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Preprint ARTICLE | doi:10.20944/preprints201703.0227.v1

New Link between Skin Microbiota Diversity and Skin Health: Proposal to Use This as a Mechanism to Determine Whether Cosmetic Products Damage the Skin and Are a Cause of the Skin Allergy Epidemic

Christopher Wallen-Russell, Sam Wallen-Russell

Subject: Medicine And Pharmacology, Dermatology Keywords: biodiversity; skin allergy; benchmark skin health values; effect of synthetic cosmetics on skin; 21st century skin ailments; measure skin health; healthy skin ecosystem; healthy skin bacteria; damaged skin bacteria; perfect skin

Online: 31 March 2017 (08:52:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0500.v1

Respect of Skin Microbiome with Different Types of LeavE-on Skincare Products, an Ecobiological Approach

Sylvie Callejon, Félix Giraud, Florence Larue, Armonie Buisson, Léa Matéos, Laurence Grare, Aurélie Guyoux, Eric Perrier, Nathalie Ardiet, Sandra Trompezinski

Subject: Medicine And Pharmacology, Dermatology Keywords: skin microbiome; skincare; cosmetic products; ecobiology; microbiome friendly

Online: 31 May 2020 (20:12:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0169.v1

Explicit Formula for Average Run Length of Double Moving Control Chart for INAR(1) Processes

Sukanya Phant, Saowanit Sukparungsee, Yupaporn Areepong

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: average run length; double moving average control chart; Poisson count process

Online: 18 August 2016 (07:27:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0020.v1

Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling

Jean Christopher Chamcheu, Islam Rady, Roxane-Cherille N. Chamcheu, Abu Bakar Siddique, Melissa B. Bloch, Sergette Banang Mbeumi, Abiola S. Babatunde, Mohammad B. Uddin, Felicite K. Noubissi, Peter W. Jurutka, Yong-Yu Liu, Vladimir S. Spiegelman, G. Kerr Whitfield, Khalid A. El Sayed

Subject: Medicine And Pharmacology, Dermatology Keywords: Annona muricata; apoptosis; basal cell carcinoma; cutaneous squamous cell carcinoma; graviola; Hedgehog signaling pathway; natural products chemistry; non-melanoma skin cancer

Online: 1 June 2018 (13:00:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0280.v1

Spraying of dsRNA Molecules Derived from Phytophthora Infestans, as a Plant Protection Strategies for the Management of Potato Late Blight

Sundaresha S., Sanjeev Sharma, Aarti Bairwa, Maharishi Tomar, Ravinder Kumar, Vinay Bhardwaj, Jeevalatha A, Rahul Bakade, Neha Salaria, Kajal Thakur, Bir Pal Singh, Chakrabarti S.K

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Double stranded RNA; Nano clay; Phytophthora infestans; Potato; Spray Induced gene silencing (SIGS)

Online: 11 February 2021 (11:07:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0256.v1

Using Double-Bounded Dichotomous-Choice to Estimate Households’ Willingness to Pay for Improved Water Quality in Bac Ninh Province of Vietnam

Nguyen Van Song , Vu Ngoc Huyen, Le Thi Phuong Dung

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: double-bounded dichotomous-choice; willingness to pay; water quality improvement; handicraft households

Online: 22 September 2019 (16:06:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0060.v1

Biomass-Derived, Interconnected and Reticular Carbon Microtubes Electrodes for Symmetric Capacitors

Nannan Wang, Ning Zhang, Wutao Wei, Shizhong Cui, Hongwei Hou, Guangshan Zhu, Weihua Chen, Liwei Mi

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: elasticbiomass; tubular structure; interconnected porous carbon; electric double layer capacitance

Online: 13 March 2017 (08:01:13 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0425.v1

Periorbital Hyperpigmentation, a Dermatologic Condition Having a Strong Geographic and Ethnic Determinism

Felicia Andrei, Daciana Grujic, Cristina Lazar, Anca Dragomirescu

Subject: Medicine And Pharmacology, Dermatology Keywords: hyperpigmentation; palpebral region; geographic skin differences; ethnic predisposition; skin disorder;

Online: 23 July 2018 (12:56:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0258.v1

Hybrid Feature Fusion and Machine Learning Approaches for Melanoma Skin Cancer Detection

Md. Mahbubur Rahman, Mostofa Kamal Nasir, Nur A-Alam, Saikat Islam Khan, Shahab Band, Iman Dehzangi, Amin Beheshti, Hamid Alinejad Rokny

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Skin cancer; Deep learning; Hybrid feature extractor; Local binary pattern; Feature extraction

Online: 18 January 2022 (12:43:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0035.v1

Characterization of a Bbotybirnavirus Conferring Hypovirulence in the Pear Stem Wart Disease Phytopathogenic Fungus Botryosphaeria dothidea

Lifeng Zhai, Mengmeng Yang, Meixing Zhang, Ni Hong, Guoping Wang

Subject: Biology And Life Sciences, Virology Keywords: Botryosphaeria dothidea botybirnavirus 1; Hypovirulence; Botybirnavirus; Genome; Botryosphaeria dothidea; double-stranded RNA virus

Online: 4 February 2019 (13:44:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0677.v1

Heterogeneous Double Metal Cyanide Catalyzed Synthesis of Poly(ε-caprolactone) Polyols for the Preparation of Thermoplastic Elastomers

Chinh Hoang Tran, Min Woong Lee, Sang Woo Park, Jae Eon Jeong, Soo Jeong Lee, Wenliang Song, PilHo Huh, Il Kim

Subject: Chemistry And Materials Science, Biomaterials Keywords: double metal cyanide; heterogeneous catalysis; caprolactone; ring-opening polymerization; thermoplastic elastomer

Online: 30 July 2021 (09:07:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202003.0293.v1

Gut Microbiome Production and Modulation of Hormones That Influence Host Skin Health

Mia Maguire, Greg Maguire

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: skin; gut; microbiome; hormones

Online: 19 March 2020 (02:23:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0133.v1

Sunburn Protection by Sunscreen Sprays at Beach

Hao Ou-Yang, Richard Bradley Rzendzian

Subject: Biology And Life Sciences, Biophysics Keywords: erythema; swimming; re-application; exposed skin surface; natural sunlight

Online: 17 March 2017 (04:59:23 CET)

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Preprint REVIEW | doi:10.20944/preprints201711.0204.v1

Pediatric Thermal Burns and Treatment: A Review of Progress and Future Prospects

Elton Mathias, Madhu Srinivas Murthy

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: burns; treatment; pediatric; autograft; biological skin substitute; thermal

Online: 30 November 2017 (14:12:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201706.0099.v1

Failure assessment of steel/CFRP double strap joints

Hamid Reza Majidi, Seyed Mohammad Javad Razavi, Filippo Berto

Subject: Engineering, Mechanical Engineering Keywords: double strap joint; failure load prediction; finite element analysis; steel; stress-based failure criterion.

