Search Subject Areas | Preprints.org

Preprint ARTICLE | doi:10.20944/preprints202404.1035.v1

Elevating Skincare Science: Grape Seed-Extract Encapsulation for Dermatological Care

Maria Leonor de Castro, João Azevedo-Silva, Diana Valente, Adriana Machado, Tânia Ribeiro, João Paulo Ferreira, Manuela Pintado, Oscar Ramos, Sandra Borges, Sara da Silva

Subject: Medicine And Pharmacology, Dermatology Keywords: Grape by-products; Phenolic compounds; Liposomes; Sustainability; Skincare

Online: 16 April 2024 (13:58:05 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0676.v1

Onychomycosis in Foot and Toe Malformations

Eckart Haneke

Subject: Medicine And Pharmacology, Dermatology Keywords: onychomycosis; predisposing factors; foot deformation; toe malposition; Hallux valgus; Hallux valgus interphalangeus; Hallux erectus

Online: 10 April 2024 (07:51:33 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Introduction: It has long been accepted that trauma is one of the most important and frequent predisposing factors for onychomycoses . However, the role of direct trauma in the pathogenesis of fungal nail infections was only recently been elucidated in a series of 32 cases of post-traumatic single-digit onychomycosis. The importance of repeated trauma due to foot and toe abnormalities was rarely investigated.Aim of the study: This is a multicenter single-author observational study over a period of 6 years performed at a specialized nail clinic in three countries. All patient photographs taken by the author during this period were screened for toenail alterations and all toe onychomycosis cases were checked whether they contained enough information to evaluate potential foot and toe abnormalities. Particular attention was paid to the presence of hallux valgus, hallux valgus interphalangeus, hallux erectus, inward rotation of the big toe and outward rotation of the little toe, as well as splay foot. Only cases with unequivocal proof of fungal nail infection by either histopathology, mycologic culture or polymerase chain reaction (PCR) were accepted.Results: Of 1653 cases, 185 were onychomycoses proven by mycologic culture, PCR or histopathology. Of these, 179 involved at least one big toenail, 6 affected one or more lesser toenails. Three patients consulted us for another toenail disease and the onychomycosis was diagnosed as a second disease. Eight patients had a pronounced tinea pedum. Relatively few patients had a normal big toe position (n = 9). Most of the cases had a mild to marked hallux valgus (HV) (105) and a hallux valgus interphalangeus (HVI) (143), hallux erectus was observed in 43 patients, the combination of HV and HVI was observed 83 times. Discussion: The very high percentage of foot and toe deformations was surprising. It may be hypothesized that this is not only a pathogenetically important factor but may also play an important role for the localization of the fungal infection as no marked hallux deviation was noted in onychomycoses that affected the lesser toes only. As the management of onychomycoses is a complex procedure involving the exact diagnosis with determination of the pathogenic fungus, the nail growth rate, the type of onychomycosis, its duration and predisposing factors, anomalies of the toe position may be important. Among the most commonly mentioned predisposing factors are peripheral circulatory insufficiency, venous stasis, peripheral neuropathy, immune deficiency and iatrogenic immunosuppression whereas foot problems are not given enough attention. Unfortunately, many of these predisposing and aggravating factors are difficult to treat or to correct. Generally, when explaining the treatment of onychomycoses to the patients, the importance of these orthopedic alterations is not or only insufficiently discussed. In view of the problems encountered with the treatment of toenail mycoses, this attitude should be changed in order to make the patient understand why there is such a low cure rate despite excellent minimal inhibitory drug concentrations in the laboratory.

Preprint ARTICLE | doi:10.20944/preprints202404.0684.v1

Synergistic Effect of Terbinafine and Blue Light on Reactive Oxygen Species Production in Human Keratinocytes: Potential Implications for Cutaneous Mycosis

Luis Alfonso Pérez-González, Maria Antonia Martínez-Pascual, Elena Toledano-Macías, Rosa Cristina Jara-Laguna, Montserrat Fernández-Guarino, Maria Luisa Hernandez-Bule

Subject: Medicine And Pharmacology, Dermatology Keywords: onychomycosis; physical therapies; keratinocytes; reactive oxygen species; blue light

Online: 9 April 2024 (15:19:41 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0109.v1

Understanding the Importance of Daily Imaging in the Treatment of Non-Melanoma Skin Cancer with Image Guided Superficial Radiation Therapy

Jeffrey Stricker, Janine Hopkins, Aaron Farberg, Peyton Harris

Subject: Medicine And Pharmacology, Dermatology Keywords: non melanoma skin cancer; basal cell carcinoma; squamous cell carcinoma; image guided superficial radiation therapy; superficial radiation therapy; image guided radiation therapy ;

Online: 1 April 2024 (14:58:26 CEST)

Show abstract| Download PDF| Share

Preprint SHORT NOTE | doi:10.20944/preprints202404.0056.v1

Image Guided Superficial Radiation Therapy Expands Access to a Multidisciplinary Cancer Care Model that Optimizes Outcomes for Underserved Rural Medical Beneficiaries

Liqiao Ma, Jeffrey Stricker, Janine Hopkins, Russell Rowe, Peyton Harris

Subject: Medicine And Pharmacology, Dermatology Keywords: non-melanoma skin cancer; image guided superficial radiation therapy; Mohs micrographic surgery; basal cell carcinoma; squamous cell carcinoma; superficial radiation therapy ;

Online: 1 April 2024 (13:32:28 CEST)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints202403.1623.v1

Lichen Amyloidosis in an Atopic Patient Treated with Dupilumab: A New Therapeutic Option

Benedetta Tirone, Gerardo Cazzato, Francesca Ambrogio, Caterina Foti, Marco Bellino

Subject: Medicine And Pharmacology, Dermatology Keywords: Lichen Amyloidosis; Atopic Dermatitis; Histopathology; Dupilumab

Online: 27 March 2024 (07:54:03 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1421.v1

Healing Potential of the Marine Polysaccharides Carrageenan and Ulvan on Second Degree Burns

Dimitra Statha, Asimina Papaioannou, Stefanos Kikionis, Maria Kostaki, Ioannis Sfiniadakis, Andreas Vitsos, Jane Anastassopoulou, Efstathia Ioannou, Vassilios Roussis, Michail Christou Rallis

