Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Botulinum Neurotoxin Type A in the Treatment of Oily Skin and Acne: Evidence and a Proposed Mechanism

Version 1 : Received: 31 October 2021 / Approved: 3 November 2021 / Online: 3 November 2021 (14:26:33 CET)

A peer-reviewed article of this Preprint also exists.

Rho, N.-K.; Gil, Y.-C. Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism. Toxins 2021, 13, 817. Rho, N.-K.; Gil, Y.-C. Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism. Toxins 2021, 13, 817.

Journal reference: Toxins 2021, 13, 817
DOI: 10.3390/toxins13110817

Abstract

Intradermal injection of botulinum neurotoxin is a frequently performed procedure in aesthetic dermatology to improve facial skin tone, texture, fine wrinkles, and enlarged pores. In practice, botulinum neurotoxin type A is also used to reduce skin oiliness of the face. There is increasing evidence that acetylcholine plays specific roles in sebum production, suggesting that botulinum neurotoxin type A may reduce sebum production by interfering with cholinergic transmission between sebaceous glands and autonomic nerve terminals. Botulinum neurotoxins can also inhibit several pathogenetic components of acne development, suggesting that botulinum neurotoxins can be used as a safe and effective treatment modality for acne and other skin disorders related to the overactivity of sebaceous glands. This review aims to explore the current evidence behind the treatment of oily skin and acne with botulinum neurotoxin type A.

Keywords

acetylcholine; acne vulgaris; botulinum toxins; cholinergic receptors; non-neuronal cholinergic system; oily skin; sebaceous glands; sebum

Subject

MEDICINE & PHARMACOLOGY, Dermatology

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