Online: 21 June 2017 (03:26:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0285.v1

Analysis of Tilt Effect on Notch Depth Profiling Using Thin-Skin Regime of Driver-Pickup Eddy-Current Sensor

Mingyang Lu, Xiaobai Meng, Ruochen Huang, Anthony Peyton, Wuliang Yin

Subject: Engineering, Electrical And Electronic Engineering Keywords: Eddy current driver–pickup sensor; surface crack; depth measurement; thin-skin regime; non-destructive testing.

Online: 13 August 2021 (08:27:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0209.v1

Skin Disease Detection: Machine Learning vs Deep Learning

Samir Bandyopadhyay, Amiya Bhaumik, Sandeep Poddar

Subject: Biology And Life Sciences, Plant Sciences Keywords: Skin Disease Detection; Machine Learning (ML); Deep Learning(DL); Artificial Intelligence

Online: 13 September 2021 (11:54:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints201705.0064.v1

Multispectral, Fluorescent and Photoplethysmographic Imaging for Remote Skin Assessment

Janis Spigulis

Subject: Physical Sciences, Optics And Photonics Keywords: multispectral skin imaging; skin autofluorescence and photobleaching; photoplethysmography imaging

Online: 8 May 2017 (12:19:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints201711.0096.v1

Roles of the Hedgehog Signaling Pathway in Skin Development, Homeostasis and Cancer

Yoshinori Abe, Nobuyuki Tanaka

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Hedgehog signaling; skin; epidermis; hair follicle; development; homeostasis; basal cell carcinoma; signaling crosstalk

Online: 15 November 2017 (07:11:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202008.0696.v1

SARS-CoV-2 Infection Reaches the Human Nervous System: How?

Vladimir N. Uversky, Fatma Elrashdy, Abdullah Aljadawi, Syed Moasfar Ali, Rizwan Hasan Khan, Elrashdy M. Redwan

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; neurotropic virus; Blood-nervous system barrier; bloodcerebrospinal-fluid-barrier; blood-brain-barrier; blood-nerve barrier; olfactory route; Lymphatic brain drainage route; Peripheral nerve or neuronal retrograde route; Macrophage/monocytes cargo route; Double membrane vesicles cargo route; nicotinic acetylcholine receptor

Online: 31 August 2020 (04:43:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints201808.0058.v1

A Review on Non-Pharmacological Treatments for Pain Management in Newborn Infants

Avneet K. Mangat, Ju-Lee Oei, Kerry Chen, Im Quah-Smith, Georg M. Schmölzer

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: infant; premature; pain; acupuncture; skin to skin contact; sucrose; massage; musical therapy; breastfeeding

Online: 3 August 2018 (04:09:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0360.v1

Controlling Systemic Inflammation by Careful Formulation of Topical Skin Care Products: Our Bodies Didn’t Evolve With All the Current Chemicals in Skin Care Products

Greg Maguire

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: skin care; topicals; toxicity; ingredients; systemic inflammation

Online: 25 February 2020 (05:23:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0100.v1

Efficacy Evaluation of Skin Care Products Using PhabrOmeter

Ning Pan, Melissa Lum, Brian Tran

Subject: Engineering, Automotive Engineering Keywords: Assessing efficacy of skin care products; PhabrOmeter; Artificial skin; Changes of skin attributes

Online: 10 January 2019 (14:02:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0215.v1

Skin Cancer Classification and Comparison of Pretrained Models Performance using Transfer Learning

Subroto Singha, Priyangka Roy

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: pretrained model; transfer learning; skin cancer; deep learning; ISIC 2020

Online: 15 September 2022 (03:02:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0088.v2

Plasmonic Refractive Index Sensor with High Figure of Merit Based on Concentric-Rings Resonator

Zhaojian Zhang, Junbo Yang, Xin He, Jingjing Zhang, Jie Huang, Dingbo Chen, Yunxin Han

Subject: Physical Sciences, Optics And Photonics Keywords: plasmonic sensor; high figure of merit; concentric double rings resonator

Online: 20 December 2017 (10:07:32 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202102.0410.v2

A Modified High-Throughput Screening Protocol to Isolate Bacteriophages from Environmental Samples

Abdallah Abdelsattar, Rana Nofal, Salsabil Makky, Amera El-Sayed, Ayman El-Shibiny

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Phage Purification; phage isolation; phage characterization; jumbo bacteriophages; top agar; double agar overlay; high throughput sequencing

Online: 19 February 2021 (09:53:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0237.v1

Effects of Different Cogging Technologies on the Inclusions in GH4738 Superalloy Produced by Double Vacuum Smelting

Zhengyang Chen, Shufeng Yang, Jingshe Li, Hao Guo, Hongbo Zheng

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: superalloy; double vacuum smelting; cogging; inclusion.

Online: 28 March 2018 (09:38:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0150.v1

Impaired skin barrier due to sebaceous gland atrophy in the latent stage of radiation-induced skin injury: application of non-invasive diagnostic methods

Hyosun Jang, Hyunwook Myung, Janet Lee, Jae Kyung Myung, Won-Suk Jang, Sun-Joo Lee, Chang-Hwan Bae, Hyewon Kim, Sunhoo Park, Sehwan Shim

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: radiation; skin barrier; sebaceous gland; transepidermal water loss; skin pH

Online: 23 November 2017 (08:33:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202103.0061.v1

Oral and Topical Vitamin D, Sunshine, and UVB Phototherapy Safely Control Psoriasis in Patients with Normal Pretreatment Serum 25-hydroxyvitamin D Concentrations: A Literature Review and Discussion of Health Implications

Patrick J McCullough, William McCullough, Douglas Lehrer MD, Jeffrey Travers MD, Steven Repas

Subject: Medicine And Pharmacology, Dermatology Keywords: vitamin D3, D2, calcitriol, oral, topical, serum 25-hydroxyvitamin D, psoriasis, skin diseases, UVB, phototherapy, sunshine, COVID-19, regulatory T lymphocytes

Online: 2 March 2021 (09:44:17 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202011.0298.v1

Emergence of the First Lumpy Skin Disease Outbreak Among Livestock in the Republic of Kazakhstan in 2016.

