) in patients presenting with shoulder MSDs. This study is a retrospective cohort study including data from 2010 to 2013 on patients initially involved in a physical rehabilitation program in a private clinic of Chicoutimi (Canada) for shoulder MSDs. Shoul-der flexion strength and range of motion were collected before and after the rehabilitation program. Forty-four patients participated in a conventional pro-gram using dumbbell (CONV group) while 72 of them completed a program on robot-assisted device with EMG and visual biofeedback (RA-EMG group), whereby both programs consisted in 2 sets of 20 repetitions at 60% of maximal capacity. Results showed that the RA-EMG had significantly greater benefits than the Conv group for shoulder flexion strength (+103.1% vs 67%, p = 0.016) and range of motion (+14.4% vs 6.1%, p = 0.046). The current retrospective co-hort study showed that a specific and tailored rehabilitation program with constant effort by automatic adjustment of the level of resistance was able to potentiate strength and range of motion shoulder flexion after an 8-week reha-bilitation period in comparison with a conventional approach in patients with shoulder MSDs. This study provides new insight on shoulder MSD rehabilita-tion and future research should be pursued to determine the added potential of this approach for abduction and external rotation with a randomized controlled design.

Preprint BRIEF REPORT | doi:10.20944/preprints202306.1409.v1

Transcutaneous Spinal Cord Stimulation Facilitates Respiratory Functional Performance in Patients with Post-acute COVID-19

Alexander Ovechkin, Tatiana Moshonkina, Natalia Shandybina, Vsevolod Lyakhovetskii, Ruslan Gorodnichev, Sergey Moiseev, Ricardo Siu, Yury Gerasimenko

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Neuromodulation; Spinal cord stimulation; Respiration; Rehabilitation; COVID-19

Online: 20 June 2023 (08:30:47 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202310.0148.v1

Beyond MOG and AQP4 Antibodies: Alternative Causes of Optic Neuritis

Giacomo Greco, Elena Colombo, Matteo Gastaldi, Lara Ahmad, Eleonora Tavazzi, Roberto Bergamaschi, Eleonora Rigoni

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neuro-ophthalmology; optic neuritis; visual loss; AQP4; MOG; GFAP; CRION; sarcoidosis; optic perineuritis

Online: 3 October 2023 (10:52:57 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202212.0183.v1

Sports Cranio-Brain Injury. Diagnostics and Prevention of Complications

Oleg Alexeevich Shevelev, Alexander Smolensky, Marina Petrova, Mikhail Yu Yuriev, Maria Aleksandrovna Zdanova, Elias Mesfin Mengistu, Inna Zelikovna Kostenkova, Darina Menzhurenkova, Sergey Vesnin, Igor Goryanin

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: hypothermia; sportstr; brain injury; rehabilitation; hyperthermia

Online: 9 December 2022 (14:50:39 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202401.2108.v1

Significant Neurodevelopmental Delays Associated with a Higher Incidence of Abnormal Behavioral Patterns and Paraphilias?

Theodor-Nicolae Carp

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: central nervous system; neurogenesis; early childhood; neurodevelopmental delay; neuro-immunological bridge; immunity; innate immunity; cytokines; chemokines; natural lymphocytes; adaptive immunity; adaptive lymphocytes

Online: 30 January 2024 (13:00:19 CET)