Subject: Medicine And Pharmacology, Dermatology Keywords: second-degree burn; mice; carrageenan; ulvan; wound healing

Online: 25 March 2024 (09:06:13 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.1368.v1

Tinea Incognito: Challenges in Diagnosis and Management

Aikaterini Zacharopoulou, Aikaterini Tsiogka, Antonios Tsimpidakis, Androniki Lamia, Dimitra Koumaki, Stamatios Gregoriou

Subject: Medicine And Pharmacology, Dermatology Keywords: tinea incognito; fungal infection; dermatophyte infection; corticosteroid; tacrolimus; pimecrolimus

Online: 22 March 2024 (11:37:12 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.0962.v1

MicroRNAs in Merkel Cell Carcinoma: A State of Art from Biogenesis to Clinical Future Perspectives and Artificial Intelligence Possible Applications

Federica Li Pomi, Lorena Incorvaia, Giuseppe Badalamenti, Antonio Russo, Mario Vaccaro, Sebastiano Gangemi, Francesco Borgia

Subject: Medicine And Pharmacology, Dermatology Keywords: merkel cell carcinoma; microRNA; miRNA; exosomes; circRNA; artificial intelligence; machine learning; merkel cell polyomavirus

Online: 18 March 2024 (16:04:14 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0483.v1

Investigating the Impact of Secukinumab Bulk and Liposome Forms on Lymphocytes from Psoriasis Patients, as Compared to Healthy Controls, to Determine the Improvement in Bioavailability of Secukinumab Nanoliposomes

Gazala Layas, Mohammad Isreb, Nader Ghaderi, Fanila Shahzad, Pouria Akhbari, Diana Anderson, Andrew Wright, Mojgan Mojgan Najafzadeh

Subject: Medicine And Pharmacology, Dermatology Keywords: Secukinumab; liposome; Psoriasis; Bioavailability; DNA damage

Online: 8 March 2024 (15:31:07 CET)

Show abstract| Download PDF| Share

Psoriasis is a multi-factorial immune-mediated disease that affects approximately 2% of the UK population and 2.5% worldwide. The condition can impact multiple organs, including the skin and joints. In moderate to severe cases, systemic and topical medications may not provide adequate relief, and as a result, biologic treatments are often administered as a monotherapy or in combination with other treatments. While biologic treatments are more effective than systemic and topical medications in treating psoriasis, patients require close supervision and monitoring while receiving this type of treatment. Liposomes are highly versatile and can be employed for therapy and research applications. They enhance drug retention at the site of administration, thereby reducing systemic side effects. Our study was the first to investigate the genotoxicity of secukinumab, an ideal biologic treatment for psoriasis (a human IgG1k antibody, anti-IL17A), in bulk and liposome nanoparticles on the lymphocytes of psoriasis patients compared to healthy individuals. We evaluated and com-pared the genotoxicity of secukinumab in bulk and liposomal form using the Comet and micronucleus assays. Both assays demonstrated that secukinumab in both forms did not ex-hibit genotoxicity and reduced DNA damage following treatment of the lymphocytes from healthy individuals and psoriatic patients with secukinumab bulk and liposomes format. Both concentrations of secukinumab used (2.1 and 2.8 µg/mL) effectively decreased H2O2-induced DNA damage in both groups to nearly the level of the negative control. Secukinumab bulk and liposome form significantly decreased H2O2-induced damage and efficiently attenuated its adverse effects both in the Comet (p<0.0001) and micronucleus assays (p<0.01). Overall, secukinumab in both forms exhibited protective and an-ti-genotoxic effects by demonstrating its potential to reduce DNA damage caused by oxida-tive stress and by not inducing any further damage in the lymphocytes of either healthy in-dividuals or patients.

Preprint REVIEW | doi:10.20944/preprints202403.0495.v1

Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation

María Luisa Hernández-Bule, Jorge Naharro-Rodriguez, Stefano Bacci, Montserrat Fernández-Guarino

Subject: Medicine And Pharmacology, Dermatology Keywords: photobiomodulation; dermatology; laser; photodynamic therapy; LED

Online: 8 March 2024 (06:27:08 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.0494.v1

Xanthone Derivatives for Potential Use in Topical Treatment of Telangiectasia and Rosacea

Katarzyna Brezdeń, Anna M. Waszkielewicz

Subject: Medicine And Pharmacology, Dermatology Keywords: xanthone, telangiectasia, rosacea, vascular disorders, cosmetics, dermatology, blood vessels

Online: 8 March 2024 (06:25:27 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1458.v1

Efficacy and Tolerability of a Microneedling Device plus Exosomes for Treating melasma

Ilaria Proietti, Chiara Battilotti, Francesca Svara, Carlotta Innocenzi, Alessandra Spagnoli, Concetta Potenza

Subject: Medicine And Pharmacology, Dermatology Keywords: Melasma; hyperpigmentation; exosomes; RSCEs; microneedling.; mMASI; GAIS

Online: 26 February 2024 (14:17:32 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.1089.v1

Contact Dermatitis Due to Hair Care Products: A Comprehensive Review

Marta Cebolla Verdugo, Juan Pablo Velasco Amador, Francisco José Navarro Triviño

Subject: Medicine And Pharmacology, Dermatology Keywords: contact dermatitis; hair; cosmetics; patch test

Online: 20 February 2024 (11:25:36 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.1023.v1

The Potential Role of Stem Cells in Wound Healing: A Systematic Review

Banu Farabi, Katie Roster, Rahim Hirani, Katharine Tepper, Mehmet Fatih Atak, Bijan Safai

Subject: Medicine And Pharmacology, Dermatology Keywords: stem cells; chronic wound; wound healing; dermatology

Online: 19 February 2024 (08:19:53 CET)

