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Preprint ARTICLE | doi:10.20944/preprints202304.0692.v1

In the wild Affect Analysis of Children with ASD using Heart rate

Kamran Ali, Sachin Shah, Charles E Hughes

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Emotion Recognition; smart bracelet; heart rate; wearable; Autism Spectrum Disorder (ASD)

Online: 21 April 2023 (08:38:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0206.v1

Innovative Multi-Site Photoplethysmography Analysis for Quantifying Pulse Amplitude and Timing Variability Characteristics in Peripheral Arterial Disease

Michael Bentham, Gerard Stansby, John Allen

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cardiovascular variability; heart-rate variability; peripheral arterial disease; photoplethysmography; pulse

Online: 10 August 2018 (13:43:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1417.v1

Harnessing the Synergy of SGLT2 Inhibitors and Continuous Ketone Monitoring (CKM) in Managing Heart Failure Among Patients with Type 1 Diabetes

Nicola Tecce, Giorgio De Alteriis, Giulia de Alteriis, Ludovica Verde, Mario Felice Tecce, Annamaria Colao, Giovanna Muscogiuri

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: heart failure; type 1 diabetes; diabetic cardiomyopathy; hospitalization; HFpEF; HFrEF; SGLT2-i; sodium-glucose cotransporter-2 inhibitors; diabetic ketoacidosis; epidemiologic studies; patient education; continuous monitoring of ketone levels; ketonemia

Online: 26 February 2024 (11:54:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1295.v1

Autonomic Function in Obese Children and Adolescents: Systematic Review and Meta-Analysis

Georgios E. Papadopoulos, Foteini Balomenou, Xenofon M Sakellariou, Christos Tassopoulos, Dimitrios N Nikas, Vasileios Giapros, Theofilos M Kolettis

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: obesity; heart rate variability; autonomic nervous system; sympathetic activity; vagal activity; children; adolescents

Online: 17 January 2024 (10:16:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0396.v1

Cardiac Laterality: Surgical Results of Right Atrial Isomerism

Diego B. Ortega-Zhindón, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, José A. García-Montes, Juan Calderón-Colmenero, Jorge L. Cervantes-Salazar

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: heterotaxy syndrome; atrial isomerism; heart surgery; congenital heart disease.

Online: 7 September 2023 (03:33:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0103.v1

Integrated Analysis of microRNA-mRNA Network Predicts Potential Regulators of Atrial Fibrillation in Human

Rong Wang, Emre Bektik, Phraew Sakon, Xiaowei Wang, Shanying Huang, Xiangbin Meng, Mo Chen, Wenqiang Han, Jie Chen, Yanhong Wang, Jingquan Zhong

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: heart disease; atrial fibrillation; atrial fibrosis; transcriptome; microRNA; RNA sequencing; syndecan-1; miR-302

Online: 7 February 2022 (19:01:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0456.v1

The Potential Use of Soluble TREM Like Transcript – 1, a Platelet-Specific Receptor, for Early Detection of Anthracyclines Induced Congestive Heart Failure (CHF) in Leukemia Patients

Siobhan Branfield, Susan LaGrand, Ian Cleary, Angelia Gibson, Anthony Valance Washington

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Keywords: keyword triggering receptor expressed in myeloid cells-like transcript (TLT-1); blood platelets; cardiovascular diseases; left ventricular ejection fraction (LVEF); biomarker; anthracyclines, Troponin I, cardiotoxicity, congestive heart failure (CHF)

Online: 7 February 2024 (17:08:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0895.v1

Ubiquitin Proteasome System Role in Diabetes-Induced Cardiomyopathy

Ortal Nahum-Ankonina, Efrat Kurtzwald-Josefson, Aaron Ciechanover, Maayan Waldman, Orna Schwartz Rohaker, Edith Hochhauser, Sam j Meyer, Dan Aravot, Moshe Philip, Yaron D. Barac

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: UPS; T2DM; Heart

Online: 11 August 2023 (08:07:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1243.v1

Thyroid and Heart: A Fatal Pathophysiological Attraction in A Controversial Clinical Liaison

Alessandro Pingitore, Francesca Mastorci, Maria Francesca Lodovica Lazzeri, Cristina Vassalle

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: thyroid; heart; thyroid abnormalities; cardioprotection; heart failure; acute myocardial infarction

Online: 17 August 2023 (05:23:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0179.v1

Analysis of the Heart Rate of Operators of Forwarding Machines during Timber Forwarding and the Dependence of Its Values on the Performed Work Activities

David Sláma, Václav Mergl, Eva Abramuszkinová Pavlíková

Subject: Engineering, Other Keywords: operator; forwarder; tractor with a timber trailer; ergonomics; heart rate; physical load

Online: 2 June 2023 (10:21:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.1143.v1

Coronary Microvascular Dysfunction and Hypertension: A Bond More Important Than We Think

Marija Zdravkovic, Viseslav Popadic, Slobodan Klasnja, Andrea Klasnja, Tatjana Ivankovic, Ratko Lasica, Dragan Lovic, Drasko Gostiljac, Zorana Vasiljevic

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronary microvascular dysfunction; hypertension; hypertensive heart disease; myocardial fibrosis; heart failure

Online: 17 November 2023 (15:28:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202105.0432.v1

Cardiac Myofibroblast and Fibrosis

Hitoshi Kurose

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: myofibroblasts; fibrosis; heart failure

Online: 19 May 2021 (07:55:59 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202401.1490.v1

Liver-Kidney-Heart Axis – A Clinical Challenge

Dina Fernandes Neto, Iago Blanco, María Melendo Viu, David Dobarro Perez, Andrés Iñiguez Romo

Subject: Medicine And Pharmacology, Internal Medicine Keywords: type-5 cardio-renal syndrome; heart failure; cirrhosis; Liver-Kidney-Heart axis

Online: 19 January 2024 (13:11:37 CET)

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Cirrhosis is a chronic disease with multiple etiologies, multiple manifestations, and multi-organ involvement. Affects about 200 million people worldwide. Its main complication is Portal hypertension (PHT). Cirrhotic cardiomyopathy is a consequence of PHT, with heart failure (HF) being the main manifestation. On the other hand, for people with cardiopathy due to other reasons beyond cirrhosis, the presence of the last could act as a trigger to acute HF. Finally, when HF and cirrhosis coexist, the renal system suffers the most, originating from type-5 cardio-renal syndrome, a complex entity with many challenges in diagnosis and treatment. This entity was recently defined and there is a lack of data on the epidemiology of this syndrome. A 77-year-old woman, with cardiovascular risk factors; heart failure with reduced ejection fraction (HFrEF), secondary ischemic and valvular cardiopathy, chronic Kidney disease (CKD), and stable decompensated cirrhosis, went to the emergency department after progressive abdominal perimeter augmentation, legs’ edema and hematochezia. It was assumed acute decompensated cirrhosis and acute decompensated chronic kidney disease, had triggered digestive bleeding and the patient stayed hospitalized. Intravenous diuretic therapy was started but, the ascites and kidney function got worse, the Nt pro-BNP grew until 1125000 pg/ml, and a transthoracic echocardiography showed important signs of congestion, isolated right ventricular dysfunction, with normal cardiac output. After teamwork’s discussion, a type-5 cardio-renal syndrome was assumed deciding not to act on tricuspid regurgitation due to the maladaptive RV remodeling. Hepatorenal syndrome treatment was begun (oral terlipressin and intravenous albumin), followed by decongestion therapy, resulting in a marked improvement in clinical presentation. The kidney, heart, and liver recovered to these basal states. With this clinical case, the authors want to show how multidisciplinary management is important to face tricuspid regurgitation and right ventricular dysfunction.