Arman Issimov, Nurkuisa Rametov, Kuandyk Zhugunissov, Lespek Kutumbetov, Assylbek Zhanabayev, Nurlybay Kazhgaliyev, Birzhan Nurgaliyev, Malik Shalmenov, Gaisa Absatirov, Laura Dushayeva, Aliya Akhmetaliyeva, Abzal Kereyev, Peter White

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: control measures; diagnosis; epidemiological data; Kazakhstan; lumpy skin disease

Online: 10 November 2020 (10:13:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0091.v1

Fisetin a 3, 7, 3′, 4′-Tetrahydroxyflavone Inhibits PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models

Jean Christopher Chamcheu, Stephane Esnault, Vaqar M. Adhami, Andrea L. Noll, Sergette Banang-Mbeumi, Tithi Roy, Sitanshu S. Singh, Shile Huang, Konstantin Gus Kousoulas, Hasan Mukhtar

Subject: Medicine And Pharmacology, Dermatology Keywords: fisetin; psoriasis; normal human epidermal keratinocyte; cell signaling; cell differentiation; proliferation; inflammatory cytokine; PBMC; CD4+ T lymphocyte; 3D psoriasis-like skin disease model

Online: 9 September 2019 (07:48:26 CEST)

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Psoriasis is a chronic immune-mediated skin disease that involves interaction of both immune and skin cells, and is characterized by cytokine-driven epidermal hyperplasia, deviant differentiation, inflammation and angiogenesis. Because available treatments for psoriasis have significant limitations, dietary products are potential natural sources of therapeutic molecules, which can rescind molecular defects associated with psoriasis and could be developed for its management. Fisetin (3,7,3′,4′- tetrahydroxyflavone), a phytochemical naturally found in pigmented fruits and vegetables has demonstrated pro-apoptotic and antioxidant effects in several malignancies. This study utilized biochemical, cellular, pharmacological and tissue-engineering tools to characterize the effects of fisetin on normal human epidermal keratinocytes (NHEKs), peripheral blood mononuclear cells (PBMC) and CD4+ T lymphocytes in 2D and 3D psoriasis-like disease models. Fisetin treatment of NHEKs dose and time-dependently induced differentiation and inhibited interleukin-22-induced proliferation, as well as activation of the PI3K/Akt/mTOR pathway. Fisetin treatment of TNF-α-stimulated NHEKs significantly inhibited the activation of p38 and JNK, but had no effect on ERK1/2. In addition, fisetin treatment significantly decreased the secretion of Th1/Th-17 pro-inflammatory cytokines, particularly IFNγ and IL-17A by 12-O- tetradecanolylphorbol 13-acetate (TPA)-stimulated NHEKs and anti-CD3/CD28-activated human PBMCs. Furthermore, we established the in-vivo relevance of fisetin functions, using a 3D full-thickness human skin model of psoriasis (FTRHSP) that closely mimics in-vivo human psoriatic skin-lesions. Herein, fisetin significantly ameliorated psoriasis-like disease features, and decreased the production of IL-17 by CD4+ T lymphocytes co-cultured with FTRHSP. Collectively, our data identify pro-differentiative, anti-proliferative and anti-inflammatory effects of fisetin, via modulation of PI3K-Akt-mTOR and p38/JNK pathways and the production of cytokines in 2D and 3D human skin model of psoriasis. These results suggest that fisetin has a great potential to be developed as an effective and inexpensive agent for the treatment of psoriasis and other related inflammatory skin disorders.

Preprint ARTICLE | doi:10.20944/preprints202012.0674.v1

Correlation Analysis of Different Measurement Places of Galvanic Skin Response in Test Groups Facing Valence and Arousal Changes

Andres Sanchez-Comas, Kåre Synnes, Diego Molina-Estren, Alexander Troncoso-Palacio, Zhoe Comas-González

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Stress; Wearable; Sensor; Physiological Signals; Galvanic Skin Response; GSR; Electrodermal activity; EDA; Valence and Arousal; Correlation

Online: 26 December 2020 (11:07:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0293.v1

Applications of Double Framed T-Soft Fuzzy Sets in BCK/BCI-Algebras

Muhammad Bilal Khan, Tahir Mahmood

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: double framed T-soft fuzzy set; double framed T-soft fuzzy algebra; double framed B-soft fuzzy algebra

Online: 23 April 2018 (12:15:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0292.v1

Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren

Sergio Castañeda-Zegarra, Camilla Huse, Øystein Røsand, Antonio Sarno, Mengtan Xing, Raquel Gago-Fuentes, Qindong Zhang, Amin Alirezaylavasani, Julia Werner, Ping Ji, Nina-Beate Liabakk, Wei Wang, Magnar Bjørås, Valentyn Oksenych

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: NHEJ; double-strand breaks; mouse model; lymphocyte; neurodevelopment

Online: 24 November 2019 (15:57:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0458.v2

Microwave Assisted Novel Efficient Pd-free Catalyst for Suzuki C-C Coupling Reaction

Ghalia Alzhrani, Nesreen Ahmed, Elham Aazam , Mohamed Mokhtar, Tamer Saleh

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Suzuki coupling reaction; Layered double hydroxides; Solid base catalyst; Microwave irradiation

Online: 8 January 2019 (15:13:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0178.v1

Treatment with DHA Improves Epidermal Eeratinocyte Differentiation and Ameliorates Inflammation in Human Keratinocytes and Reconstructed Human Epidermis Models

Tinghan Jia, Wu Qiao, Qifeng Yao, Wenhui Wu, Ken Kaku

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DHA; reconstructed human models; filaggrin; skin barrier; inflammation

Online: 16 August 2019 (08:17:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202302.0074.v3

Lumpy Skin Disease: A Comprehensive Review on Virus Biology, Pathogenesis, and Sudden Global Emergence

Gaurav Moudgil, Jatin Chadha, Lavanya Khullar, Sanjay Chhibber, Kusum Harjai

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Lumpy skin disease virus; lumpy skin disease; epidemiological footprint and multi-country outbreak; transboundary spread and disease resurgence; diagnosis and vaccines

Online: 13 February 2023 (14:44:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0366.v2

Mapping the Non-Structural Transmembrane Proteins of SARS-CoV-2

Sunil Thomas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; COVID-19; coronavirus; non-structural proteins; nsps; nsp3; nsp4; nsp6; Orf1ab; Orf3a; endoplasmic reticulum; double membrane vesicle

Online: 11 October 2022 (16:19:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0227.v1