Show abstract| Download PDF| Supplementary Files| Share

Introduction: Wound healing is a complex cascade involving the orchestration of inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. These cells achieve tissue repair through an interchange of cytokines and growth factors through a controlled inflammation, angiogenesis, and remodeling process. Disruptions in the wound-healing process by comorbid conditions lead to significant morbidity and mortality. Stem cell therapy has emerged as a new strategy to facilitate the wound healing process. Stem cells harvested from different sources can be used for wound repair and regeneration (endothelial progenitor cells, bone marrow, adipose tissue, dermal and inducible pluripotent stem cells). We aimed to review clinical, translational, and primary literature on stem cell therapies in chronic wounds and summarize practical clinical applications to dermatological care. Materials and Methods: A comprehensive search of Pubmed, Embase, Web of Science, Google Scholar, and Cochrane Library was conducted for studies relating to stem cells and wound healing. Duplicate results were removed using Covidence. Titles and abstracts were screened by two independent researchers (BF and KR), with discrepancies resolved through discussion and mutual agreement. Articles were excluded if they were review-type or commentary-type articles. Results: A total of 22,454 articles were retrieved from the search. Deduplication removed 905, and automation removed an additional 18,363 articles. After an initial screening of titles and abstracts, 170 articles remained. Full-text screening resulted in an additional 126 articles being removed, leaving 44 included studies. Discussion: Stem cells used for wound repair and regeneration include endothelial progenitor stem cells and adult stem cells, in the forms of bone marrow-derived mesenchymal stem cells, adipose tissue stem cells, and inducible pluripotent stem cells. Among these sources, adipose tissue-derived mesenchymal stem cells (AD-MSCs) are ideally used due to the abundant supply of fat tissue, ease of isolation, extensive proliferative capacities ex vivo, and their ability to secrete pro-angiogenic factors. AD-MSCs have been used to enhance wound healing in peripheral arterial disease, diabetic wounds, hypertensive ulcers, bullous diabeticorum, venous ulcers, and postsurgical wounds after Mohs micrographic surgery. These cells have been delivered to the tissue topically, with scaffolds, combined with plasma-rich proteins, and through atelocollagen in various human studies. These approaches, when combined with local wound care practices, resulted in decreased pain, shorter wound healing times, and better cosmesis. Conclusions: Stem cell transplantation is a potential therapeutic approach in the wound healing process. Transplanted stem cells do not only differentiate into multiple skin cell types but also provide cytokine and growth factors required for wound healing resulting in increased angiogenesis. Thus, this approach may be regarded as an attractive option for intractable wounds that cause major clinical problems, especially chronic lower leg wounds. It can also be used after Mohs micrographic surgery for defects left to heal by secondary intention. Stem cell application may reduce the overall cost burden on the healthcare system and improve the quality of life for patients.

Preprint ARTICLE | doi:10.20944/preprints202402.0865.v1

A Prospective Longitudinal Study of Dynamic of Human Papillomavirus 6 and 11 Infection in Anogenital Hairs and Eyebrows of Male Patients with Anogenital Warts and Age-Matched Controls

Vesna Tlaker, Lea Hošnjak, Mateja Kolenc, Tomaž Mark Zorec, Boštjan Luzar, Marko Potočnik, Jovan Miljković, Katja Seme, Mario Poljak

Subject: Medicine And Pharmacology, Dermatology Keywords: human papillomavirus; HPV; HPV6; HPV11; genetic variants; anogenital warts; persistence; recurrence; prospective study

Online: 15 February 2024 (15:44:37 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.0216.v1

The Role of Cytokines in Cutaneous T-cell Lymphoma: Focus on the State of the Art and Possible Therapeutic Targets

Alba Guglielmo, Corrado Zengarini, Claudio Agostinelli, Elena Sabattini, Alessandro Pileri

Subject: Medicine And Pharmacology, Dermatology Keywords: CTCL; Lymphoma; cutaneous; skin, oncology; chemokine; inflammatory; mediators; protein

Online: 5 February 2024 (10:55:55 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.2181.v1

Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection-Sepsis Relationship

Adriana Ionela Pătrașcu, Dan Vâță, Doinița Temelie-Olinici, Mădălina Mocanu, Dumitriţa Lenuţa Guguluş, Mădălina Marinescu, Liviu Stafie, Bogdan Marian Tarcău, Ioana Adriana Popescu, Ioana Creţu, Carmen Diana Cimpoeşu, Laura Gheucă-Solovăstru

Subject: Medicine And Pharmacology, Dermatology Keywords: skin lesions with loss of tissue; cutaneous-onsetsepsis; acute infections; skin microbiome

Online: 31 January 2024 (08:08:20 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202401.1632.v1

The Efficacy of a Novel Compound from Bovine Milk Colostrum Exosomes and Its Growth Factors in Enhancing the Process of Wound Healing

Mojgan Najafzadeh, Shohreh Jafarinejad, Adi Baumgartner, Jacobo Elies Gomez

Subject: Medicine And Pharmacology, Dermatology Keywords: Bovine Colostrum; Wound healing; Repair; Chronic wound

Online: 23 January 2024 (07:27:48 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0830.v2

The Economic Burden of Atopic Dermatitis in Romania: A Broad Perspective

Alin Codrut Nicolescu, Stefan Strilciuc, Rozalina Lapadatu, Diana Alecsandra Grad, Cristian Vladescu, Rodica Olteanu

Subject: Medicine And Pharmacology, Dermatology Keywords: Atopic dermatitis, economic burden of disease, cost of illness

Online: 16 January 2024 (10:29:04 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0861.v1

The Economic Burden of Alopecia Areata in Romania

Stefan Strilciuc, Rodica Olteanu, Rozalina Lăpădatu, Diana-Alecsandra Grad, Cristian Vlădescu, Alin Codruț Nicolescu

Subject: Medicine And Pharmacology, Dermatology Keywords: alopecia areata, cost of illness, economic burden

Online: 11 January 2024 (10:29:25 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0830.v1

The Economic Burden of Atopic Dermatitis in Romania: A Broad Perspective

Alin Codrut Nicolescu, Stefan Strilciuc, Rozalina Lapadatu, Diana Alecsandra Grad, Cristian Vladescu, Rodica Olteanu

Subject: Medicine And Pharmacology, Dermatology Keywords: Atopic dermatitis, economic burden of disease, cost of illness

Online: 10 January 2024 (12:02:23 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202401.0800.v1