Preprint COMMUNICATION | doi:10.20944/preprints202309.1187.v1

Preliminary Study on the Immunohistochemical Expression of Galectin-3 in Hypertrophic Hearts

Cecilia Salzillo, Lorenzo Giovannico, Giuseppe Fischetti, Gerardo Cazzato, Mario Magistro, Grazia Nucci, Gabriella Serio, Andrea Marzullo

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: galectin-3; cardiac hypertrophy; immunohistochemical expression; heart transplantation; heart disease; cardiorenal syndrome

Online: 19 September 2023 (03:42:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0131.v2

Use of Deep Learning to Detect the Maternal Heart Rate and False Signals on Fetal Heart Rate Recordings

Samuel Boudet, Agathe Houzé de l'Aulnoit, Laurent Peyrodie, Romain Demailly, Denis Houzé de l'Aulnoit

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: fetal heart rate; maternal heart rate; cardiotocogram; gated recurrent unit; deep learning

Online: 22 July 2022 (03:08:59 CEST)

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We have developed deep learning models for automatic identification of the maternal heart rate (MHR) and, more generally, false signals (FSs) on fetal heart rate (FHR) recordings. The models can be used to preprocess FHR data prior to automated analysis or as a clinical alert system to assist the practitioner. Three models were developed and used to detect (i) FSs on the MHR channel (the FSMHR model), (ii) the MHR and FSs on the Doppler FHR sensor (the FSDop model), and (iii) FSs on the scalp ECG channel (the FSScalp model). The FSDop model was the most useful because FSs are far more frequent on the Doppler FHR channel. All three models were based on a multilayer, symmetric, GRU and were trained on data recorded during the first and second stages of delivery. The FSMHR and FSDop models were also trained on antepartum recordings. The training dataset contained 1030 expert-annotated periods (mean duration: 36 min) from 635 recordings. In an initial evaluation of routine clinical practice, 30 fully annotated recordings for each sensor type (mean duration: 5 h for MHR and Doppler sensors, and 3 h for the scalp ECG sensor) were analyzed. The sensitivity, positive predictive value (PPV) and accuracy were respectively 62.20%, 87.1% and 99.90% for the FSMHR model, 93.1%, 95.6% and 99.68% for the FSDop model, and 44.6%, 87.2% and 99.93% for the FSScalp model. We built a second test dataset with a more solid ground truth by selecting 45 periods (lasting 20 min, on average) on which the Doppler FHR and scalp ECG signals were recorded simultaneously. Using scalp ECG data, the experts estimated the true FHR value more reliably and thus annotated the Doppler FHR channel more precisely. The models achieved a sensitivity of 53.3%, a PPV of 62.4%, and an accuracy of 97.29%. In comparison, two experts (blinded to the scalp ECG data) respectively achieved a sensitivity of 15.7%, a PPV of 74.3%, and an accuracy of 96.91% and a sensitivity of 60.7%, a PPV of 83.5% and an accuracy of 98.24%. Hence, the models performed at expert level (better than one expert and worse than the other), although a well-trained expert with good knowledge of FSs could probably do better in some cases. The models and datasets have been included in the Fetal Heart Rate Morphological Analysis open-source MATLAB toolbox and can be used freely for research purposes.

Preprint ARTICLE | doi:10.20944/preprints202403.0565.v1

Heart-Cutting Bidimensional Liquid Chromatography for the Simultaneous Analysis of Veterinary Drugs Residues and Nucleotides Monophosphate in Sheep’s Milk

Noelia Caballero-Casero, Diego García-Gómez, José Luis Pérez Pavón, Encarnación Rodríguez-Gonzalo

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Two-dimensional liquid chromatography; heart-cutting 2D-LC; veterinary drug residue; nucleotides monophosphate; sheep’s milk

Online: 11 March 2024 (08:59:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1067.v1

Effects of Stress and Anxiety on Pregnant Women's Cardiovascular Health: A Narrative Review

Brenda-Cristiana Bernad, Mirela-Cleopatra Tomescu, Lavinia Hogea, Dana Emilia Velimirovici, Minodora Andor, Diana Lungeanu, Virgil Enătescu, Adina-Ioana Bucur, Ana Lascu, Rata Andreea Luciana, Elena Silvia Bernad, Vlad Nicoraș, Diana-Aurora Arnautu

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: pregnancy; fetus; stress; anxiety; cardiovascular diseases; heart disease risk factors; psychological; mental health

Online: 19 March 2024 (05:10:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0470.v1

From Detection to Action: A Retrospective Analysis on the Impact of Screening for Congenital Heart Disease in the NICU

Ioana Roșca, Daniela-Eugenia Popescu, Ana Maria Cristina Jura, Alina Turenschi, Cristina Filip, Alexandru Dinulescu, Andreea Teodora Constantin

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital heart disease; neonatology; prenatal diagnosis; parent support; neonatal intensive care unit; pulse oximetry; screening; echocardiography

Online: 7 April 2024 (10:34:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1122.v1

Electronic Heart (ECG) Monitoring at Birth and Newborn Resuscitation

Sarah Mende, Syed Ahmed, Lise DeShea, Edgardo Szyld, Birju A. Shah

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: electrocardiogram; heart rate; neonatal resuscitation

Online: 17 April 2024 (08:33:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1198.v1

Pirfenidone Prevents the Onset of Heart Fibrosis during Chronic Chagas Disease Cardiomyopathy

Tatiana Araújo Silva, Diane Thomas, Jair Lage Siqueira-Neto, Claudia Magalhaes Calvet

Subject: Biology And Life Sciences, Parasitology Keywords: Heart fibrosis; Chagas disease; Pirfenidone

Online: 20 November 2023 (07:34:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0466.v1

Prevalence and Intensity of Sarcocystis Infections in Alpine Chamois (Rupicapra r. rupicapra) in Germany

Steffen Rehbein, Martin Visser

Subject: Biology And Life Sciences, Parasitology Keywords: Sarcocystis; chamois; heart; diaphragm; Germany

Online: 9 October 2023 (07:36:37 CEST)

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Chamois are mountain ungulates (Subfamily Caprinae) which inhabit several medium and high altitude mountain ranges from southern Europe to the Near East. The first findings of Sarcocystis cysts in the musculature of chamois were reported in the 1970s. However, only limited work on the epidemiology of sarcocystosis and identification of the species of Sarcocystis in chamois has been done in the past. The present work was part of a comprehensive study on the parasites of chamois in Germany aiming to provide, for the first time, data on the prevalence and intensity of Sarcocystis infection in native Alpine chamois using histology examination of heart and/or diaphragm tissue samples collected from 216 chamois (40 kids and 176 chamois ranging of one up to 18 years of age). Sarcocysts were detected in either heart or diaphragm of 167/216 chamois (77.3%) with 131 of 183 heart samples and 127 of 215 diaphragm samples testing sarcocyst positive. Of the 181 chamois with both heart and diaphragm available (34 kids and animals up to 18 years of age), sarcocysts were detected in heart and/or diaphragm of 142 animals translating in an overall 78.5% prevalence of Sarcocystis infection (95%CI 72.5% - 84.4%). Sarcocysts were more frequently recorded in heart vs. diaphragm (72.4% vs. 56.4%; p=0.0021), and diaphragm positivity was associated with heart positivity (p=0.0001). Sarcocyst positivity (heart and/or diaphragm) was significantly (p<0.001) lower in kids than in the older chamois (27.1% vs. 88.6%, respectively) but prevalence did not differ between the sexes, regardless of the chamois’ age (p>0.3). Intensity of infection was generally low (<10 sarcocysts per cm² muscle cut) in both heart positive and diaphragm positive animals (94.7% and 93.7%, respectively) with heart yielding higher sarcocyst counts than diaphragm (p<0.001). Both heart and diaphragm sarcocyst counts were significantly (p<0.001) lower in kids than in the older chamois. Sarcocystis infection was demonstrated to be prevalent in chamois in Germany but intensity is apparently low. Further studies are desired to identify the species of Sarcocystis parasitizing the chamois using both phenotypic and molecular characteristics.

Preprint ARTICLE | doi:10.20944/preprints202306.0800.v1

The Role of Right Ventriculo-Arterial Coupling in Symptoms Presentation of Patients With Hypertrophic Cardiomyopathy

Andreas Angelopoulos, Evangelos Oikonomou, Alexios S. Antonopoulos, Panagiotis Theofilis, Konstantinos Kalogeras, Paraskevi Papanikolaou, George Lazaros, Gerasimos Siasos, Dimitris Tousoulis, Konstantinos Tsioufis, Charalambos Vlachopoulos

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: hypertrophic cardiomyopathy; cardiomyopathies; heart failure

Online: 12 June 2023 (08:41:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0290.v2

A New Algorithm for Estimating Fast Variations in the Heart Rate

Enrico Maria Staderini, Harish Kambampati, Amith K. Ramakrishnaiah, Stefano Mugnaini, Andrea Magrini, Sandro Gentili

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart rate variability; signal analysis

Online: 6 February 2023 (04:45:25 CET)

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Preprint REVIEW | doi:10.20944/preprints201910.0040.v1

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Dae Yun Seo, Jeong Rim Ko, Jung Eun Jang, Tae Nyun Kim, Jae Boum Youm, Hyo-Bum Kwak, Jun Hyun Bae, Amy Hyein Kim, Kyung Soo Ko, Byoung Doo Rhee, Jin Han

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: diabetes; exercise; cardiomyopathy; heart failure

Online: 3 October 2019 (13:59:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0235.v1

Bile Acid Signaling and Cardioprotection

Noorul Izzati Hanafi, Anis Syamimi Mohamed, Siti Hamimah Sheikh Abdul Kadir

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: heart; ursodeoxycholic acid; cardioprotection; signaling

Online: 11 October 2018 (08:35:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1985.v1

Analysis of P(v-a)CO2/C(a-v)O2 Ratio and Other Perfusion Markers in a Population of 98 Pediatric Patients Undergoing Cardiac Surgery

Matteo Taiana, Irene Tomasella, Alessandro Russo, Annalisa Lerose, Marcello ceola Graziadei, Luisa Corubolo, Jacopo Rama, Vittorio Schweiger, A Vignola, Enrico Polati, Giovanni Battista Luciani, Francesco Onorati, Katia Donadello, Leonardo Gottin