Frontiers in Pigment Cell and Melanoma Research

Fabian V. Filipp, Stanca Birlea, Marcus W. Bosenberg, Douglas Brash, Pamela B. Cassidy, Suzie Chen, John August D'orazio, Mayumi Fujita, Boon-Kee Goh, Meenhard Herlyn, Arup K. Indra, Lionel Larue, Sancy A. Leachman, Caroline Le Poole, Feng Liu-Smith, Prashiela Manga, Lluis Montoliu, David A. Norris, Yiqun Shellman, Keiran S. M. Smalley, Richard A. Spritz, Richard A. Sturm, Susan M. Swetter, Tamara Terzian, Kazumasa Wakamatsu, Jeffrey S. Weber, Neil F. Box

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: melanocyte; melanoma; oncology; precision medicine; immunotherapy; pigmentation; vitiligo; albinism; melasma; melanin; dermatology; skin; UV; cancer prevention; IFPCS; PASPCR; SMR; IPCC

Online: 13 August 2018 (11:04:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0135.v1

Isolation and Culture of Skin-Derived Differentiated and Stem-Like Cells Obtained from the Arabian Camel (Camelus dromedarius)

Islam Saadeldin, Ayman Swelum, Ahmed Noreldin, Hammed Tukur, Aaser Abdelazim, Mosleh Abomughaid, Abdullah Alowaimer

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Skin; Cell culture; Stem cells; Differentiation; Camel

Online: 10 May 2019 (15:04:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0101.v1

Active Prior Tactile Knowledge Transfer for Learning Tactual Properties of New Objects

Di Feng, Mohsen Kaboli, Gordon Cheng

Subject: Engineering, Electrical And Electronic Engineering Keywords: tactile sensing; artificial robotic skin; active tactile object perception; active tactile object learning; active tactile transfer learning

Online: 16 November 2017 (03:49:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0016.v1

MgAl-Layered Double Hydroxide Solid Base Catalysts for Henry Reaction: A Green Protocol

Magda H. Abdellattif, Mohamed Mokhtar

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: C-C bond formation; henry reaction; solid base catalyst; layered double hydroxide

Online: 2 March 2018 (04:05:24 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202109.0133.v1

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium

Gregory D. Scott, Moriah R. Arnold, Thomas G. Beach, Christopher H. Gibbons, Anumantha G. Kanthasamy, Russell M. Lebovitz, Afina W. Lemstra, Leslie M. Shaw, Charlotte E. Teunissen, Henrik Zetterberg, Angela S. Taylor, Todd C. Graham, Bradley F. Boeve, Stephen N. Gomperts, Neill R. Graff-Radford, Charbel E.-H. Moussa, Kathleen L. Poston, Liana S. Rosenthal, Marwan N. Sabbagh, Ryan R. Walsh, Miriam T. Weber, Melissa J. Armstrong, Jee A. Bang, Andrea C. Bozoki, Kimiko Domoto-Reilly, John E. Duda, Jori E. Fleisher, Douglas R. Galasko, James E. Galvin, Jennifer G. Goldman, Samantha K. Holden, Lawrence S. Honig, Daniel E. Huddleston, James B. Leverenz, Irene Litvan, Carol A. Manning, Karen S. Marder, Alexander Y. Pantelyat, Victoria S. Pelak, Douglas W. Scharre, Sharon J. Sha, Holly A. Shill, Mari Zoltan, Joseph F. Quinn, David J. Irwin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebrospinal fluid; alpha-synuclein; skin biopsy; seeded aggregation assays; tau, amyloid; Lewy body dementia

Online: 7 September 2021 (16:26:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0231.v1

Stochastic Activation Function Layers for Convolutional Neural Networks

Loris Nanni, Alessandra Lumini, Stefano Ghidoni, Gianluca Maguolo

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Convolutional Neural Networks; ensemble of classifiers; activation functions; image classification; skin detection

Online: 17 February 2020 (01:50:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0086.v1

Botulinum Neurotoxin Type A in the Treatment of Oily Skin and Acne: Evidence and a Proposed Mechanism

Nark-Kyoung Rho, Young-Chun Gil

Subject: Medicine And Pharmacology, Dermatology Keywords: acetylcholine; acne vulgaris; botulinum toxins; cholinergic receptors; non-neuronal cholinergic system; oily skin; sebaceous glands; sebum

Online: 3 November 2021 (14:26:33 CET)

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Working Paper ARTICLE

Could Strengthening the Gut and Skin Microbiome Help with the Adverse Effects after Stopping Long Term Topical Steroid Use?

Christopher Wallen-Russell, Anja Gijsberts-Veens, Samuel Wallen-Russell

Subject: Medicine And Pharmacology, Dermatology Keywords: topical steroid withdrawal; topical steroids; eczema; atopic dermatitis; skin microbiome; gut mi-crobiome; microbiome; biodiversity; skin allergy epidemic;

Online: 8 September 2021 (20:19:35 CEST)

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We set up this preliminary study to evaluate one main question: could strengthening the microbiome have potential benefits for patients suffering with adverse effects after stopping long term topical steroid use? We aim to turn it into a much larger study if the results show promise. After commonly being prescribed for eczema, cessation of topical steroid use, especially after long periods of inappropriate use, can leave lasting adverse effects on the body and skin, known by some as topical steroid withdrawal (TSW). Furthermore, the subsequent withdrawal the body experiences when coming off the drug can leave lasting adverse effects on the body and skin, known by some as topical steroid withdrawal (TSW). This preliminary study involved seven human participants suffering with skin problems associated with TSW who approached Dr. Anja Gijsberts-Veens of their own volition because they were interested in more natural recovery methods. Five completed the study in full. Progress in skin condition was tracked by self-assessed symptom severity questionnaires filled out at the beginning and end of the study. The skin microbiome was addressed by using a 100% natural product shown in previous work to significantly increase skin microbiome biodiversity. Three participants implemented dietary changes and supplementation in response to guidance after fecal sample analysis to improve their gut health and biodiversity. The average improvement in skin symptoms for all participants was 40% and average symptom improvement ranged from 14% for Patient 5 to 92% for Patient 1. On average, the participants saw an improvement in 85% of their symptoms and a stagnation or regression in 11% and 4% respectively. We believe these results show enough promise to warrant expansion of this research to use a larger sample size, preferably 50+ participants, in future work. We also aim to swab the skin of participants to assess the effect on the skin microbiome from skin and gut treatments, as well as including more in-depth analysis of skin and gut microbiomes.