New and Emerging Biological and Oral/Topical Small-Molecule Treatments for Psoriasis

Elena Carmona-Rocha, Lluís Rusiñol, Lluís Puig

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; oral therapies; topical therapies; biologics; Jak inhibitors; PDE4 inhibitors; systemic treatment; IL-17 inhibitors; IL-23 inhibitors; tapinarof; roflumilast

Online: 10 January 2024 (08:49:06 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0610.v1

Hyper- and Hypopigmentation in a Subject with Fitzpatrick VI Skin Phototype: A new Treatment Option

Sheila Veronese, Rajeev Aggarwal, Tiziana Giovanelli, Andrea Sbarbati

Subject: Medicine And Pharmacology, Dermatology Keywords: dyschromia; dark colour skin; laser side effects; electromagnetic field; vacuum

Online: 8 January 2024 (09:22:58 CET)

Show abstract| Download PDF| Share

Preprint SHORT NOTE | doi:10.20944/preprints202401.0497.v1

Differentiating Red From Red: A guide to understanding Dermatological lesions

Dev Desai, Ahmed Gamal Abouarab

Subject: Medicine And Pharmacology, Dermatology Keywords: skin conditions; dermatological lesions

Online: 5 January 2024 (14:51:38 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0141.v1

Cutaneous Reactions after COVID-19 Vaccines – Analysis of the Clinical and Histological Spectrum – Case Series and Review of the Literature

Ursina Schmid, Jörg Galambos MD, Katrin Pfaltz MD, Ivan Hegyi MD, Salomé Courvoisier MD, Werner Kempf Prof. MD

Subject: Medicine And Pharmacology, Dermatology Keywords: cutaneous; adverse; COVID-19; vaccine; histology; clinicopathologic correlation

Online: 3 January 2024 (05:39:23 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0054.v1

CO2 Laser Frenuloplasty: Advancing Minimally Invasive Techniques for Rapid Healing and Improved Patient Outcomes

Simone Amato, Steven Nisticò, Luigi Bennardo, Giovanni Pellacani, Giovanni Cannarozzo

Subject: Medicine And Pharmacology, Dermatology Keywords: Co2 laser; Frenuloplasty; laser therapy; Minimally Invasive Surgical Techniques

Online: 2 January 2024 (09:27:28 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202312.2196.v1

A Comprehensive Review of the Cosmetic Application of Kojic Acid Dipalmitate: Kojic Acid Derivative with Improved Properties

Angreni Ayuhastuti, Insan Sunan Kurniawan Syah, Sandra Megantara, Anis Yohana Chaerunisaa

Subject: Medicine And Pharmacology, Dermatology Keywords: kojic acid dipalmitate; cosmeceuticals; cosmeceuticals

Online: 28 December 2023 (14:39:28 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202312.1446.v1

The Escalating Specter of Antifungal Resistance in Superficial Mycoses

Ahmed Kadry Eltokhy, Ali Mohamed El-Abbasi, Mohamed Kadri Eltoukhi, Sidi Mohammed lahbib Seddiki, Mahmoud Afif Ghannoum

Subject: Medicine And Pharmacology, Dermatology Keywords: Antifungal resistance; superficial mycoses; antifungal susceptibility; Terbinafine resistant Trichophyton

Online: 19 December 2023 (15:57:37 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.0350.v1

Involvement of Par-2 in the Induction of Matrix Metalloproteinase-2 by Activated Protein C in Cutaneous Wound Healing

Sohel M Julovi, Kelly McKelvey, Nikita Minhas, Agnes Chan, Meilang Xue, Christopher J. Jackson

Subject: Medicine And Pharmacology, Dermatology Keywords: Activated protein C; cutaneous wound healing; murine; matrix metalloproteinase-2, 9; and protease activated receptor-2

Online: 12 December 2023 (08:26:11 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.0486.v1

Mucocutaneous Manifestations Reported by Inflammatory Bowel Disease Patients in University Hospital

Ieva Renata Jonaitytė, Vita Karpavičiūtė, Gediminas Kiudelis, Juozas Kupčinskas, Laimas Jonaitis

Subject: Medicine And Pharmacology, Dermatology Keywords: ulcerative colitis; Crohn’s disease; extraintestinal manifestation; skin lesions; mucocutaneous lesions

Online: 7 December 2023 (16:37:53 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202311.1810.v1

Lines and Dots Technique: A Novel Precision Approach in BoNT-A Administration for Horizontal Forehead Lines

Kamal Alhallak

Subject: Medicine And Pharmacology, Dermatology Keywords: Botulinum Toxin Type A (BoNT-A); Cosmetic Dermatology; Frontalis Muscle; Forehead Lines; Supraorbital Nerve; Supratrochlear Nerve

Online: 29 November 2023 (07:27:32 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202307.2097.v2

Progress in Wound Healing Products based on Natural Compounds, Stem Cells and MicroRNA-based Biopolymers in the European, USA, and Asian Markets: Opportunities, Barriers, and Regulatory Issues

Girish Kumar Srivastava, Sofía Martínez Rodríguez, Nur Izzah Md Fadilah, Daniel Looi Qi Hao, Gavin Markey, Priyank Shukla, Mh Busra Fauzi, Fivos Panetsos

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin injuries; Therapy; Caring; Natural Materials; Regulatory Issues; ISO

Online: 22 November 2023 (07:43:24 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202311.1190.v1

Endotypes of Atopic Dermatitis: Correspondence to Classical Subtypes

Tsuyoshi Suzuki, Shumpei Kondo, Yasuaki Ogura, Masaki Otsuka, Yoshiki Tokura

Subject: Medicine And Pharmacology, Dermatology Keywords: atopic dermatitis; endotype; extrinsic type; intrinsic type; subtype; phenotype

Online: 20 November 2023 (11:10:34 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.1152.v1

Development of Multibacillary Leprosy Medication Adherence Evaluation Questionnaire (ML-MAEQ) in Indonesian Patients

Laura Sendy Simamora, Sri Linuwih Menaldi, NFN Herqutanto, Eliza Miranda, Kusmarinah Bramono

Subject: Medicine And Pharmacology, Dermatology Keywords: adherence; instrument; leprosy; MDT; questionnaire