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Venoarterial carbon dioxide difference; congenital heart disease; cardiopulmonary bypass; post-operative care; physiologic monitoring, infant

Online: 29 August 2023 (14:20:31 CEST)

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BACKGROUNDː The so-called Low Cardiac Output Syndrome (LCOS) is one of the most common complications in pediatric patients with congenital heart disease undergoing corrective surgery. LCOS requires high concentrations of inotropes to support cardiac contractility and improve cardiac output, allowing for a better systemic perfusion. To date, serum lactate concentrations and central venous oxygen saturation (ScVO2) are the most commonly used perfusion markers, but they are not completely reliable to identify a state of global tissue hypoxia. The study aims to evaluate whether the venoarterial carbon dioxide difference/arterial-venous oxygen difference ratio [P(v-a)CO2/C(a-v)O2] can be a good index to predict the development of LCOS in the aforemen-tioned patients, so as to treat it promptly. METHODSː This study followed a population of 98 children undergoing corrective cardiac surgery from June 2018 to October 2020 at the Department of Cardiac Surgery of University Hospital Inte-grated Trust and their subsequent admission at the Postoperative Cardiothoracic Surgery Intensive Care Unit. During the study, central arterial and venous blood gas analysis were carried out before and after cardiopulmonary bypass (CPB) (pre-CPB and post-CPB), at admission to intensive care unit, before and after extubation and at any time of instability or modification of the patient’s clinical and therapeutic conditions. RESULTSː The data analysis shows that 46.9% of the children developed a LCOS (in line with the current literature) but that there is no statistically significant association between the P(v-a)CO2/C(a-v)O2 ratio and LCOS onset. Despite the limits of statistical significance, however, a 31% increase in the ratio emerged from the pre-CPB phase to the post-CPB phase when LCOS is present. CONCLUSIONSː This study confirms a statistically significant association between the most used markers in adult patients (serum lactate concentration, ScVO2 and oxygen extraction ratio-ERO2) measured in the pre-CPB phase and the incidence of LCOS onset, especially in patients with he-modynamic instability before surgery.

Preprint CASE REPORT | doi:10.20944/preprints202307.0438.v1

Exercise-Induced Arrhythmia or Munchhausen Syndrome in a Marathon Runner?

Robert Gajda, Wojciech Drygas, Jacek Gajda, Pawel Kiper, Beat Knechtle, Magdalena Kwaśniewska, Maciej Sterliński, Elżbieta Katarzyna Biernacka

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart rate monitor; endurance running; arrhythmia, tachycardia; artifacts; exertion rhythm disorders; Munchhausen syndrome; athlete's heart

Online: 7 July 2023 (07:41:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2160.v1

Wavelet Analysis of Respiratory Muscle sEMG Signals During the Physiological Breakpoint of Static Dry End-Expiratory Breath-Holding in Naive Apneists: A Pilot Study

Nataša Ž. Mišić, Mirko Ostojić, Saša Cvetković, Petar Miodragović, Zdravko Aničić, Anita Popović, Đorđe Stefanović

Subject: Engineering, Electrical And Electronic Engineering Keywords: breath-holding; hypoxia; hypercapnia; involuntary breathing movement; muscle fiber subtypes; heart rate variability; wavelet analysis; multiresolution analysis

Online: 31 May 2023 (02:41:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1181.v1

Hemodialysis Efficiency Predictor in End Stage Kidney Disease Using Real-Time Heart Rate Variability

Sung Il Im, Ye Na Kim, Hyun Su Kim, Soo Jin Kim, Su Hyun Bae, Bong Joon Kim, Jung Ho Heo, YeonSoon Jung, Hark Rim, Sung Pil Cho, Jung Hwan Park, Ho Sik Shin

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: predictors of hemodialysis; heart rate variability

Online: 16 January 2024 (13:55:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0346.v1

Heart in Patients Infected with 2019 Novel Coronavirus (COVID-19)

Abdallah Fayssoil, Benjamin Davido, Hazrije Mustafic, Aurélien Dinh, Nicolas Mansencal

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronavirus; heart; prognosis; COVID-19; ICU

Online: 19 April 2020 (13:15:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints201808.0027.v1

The Hedgehog Signaling Pathway in the Ischemic Heart, Brain, and Skeletal Muscle

Igor Giarretta, Eleonora Gaetani, Paolo Tondi, Takayuki Asahara, Roberto Pola

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Hedgehog; Ischemia; Heart; Brain; Skeletal muscle

Online: 1 August 2018 (16:31:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0100.v1

Role of Cardiac Troponin I level in predicting in-hospital outcomes in patients with ST-segment elevation myocardial infarction in Erbil-Iraq

Salam Zangana, Abdulkareem Al-Othman, Namir Al-Tawil

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cardiac troponin I; Ischemic heart disease

Online: 9 August 2016 (14:31:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0087.v1

Difference between Serum BNP Admission Level and that Detected at Discharge in Patients with ADHF Predicts Six-Month Mortality in a More Reliable Manner with Respect to Isolated BNP Determination Taken on Admission

Renato De Vecchis, Carmelina Ariano, Cesare Baldi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: natriuretic peptides; heart failure; congestion; outcome

Online: 9 August 2016 (11:33:03 CEST)

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Background According to some authors, a single isolated measurement of serum BNP executed on hospital admission would not be a sufficiently accurate method to predict the outcome of patients with ADHF. Aims For verifying this assumption, a retrospective study was conducted on patients hospitalized for ADHF. Our main objective was to ascertain whether there was any difference in midterm mortality among patients with rising BNP at discharge as compared to those with decreasing BNP at discharge. Methods Medical records were examined so as to make a partition of the ADHF patient population into two groups, the former characterized by a rise in BNP during hospitalization, and the latter exhibiting a decrease in BNP in the measurement taken at hospital discharge. Results 177 patients were enrolled in a retrospective study. Among them, 53 patients (29.94%) had increased BNPs at the time of discharge, whereas 124 (70.06%) showed decreases in serum BNP during their hospital stay. The group with patients who exhibited BNP increases at the time of discharge had higher degree of congestion evident in the higher frequency of persistent jugular venous distention and persistent orthopnea at discharge. Moreover, patients with increased BNP at the time of discharge had a lower reduction in inferior vena cava maximum diameter [1.58 ± 2.2 mm vs. 6.32 ± 1.82 mm; p (one-way ANOVA)=0.001]. In contrast, there was no significant difference in weight loss when patients with increased BNP at discharge were compared to those with no such increase. A total of 14 patients (7.9%) died during the six-month follow-up period. Cox proportional hazard analysis revealed that BNP increase at the time of discharge was an independent predictor of six-month all-cause mortality after adjustment for age, sodium at discharge, creatinine at discharge and New York Heart Association (NYHA) class at discharge (hazard ratio 34.49; 95% confidence intervals: 4.55–261.06; P =0.001). Conclusions Among patients with history of ADHF, more elevated BNP levels at the time of discharge from the hospital compared to those detected at admission identify a patient subset with higher grade of congestion and higher six-month mortality.

Preprint ARTICLE | doi:10.20944/preprints202307.2058.v1

What Are the Causes of Death Among Patients Admitted to a Contemporary Tertiary Level Cardiology Department? An Analysis of 10 Years of Morbidity & Mortality Meetings

Chun Shing Kwok, Jacopo Tafuro, Chun Wai Wong, Sadie Bennett, Donah Zachariah, Diane Barker, Adrian Morley-Davies, Duwarakan Satchithananda, Mark Gunning, Josip Andelo Borovac

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: death; acute myocardial infarction; heart failure; cardiac arrest; cardiovascular departments; sepsis; causes of death; outcomes; medical ward

Online: 31 July 2023 (09:46:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0788.v1

The Lipid-Heart Hypothesis and the Keys Equation Defined the Dietary Guidelines but Ignored the Impact of Trans-fat and High Linoleic Acid Consumption

Academic Editor: Mary T Newport, Fabian M Dayrit

Subject: Public Health And Healthcare, Health Policy And Services Keywords: lipid-heart hypothesis; Ancel Keys; saturated fat; trans-fat; polyunsaturated fat; cholesterol; heart disease; dietary guidelines

Online: 11 April 2024 (10:20:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0867.v1

Missed or Delayed Diagnosis of Heart Disease by the General Pediatrician

Ageliki A Karatza, Sotirios Fouzas, Despoina Gkentzi, Eirini Kostopoulou, Nikoleta Oikonomou, Gabriel Dimitriou, Xenophon Sinopidis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital heart disease; acquired heart disease; children; diagnostic errors; missed diagnosis; delayed diagnosis; primary care pediatrician

Online: 17 March 2024 (16:01:57 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202405.0301.v1

Congenital Complete Heart Block—To Stimulate (When?) or Not to Stimulate?