Preprint ARTICLE | doi:10.20944/preprints202006.0166.v2

The Effect of a Color Tattoo on the Local Skin Redox Regulatory Network: An N-of-1 Study

Jan Homolak

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Tattoo; Tattoo ink; Oxidative stress; Phthalocyanine; Skin

Online: 2 December 2020 (11:05:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0385.v1

Stability Control of Double Inverted Pendulum on a Cart Using Full State Feedback with H infinity and H 2 Controllers

Mustefa Jibril, Messay Tadese, Reta Degefa

Subject: Engineering, Control And Systems Engineering Keywords: Double inverted pendulum on a cart, Full state feedback H infinity controller, Full state feedback H 2 controller

Online: 18 August 2020 (11:11:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0427.v1

Effect of Spirulina maxima Supplementation and a Systematic Physical Exercise Program on Body Composition and Cardiorespiratory Fitness of Overweight or Obese Subjects: A Double Blind Randomized, Crossover Controlled Trial

Marco Antonio Hernández-Lepe, José Alberto López-Díaz, Marco Antonio Juárez-Oropeza, Rosa Patricia Hernández-Torres, Abraham Wall-Medrano, Arnulfo Ramos-Jiménez

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: overweight; obesity; body fat; maximal oxygen uptake; double-blind; randomized controlled trial

Online: 24 August 2018 (07:40:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0564.v1

Antioxidant and Reduced Skin Ageing Effects of A Polyphenol-Enriched Dietary Supplement in Response to Air Pollution: A Randomized, Double-Blind, Placebo-Controlled Study

Vincenzo Nobile, Irene Schiano, Ana Peral, Silvana Giardina, Eleanora Sparta, Nuria Caturla

Subject: Biology And Life Sciences, Aging Keywords: air pollution; skin; nutraceutical; natural compound; polyphenols; antioxidant; skin barrier; anti-agein; clinical trial

Online: 24 September 2020 (04:38:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0105.v1

Commercial Topical Probiotics for the Skin Microbiome: The Majority Do Not Contain Live Microbes and May Not Satisfy Criteria for Safe and Effective Use

Christopher Wallen-Russell, Samuel Wallen-Russell

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: topical probiotics; skin microbiome; probiotics; biodiversity; microbiome; skin allergy; cosmetics

Online: 9 October 2022 (03:34:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0722.v1

Cytotoxic Evaluation of Hair Relaxers and Straighteners Actives in Human-Derived Skin Cells

Maribanyana Lebeko, Elvis Kidzeru, Ntombenhle Sishi, Jamie Pillaye, Thulisa Mkatazo, Afolake Arowolo, Nonhlanhla Khumalo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Hair cosmetic toxicity; Skin models; Chemical hair straighteners actives

Online: 30 June 2021 (09:38:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0192.v1

Nicotinamide (aka Niacinamide) Mitigates SASP-Related Inflammation Induced by Environmental Stressors in Human Epidermal Keratinocytes

John C. Bierman, Timothy Laughlin, Makio Tamura, Ben C. Hulette, Catherine E. Mack, Christina Y. R. Tan, Malgorzata Morenc, Sophie Bellanger, John E. Oblong

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: epidermal keratinocytes; inflammation; nicotinamide; skin; ultraviolet radiation; environmental stressors

Online: 12 March 2020 (03:23:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0037.v1

Characterization and Antimicrobial Efficacy of Bovine Dermcidin, a Novel Antimicrobial Peptide Gene

Nevien Sabry, Tarek Moussa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Bos taurus; skin; bovine dermcidin; RT-PCR; antimicrobial activity

Online: 6 May 2019 (08:35:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0381.v1

The Double Roman Domination Numbers of Generalized Petersen Graphs P(n, 2)

Huiqin Jiang, Pu Wu, Zehui Shao, Jia-Bao Liu

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: double Roman domination; discharging approach; generalized Petersen graphs

Online: 20 July 2018 (11:59:01 CEST)

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Working Paper ARTICLE

Evaluation of Punicalagin Niosomes for Skin Aging

Ebtesam A. Mohamad, Aya A. Aly, Aya A. Khalaf, Mona I. Ahmed, Reham M. Kamel, Sherouk M. Abdelnaby, Yasmine H. Abdelzaher, Marize G. Sedrak, Shaker A. Mousa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: skin aging; punicalagin; niosomes; UV radiation; collagen

Online: 24 March 2021 (17:35:18 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202009.0009.v1

Efficacy of Double Dose Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome (PTLDS) and Associated Co-infections: A Report of Three Cases

Richard Horowitz, Phyllis R. Freeman

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Lyme disease; Post-Treatment Lyme Disease Syndrome (PTLDS); dapsone combination therapy (DDS CT); double dose dapsone combination therapy (DDD CT); babesiosis; persistent infection

Online: 1 September 2020 (11:30:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0263.v1

Exploration of an Ethical Quagmire: The Doctrine of Double-Effect in Neonatal Palliative Care

Victoria J Kain, Joana Mendes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: neonatal palliative care; Doctrine of Double Effect; perinatal palliative care; neonatal end-of-life care

Online: 10 February 2021 (15:38:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0036.v1

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Martin Voss, Johanna Kotrba, Evelyn Gaffal, Konstantinos Katsoulis-Dimitriou, Anne Dudeck

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mast cells; innate immunity; host defense; skin; inflammatory skin disorders

Online: 1 April 2021 (17:44:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0142.v1

Chronic Kidney Disease–Associated Pruritus is Caused by Dysregulated Ion Channels in Sensory Neurons

Akishi Momose, Michihiko Yabe, Shigetoshi Chiba, Kenjirou Kumakawa, Yasuo Shiraiwa, Hiroki Mizukami

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: uremic pruritus; ion channels; cell signaling; Cav3.2 calcium channel; RT-PCR; skin

Online: 14 September 2019 (19:00:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0407.v1

Novel Whole-Cell Inactivated Neisseria Gonorrhoeae Microparticle Vaccine Formulation in Microneedles for Transdermal Immunization

Rikhav P. Gala, Rokon Uz Zaman, Martin J. D'Souza, Susu M. Zughaier

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: neisseria gonorrhoeae; gonorrhea; vaccine; microneedle; skin patch; nanotechnology; antigen-specific antibody; antigen-specific CD4 T lymphocytes

Online: 23 July 2018 (09:43:29 CEST)

