Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Co-ultraPEALut in Subjective Cognitive Impairment Following SARS-CoV-2 Infection: An Exploratory Retrospective Study

Version 1 : Received: 8 February 2024 / Approved: 9 February 2024 / Online: 9 February 2024 (10:52:46 CET)

A peer-reviewed article of this Preprint also exists.

Cenacchi, V.; Furlanis, G.; Menichelli, A.; Lunardelli, A.; Pesavento, V.; Manganotti, P. Co-ultraPEALut in Subjective Cognitive Impairment Following SARS-CoV-2 Infection: An Exploratory Retrospective Study. Brain Sci. 2024, 14, 293. Cenacchi, V.; Furlanis, G.; Menichelli, A.; Lunardelli, A.; Pesavento, V.; Manganotti, P. Co-ultraPEALut in Subjective Cognitive Impairment Following SARS-CoV-2 Infection: An Exploratory Retrospective Study. Brain Sci. 2024, 14, 293.

Abstract

Neurological involvement following COronaVIrus Disease 19 (COVID-19) is thought to have a neuroinflammatory etiology. Co-ultraPEALut (an antiinflammatory molecule) and luteolin (an antioxidant) yielded promising results as neuroinflammation antagonists. This study aimed at describing cognitive impairment in post-COVID patient treated with co-ultraPEALut. Montreal Cognitive Assessment (MoCA), Prospective-Retrospective Memory Questionnaire (PRMQ), Fatigue Severity Scale (FSS) and a subjective evaluation were administered at baseline and after 10 months. Co-ultraPEALut-treated patients were retrospectively compared with controls. 26 co-ultraPEALut-treated patients showed significant improvement in PRMQ (T0: 51.94±10.55, T1: 39.67±13.02, p

Keywords

Long-COVID; neuro-long-COVID; SARS-CoV-2; Cognitive impairment; Co-ultraPEALut

Subject

Medicine and Pharmacology, Neuroscience and Neurology

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