Piotr Kukla, Beata Podlejska, Jerzy Wiliński

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: congenital heart block; cardiac pacemaker; atropine; salbutamol

Online: 6 May 2024 (12:36:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0020.v1

Tachycardia-Induced Cardiomyopathy in an Infant with Atrial Flutter and Prolonged Recovery of Cardiac Function

Tomohide Sakai, Kaori Tsuboi, Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka W Ozawa, Yukiko Hata, Shojiro Ichimata, Naoki Nishida, Keiichi Hirono

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: tachycardia-induced cardiomyopathy; atrial flutter; heart failure

Online: 1 May 2024 (04:30:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0029.v1

Apolipoprotein E Gene Variation in Pakistani Type 2 Diabetic Subjects with and without Cardiovascular Complications

Shehwar Nadeem, Tahir Maqbool, Javed Anver Qureshi, Awais Altaf, Sadia Naz, Muzmmal Mateen Azhar, Inam Ullah

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Apolipoprotein E; polymorphisms; Ischemic heart disease; stroke

Online: 1 April 2024 (10:26:55 CEST)

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Background Apolipoprotein E (APOE) gene polymorphism has been implicated in the pathogenesis of various metabolic disorders, including type 2 diabetes mellitus (T2DM). Type 2 diabetes mellitus (T2DM) is a major public health concern worldwide, including in Pakistan. Cardiovascular problems linked with T2DM have a significant impact on people and society. The study's goal is to investigate the relationship between Apolipoprotein E (ApoE) genotypes, lipid profiles, and cardiovascular complications such as ischemic heart disease (IHD) and stroke. Methods: This study was carried out on 260 subjects, divided into control D1: Diabetics without cardiovascular issues. D2: Diabetics with heart disease. D3: Diabetics with stroke. D4: Diabetics with both heart disease and stroke. Anthropometric parameters (age, BMI) and risk factors (smoking, diabetes duration, hypertension) were assessed in all groups. Serum levels of TC, TG, LDL, HDL, VLDL, creatinine, BSF, and HbA1c were measured. Apolipoprotein E gene polymorphism was determined using PCR-RFLP. Results: Hypertension, BMI, and dyslipidemia, defined as elevated levels of total cholesterol, triglycerides, LDL, HDL, and VLDL, as well as uncontrolled hyperglycemia (elevated fasting blood sugar and glycated hemoglobin) in T2DM, were linked to vascular complications such as IHD and stroke. Hypertension was prevalent in 75.4% of the population, with greater rates among the elderly. Stage 2 hypertension was more prevalent in all age groups. Apolipoprotein E gene polymorphism was discovered, with genotypes 3/3, 4/4, 2/3, and 3/4 being the most prevalent. Genotype 3/4 was more common in diabetics who had IHD/stroke or both problems, whereas genotype 2/3 was linked to DM and stroke. Conclusion: It is concluded that BMI, hypertension, hyperglycemia, atherosclerosis, and dyslipidemia are linked with cardiovascular complications of type 2 diabetes. Apolipoprotein E gene polymorphism is associated with cardiovascular disease in diabetic patients by affecting the lipid profile.

Preprint REVIEW | doi:10.20944/preprints202403.0531.v1

Challenges in Echocardiography for the Diagnosis and Prognosis of Non-ischemic Hypertensive Heart Disease

Nikolaos PE Kadoglou, Angeliki Mouzarou, Nikoleta Hadjigeorgiou, Ioannis Korakianitis, Michael Myrianthefs

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Hypertensive heart disease; echocardiography; prognosis; speckle tracking

Online: 8 March 2024 (16:49:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.2153.v1

Different Mechanisms in Doxorubicin-induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations

Hien C. Nguyen, Jefferson C. Frisbee, Krishna K. Singh

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: BRCA2; BRCA1; doxorubicin; breast cancer; heart failure

Online: 28 December 2023 (05:10:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0661.v1

Survival and Recurrence of Endocarditis Following Mechanical vs. Biological Aortic Valve Replacement in Patients Aged 40 to 65 Years: Data from the INFECT-REGISTRY

Antonio Salsano, Michele Di Mauro, Laura Labate, Alessandro Della Corte, Federica Lo Presti, Michele De Bonis, Cinzia Trumello, Mauro Rinaldi, Erik Cura Stura, Guglielmo Actis Dato, Giuseppe Punta, Francesco Nicolini, Davide Carino, Carlo De Vincentiis, Andrea Garatti, Giangiuseppe Cappabianca, Andrea M Musazzi, Diego Cugola, Maurizio Merlo, Davide Pacini, Gianluca Folesani, Sandro Sponga, Igor Vendramin, Alberto Pilozzi Casado, Francesco Rosato, Elisa Mikus, Carlo Savini, Francesco Onorati, Giovanni Battista Luciani, Roberto Scrofani, Francesco Epifani, Francesco Musumeci, Antonio Lio, Andrea Colli, Giosuè Falcetta, Salvatore Nicolardi, Salvatore Zaccaria, Enrico Vizzardi, Antonio Pantaleo, Giuseppe Minniti, Emmanuel Villa, Margherita Dalla Tomba, Francesco Pollari, Fabio Barili, Alessandro Parolari, Roberto Lorusso, Francesco Santini

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: endocarditis; aortic valve replacement; prosthetic heart valve.

Online: 9 November 2023 (15:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1483.v1

Radiation Exposure Assessment in Coronary Angiography CT Scan: Establishing Diagnostic Reference Level for Northeast Assam Population

Arnabjyoti Deva Sarma, Jibon Sharma, Manash Pratim Sarma, Mrinal Kanti Singha

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: radiology; computed tomography; coronary angiography; phantom; heart

Online: 22 September 2023 (05:16:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0185.v1

Role of Chest Radiographs and Electrocardiograms in Predicting the Hemodynamics of Congenital Heart Disease

Romila Chimoriya, Gaurav Kumar, Kritika Rana, Ritesh Chimoriya, Reena Anand, Kulbhusan S. Dagar, Neeraj Awasthy

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital heart disease; chest radiograph; electrocardiogram; echocardiography

Online: 14 September 2022 (02:55:41 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202206.0258.v1

Comparison of the Use of Desflurane vs. Propofol in Aortic Valve Replacement Surgery: Differences in Nephroprotection

Jose Luis Guerrero Orriach, Alfredo Malo-Manso, Mercedes Nuñez Galo, Inmaculada Bellido Estevez, Amalio Ruiz Salas, Jose Cruz Mañas, Lourdes Garrido Sanchez, Laura Gonzalez-Alvarez

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: desflurane; cardiac surgery; halogenated; kidney; heart; preconditioning

Online: 20 June 2022 (04:52:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0116.v1

Cardioprotection of Immature Heart by Simultaneous Activation of PKA and EPAC : A Role for the Mitochondrial Permeability Transition Pore

Martin John Lewis, Igor Khaliulin, Katie Hall, M.Saadeh Suleiman

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Ischaemia/reperfusion injury; Development; Mitochondria; Immature Heart

Online: 10 January 2022 (13:38:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0493.v1

Obesity and COVID-19 Infection Severity: From Pathophysiology to Clinical Implications

Abdallah Fayssoil, Marie Charlotte De Carne De Carnavalet, Nicolas Mansencal, Frédéric Lofaso, Benjamin Davido

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; Obesity; BMI; heart; lung; severity

Online: 23 October 2020 (13:28:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0034.v1

Acupuncture on Lactate, Perceived Exertion in Recreational Athletes Submitted to HIIT

Carlos Soares Pernambuco, Rodrigo Gomes de Souza Vale, João Rafael Valentim-Silva, Carlos Alberto de Souza Filho, Vinicius do Espirito Santo de Jesus, Eliane da Silva Borges, Leandra Silva Cardoso, Isabel Cristina Regazzi, Estelio Henrique Martin Dantas

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Acupuncture; lactate; heart rate; physical performance; sustainability

Online: 2 August 2020 (14:46:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0325.v1

Effects of Acute Hypoxic Provocation on Autonomic Nervous System in Young “Healthy” Smokers Measured by Heart Rate Variability

Zdravko Taralov, Peter Dimov, Kiril Terziyski, Blagoi Marinov, Mariyan Topolov, Stefan Kostianev

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart rate variability, smoking, hypoxia, autonomic dysfunction

Online: 20 June 2018 (15:38:52 CEST)

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Background and objectives: Smoking leads to autonomic dysfunction. However, the clinical methods for diagnosing this dysfunction are not sufficient. Since exogenous hypoxia leads to changes in the autonomic cardiac control, the aim of our study was to compare the activity of the autonomic nervous system via heart rate variability (HRV) in young “healthy” smokers and non-smokers before, during and after a short-term exogenous hypoxic exposure. Methods: Twenty-one healthy non-smoking males aged 28.0±7.4 (mean±SD) and fourteen healthy smoking males aged 28.1±4.3 with 9.2±5.6 pack-years were subjected to one-hour hypoxic exposure (FiО2=12.3±1.5%) via hypoxicator (AltiPro 8850 Summit+, Altitude Tech, Canada) with simultaneous recording of electrocardiography and pulse oximetry. HRV data was derived via specific software (Kubios HRV, Finland) by analyzing the pre-hypoxic, hypoxic and post-hypoxic periods. Results: Standard deviation of the intervals between normal beats (SDNN) was higher in non-smokers in the pre-hypoxic period (62.0±32.1 vs 40.3±16.2, p=0.013) but not in hypoxia (75.7±34.8 vs 57.9±18.3, p=0.167). When comparing intragroup HRV changes of shifting from hypoxic to post-hypoxic (normoxic) conditions we found that there is a significant increase in the root mean square of successive RR interval differences (RMSSD) (65.9±40.2 vs 75.1±45.9, p=0.011) and in the high frequency (lnHF) (6.8±1.4 vs 7.2±1.3, p=0.014) and a decrease in LF/HF (3.0±2.3 vs 1.9±1.5, p<0.001), but these changes were observed only in the group of non-smokers. Conclusions: Smoking likely impairs autonomic regulation in young healthy males and may lead to a decreased HRV even before subjective clinical signs and symptoms. Hypoxic exposure test could be applied in clinical practice for early detection of autonomic dysfunction in smokers, because their parasympathetic reactivation is blunted when shifting from hypoxic to normoxic ambient conditions measured by HRV.

