Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Regional Brain Volume Prior to Treatment Is Linked to Outcome after Cognitive Rehabilitation in Traumatic Brain Injury

Version 1 : Received: 11 March 2022 / Approved: 14 March 2022 / Online: 14 March 2022 (11:27:15 CET)

How to cite: Olsen, A.; Dennis, E.L.; Stubberud, J.E.; Hovenden, E.S.; Solbakk, A.; Endestad, T.; Hol, P.K.; Schanke, A.; Løvstad, M.; Tornås, S. Regional Brain Volume Prior to Treatment Is Linked to Outcome after Cognitive Rehabilitation in Traumatic Brain Injury. Preprints 2022, 2022030186 (doi: 10.20944/preprints202203.0186.v1). Olsen, A.; Dennis, E.L.; Stubberud, J.E.; Hovenden, E.S.; Solbakk, A.; Endestad, T.; Hol, P.K.; Schanke, A.; Løvstad, M.; Tornås, S. Regional Brain Volume Prior to Treatment Is Linked to Outcome after Cognitive Rehabilitation in Traumatic Brain Injury. Preprints 2022, 2022030186 (doi: 10.20944/preprints202203.0186.v1).

Abstract

Cognitive rehabilitation is useful for many after traumatic brain injury (TBI), but we lack critical knowledge about which patients benefit the most from different approaches. Advanced neuroimaging techniques have provided important insight into brain pathology and systems plasticity after TBI and have potential to inform new practices in cognitive rehabilitation. In this study, we aimed to identify candidate structural brain measures with relevance for rehabilitation of cognitive control (executive) function after TBI. Twenty-eight patients (9 female, mean age 40.5 (SD = 13.04) years) with moderate/severe TBI (>21 months since injury) that participated in a randomized controlled cognitive rehabilitation trial (NCT02692352) were included in the analyses. Regional brain volume was extracted from T1-weighted MRI scans before treatment using tensor-based morphometry. Both positive and negative associations between treatment outcome (everyday cognitive control function) and regional brain volume were observed. The most robust structural brain measures with relevance for improvement in function were observed in midline fronto-parietal regions, including the anterior and posterior cingulate cortices. The study pro-vides proof of concept and valuable insight for planning future studies focusing on neuroimaging in cognitive rehabilitation after TBI.

Keywords

rehabilitation medicine; magnetic resonance imaging; brain injury; executive function; personalized treatment

Subject

MEDICINE & PHARMACOLOGY, Clinical Neurology

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