Online: 17 November 2023 (09:49:18 CET)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202311.1137.v1

An Exosome-Rich Conditioned Medium from Human Amniotic Membrane Stem Cells Facilitates Wound Healing via Increased Reepithelization, Collagen Synthesis, and Angiogenesis

Chan Ho Noh, Sangryong Park, Hye-Rim Seong, Ah-young Lee, Khan-Erdene Tsolmon, Dong Ho Geum, Soon-Cheol Hong, Tae Myoung Kim, Ehn-Kyoung Choi, Yun-Bae Kim

Subject: Medicine And Pharmacology, Dermatology Keywords: amniotic membrane stem cell; exosome-rich conditioned medium (ERCM); growth factor; neurotrophic factor; wound healing; keratinocyte proliferation; collagen synthesis; angiogenesis

Online: 17 November 2023 (07:53:56 CET)

Show abstract| Download PDF| Share

Tissue regeneration is an essential requirement for wound healing and recovery of organs’ function. It has been demonstrated that wound healing can be facilitated by activating paracrine signaling mediated by exosomes secreted from stem cells, since exosomes deliver many functional molecules including growth factors (GFs) and neurotrophic factors (NFs) effective for tissue regeneration. In this study, an exosome-rich conditioned medium (ERCM) was collected from human amniotic membrane stem cells (AMSCs) by cultivating the cells under a low oxygen tension (2% O2 and 5% CO2). The contents of GFs and NFs including keratinocyte growth factor, epidermal growth factor, fibroblast growth factor 1, transforming growth factor-β, and vascular endothelial growth factor responsible for skin regeneration were much higher (10-30 folds) in the ERCM than in normal conditioned medium (NCM). In was found that CM-DiI-labeled exosomes readily entered keratinocytes and fibroblasts, and that ERCM not only facilitated the proliferation of keratinocytes in normal condition, but also protected against H2O2 cytotoxicity. In cell-migration assay, the scratch wound in keratinocyte culture dish was rapidly closed by treatment with ERCM. Such wound-healing effects of ERCM were confirmed in a rat whole skin-excision model: i.e., the wound closure was significantly accelerated, remaining minimal crusts, by topical application of ERCM solution (4 x 109 exosome particles/100 μL) at 4-day intervals. In the wounded skin, the deposition of collagens was enhanced by treatment with ERCM, which was supported by the increased production of collagen-1 and collagen-3. In addition, enhanced angiogenesis in ERCM-treated wounds was confirmed by increased von Willebrand factor (vWF)-positive endothelial cells. The results indicate that ERCM from AMSCs with high concentrations of GFs and NFs improves wound healing through tissue regeneration not only by facilitating keratinocyte proliferation for skin repair, but also activating fibroblasts for extracellular matrix production, in addition to the regulation of angiogenesis and scar tissue formation.

Preprint ARTICLE | doi:10.20944/preprints202311.1067.v1

The Association of Vitamin D with Non-melanoma Skin Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses

Konstantinos Seretis, Nikolaos Bounas, Chrissa Sioka

Subject: Medicine And Pharmacology, Dermatology Keywords: Non-melanoma skin cancer; Vitamin D; risk; Vitamin D receptor; review; VDR polymorphism

Online: 16 November 2023 (10:46:20 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0921.v1

Assessment of Standard Surgical Excision Efficacy and Analysis of Recurrence-Associated Factors in 343 Cases of Nasal Basal Cell Carcinoma: a single-center retrospective study

Karolina Baltrušaitytė, Ernest Zacharevskij, Loreta Pilipaitytė, Kęstutis Braziulis, Arūnas Petkevičius

Subject: Medicine And Pharmacology, Dermatology Keywords: Basal Cell Carcinoma; non– melanoma skin cancer; recurrence; Standard Surgical Excision

Online: 15 November 2023 (04:03:17 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202311.0767.v1

CD147/Basigin Is Involved in the Development of Malignant Tumors and T Cell Mediated Immunological Disorders via Regulation of Glycolysis

Takuro Kanekura

Subject: Medicine And Pharmacology, Dermatology Keywords: CD147; glycolysis; malignant tumor; psoriasis; immune disorder

Online: 13 November 2023 (08:39:03 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202311.0772.v1

Clinical, Histopathological and Molecular Spectrum of Cutaneous Lesions in Myelodysplastic Syndrome and Myeloproliferative Neoplasms (MDS/MPN): A Review and A Proposed Classification

Lucía Prieto-Torres, Luis Requena, Socorro Maria Rodríguez-Pinilla

Subject: Medicine And Pharmacology, Dermatology Keywords: myelodysplastic and myeloproliferative neoplasms; CMML; skin

Online: 13 November 2023 (08:37:06 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202311.0259.v1

Phosphodiesterase 4 Inhibition in the Management of Psoriasis

Erika L Crowley, Melinda J Gooderham

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; PDE4 inhibitor; apremilast; roflumilast; crisaborole; clinical trials; review

Online: 6 November 2023 (07:07:05 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0932.v1

Analysis of Depigmenting Substances of Interest (Hydroquinone, Kojic Acid and Clobetasol Propionate) Contained in Lightening Cosmetic Products Marketed in Burkina Faso

B. Gérard Josias YAMEOGO, B. A. Lydiane Sandra ILBOUDO, Nomtondo Amina OUEDRAOGO, Mohamed BELEM, Ouéogo NIKIEMA, W. Bertrand GOUMBRI, B. Charles SOMBIE, Hermine ZIME DIAWARA, Elie KABRE, Rasmané SEMDE

Subject: Medicine And Pharmacology, Dermatology Keywords: lightening cosmetic; hydroquinone; clobetasol propionate; kojic acid; HPLC analysis

Online: 16 October 2023 (10:59:28 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0724.v1

Seaweeds Calliblepharis jubata and Fucus vesiculosus Pigments: Antidermatophytic Activity

Louisa Gomes, João Cotas, Chantal Fernades, Teresa Gonçalves, Leonel Pereira

Subject: Medicine And Pharmacology, Dermatology Keywords: Seaweeds; pigments; natural extracts; antifungal activity; UV Spectrophotometry; TLC; FTIR

