Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Application of Next Generation Sequencing in Recurrent Glioblastoma

Daniel Zeitouni
,
Michael Catalino
ORCID logo ,
Jordan Wise
,
Sean McCabe
,
Kathryn Pietrosimone
,
Naim Rashid
,
Simon Khagi
*
Version 1 : Received: 12 July 2021 / Approved: 13 July 2021 / Online: 13 July 2021 (09:28:35 CEST)

A peer-reviewed article of this Preprint also exists.

Zeitouni, D.; Catalino, M.P.; Wise, J.; McCabe, S.; Pietrosimone, K.; Rashid, N.; Khagi, S. Clinical Application of Next-Generation Sequencing in Recurrent Glioblastoma. Onco 2021, 1, 38-48. Zeitouni, D.; Catalino, M.P.; Wise, J.; McCabe, S.; Pietrosimone, K.; Rashid, N.; Khagi, S. Clinical Application of Next-Generation Sequencing in Recurrent Glioblastoma. Onco 2021, 1, 38-48.

Abstract

BACKGROUND: Glioblastoma (GBM) is driven by various genomic alterations. Next generation sequencing (NGS) could yield targetable alterations that may impact outcomes. The goal of this study was to describe how NGS can inform targeted therapy (TT) in this patient population. METHODS: The medical records of patients (pts) with a diagnosis of GBM from 2017-2019 were reviewed. Records of patients with recurrent GBM and genomic alterations were evaluated. Objective response rates and disease control rates were deter-mined. RESULTS: A total of 87 pts with GBM underwent NGS. Forty percent (n = 35) were considered to have actionable alterations. Of the 35, 40% (n=14) pts had their treatment changed due to an alteration. The objective response rate (ORR) of this population was 43%. The disease control rate (DCR) was 100%. The absolute mean decrease in contrast enhancing disease was 50.7% (95% CI 34.8 – 66.6). CONCLUSION: NGS for GBM, particularly in the recurrent setting, yields a high rate of actionable alterations. We observed a high ORR and DCR, reflecting the value of NGS in deciding on TT to match alterations that are likely to respond. In conclusion, patient selection and availability of NGS may impact outcomes in select pts with recurrent GBM.

Keywords

Glioblastoma; Precision Medicine; Targeted Therapy; Genomics; Neuro-Oncology

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.