Show abstract| Download PDF| Share

Neurodevelopmental disorders are characterized by an amalgam of genetic and epigenetic faults implicating neuronal protein-related loss-of-function and gain-of-function respectively, hence their inclusion into the category of complex diseases. Neurodevelopmental disorders are regarded as autism spectrum disorder due to this reason; that the risk factors and phenotype constitute a spectrum of faults and protein overactivity. One example of an epigenetic factor leading to the onset of neurodevelopmental delays constitutes a set of immune response-based dysregulations, as well as the excessive growth of the adaptive immune memory of the fetus or the baby following significant infectious disease during pregnancy, as well as in babies aged 0-2, given the existence of profound links between developmental immunity and developmental neurology. Given that genetic information very likely represents a form of energy, the intake of excessive pathogen-related information may transiently overload the adaptive immune memory similarly to the manner functional pathogens do whilst inducing significant illness, and if events as such occur during important stages of neuro-immunological development, then there could often be irreversible effects upon the rate of development in neurological networks that normally have a major importance in the modulation of the related cognitive and behavioral phenotype. The full extent of evidence may only be obtained via a thorough study of the applications of physical laws into biology and medicine, given the foundational role of the physical matter in the development and maintenance of life. A common misconception is that neurodevelopmental delays are characterized solely by an accumulation of protein loss-of-function incidences in the central nervous system area, rather than a disruption of neuronal region developmental rates. For example, an overexpression of neuronal proteins related to cognition factors that is accompanied by an underexpression of proteins related to social behavior is phenotypically manifested in people with sharper rational thinking and poorer communication skills, with an impact on the abilities of decision-making as well, and this tends to be regarded as a classical example of the clinical manifestation of neurodevelopmental delays. More severe forms of autism spectrum disorder tend to implicate a more generalistic impact upon the developmental rates of key human behaviors, including those related with the development and maintenance of social and intimate relationships. Likewise, more severe implications upon regular developmental rates tend to bring a major impact upon the healthy function of related functions. As a result, lower functioning forms of neurodevelopmental delays bring fresh concerns with regards to a possible uncanny increase of incidences of deviated sexuality during years of adulthood, and in the worst cases, such deviations may lead to the planning and development of criminal activity, particularly in individuals who are or become prone to breaking the moral code that established the civilized society. What holds the concerns valid is the exponential increase in the number of lower functioning autism cases throughout the world and the major signs that such an increase will continue with a full force. One major solution to this potential future problem would be a much higher investment into awareness of the exact genetic and environmental factors that directly or indirectly result in the onset of lower-functioning autism and of the current research efforts to develop the matching support for people found in situations as such. The most important aim of future research with regards to such a scenario would be a separation of disease and disability with choices made to step into more severe forms of disease and into areas that are outside of the established moral circle.

Preprint REVIEW | doi:10.20944/preprints202401.0810.v1

Leveraging Mobile Health for Rehabilitation of Long-COVID Patients: A Scoping Review

Kim Daniels, Joanna Mourad, Bruno Bonnechère

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: telerehabilitation; COVID-19; digital healthcare; post-COVID care; health-related consequence; rehabilitation; COVID-19 sequelae

Online: 10 January 2024 (09:24:48 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202309.0358.v1

Comparison of Early Versus Traditional Rehabilitation Protocol after Rotator Cuff Repair: An Umbrella-Review

Teresa Paolucci, Francesco Agostini, Marco Conti, Sara Cazzolla, Elena Mussomeli, Gabriele Santilli, Federica Poso, Andrea Bernetti, Marco Paoloni, Massimiliano Mangone

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: rotator cuff; shoulder; rehabilitation; physiotherapy; physical therapy; exercise, pain.

Online: 6 September 2023 (10:23:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0544.v1

Co-ultraPEALut in Subjective Cognitive Impairment Following SARS-CoV-2 Infection: An Exploratory Retrospective Study

Valentina Cenacchi, Giovanni Furlanis, Alina Menichelli, Alberta Lunardelli, Valentina Pesavento, Paolo Manganotti

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Long-COVID; neuro-long-COVID; SARS-CoV-2; Cognitive impairment; Co-ultraPEALut

Online: 9 February 2024 (10:52:46 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202211.0422.v1

A Novel Adaptive Neuro-Fuzzy Based Cascaded PIDF-PIDF Controller for Automatic Generation Control Analysis of Multi-Area Multi-Source Hydrothermal System

Abinands Ramshanker, Ravi K., Jacob I. Raglend, Belwin J. Edward

Subject: Engineering, Electrical And Electronic Engineering Keywords: Automatic generation controls (AGC); Adaptive Neuro-Fuzzy controller; cascaded controller; parallel High voltage direct current (HVDC) tie-lines; Skill Optimization Algorithm (SOA)

Online: 22 November 2022 (11:24:41 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.1786.v1

The Development of a Multi-Modal Cancer Rehabilitation (including Prehabilitation) Service in Sheffield, UK: Designing the Active Together Service

Liam Humphreys, Anna Myers, Gabriella Frith, Michael Thelwell, Katie Pickering, Gary Mills, Karen Kerr, Patricia Fisher, John Kidder, Carol Keen, Suzanne Hodson, Gail Phillips, Rachel Smith, Laura Evans, Sarah Thornton, Emma Dale, Louise Maxwell, Diana M Greenfield, Robert Copeland

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Exercise prescription, exercise, physical activity, psychology, nutrition, cancer, oncology, rehabilitation, prehabilitation, barriers

Online: 25 December 2023 (09:15:52 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.2117.v1

Design and Characterization of a Self-Aligning End-Eﬀector Robot for Single-Joint Arm Movement Rehabilitation

Prem Kumar Mathavan Jeyabalan, Aravind Nehrujee, Samuel Elias, Magesh Kumar M, Sujatha Srinivasan, Sivakumar Balasubramanian