Online: 11 October 2023 (10:39:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0539.v1

Efficacy and Safety of LASERs in Treatment of Dermal Pigmentation: A Five-Year Experience of 122 patients from North India

Suruchi Garg, Diksha Garg, Bhavni Oberoi, Geeta Sharma

Subject: Medicine And Pharmacology, Dermatology Keywords: Pigmentation; Melasma; Q switch laser; tattoo; birth marks

Online: 10 October 2023 (10:23:38 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202310.0472.v1

Acne Transcriptomics: Fundamentals in Acne Pathogenesis and Isotretinoin Treatment

Bodo C. Melnik

Subject: Medicine And Pharmacology, Dermatology Keywords: acne; apoptosis; FoxO1; FoxO3; isotretinoin; mTORC1; p53; pathogenesis; therapy; transcriptomics

Online: 9 October 2023 (07:48:02 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0242.v1

Influence of Dose, Particle Size &Amp; Concentration on Dermal Penetration Efficacy of Curcumin

Em-on Chaiprateep, Sabrina Wiemann, Ralph W Eckert, Christian S. Raab, Soma Sengupta, Cornelia M. Keck

Subject: Medicine And Pharmacology, Dermatology Keywords: nanocrystals; curcumin; aqueous meniscus; dermal penetration; ex-vivo model; porcine skin

Online: 5 October 2023 (02:10:32 CEST)

Show abstract| Download PDF| Share

Preprint INTERESTING IMAGES | doi:10.20944/preprints202310.0125.v1

Individual Keratinocyte Necrosis in the Epidermis Includes Apoptosis in the Skin: A Case Report.

Mitsuhiro Tachibana, Hideki Hamayasu, Kazuki Tomita, Yuta Kage

Subject: Medicine And Pharmacology, Dermatology Keywords: keratinocyte necrosis; apoptosis; cleaved caspase-3; skin

Online: 3 October 2023 (10:49:24 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.1665.v1

Generalized Rash in Severe Hospitalized COVID Patients: Correlation between Histological Examination, Drug Intake, Blood Interleukins Profileand Long-Term Follow-Up

Montserrat Fernández-Guarino, Vivian Stewart, Diego Fernández-Nieto, Carmen Moreno Garcia del Real, David Gonzalez de Olano, Carolina Blanco, Emilio Solano-Solares, Belen De la Hoz Caballer, Javier Martínez-Botas, Maria Laura Garcia-Bermejo, Ana Andrés-Martín

Subject: Medicine And Pharmacology, Dermatology Keywords: skin; COVID infection; cytokines; SARS-CoV-2

Online: 25 September 2023 (09:37:37 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.1065.v1

Plasma Cytokines for Prediction of the Effectiveness of TNFα Inhibitors Etanercept, Infliximab, and Adalimumab in the Treatment of Psoriasis

Karamova Arfenya, Ludmila Znamenskaya, Anastasiia Vorontsova, Olga Obraztsova, Alexandr Nikonorov, Eugenia Nikonorova, Dmitry Deryabin, Alexey Kubanov

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; plasma cytokines; TNFα inhibitors; etanercept; infliximab; adalimumab

Online: 18 September 2023 (02:32:17 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202309.0375.v1

Accelerated Burn Healing in a Mouse Experimental Model by α-gal Nanoparticles

Uri Galili

Subject: Medicine And Pharmacology, Dermatology Keywords: Burn healing; anti-Gal antibody; -gal epitope; -gal nanoparticles; macrophage migration; -gal therapy; mesenchymal stem cells.

Online: 6 September 2023 (10:23:59 CEST)

Show abstract| Download PDF| Share

Macrophages play a pivotal role in the process of healing burns. One of the major risks in the course of burns healing, in the absence of regenerating epidermis, is infections which greatly contribute to morbidity and mortality in such patients. Therefore, it is widely agreed that accelerating recruitment of macrophages into burns may contribute to faster regeneration of the epidermis and thus, decreasing the risk of infections. This review describes a unique method for rapid recruitment of macrophages into burns and activation of these macrophages to mediate accelerated regrowth of the epidermis and healing of burns. The method is based on application of bio-degradable “alpha-gal” nanoparticles to burns. These nanoparticles present multiple alpha-gal epitopes (Gal alpha1-3Gal beta1-4GlcNAc-R) which bind the abundant natural anti-Gal antibody that constitutes ~1% of immunoglobulins in humans. Anti-Gal/alpha-gal nanoparticles interaction activates the complement system, resulting in localized production of the complement cleavage-peptides C5a and C3a that are highly effective chemotactic factors for monocytes derived macrophages. The macrophages recruited into the alpha-gal nanoparticles treated burns are activated following interaction between the Fc portion of anti-Gal coating the nanoparticles and the multiple Fc receptors on macrophages cell membranes. The activated macrophages secrete a variety of cytokines/growth factors that accelerate the regrowth of the epidermis and regeneration of the injured skin, thereby cutting the healing time by half. Studies on healing of thermal injuries in the skin of anti-Gal producing mice, demonstrated a much faster recruitment of macrophages into burns treated with alpha-gal nanoparticles than in control burns treated with saline and healing of the burns within 6 days, whereas healing of control burns takes ~12 days. alpha-Gal nanoparticles are non-toxic, and do not cause chronic granulomas or keloids. These findings suggest that alpha-gal nanoparticles treatment may harness anti-Gal for inducing similar accelerated burn healing effects also in humans.

