Version 1
: Received: 16 April 2021 / Approved: 19 April 2021 / Online: 19 April 2021 (14:46:46 CEST)
How to cite:
Heredia, M.; Sánchez-Robledo, V.; Gómez, I.; Criado, J.M.; Fuente, A.D.L.; Devesa, J.; Devesa, P.; Riolobos, A.S. Cell Proliferation in the Piriform Cortex of Rats with Motor Cortex Ablation Treated with Growth Hormone and Rehabilitation. Preprints2021, 2021040500. https://doi.org/10.20944/preprints202104.0500.v1
Heredia, M.; Sánchez-Robledo, V.; Gómez, I.; Criado, J.M.; Fuente, A.D.L.; Devesa, J.; Devesa, P.; Riolobos, A.S. Cell Proliferation in the Piriform Cortex of Rats with Motor Cortex Ablation Treated with Growth Hormone and Rehabilitation. Preprints 2021, 2021040500. https://doi.org/10.20944/preprints202104.0500.v1
Heredia, M.; Sánchez-Robledo, V.; Gómez, I.; Criado, J.M.; Fuente, A.D.L.; Devesa, J.; Devesa, P.; Riolobos, A.S. Cell Proliferation in the Piriform Cortex of Rats with Motor Cortex Ablation Treated with Growth Hormone and Rehabilitation. Preprints2021, 2021040500. https://doi.org/10.20944/preprints202104.0500.v1
APA Style
Heredia, M., Sánchez-Robledo, V., Gómez, I., Criado, J.M., Fuente, A.D.L., Devesa, J., Devesa, P., & Riolobos, A.S. (2021). Cell Proliferation in the Piriform Cortex of Rats with Motor Cortex Ablation Treated with Growth Hormone and Rehabilitation. Preprints. https://doi.org/10.20944/preprints202104.0500.v1
Chicago/Turabian Style
Heredia, M., Pablo Devesa and Adelaida Sánchez Riolobos. 2021 "Cell Proliferation in the Piriform Cortex of Rats with Motor Cortex Ablation Treated with Growth Hormone and Rehabilitation" Preprints. https://doi.org/10.20944/preprints202104.0500.v1
Abstract
Traumatic brain injury represents one of the main health problems in developed countries. Growth Hormone (GH) and rehabilitation have been claimed to significantly contribute to the recovery of lost motor function after acquired brain injury, but the mechanisms by which this occurs are not well understood. In this work, we have investigated cell proliferation in the piriform cortex (PC) of adult rats with ablation of the frontal motor cortex treated with GH and rehabilitation, in order to evaluate if this region of the brain, related to the sense of smell, could be involved in benefits of GH treatment. Male rats were either ablated the frontal motor cortex in the dominant hemisphere or sham-operated and treated with GH or vehicle at 35 days post-injury (dpi) for five days. At 36 dpi, all rats received daily injections of bromodeoxyuridine (BrdU) for 4 days. We assessed motor function through the paw-reaching-for-food task. GH treatment and rehabilitation at 35 dpi significantly improved the motor deficit caused by the injury and promoted an increase of cell proliferation in the PC ipsilateral to the injury, which could be involved in the improvement observed. Cortical ablation promoted greater number of BrdU+ cells in the piriform cortex that was maintained long-term, which could be involved in the compensatory mechanisms of the brain after injury.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