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Neisseria gonorrhoeae is a strict human pathogen responsible for more than 100 million new sexually transmitted infections worldwide each year. Due to the global emergence of antibiotic resistance, the CDC recently listed N. gonorrhoeae as an urgent threat to public health. No vaccine is available in spite of the huge disease burden and the possibility of untreatable gonorrhea. The aim of this study is to investigate the immunogenicity of a novel whole-cell based inactivated gonococcal microparticle vaccine formulation loaded in dissolvable microneedles for transdermal administration. The nanotechnology-based vaccine formulation consists of inactivated whole-cell gonococci strain CDC-F62, spray dried and encapsulated into biodegradable cross-linked albumin matrix with sustained slow antigen release. The dry vaccine nanoparticles were then loaded in a dissolvable microneedle skin patch for transdermal delivery. The efficacy of the whole-cell microparticles vaccine formulation loaded in microneedles was assessed in vitro using dendritic ,cells and macrophages as well as in vivo mouse model. Antibody titers were measured using an ELISA and antigen-specific T lymphocytes were assessed in spleens and lymph nodes. Here we report that whole-cell based gonococcal microparticle vaccine loaded in dissolvable microneedles for transdermal administration induced significant increase in antigen-specific IgG antibody titers and antigen-specific CD4 and CD8 T lymphocytes in mice compared to gonococcal antigens in solution or empty microneedles. Significant increase in antigen-specific IgG antibody levels was observed at end of week 2 in groups that received the vaccine compared to the group receiving empty nanoparticles. The advantages of using formalin-fixed whole-cell gonococci that all immunogenic epitopes are covered and preserved from degradation. The spherical shaped micro and nanoparticles are biological mimics of gonococci, therefore present to the immune system as invaders but without the ability to suppress adaptive immunity. In conclusion, the transdermal delivery of microparticles vaccine via a microneedle patch was shown to be an effective system for vaccine delivery. The novel gonorrhea nanovaccine is cheap to produce in a stable dry powder and can be delivered in microneedle skin patch obviating the need for needle use or the cold chain.

Preprint ARTICLE | doi:10.20944/preprints201809.0490.v1

Anti-Aging Efficacy of Melatonin-Based Cream: Clinical and Instrumental Skin Evaluation

Massimo Milani, Mario Puviani

Subject: Medicine And Pharmacology, Dermatology Keywords: melatonin, skin aging, ANTERA 3D.

Online: 25 September 2018 (15:43:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0215.v1

Major Depressive Disorder is Associated with Impaired Mitochondrial Function in Skin Fibroblasts

Kerstin Kuffner, Julian Triebelhorn, Katrin Meindl, Christoph Benner, André Manook, Daniel Sudria, Ramona Siebert, Caroline Nothdurfter, Thomas C. Baghai, Konstantin Drexler, Mark Berneburg, Rainer Rupprecht, Vladimir M. Milenkovic, Christian H. Wetzel

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: major depression; skin fibroblasts; mitochondria; bioenergetics; oxidative phosphorylation; adenosine triphosphate; calcium imaging; mitochondrial membrane potential; mitochondrial DNA copy number

Online: 12 March 2020 (14:11:25 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0570.v1

Skin Involvement in Paediatric Patients with Type 1 Diabetes

Stefano Passanisi, Giuseppina Salzano, Fortunato Lombardo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Advanced glycation end-products; contact dermatitis; granuloma annulare; insulin; lipoatrophy; lipohypertrophy; necrobiosis lipoidica; skin autofluorescence

Online: 27 January 2021 (16:24:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0756.v1

Realistic Hair Simulator for Skin lesion Images Using Conditional Generative Adversarial Network

Mohamed Attia, Mohammed Hossny, Hailing Zhou, Anosha Yazdabadi, Hamed Asadi, Saeid Nahavandi

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Dermoscopic Image, Skin Lesion, Melanoma, Simulation, Generative Adversarial Networks, Deep Learning

Online: 1 November 2018 (17:54:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0174.v1

Computing the Effect of Environmental Damage on Aircraft Structural Integrity

Rhys Jones, Daren Peng, Neil Matthews, Nam Phan

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: operational aircraft; skin corrosion; fatigue crack growth; stress corrosion cracking; buckling

Online: 12 June 2018 (08:36:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0177.v1

The Role of Every-Day Cosmetics in Altering the Skin Microbiome: A Study Using Biodiversity

Christopher Wallen-Russell

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: skin allergy epidemic; skin microbiome; skin microbiome diversity; effect of synthetic cosmetics on skin; biodiversity; synthetic ingredients in modern cosmetics; skin health; healthy skin bacteria; damaged skin bacteria

Online: 17 December 2018 (07:27:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0235.v1

Rough I₂-Lacunary Statistical Convergence of Double Sequences

Ömer Kişi, Erdinç Dündar

Subject: Computer Science And Mathematics, Analysis Keywords: statistical convergence; I-convergence; rough convergence; lacunary sequences; double sequences

Online: 14 June 2018 (12:31:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0378.v1

Salt-Cured Atlantic Cod Skin: A Sustainable Source of Acid-Soluble Type I Collagen

Ezequiel Coscueta, María Emilia Brassesco, Manuela Pintado

Subject: Chemistry And Materials Science, Biomaterials Keywords: salt-cured cod skin; Gadus morhua; collagen; fishery by-products; biomaterials

Online: 17 February 2021 (10:39:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0176.v1

Recent Advances of Natural Cellulosic Non-Woven Scaffolds for Tissue Engineering

Mohammadreza Aghazadeh, Sheyda Delfanian, Pouria Aghakhani, Shahin Homaeigohar, Atefeh Alipour, Hosein Shahsavarani

Subject: Engineering, Bioengineering Keywords: Polymeric Biomaterials; Natural Cellulose; Tissue Engineering; Differentiation; Bone Regeneration; Skin Regeneration; Cardiac Regeneration; Vascular Regeneration; Neural Regeneration

Online: 14 February 2022 (14:02:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0607.v1

Effects of Limonene on the PAHs mutagenicity risk in Roasted Fish Skin

Yu-Wei Chen, Ping-Hsiu Huang, Yung-Hsiang Tsai, Chii-Ming Jiang, Chih-Yao Hou

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Roasted Fish Skin, PAHs mutagenicity risk, Limonene

Online: 30 September 2018 (10:03:24 CEST)

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Working Paper ARTICLE

Synchronized Oscillations in Double-Helix B-DNA Molecules with Mirror-Symmetric Codons

Enrique Maciá

Subject: Biology And Life Sciences, Biophysics Keywords: double-stranded DNA; DNA dynamical models; correlated oscillations in macromolecules; epigenetic changes

Online: 4 January 2021 (16:35:40 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0215.v1

Elucidating Role of Bacteria in Psoriatic Disease: From Skin and Gut Perspectives

Bakytgul Yermekbayeva, Togzhan Algazina, Madina Razbekova, Albert Pinhasov, Gulnar Batpenova, Almagul Kushugulova

Subject: Medicine And Pharmacology, Dermatology Keywords: gut microbiota; skin microbiota; inflammation; psoriasis; psoriatic arthritis; dysbiosis