Preprint ARTICLE | doi:10.20944/preprints202308.0249.v1

Ultra-High Resolution Electrocardiography Enables Earlier Detection of Transmural and Subendocardial Myocardial Ischemia Compared to Conventional Electrocardiography

Kirill V. Zaichenko, Anna A. Kordyukova, Dmitry L. Sonin, Michael M. Galagudza

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart; ischemia; reperfusion; electrocardiography; ultra-high resolution electrocardiography; power spectral density; ischemic heart disease; subclinical atherosclerosis; sensitivity; risk stratification

Online: 3 August 2023 (05:17:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0508.v1

Is Continuous ECG Recording on Heart Rate Monitors the Most Expected Function by Endurance Athletes, Coaches, and Doctors?

Robert Gajda

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: heart rate monitor; ECG; portable/wearable monitoring system; heart rate variability; long-term assessment; arrhythmia; QARDIO MD VSI system

Online: 24 August 2020 (07:45:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1054.v1

Genetics and Molecular Mechanisms of Idiopathic Dilated Cardiomyopathy, a Possible Guide to Individualized Management

Diana-Aurora Arnautu, Octavian-Marius Cretu, Daniel Florin Lighezan, Minodora Andor, Ioana Citu, Dragoș Cozma, Brenda-Cristiana Bernad, Adrian-Pavel Trifa, Diana Lighezan, Elena-Silvia Bernad, Dragos Catalin Jianu, Cristian Oancea, Ioan-Radu Lala, Sergiu-Florin Arnautu, Mirela-Cleopatra Tomescu

Subject: Biology And Life Sciences, Life Sciences Keywords: dilated cardiomyopathy; genetics; heart failure; genotype - specific therapy

Online: 16 April 2024 (15:53:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0573.v1

Within-week variation of training load in Turkish elite soccer players by players positions (a GPS technology study)

Hakan BAYRAKTAR, Erkan GÜNAY, Erhan Çene, Egemen Mancı, Zeki Akyıldız

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Soccer; TRIMP; Workload; Players; Heart Rate; GPS; Microcycles.

Online: 8 April 2024 (15:01:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1313.v1

Hearables: In-ear Multimodal Data Fusion for Robust Heart Rate Estimation

Marek Zylinski, Amir Nassibi, Edoardo Occhipinti, Adil Malik, Matteo Bermond, Harry J. Davies, Danilo P. Mandic

Subject: Engineering, Bioengineering Keywords: Data fusion method; Heart rate tracing; Hearables; Wearables

Online: 22 February 2024 (12:21:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1004.v1

Predicting Long-Term Childhood Survival of Newborns with Congenital Heart Defects: A Population-Based, Prospective Cohort Study (EPICARD)

Makan Rahshenas, Nathalie Lelong, Damien BONNET, Lucile Houyel, Babak Choodari-Oskooei, Mithat Gonen, Francois Goffinet, Babak KHOSHNOOD

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: congenital heart defects; mortality; prediction; long-term; childhood

Online: 12 January 2024 (11:37:40 CET)

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Introduction: Congenital heart defects (CHD) are the most frequent group of major congenital anomalies, accounting for almost 1% of all births. They comprise a very heterogeneous group of birth defects in terms of their severity, clinical management, epidemiology and embryologic origins. Taking this heterogeneity into account is an important imperative to provide reliable prognostic information to patients and their caregivers, as well as to compare results between centers or to assess alternative diagnostic and treatment strategies. The Anatomic and Clinical Classification of CHD (ACC-CHD) aims to facilitate both the CHD coding process and data analysis in clinical and epidemiological studies. Objectives: 1) To describe the long-term childhood survival of newborns with CHD and 2) To develop and validate predictive models of infant mortality based on the ACC-CHD. Materials and Methods: This study is based on data from a population-based, prospective cohort study: Epidemiological Study of Children with Congenital Heart Defects (EPICARD). The final study population comprised 1881 newborns with CHD after excluding cases that were associated with chromosomal and other anomalies. Statistical analysis included non-parametric survival analysis and flexible parametric survival models. The predictive performance of models was assessed by Harrell’s C index and the Royston-Sauerbrei R2 with internal validation by bootstrap. Results: The overall 8-year survival rate for newborns with isolated CHD was 0.96 [0.93- 0.95]. There was a substantial difference between the survival rate of the categories of ACC-CHD. The highest and lowest 8-year survival rates were 0.995 [0.989-0.997] and 0.34 [0.21-0.50] for “interatrial communication abnormalities and ventricular septal defects” and "functionally univentricular heart", respectively. Model discrimination as measured by Harrell’s C was 87% and 89% for the model with ACC-CHD alone and the full model, which included other known predictors of infant mortality, respectively. The predictive performance as measured by R2 was 45% and 50%, for the ACC-CHD alone and the full model. These measures were essentially the same after internal validation by bootstrap. Conclusion: The ACC-CHD classification provided the basis of a highly discriminant survival model with good predictive ability for the 8-year survival of newborns with CHD. Prediction of individual outcomes remains an important clinical and statistical challenge.

Preprint CASE REPORT | doi:10.20944/preprints202311.1692.v1

One-Year Real-World Experience with Mavacamten and its Physiologic Effects on Obstructive Hypertrophic Cardiomyopathy

Daniel Kim, Emily Chu, Emily Keamy-Minor, Ishan Paranjpe, Wilson Tang, Jack O'Sullivan, Yaanik Desai, Michael Liu, Elise Munsey, Kimberly Hecker, Isabella Cuenco, Beth Kao, Ellen Bacolor, Colleen Bonnett, Andrea Linder, Kathleen Lacar, Nancy Robles, Cynthia Lamendola, Allysonne Smith, Joshua Knowles, Marco Perez, Masataka Kawana, Karim Sallam, Chad Weldy, Matthew Wheeler, Victoria Parikh, Heidi Salisbury, Euan Ashley

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: mavacamten; cardiac myosin inhibitor; hypertrophic cardiomyopathy; heart failure

Online: 27 November 2023 (11:50:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0293.v1

A Systematic Review of Individualized Heart Surgery with a Personalized Prosthesis

Faizus Sazzad, KR Ramanathan, Irwan Shah Moideen, Abdulrahman El Gohary, John C Stevens, Theo Kofidis

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: personalized; individualized; open heart surgery; implantation; systematic review

Online: 5 October 2023 (13:45:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1262.v1

Gender-Based Clinical, Therapeutic Strategies and Prognosis Differences in Atrial Fibrillation

Aurelio Quesada, Javier Quesada-Ocete, Blanca Quesada-Ocete, Victor Del Moral-Ronda, Javier Jiménez-Bello, Ricardo Rubini-Costa, Carl J. Lavie, Daniel P. Morin, Fernando De la Guía-Galipienso, Ricardo Rubini-Puig, Fabian Sanchis-Gomar

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atrial fibrillation; gender; electrical cardioversion; heart failure; mortality

Online: 17 August 2023 (07:15:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1254.v1

Parkinson's Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine model

Victor Silva da Fonsêca, Valeria de Cassia Gonçalves, Mario Augusto Izidoro, Antônio-Carlos G. de Almeida, Fernando Luiz Affonso Fonseca, Fulvio Alexandre Scorza, Josef Finsterer, Carla Alessandra Scorza

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; cardiac metabolism; heart; 6-hydroxydopamine; metabolites

Online: 16 June 2023 (14:16:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0731.v1

The Effect of Drotaverine on Gastrointestinal Motility and Heart Rate Variability in Normal, Resting Horses

Alina Anton

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: antispasmodic; heart rate variability; intestinal function; parasympathetic activity

Online: 9 June 2023 (15:50:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0415.v1