Subject: Engineering, Bioengineering Keywords: stroke; neurorehabilitation; arm rehabilitation robot; transparency; adaptive weight support; end-effector robot

Online: 1 August 2023 (03:29:32 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Traditional end-effector robots for arm rehabilitation are usually attached at the hand, primarily focusing on coordinated multi-joint training. Therapy at an individual joint level of the arm for severely impaired stroke survivors is not always possible with existing end-effector robots. The Arm Rehabilitation Robot (AREBO)—an end-effector robot—was designed to provide both single and multi-joint assisted training while retaining the advantages of traditional end-effector robots, such as ease of use and cost-effectiveness (compared to exoskeletons). This work presents the design, optimization, and characterization of AREBO for training single-joint movements of the arm. The AREBO has three actuated and three unactuated degrees of freedom, allowing it to apply forces in any arbitrary direction at its endpoint and self-align to arbitrary orientations within its workspace. The AREBO’s link lengths were optimized to maximize its workspace and manipulability. The AREBO provides single-joint training in both unassisted and adaptive weight support modes using a human arm model to estimate the human arm's kinematics and dynamics without using additional sensors. The characterization of the robot’s controller and the algorithm for estimating the human arm parameters were performed using a two degrees of freedom mechatronic model of the human shoulder joint. The results demonstrate that: (a) the movements of the human arm can be estimated using a model of the human arm and robot’s kinematics, (b) the AREBO has similar transparency to that of existing arm therapy robots in the literature, and (c) the adaptive weight support mode control can adapt to different levels of impairment in the arm. This work demonstrates how an appropriately designed end-effector robot can be used for single-joint training, which can be easily extended to multi-joint training. Future work will focus on the evaluation of the system on patients with any neurological condition requiring arm training.

Preprint ARTICLE | doi:10.20944/preprints202305.1559.v1

Educational Intervention Effects on Depression and Anxiety in Patients After Myocardial Infarction: A Randomized Controlled Trial

Lazzat M. Zhamaliyeva, Damira G. Zhamankulova, Nurgul A. Abenova, Gulbakit K. Koshmaganbetova

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: anxiety; cardiac rehabilitation; depression; medical education; primary care

Online: 23 May 2023 (04:16:09 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.0443.v1

Barriers to Cardiac Rehabilitation among Patients Diagnosed with Cardiovascular Diseases- A Scoping Review

Pupalan Iyngkaran, Pavithra Yapa Appuhamilage, Gayani Patabandige, Prasadi Saubhagya Sarathchandra Peru Kandage, Wania Usmani, Fahad Hanna

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Barriers; Cardiac Rehabilitation; Cardiovascular Diseases; prevention; scoping review

Online: 8 February 2024 (02:21:48 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.1071.v1

Error-enhancement for upper limb rehabilitation in the chronic phase after stroke: a 5-day pre-post intervention study

Marjan Coremans, Eli Carmeli, Ineke De Bauw, Bea Essers, Robin Lemmens, Geert Verheyden

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: stroke; upper limb rehabilitation; error-enhancement

Online: 14 December 2023 (10:44:20 CET)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202309.0782.v1

Implementing a Pulmonary Telerehabilitation Program for Young Adults with Post-COVID-19 Syndrome. A Brief Report

Wilmer Esparza, Alfredo Noboa, Camila Madera, Naif Mina, Patricia Acosta-Vargas, Gloria Acosta-Vargas, Mayra Carrión-Toro, Marco Santórum, Manuel Ayala-Chauvin, And Guillermo Santillán

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: telerehabilitation; COVID-19; pulmonary rehabilitation; aerobic exercises

Online: 12 September 2023 (10:42:59 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202303.0400.v1

Validity of the Maximal Heart Rate Prediction Models among Runners and Cyclists

Przemysław Seweryn Kasiak, Szczepan Wiecha, Igor Cieśliński, Tim I.M. Takken, Jacek Lach, Marcin Lewandowski, Marcin Barylski, Artur Mamcarz, Daniel Śliż

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: maximal heart rate; endurance athletes; cardiopulmonary exercise test; HRmax; cardiac rehabilitation; running; cycling

Online: 22 March 2023 (14:26:11 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.1170.v1

Research Hotspots and Trends in the Research on the Application of VR in Rehabilitation Medicine

Chen Wang, Jingqi Kong, Huiying Qi

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: VR, rehabilitation; bibliometric; research focuses; development trend

Online: 16 June 2023 (08:52:37 CEST)

Show abstract| Download PDF| Share

Search Results

292 articles found