Online: 12 September 2018 (07:49:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0208.v1

A Quantitative Prediction Method for Fracture Density Based on the Equivalent Medium Theory

Liang Sun, Suping Peng, Dengke He, Shu Wang

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: fracture density; double-layer model; unconventional reservoirs; multicomponent seismic; shear-wave splitting

Online: 16 April 2018 (11:33:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0368.v1

Effect of Multiple Layers of Carbon Fiber Reinforced Polymer on Flexural Strength of Reinforced Concrete

Ali Raza Khoso, Muhammad Akram Akhund, Shankar Lal Menghwar, Fida Hussain Siddiqui

Subject: Engineering, Civil Engineering Keywords: CFRP; double layers of CFRP; concrete repair; flexural behavior; load deflection curve

Online: 20 July 2018 (03:49:56 CEST)

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Working Paper ARTICLE

KIT Mutation Incidence and Pattern of Skin Melanoma in a Central European Country

Viktoria Doma, Tamas Barbai, Marius Beleaua, Ilona Kovalszky, Erzsebet Raso, Jozsef Timar

Subject: Medicine And Pharmacology, Dermatology Keywords: skin melanoma, KIT mutation, Sanger sequencing

Online: 6 August 2019 (12:33:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0004.v2

Spirals and Rings in Barred Galaxies by the ROTASE Model

Hongjun Pan

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: ROTASE model; formation of spiral arms; X-matter; black hole; matter conversion; hydrogen generation; chain-link; single ring; double rings; ring crossing

Online: 2 November 2021 (17:48:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202103.0229.v1

The Application of Mesenchymal Stem Cells on Wound Repair and Regeneration

Bruna Lopes, Patrícia Sousa, Rui D. Alvites, Mariana Vieira Branquinho, Ana Catarina Sousa, Carla Mendonça, Luís Miguel Atayde, Ana Colette Maurício

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: skin regeneration; wound healing; skin stem cells; skin vascularization; 3D printing.

Online: 8 March 2021 (15:26:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0614.v1

Comparative Study of Biological Characteristics, and Osteoblast Differentiation of Mesenchymal Stem Cell Established From Camelus Dromedaries Skeletal Muscle, Dermal Skin, and Adipose Tissues

Young-Bum Son, Yeon Ik Jeong, Yeon Woo Jeong, Mohammad Shamim Hossein, Alex Tinson, Kuhad Kuldip Singh, Woo Suk Hwang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Mesenchymal stem cells; Camelus dromedaries; skeletal muscle; dermal skin; adipose tissue; differentiation

Online: 1 March 2021 (17:40:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0217.v1

Uptake Fluoride from Water by Starch Stabilized Layered Double Hydroxide

Jiming Liu, Xiuping Yue, Xinyu Lu, Yu Guo

Subject: Engineering, Civil Engineering Keywords: Layered double hydroxides; Hydrotalcite; Starch; Fluoride; Adsorption property; Thermodynamics

Online: 15 May 2018 (11:39:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0420.v1

On the Rehydration of Organic Layered Double Hydroxides to Form Graphene-LDH Nanocomposites

Eleonora Conterosito, Luca Palin, Diego Antonioli, Maria Pia Riccardi, Enrico Boccaleri, Maurizio Aceto, Marco Milanesio, Valentina Gianotti

Subject: Chemistry And Materials Science, Nanotechnology Keywords: layered double LDHs; graphene; mixed oxides; re-hydration; memory Effect; X-ray diffraction; Raman spectroscopy; scanning electron microscopy

Online: 23 July 2018 (12:02:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0274.v1

The Non-Uniform and Asymmetric Thermal Radiation upon the Human Physiological Responses in Outdoor Environment

Yoshihito Kurazumi, Kenta Fukagawa, Tomonori Sakoi, Ariya Aruninta, Ken Yamashita

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: asymmetry; mean skin temperature; non-uniform; outdoor environment; physiological response; skin temperature; solar radiation

Online: 16 July 2018 (10:46:36 CEST)

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Working Paper ARTICLE

An Electronic Skin Readout System for Liquid Metal based Flexible Resistor Sensor Array

Huan Qian Zhang, Jee Chin Teoh, Jian Feng Wu, Longteng Yu, Rui-Heng Wang, Deleon Mark Francis, Chwee Teck Lim

Subject: Engineering, Electrical And Electronic Engineering Keywords: Resistive sensor array; measurement error; zero potential methods; liquid metal; flexible electrical skin

Online: 24 January 2020 (14:49:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0550.v1

Graphene Oxide Topical Administration: Skin Permeability Studies

Filipa A. L. S. Silva, Raquel Costa-Almeida, Licínia Timochenco, Sara I. Amaral, Soraia Pinto, Inês C. Gonçalves, José R. Fernandes, Fernão D. Magalhães, Bruno Sarmento, Artur M. Pinto

Subject: Chemistry And Materials Science, Biomaterials Keywords: biocompatibility; carbon nanomaterials; graphite; phototherapy; skin disease.

Online: 22 March 2021 (15:47:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0189.v1

An Advanced Mode of Antioxidants Delivery System Effective in the Treatment of ROS and Skin Permeation of The Cosmetic Formulations - The Possible Application of Clove Oil, Eugenol and New Eugenol Derivative

Edyta Makuch, Anna Nowak, Andrzej Günther, Robert Pełech, Łukasz Kucharski, Wiktoria Duchnik, Adam Klimowicz

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: antioxidants for the treatment of ROS; new ester of eugenol; cosmetic formulations with clove water; skin penetration; Franz cell

Online: 9 October 2020 (08:59:05 CEST)

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The main focus of this work is to extend the knowledge about the complexity of issues of oxidative stress. Natural compounds play a serious role in multiple aspects of both human, leading to clear health-promoting effects. This work is focused on the potential application cosmetic formulations containing including but not limited to of clove water and isolated clove oils on their aid in the control of the diseases. The aim of our work was to prepare to evaluate cosmetic formulations containing clove oil, eugenol or new eugenol ester derivative (eugenyl dichloroacetate - EDChA) but also cosmetic formulations containing the aqueous phase obtained after separation of essential oil following the clove buds steam distillation. To evaluate the antioxidants transdermal delivery system, in vitro permeation experiments in a Franz diffusion cell were performed using pig skin. The antioxidative capacity of the cosmetic formulations obtained was determined by the DPPH free radical reduction method. In the next stage, the antioxidant activity (DPPH, ABTS, and Folin–Ciocalteu methods) of the fluid that penetrated through pig skin and of the fluid obtained after skin extraction, were also evaluated. For comparison, studies of cosmetic formulation containing alone dichloroacetic acid (DChAA) were as well carried out. The obtained cosmetic formulations were characterized by of antioxidant activity estimated after 24 hours of conducting the experiment, which indicates long-term protection against reactive oxygen species (ROS) in the deeper layers of the skin. The results of this work contribute to the development of cosmetic formulations with antioxidant potential, emphasizing that the water phases are waste from the process of cloves steam distillation and are not used to prepare cosmetic formulations. The use of waste water from the clove buds steam distillation process is environmentally friendly and not allows us to waste, containing however valuable biologically active compounds (furfural, methyl salicylate, 4-allilofenol, eugenol, α- and β-caryophyllene, eugenyl acetate, β-caryophyllene oxide). Together, these results suggest that cosmetic formulations may be potential drug candidates for chemopreventive, antineoplastic and antimutagenic therapy.