Preprint REVIEW | doi:10.20944/preprints202309.0059.v1

Enhancing Skin Anti-Aging Through Healthy Lifestyle Factors

Helen Knaggs, Edwin D Lephart

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin; Anti-aging; Health, Lifestyle Factors, Diet, Sleep, Exercise, Social interactions, Polyphenols, Vitamins

Online: 1 September 2023 (10:30:06 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202308.0827.v1

Assessment of NADH/NAD+ Redox Imbalance in Psoriatic Lesions Using the FMSF Technique: Therapeutic Aspects

Jerzy Gebicki, Tomasz Filipiak, Andrzej Marcinek, Anna Woźniacka

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; NADH/NAD+ redox imbalance; NADH fluorescence; FMSF technique

Online: 10 August 2023 (07:12:46 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0569.v1

Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-inflammatory Cytokine Secretion in Keratinocytes

Thi Huyen Dang, Ji Yeong Kim, Hyun Jong Kim, Byung Joo Kim, Woo Kyung Kim, Joo Hyun Nam

Subject: Medicine And Pharmacology, Dermatology Keywords: Keratinocytes; alpha-mangostin; TRPV3; skin inflammation; dermatitis

Online: 8 August 2023 (03:42:33 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202308.0582.v1

Simplifying Forehead and Temple Reconstruction

Pedro Redondo

Subject: Medicine And Pharmacology, Dermatology Keywords: forehead; temple reconstruction; frontalis myocutaneous trasposition flap; preauricular skin advancement flap; glabela; eyebrows

Online: 8 August 2023 (02:51:03 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0511.v1

Selected miRNA and Psoriasis—Cardiovascular Disease (CVD)—Overweight/Obesity Network

Anna Michalak-Stoma, Katarzyna Walczak, Michał Adamczyk, Małgorzata Kowal, Dorota Krasowska

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; psoriatic arthritis (PsA); overweight; obesity; cardiovascular disease (CVD); miR-22-3p; miR-133a-3p; miR-146a-5p; miR-369-3p; Let-7b-5p

Online: 7 August 2023 (11:50:50 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0463.v1

Investigations of 13 Genes in Non-Cicatricial Alopecia

Monica Păun, Gustavo Torres, George Sorin Țiplica, Victor Mihail Cauni

Subject: Medicine And Pharmacology, Dermatology Keywords: alopecia areata; androgenetic alopecia; genetic test; DNA analysis

Online: 7 August 2023 (10:13:57 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0347.v1

Neutrophil-to-Lymphocyte Ratio, Neutrophil-to-Monocyte Ratio, Platelet-to-Lymphocyte Ratio, and Systemic Immune-Inflammation Index in Psoriasis Patients: Response To Treatment With Biological Drugs

Hulya Albayrak

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; neutrophil/lymphocyte ratio; platelet/lymphocyte ratio; neutrophil/monocyte ratio; systemic immune-inflammation index

Online: 4 August 2023 (07:52:53 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0361.v1

Genetical Signature – An Example of Personalized Skin Aging Investigation with Possible Implementation to Clinical Practice

Ramune Sepetiene, Vaiva Patamsyte, Paulius Valiukevicius, Emilija Gecyte, Vilius Skipskis, Dovydas Gečys, Zita Stanioniene, Svajunas Barakauskas

Subject: Medicine And Pharmacology, Dermatology Keywords: skin aging; polymorpysms; laboratory analysis

Online: 3 August 2023 (14:42:49 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0150.v1

Development of a Low-Temperature Process for the Formulation of Nanoemulsion-Gel Encapsulating Essential Oil: Investigation on the Wound Healing Effect

Badr Bahloul, Enis Ben Bnina, Assia Hamdi, Luis Castillo, Dhaou Baccar, Nesrine Kalboussi, Aymen Abbassi, Nathalie Mignet, Guido Flamini, José Vega-Baudrit

Subject: Medicine And Pharmacology, Dermatology Keywords: nanoemulsion; wound healing effect; essential oil

Online: 2 August 2023 (08:29:35 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202308.0124.v1

Wound-Healing Effects of an Exosome-Rich Conditioned Medium from Human Amniotic Membrane Stem Cells

Chan Ho Noh, Sangryong Park, Hye-Rim Seong, Ah-young Lee, Khan-Erdene Tsolmon, Dong Ho Geum, Soon-Cheol Hong, Tae Myoung Kim, Ehn-Kyoung Choi, Yun-Bae Kim

Subject: Medicine And Pharmacology, Dermatology Keywords: amniotic membrane stem cell; exosome-rich conditioned medium (ERCM); growth factor; neurotrophic factor; wound healing; keratinocyte proliferation; collagen synthesis

Online: 2 August 2023 (07:32:13 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202307.2097.v1

Progress in Wound Healing Products Based on Natural Compounds, Stem Cells and MicroRNA-Based Biopolymers in the European, USA, and Asian Markets: Opportunities, Barriers, and Regulatory Issues

Girish Kumar Srivastava, Sofía Martínez Rodríguez, Nur Izzah Md Fadilah, Gavin Markey, Daniel Looi Qi Hao, Priyank Shukla, Mh Busra Fauzi, Fivos Panetsos

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin injuries; Therapy; Caring; Natural Materials; Regulatory Issues; ISO

Online: 31 July 2023 (10:38:44 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202307.1499.v1

Genetic and Epigenetic Mechanisms of Psoriasis

Laura Mateu-Arrom, Lluís Puig

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; genetics; epigenomics

Online: 21 July 2023 (10:27:08 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.0998.v1

Insulin Resistance in Patients with Acne Vulgaris– Original Paper and Systematic Review

Michalina Gruszczyńska, Anna Sadowska-Przytocka, Weronika Szybiak, Barbara Więckowska, Katarzyna Lacka

Subject: Medicine And Pharmacology, Dermatology Keywords: acne vulgaris; insulin resistance; HOMA-IR; resistant acne

Online: 14 July 2023 (11:12:45 CEST)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints202307.0971.v1

Complementary Use of a Next-Generation Emollient Plus and Pimecrolimus in Atopic Dermatitis: A Case Report

Tiago Torres

Subject: Medicine And Pharmacology, Dermatology Keywords: atopic dermatitis; emollient plus cream; topical corticosteroids; topical calcineurin inhibitors; case report

Online: 14 July 2023 (09:18:55 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202307.0996.v1

Hereditary Angioedema

Cristina Violeta Tutunaru, Oana Maria Ică, George F. Mitroi, Carmen Daniela Neagoe, George G. Mitroi, Simona Laura Ianosi

Subject: Medicine And Pharmacology, Dermatology Keywords: hereditary angioedema guidelines; treatment; prophylaxis; management

Online: 14 July 2023 (08:49:28 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202307.0554.v1

Alopecias: Practical Tips For The Management Of Biopsies And Main Diagnostic Clues For The General Pathologist And Dermatopathologist