Heart Rate Estimation by Video-Based Reflec-tance Photoplethysmography

Ozzy King

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: reflectance PPG; reflectance photoplethysmography; heart rate estimation; video

Online: 24 February 2023 (02:52:59 CET)

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Non-invasive heart rate (HR) monitoring is important in clinical settings as it plays a critical role in diagnosing a range of health conditions and assessing well-being. Presently, the gold standards for HR measurement are all based on sensors which require skin contact. Apart from inconvenience, contact sensors have proven problematic in certain scenarios – they cannot be used when mechanical isolation of the patient is imperative (burn victims, patients with shaky hands and feet), cause skin damage to premature babies in the ICU and increase the risk of spreading infections. Non-contact HR monitoring using a camera has been recently shown to be a viable alternative. It is now possible to record cardiac-synchronous blood volume variations from facial videos of human subjects under ambient lighting. These variations produce corresponding changes in skin reflectance which can be extracted as a raw reflectance photoplethysmography (rPPG) signal and processed to reveal HR. In this project, an algorithmic framework for webcam-based HR detection was successfully implemented in MATLAB. The investigation was based on 100 self-captured videos (dark-skinned subject) and 48 videos (from 12 subjects, all but one fair-skinned) obtained from COHFACE – an online database of facial videos and corresponding physiological signals. While the performance metrics (mean error, SNR) of the rPPG signals obtained from the self-captured videos were poor (best case mean error of 22%), they were good enough to demonstrate the success of the implementation. The poor results were primarily imputed to skin tone as rPPG SNR is known to be particularly low for dark tones. The results of the COHFACE videos were far superior, with mean error ranging from 3% to 15% (among 8 different rPPG signals) and 0% to 9% under ambient and dedicated lighting, respectively. This investigation sets the foundation for future research directed at optimizing rPPG performance metrics for dark-skinned subjects.

Preprint ARTICLE | doi:10.20944/preprints202212.0376.v2

A Fresh View at Sports PSM-Systems

Vladimir Savostyanov, Alexander Kobelev

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Sport; Heart Rate; Breathe Rate; Monitoring; Functional Athlete Readiness; Impedance; Rheography

Online: 6 January 2023 (02:04:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0250.v1

Folic Acid Exerts Dose-Dependent Biphasic Effects on Cardiac Development of Zebrafish Embryos

Xuhui Han, Bingqi Wang, Hongjie Wang, Yao Zu

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: mthfr; folic acid; heart development; zebrafish; CRISPR/Cas9

Online: 15 September 2021 (09:16:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0110.v1

Effects of Sex and 17β-Estradiol on Cardiac Fibroblast Morphology and Signaling Activities in vitro

Kelsey Watts, Will Richardson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cardiac fibroblasts; sex-specific; estrogen; fibrosis; heart failure

Online: 6 September 2021 (17:24:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0655.v1

ATPase Inhibitor Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ

Mario Pavez-Giani, Pablo Sanchez-Aguilera, Nils Bomer, Shigeki Miyamoto, Paula Giraldo, Silke Oberdorf-Maass, Kirsten Nijholt, Salva Yurista, Hendrik Milting, Joan Heller Brown, Peter Van Der Meer, Rudolf A. de Boer, Herman H.W. Silljé, B. Daan Westenbrink

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mitochondria; Ca2+ handling; heart failure; CaMKII; cardiomyocyte hypertrophy

Online: 26 March 2021 (10:41:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0278.v1

Perinatal Cardiovascular Evaluation in Dorper Sheep: Echocardiographic Description and Behavior of the Heart Rate Variability on the Field

Amanda Sarita Cruz Aleixo, Mayra de Castro Ferreira Lima, Ana Luisa Holanda de Albuquerque, Raphael Tortorelli Teixeira, Renata Alves de Paula, Marina Cecília Grandi, Danilo Otávio Laurenti Ferreira, Lukas Garrido Albertino, Miriam Harumi Tsunemi, Simone Biagio Chiacchio, Maria Lucia G. Lourenço

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: sheep; gestation; hemodinamycs; heart rate variability; cardiac output

Online: 13 October 2020 (12:15:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0174.v1

Strangers, Friends, and Lovers Show Specific Physiological Synchronies In Different Emotional Contexts

Andrea Bizzego, Atiqah Azhari, Nicola Campostrini, Anna Truzzi, Li Ying Ng, Giulio Gabrieli, Marc H. Bornstein, Peipei Setoh, Gianluca Esposito

Subject: Social Sciences, Behavior Sciences Keywords: heart rate variability; dyads; physiological synchrony; relationship; emotion

Online: 15 November 2019 (06:09:04 CET)

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Preprint REVIEW | doi:10.20944/preprints201901.0312.v1

Functional Morphology of the Cardiac Jelly in the Tubular Heart of Vertebrate Embryos

Jörg Männer, Talat Mesud Yelbuz

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: embryonic heart tube; extracellular matrix; cardiac jelly; hydraulic skeleton; heart skeleton; valveless pumping; blood flow; non-circular cross sections; ballooning; trabeculation

Online: 30 January 2019 (11:16:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1922.v1

Statistical and Diagnostic Properties of pRR30, pRR3.25% and Asymmetrical Entropy Descriptors in Atrial Fibrillation Detection

Bartosz Biczuk, Szymon Buś, Sebastian Żurek, Jarosław Piskorski, Przemysław Guzik

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: atrial fibrillation; cardiac arrhythmia; electrocardiography; heart rate variability; entropy

Online: 26 January 2024 (13:50:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1359.v1

Recipient Pericardial Apolipoprotein Levels Might Be an Indicator of Worse Outcomes after Orthotopic Heart Transplantation

Székely Andrea MD PhD, Pállinger Éva MD PhD, Töreki Evelin MD, Ifju Mandula, Barta Bálint András MD, Szécsi Balázs MD, Losoncz Eszter MD, Dohy Zsófia MD, Barabás Imre János MD PhD, Kosztin Annamária MD PhD, Buzas I Edit MD PhD, Radovits Tamás MD PhD, Merkely Béla MD PhD

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: organ recipient; heart transplantation; primary graft dysfunction; interleukin; apolipoprotein

Online: 20 October 2023 (13:40:14 CEST)

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End-stage heart failure (ESHF) leads to hypoperfusion and edema formation in the whole body and is accompanied by neurohormonal and immunological alterations. Orthotopic heart transplantation (HTX) has been used as a beneficial option for ESHF. Due to the shortage of donor hearts, the ideal matching and timing of donors and recipients has become more important. Our aim was to explore the relationship between the clinical outcome of HTX and the cytokine and apolipoprotein profiles of the recipient pericardial fluid obtained at transplantation after opening the pericardial sac. The clinical data and the interleukin, adipokine and lipoprotein levels in the pericardial fluid of twenty recipients were investigated. Outcome variables included primer graft dysfunction (PGD), need for posttransplantation mechanical cardiac support (MCS), International Society for Heart and Lung Transplantation grade ≥ 2R rejection and mortality. Recipient risk scores were also investigated. Leptin levels were significantly lower in patients with PGD than in those without PGD (median: 6.36 [IQR: 5.55-6.62]; versus 7.54 [IQR=6.71-10.44]; p = 0.029). Higher ApoCII levels (median: 14.91 [IQR: 11.55-21.30] versus 10.31 [IQR=10.02-13.07]; p = 0.042) and ApoCIII levels (median: 60.32 [IQR: 43.00-81.66] versus 22.84 [IQR=15.84-33.39]; p=0.005) were found in patients (n=5) who died in the first 5 years after HTX. In patients who had rejection (n=4) in the first month after transplantation, the levels of adiponectin (median: 74.48 [IQR: 35.51-131.70] versus 29.96 [IQR: 19.86-42.28]; p=0.039), ApoCII (median: 20.11 [IQR: 13.06-23.54] versus 10.32 [IQR: 10.02-12.84]; p=0.007) and ApoCIII (median: 70.97 [IQR: 34.72-82.22] versus 26.33 [IQR: 17.18-40.17; p=0.029) were higher than those in the nonrejection group. Moreover, the pericardial thyroxine (T4) levels (median: 3.96 [IQR: 3.49-4.46] versus 4.69 [IQR: 4.23-5.77]; p=0.022) were lower in patients with rejection than in patients who did not develop rejection. Our results indicate that apolipoproteins can facilitate the monitoring of rejection and could be a useful tool in the forecast of early and late complications.