Working Paper ARTICLE

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Xing Li, Tomohiro Matsumoto, Miho Takuwa, Mahmood Saeed Ebrahim Shaikh Ali, Takumi Hirabayashi, Hiroyo Kondo, Hidemi Fujino

Subject: Biology And Life Sciences, Aging Keywords: astaxanthin; antioxidant; skin; ultraviolet; photoaging; capillary

Online: 20 January 2020 (09:55:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0107.v1

The Potential Implementation of Biosensors for the Diagnosis of Biomarkers of Various Cancer

Sameer Quazi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Nanobiotechnology; Biomarkers; Biosensors; Lung cancer; Skin Cancer; Colorectal Cancer

Online: 7 March 2022 (15:03:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0117.v1

Targeting GPCRs & their Signaling as a Therapeutic Option in Melanoma

Jeremy H Raymond, Zackie Aktary, Lionel Larue, Véronique Delmas

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: G protein-coupled receptor; mouse models; skin cancer; UVR; drug; network

Online: 10 January 2022 (13:41:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0073.v1

Engaging the Senses: The Potential of Emotional Data as a New Information Layer in Urban Planning

Afif Fathullah, Katharine S. Willis

Subject: Arts And Humanities, Architecture Keywords: emotions; planning; participation; digital participation; physiological sensors; galvanic skin response; GSR; stress levels; emotional layer; urban; city

Online: 4 July 2018 (11:53:17 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202011.0324.v1

Tracking Double-up Food Bucks (DUFB) Program Use Among Supplemental Nutrition Assistant Program (SNAP) Recipients and the Implications for Healthy Food Access

Abiodun Atoloye, Carrie Durward

Subject: Social Sciences, Psychology Keywords: Farmers' market; Incentive program; SNAP benefits; Double-up Food Buck; Incentive tracking system

Online: 10 November 2020 (15:53:21 CET)

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Working Paper ARTICLE

Skin Doctor: Machine Learning Models for Skin Sensitization Prediction that Provide Estimates and Indicators of Prediction Reliability

Anke Wilm, Conrad Stork, Christoph Bauer, Andreas Schepky, Jochen Kühnl, Johannes Kirchmair

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: skin sensitization potential; prediction; in silico models; machine learning; local lymph node assay (LLNA); cosmetics; drugs; pesticides; chemical space; applicability domain

Online: 29 August 2019 (04:38:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0500.v3

Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs

Roopa Thapar

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: DNA repair; long non-coding RNA; microRNA; DNA damage; double-strand breaks; NHEJ; HR

Online: 26 October 2018 (10:22:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202101.0314.v1

Development of Cryogenic Detectors for Neutrinoless Double Beta Decay Searches

Mattia Beretta, Lorenzo Pagnanini

Subject: Physical Sciences, Acoustics Keywords: Neutrinoless Double Beta Decay; Lepton Number Violation; Rare event search; Cryogenic detector

Online: 18 January 2021 (10:32:28 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201912.0170.v1

Necrotic Skin Infection by Sphingomonas Paucimobilis in Amazonia Region

Talles Henrique Pichinelli Maffei, Frederico Alberto Bussolaro, Arlei Belaus, Alexandra Prevedello, Claudine Thereza-Bussolaro

Subject: Medicine And Pharmacology, Dermatology Keywords: sphingomonas; gram-negative bacterial infection; skin disease; bacterial

Online: 12 December 2019 (10:01:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0122.v1

On Conformable Double Laplace Transform and One Dimensional Fractional Coupled Burgers' Equation

Hassan Eltayeb, Imed Bachar, Adem Kilicman

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: conformable fractional derivative; conformable partial fractional derivative; conformable double Laplace decomposition method; conformable Laplace transform; Singular one dimensional coupled Burgers equations

Online: 14 January 2019 (07:04:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0135.v1

Recent Advances in Wearable Optical Sensors Automation Powered by Battery Versus Skin-Like Battery-Free Devices for Personal Healthcare - A Review

Nikolay L Kazanskiy, Muhammad A Butt, Svetlana N Khonina

Subject: Chemistry And Materials Science, Biomaterials Keywords: Wearable sensors; skin-like; heart rate monitoring; continuous glucose monitoring; battery-free sensors

Online: 11 January 2022 (12:18:36 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0772.v1

Beneficial Effects of Marine Algae-Derived Carbohydrates for Skin Health

Ji Hye Kim, Jae-Eun Lee, Kyoung Heon Kim, Nam Joo Kang

Subject: Medicine And Pharmacology, Dermatology Keywords: Marine algae; Carbohydrates; Oligosaccharides; Monosaccharides; Skin health; Cosmeceuticals

Online: 1 November 2018 (18:19:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0331.v1

Capacitive Imaging for Skin Characterizations and Solvent Penetration Measurements

Xu Zhang, Christos Bontozoglou, Elena Chirikhina, Majella E. Lane, Perry Xiao

Subject: Engineering, Electrical And Electronic Engineering Keywords: capacitive imaging; skin hydration; solvent penetration; water content; solvent content

Online: 21 June 2018 (05:21:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0011.v1

Double Burden of Malnutrition (DBM) and Anaemia under the Same Roof: A Bangladesh Perspective

Sumaiya Mamun, Christopher Guy Nicholas Mascie-Taylor

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: double burden of malnutrition; anaemia; undernutrition; overweight; obesity

Online: 3 September 2018 (05:45:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0176.v1

A Graphical Based Video Steganography

Samir Bandyopadhyay, Payal Bose, Vishal Goyel

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Video Steganography, Least Significant Bit (LSB) Coding, Double key Encryption, Decryption, Password Verification, Signature Verification

Online: 10 May 2021 (11:21:29 CEST)

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