Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Morphological Integration in Human Skull and Its Possible Role in Etiogenesis of Neuropsychiatric Disorders: Deciphering the Link between Evolution, Development and Disease

Version 1 : Received: 5 October 2020 / Approved: 6 October 2020 / Online: 6 October 2020 (08:29:01 CEST)

How to cite: Kumar, A.; Pandey, S.N.; Faiq, M.A.; Pareek, V.; Narayan, R.K. Morphological Integration in Human Skull and Its Possible Role in Etiogenesis of Neuropsychiatric Disorders: Deciphering the Link between Evolution, Development and Disease. Preprints 2020, 2020100108 (doi: 10.20944/preprints202010.0108.v1). Kumar, A.; Pandey, S.N.; Faiq, M.A.; Pareek, V.; Narayan, R.K. Morphological Integration in Human Skull and Its Possible Role in Etiogenesis of Neuropsychiatric Disorders: Deciphering the Link between Evolution, Development and Disease. Preprints 2020, 2020100108 (doi: 10.20944/preprints202010.0108.v1).

Abstract

Structure - function interdependence is a universal phenomenon in biological systems. Any alteration in structural features may result in change in functions–leading to natural selection of a particular trait, or dysfunctions thereof. Many such alterations arise during the course of evolution of a species and may meticulously be traced during embryonic development of an organism. Through the theoretical construct of morphological integration, a set of phenotypic traits alter in a coordinated and integrated manner during evolution and embryonic development of an organism yielding efficient environmentally adapted physiological functions pertinent to those structures. Such integration may go awry sometimes, setting the basis for genesis of diseases. Morphological integration in human skull has been established through various methods. The brain-skull co-development is handcuffed through evolution and development, and the very basis of a neuro-psychiatric disorder could be underlying in dysmorphogenesis of the skull, its consequent effect on structures, and thus functions of the pertinent brain components. Here we propose that morphological integration in human skull may be mechanistically implied in etiogenesis of certain neuro-psychiatric disorders and should be borne in mind during clinical diagnosis and therapeutic interventions.

Subject Areas

Morphological integration; dysmorphogenesis; skull; etiogenesis; neuro-psychiatric disorders

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