Preprint ARTICLE | doi:10.20944/preprints202309.1894.v1

Personality Changes Associated with Organ Transplants

Brian Carter, Laveeen Khoshnaw, Megan Simmons, Lisa Hines, Brandon Wolfe, Mitchell Liester

Subject: Medicine And Pharmacology, Transplantation Keywords: Personality change; organ transplant; heart transplant; temperament; emotions; preferences

Online: 27 September 2023 (11:08:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1645.v1

Dilated Cardiomyopathy: A New Era of Treatment

Vinicius Machado Correia, Lucas Lentini Herling de Oliveira, Vagner Madrini Junior, Ruiza Gonçalves Rocha, Juliana Alzira Gonzales O. Leguizamon, Leandro Menezes Alves da Costa, Fábio Fernandes, José Eduardo Krieger, Paulo Rogério Soares, Thiago Luis Scudeler

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: dilated cardiomyopathy; heart failure; cardiac device therapy; genetic analysis

Online: 23 August 2023 (09:20:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0732.v1

Heart Rate Variability Measurement through a Wearable Device: Another Breakthrough for Personal Health Monitoring?

Ke Li, Cristiano Cardoso, Angel Moctezuma-Ramirez, Abdelmotagaly Elgalad, Emerson Perin

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Heart rate variability, wearable device, autonomic nervous system, stress

Online: 9 August 2023 (08:13:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1283.v2

The Future of Stress Management: Integration Smartwatches and HRV Technology

Ravinder Jerath, Mohammad Syam, Shajia Ahmed

Subject: Biology And Life Sciences, Life Sciences Keywords: smartwatch; stress; wearable device; heart rate variability; comparative analysis

Online: 25 July 2023 (09:28:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0511.v1

Ergonomic Workload Evaluation of Motor-Manual Tree Processing

Eva Abramuszkinová Pavlíková, Pavel Nevrkla, Martin Rohrich

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: tree processing; ergonomic evaluation; workload; heart rate; wearable technology

Online: 7 July 2023 (13:09:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2247.v1

Experimental One Side Choppers Relating Neuro-Muscular Human Abilities to Heart Rates and Technological Evolution

Igor Parra, Maria Luisa Morales, Francisco Javier Mar, Eudald Carbonell

Subject: Arts And Humanities, Archaeology Keywords: hominins; chopper; human evolution; heart rate; piano playing; technome

Online: 30 June 2023 (11:47:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0346.v1

The Effects of Low-Dose Empagliflozin on Cardiac Function and Β-Adrenoceptor Responses in a Rat Model of Streptozotocin-Induced Diabetes

Zeynep Elif Yesilyurt, Irem Karaomerlioglu, Betul Rabia Erdogan, Gaye Ozturk, Martin C. Michel, Ebru Arioglu-Inan

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: β-adrenoceptor; diabetes; empagliflozin; heart; pressure-volume loop analysis

Online: 25 May 2022 (09:59:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0437.v1

Current Status of Glucocorticoid Usage in Solid Organ Transplantation

Simin Dashti-Khavidaki, Reza Saidi, Hong Lu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Corticosteroids; Glucocorticoids; Solid organ transplantation; Liver; Kidney; Heart; Lung

Online: 16 June 2021 (10:30:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0167.v1

Predictive Utility of Changes in Optic Nerve Sheath Diameter after Cardiac Arrest for Neurologic Outcomes

Heekyung Lee, Joonkee Lee, Hyungoo Shin, Changsun Kim, Hyuk Joong Choi, Bo Seung Kang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Heart arrest; optic nerve sheath diameter; Patient outcome assessment

Online: 10 May 2021 (10:51:42 CEST)

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Working Paper BRIEF REPORT

The Potential Role of Th17 Immune Responses in Coronavirus Immunopathology and Vaccine-induced Immune Enhancement

Peter Hotez

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: COVID-19; SARS 2; coronavirus; Th17; eosinophils; heart disease

Online: 9 April 2020 (14:45:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0384.v1

Moderate Effect of Flavonoids on Vascular and Renal Function In Spontaneously Hypertensive Rats

María Dolores Paredes, Paola Romecín, Noemi Atucha, Francisco O’Valle, Julian Castillo, M. Clara Ortiz, Joaquin Garcia-Estañ

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Flavonoids, nitric oxide, heart, kidney, sodium balance, phenylephrine, acetylcholine

Online: 20 July 2018 (12:57:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0190.v1

NOX Inhibition Improves β Adrenergic-Stimulated Contractility and Intracellular Calcium Handling in the Aged Heart

Alvaro Valdés, Guillermo Barrios, Nikol Ponce, Raul A Dulce, Daniel R Gonzalez

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: NADPH oxidases; apocynin; VAS2870; aged heart; cardiomyocytes; isoproterenol; TBARS

Online: 16 April 2018 (06:17:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0060.v1

Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats

María Dolores Paredes, Paola Romecín, Noemí M. Atucha, Francisco O’Valle, Julián Castillo, M. Clara Ortiz, Joaquín García-Estañ

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: flavonoids; nitric oxide; heart; kidney; sodium balance; phenylephrine; acetylcholine

Online: 8 March 2018 (03:31:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0744.v1

Comparative Analysis of Frailty Identification Criteria on Continuous Non-invasive Neurocardiovascular Signals during an Active Stand Test in the Irish Longitudinal Study on Ageing (TILDA)

Feng Xue, Silvin P. Knight, Emma Connolly, Aisling M. O’Halloran, Morgana Afonso Shirsath, Louise Newman, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno

Subject: Engineering, Bioengineering Keywords: NIRS; Frailty; active stand; Frailty Phenotype; Frailty Index; Clinical Frailty Scale; cardiovascular; cerebrovascular; neurocardiovascular; statistical parametric mapping; SPM; blood pressure; heart rate; brain oxygenation; TSI

Online: 13 November 2023 (10:50:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0842.v1

Prognostic Value and Limits of Heart Rate and QT-Corrected in A Large Population

Paolo Giovanardi, Cecilia Vernia, Sara Roversi, Enrico Tincani, Giuseppe Spadafora, Federico Silipo, Claudio Giberti

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: electrocardiogram; QT corrected; Bazett; heart rate; all-cause death; mortality

Online: 12 April 2024 (09:54:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0277.v1

Compartmentalized Development of the Chordae Tendineae and Anterior Leaflet of the Bovine Mitral Valve

Meghan Martin, Chih-Ying Chen, Timothy McCowan, Sarah Wells

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart valves; extracellular matrix; remodeling; elastin; cardiac development; collagen; valvulogenesis

Online: 5 March 2024 (15:05:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1191.v1

Combined Pharmacological Modulation of Translational and Transcriptional Activity Signaling Pathways as a Promising Therapeutic Approach in Children With Myocardial Changes

Andrii Kamenshchyk, Igor Belenuchev, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: myocardial hypertrophy; children; gene expression signaling pathways; pharmacological modulation; heart

Online: 21 February 2024 (04:42:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1697.v1

Interplay of Angiotensin Peptides, Vasopressin and Insulin in the Heart: Altered Interactions in Obesity and Diabetes Mellitus

Ewa Szczepańska-Sadowska

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Angiotensin; diabetes mellitus; heart failure; hypertension; hypoxia; insulin; obesity; vasopressin

Online: 22 December 2023 (08:12:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1152.v1

A Technical Comparative Heart Disease Prediction Framework Using Boosting Ensemble Techniques

Najmu Nissa, Sanjay Jamwal, Mehdi Neshat

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Heart Disease; Diagnosis, Machine Learning; Boosting; Ensemble learning; Comparative framework

Online: 18 December 2023 (02:45:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0576.v1

Acute Effect of Positive Airway Pressure on Heart Rate Variability in Obstructive Sleep Apnea

Ji Hye Shin, Min Ji Song, Ji Hyun Kim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Obstructive sleep apnea; heart rate variability; continuous positive airway pressure

Online: 9 November 2023 (09:13:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1332.v1

Hippo Signaling Mediates TGFβ-Dependent Transcriptional In-Puts in Cardiac Cushion Mesenchymal Cells to Regulate Extracel-Lular Matrix Remodeling

Mrinmay Chakrabarti, Ahad Chattha, Abhijith Nair, Kai Jiao, Jay D Potts, Lianming Wang, Scotty Branch, Shea Harrelson, Saeed Khan, Mohamad Azhar

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Transforming growth factor beta; YAP; SMAD3; Heart Valve; Extracellular matrix

Online: 20 October 2023 (12:22:01 CEST)

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Abstract: The transforming growth factor beta (TGFβ) and Hippo signaling pathways are evolutionarily conserved pathways that play a critical role in cardiac fibroblasts during embryonic development, tissue repair, and fibrosis. TGFβ and Hippo signaling is also important for cardiac cushion remodeling and septation during embryonic development. Loss of TGFβ2 in mice causes cardiac cushion remodeling defects resulting in congenital heart disease. In this study, we used in vitro molecular and pharmacologic approaches in the cushion mesenchymal cell line (tsA58-AVM) and investigated if Hippo pathway acts as a mediator of TGFβ2 signaling. Immunofluorescence staining showed that TGFβ2 induced nuclear translocation of activated SMAD3 in the cushion mesenchymal cells. In addition, the results indicated increased nuclear localization of Yes associated protein 1 (YAP1) following a similar treatment of TGFβ2. In collagen lattice formation assays, TGFβ2 treatment of cushion cells resulted in an enhanced collagen contraction compared to the untreated cushion cells. Interestingly, verteporfin, a YAP1 inhibitor, significantly blocked the ability of cushion cells to contract collagen gel in absence or presence of by exogenously added TGFβ2. To confirm the molecular mechanisms of verteporfin induced inhibition of TGFβ2-dependent extra-cellular matrix (ECM) reorganization we performed gene expression analysis of key mesenchymal genes involved in ECM remodeling in heart development and disease. Our results confirmed that verteporfin significantly decreased the expression of α-smooth muscle actin (Acta2), collagen 1a1 (Col1a1), Ccn1 (i.e., Cyr61), and Ccn2 (i.e., Ctgf). Western blot analysis indicated that verteporfin treatment significantly blocked TGFβ2-induced activation of SMAD2/3 in cushion mesenchymal cells. Collectively, these results indicate that TGFβ2 regulation of cushion mesenchymal cell be-havior and ECM remodeling is mediated by YAP1. Thus, TGFβ2 and Hippo pathway integration represents an important step in understanding the etiology of congenital heart disease.

Preprint ARTICLE | doi:10.20944/preprints202310.0971.v1

Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease

Amanda Fortes Francisco, Giovane R. Sousa, Mhairi Vaughan, Harry Langston, Archie Khan, Shiromani Jayawardhana, Martin C. Taylor, Michael D. Lewis, John M. Kelly

Subject: Biology And Life Sciences, Parasitology Keywords: Trypanosoma cruzi; electrocardiography (ECG); Chronic Chagas Cardiomyopathy; Chagas heart disease

Online: 16 October 2023 (12:36:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1743.v1

Aggravation of Health Problems Subsequent to COVID-19 Lockdown

Fatma Nese Efil, Sania Qureshi, Nezihal Gokbulut, Evren Hınçal, Amanullah Soomro

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Covid-19; mathematical modeling; cancer; diabetes; heart diseases; sensitivity analysis

Online: 26 September 2023 (10:40:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0500.v2

Cardiovascular Response to Exercise in Vertebrates: Update

Antonio López-Román, Raquel Gómez-Lucas, Elena Jiménez-Herranz, Francisco Javier Calderón-Montero, Juan José Ramos-Álvarez

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: ; vertebrates; arterial pressure; cardiac output; exercise; heart rate; stroke volume ;

Online: 17 January 2024 (13:19:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.2222.v1

Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?

Martina Belli, Lucy Barone, Susanna Longo, Francesca Romana Prandi, Dalgisio Lecis, Rocco Mollace, Davide Margonato, Saverio Muscoli, Domenico Sergi, Massimo Federici, Francesco Barillà

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Gut microbiota; Cardiovascular diseases; Trimethylamine N-Oxide; Heart failure; Atherosclerosis

Online: 30 June 2023 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0362.v1

Cardioprotective Potential of the Ethanol and Water Extracts of Four Psilocybin Mushrooms on Angiotensin II-Induced Hypertrophy and Oxidative Stress on H9C2 Cardiomyocytes

Sanah Malomile Nkadimeng, Christiaan Martin Steinmann, Jakobus Nicolaas Eloff

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: reactive oxygen species; angiotensin II; hypertrophy; psilocybin mushrooms; heart failure

Online: 6 June 2023 (03:07:37 CEST)

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Psilocybin-containing mushrooms, commonly known as magic mushrooms have antidepressant effect, however, their safety in cardiovascular diseases such as heart failure is not fully known and needs to be investigated. Cardiac hypertrophy is an independent risk factor for heart failure morbidity and mortality. Angiotensin II (Ang-II) plays a major role in the pathogenesis of cardiac hypertrophy. We investigated the cardiovascular safety of extracts of Panaeolus cyanescens, Psilocybe natalensis, Psilocybe cubensis, and Psilocybe cubensis leucistic A+ strain mushrooms, well-known psilocybin-containing mushrooms in the Panaeolus and Psilocybe genus on Ang II-induced hypertrophy oxidative stress. The four mushrooms were grown, dried and extracted with 70% ethanol, cold and hot water. Extracts were tested for cytotoxicity on H9C2 cardiomyoblast cells. The cardiomyocytes were induced with (10 µM) AngII and treated with the three extracts of the four mushrooms over 48 hours. Control cells were serum starved but neither AngII induced nor treated while AngII cells were serum starved and stimulated with AngII but not treated. Losartan, an inhibitor of AngII type 1 receptor was used as positive control. Effects of the extracts on actin-filament labelling and cell surface area, mitochondrial activity, reactive oxygen species (ROS) and atrial natriuretic peptide levels were determined. Stimulation with AngII lowered cell viability, increased the cell width measurements and intracellular ROS levels significantly compared to control cells. The results indicated that the ethanol and water extracts of the four psilocybin mushrooms did not exacerbate the angiotensin II-induced hypertrophy conditions, but the extracts had cardio-protective activity against angiotensin II-induced oxidative stress. The phytochemical analysis of the extracts confirmed detections of known compounds with antioxidant and anti-inflammatory effects in the water and ethanol extracts of these four psilocybin mushrooms.

Preprint ARTICLE | doi:10.20944/preprints202305.1899.v1

The Effect of Caffeine on the Heart Rate Variability in Newborns: A Pilot Study

Helena Lenasi, Eva Rihar, Jerneja Filipič, Matjaž Klemenc, Petja Fister

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: newborn; heart rate variability; caffeine; apnoea; apnea; autonomic nervous system

Online: 26 May 2023 (09:36:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0784.v1

Clinical, Genetic, and Epidemiological Characteristics of Ar-Rhythmogenic Cardiomyopathy Associated With the Pathogenic Founder Variant NP_00454563.2 (p.Glu259Glyfs*77) in Gene PKP2

Ainhoa Robles-Mezcua, Amalio Ruiz-Salas, Carmen Medina-Palomo, María Robles-Mezcua, Arancha Díaz-Expósito, María Victoria Ortega-Jiménez, Juan Ramón Gimeno-Blanes, Manuel Jiménez-Navarro, José Manuel García-Pinilla

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Arrhythmogenic Cardiomyopathy; PKP2; Founder pathogenic variant; Arrhythmic events; Heart Failure

Online: 11 May 2023 (04:38:37 CEST)

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Introduction and objectives: arrhythmogenic cardiomyopathy (ACM) is a hereditary heart disease defined by the progressive replacement of the ventricular myocardium with fibroadipose tissue, which can act as a substrate for arrhythmias, sudden death, or even give rise to heart failure (HF). Sudden death is frequently the first manifestation of the disease, particularly among young patients. The aim of this study is to describe a new pathogenic variant in the PKP2 gene. Methods: A descriptive observational study that included 8 initially non-interrelated families with a diagnosis of ACM undergoing follow-up at our HF and Familial Cardiomyopathies Unit, who were carriers of the NM_004572.3:c.775_776insG; p. (Glu259Glyfs*77) variant in PKP2 gene. The genetic testing employed next-generation sequencing for the index cases, and the Sanger method for the targeted study with family members. We compiled personal and family histories, demographic and clinical characteristics, data from the additional tests at the time of diagnosis, and arrhythmic events at diagnosis and during follow-up. Results: We included 47 subjects, of whom 8 were index cases (17%). Among the evaluated family members, 16 (34%) were carriers of the genetic variant, 3 of whom also had a diagnosis of ACM. The majority were women (26 patients; 55.3%), with a mean age on diagnosis of 48.9 ± 18.6 years, and a median follow-up of 39 [24-59] months. Worthy of note are the high incidence of arrhythmic events as the form of presentation and in follow-up (21.5% and 20.9% respectively), and the onset of HF in 25% of the sample. The most frequent ventricular involvements were right (4 patients 16.7%) and biventricular (4 patients 16.7%); we found no statistical differences in any of the variables analysed. Conclusions: This variant is a pathogenic variant of gene PKP2 that has not previously been described and is not present in the control groups associated with ACM. It has incomplete penetrance, a highly variable phenotypic expressivity, and was identified in 8 families of our geographical area in Malaga (Andalusia, Spain), where we can establish a founder effect and describe the clinical and risk characteristics.

Preprint ARTICLE | doi:10.20944/preprints202305.0713.v1

ECG Recordings as Predictors of Very Early Autism Likelihood: A Machine Learning Approach

Deepa Tilwani, Jessica Bradshaw, Amit P. Sheth, Christian O'Reilly

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Autism Spectrum Disorder, Biomarker, Electrocardiograms, Machine Learning, Heart rate variability.

Online: 10 May 2023 (08:42:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0097.v1

Prognostic Implications of Physical Activity on Mortality from Ischaemic Heart Disease: Longitudinal Cohort Study Data

Dalia Luksiene, Vilma Jasiukaitiene, Ricardas Radisauskas, Abdonas Tamosiunas, Martin Bobak

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: physical activity; mortality risk; ischaemic heart disease; longitudinal cohort study

Online: 3 May 2023 (04:52:51 CEST)

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