Fernando Pinedo Moraleda, Belen Tristan Martin, Giulia Greta Dradi

Subject: Medicine And Pharmacology, Dermatology Keywords: alopecia; cicatricial alopecia; follicular cycle; follicle histopathology; hair; hair loss; noncicatricial alopecia; nonscarring alopecia; scarring alopecia

Online: 10 July 2023 (08:53:59 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202307.0397.v1

Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates

Chengqian Chen, Peiru Wang, Linglin Zhang, Xiaojing Liu, Haiyan Zhang, Yajing Cao, Xiuli Wang, Qingyu Zeng

Subject: Medicine And Pharmacology, Dermatology Keywords: Rosacea; inflammation; inflammatory skin disease; pathogenesis; therapeutic strategies; treatment options

Online: 6 July 2023 (09:02:30 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202306.1811.v1

Efficacy of Pembrolizumab in Advanced Melanoma: A Narrative Review

Giulio Rizzetto, Edoardo De Simoni, Elisa Molinelli, Annamaria Offidani, Oriana Simonetti

Subject: Medicine And Pharmacology, Dermatology Keywords: advanced melanoma; pembrolizumab; immunotherapy

Online: 26 June 2023 (12:07:15 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.1726.v1

Investigating the Causal Relationship of Gut Microbiota with Psoriasis and Psoriatic Arthritis: A Bidirectional Two-Sample Mendelian Randomization Study.

Nianzhou Yu, Jiayi Wang, Yuancheng Liu, Yeye Guo

Subject: Medicine And Pharmacology, Dermatology Keywords: Gut Microbiota (GM); Psoriasis (Ps); Psoriatic Arthritis (PsA); Mendelian randomization(MR); Causal effect

Online: 25 June 2023 (08:26:05 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Background: Numerous investigations have shed light on the intriguing interplay between gut microbiota(GM) and psoriasis (Ps) as well as psoriatic arthritis (PsA). However, the precise nature of the causal relationship between them remains an area of active investigation. Methods: For the purpose of our investigation, we meticulously curated a collection of genetic variants (P < 1 × 10−5) associated with GM (n = 18,340) derived from the MiBioGen study. To explore the intricate relationship between GM and Ps as well as PsA, we harnessed the comprehensive resources of the FinnGen database, encompassing a vast cohort of individuals, including 4,510 Ps cases and 212,242 controls, and 1,637 PsA cases and 212,242 controls. Even complementary MR methods were implemented, including an inverse variance weighting method, followed by a sensitivity analysis to verify the robustness of the results. Results: In this study, we found that certain bacterial taxa, such as Lactococcus, Ruminiclostridium 5, and Eubacterium fissicatena, were identified as risk factors. Conversely, Alloprevotella and Odoribacter demonstrated a protective effect against Ps. In the case of PsA, our results revealed a distinct set of risk factors and protective factors among the gut bacterial taxa. Lactococcus, Verrucomicrobiales, Akkermansia, Coprococcus 1, Lachnospiraceae, and Verrucomicrobiaceae were identified as risk factors for PsA. On the other hand, Odoribacter, Rikenellaceae, Clostridium innocuum, and Marvinbryantia exhibited a protective effect against the development of PsA. Conclusion: Our findings shed light on the distinctive disease characteristics and onset features between Ps and PsA. Notably, certain intestinal flora were implicated in the pathogenesis of PsA, suggesting their potential role as early diagnostic indicators. Furthermore, we identified several bacterial flora that exhibit a potential protective effect against the occurrence of Ps and PsA. These discoveries lay a solid foundation for future endeavors in the prevention and treatment of these conditions.

Preprint REVIEW | doi:10.20944/preprints202306.1647.v1

Clinical Applications of Polypodium leucotomos (Fernblock®): An Update

Azahara Rodríguez-Luna, Alicia Zamarrón, Ángeles Juarranz, Salvador González

Subject: Medicine And Pharmacology, Dermatology Keywords: Polypodium leucotomos; Fernblock®; photoprotection; photodermatoses; photoaging; hyperpigmentation

Online: 23 June 2023 (08:58:58 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202306.1290.v1

The Genetic Susceptibility to Psoriasis and the Relationship of Linked Genes to our Treatment Options

Heli A. Patel, Rishab Revankar, Sofia T. Pedroza, Shaveonte Graham, Steven R. Feldman

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; genetics; biologics; cytokines; interleukins; small molecules; JAK-STAT

Online: 19 June 2023 (04:59:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.1248.v1

Sequential and Combined Efficacious Management of Auricular keloid: A Novel Treatment Protocol Employing Ablative CO₂ and Dye Laser Therapy – An Advanced Single-Center Clinical Investigation

Simone Amato, Steven Paul Nisticò, Giovanni Pellacani, Stefania Guida, Anthony Rossi, Caterina Longo, Enzo Berardesca, Giovanni Cannarozzo

Subject: Medicine And Pharmacology, Dermatology Keywords: Auricular keloids, CO2 laser therapy, Dye laser therapy, Multispectral analysis; scar; Vancouver scar scale; Patient and Observer Scar Assessment Scale

Online: 16 June 2023 (13:46:19 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0583.v1

Cosmetics Pattern Map Considering their Effects on Skin Microbiota-Principal Component Analysis of the Effects on Short Chain Fatty Acid Production by Skin Microbiota Staphylococcus epidermidis

Kurumi Tanabe, Chihiro Moriguchi, Nao Fujiyama, Yuka Shigematsu, Nanami Haraguchi, Yuto Hirano, Huanghuang Dai, Shigeki Inaba, Yoshihiro Tokudome, Hiroshi Kitagaki

Subject: Medicine And Pharmacology, Dermatology Keywords: cosmetics; skin microbiota; Staphylococcus epidermidis; lactic acid; PCA

Online: 8 June 2023 (04:09:58 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0301.v1

Remote Monitoring of Canine Patients Treated for Pruritus during the COVID Pandemic in Florida Using a 3-D Accelerometer

Michael Canfield, Robert P. Lavan, Timberly Canfield, Gal Gingold, Jennifer Thomas, Bridgette Sampeck, Tonya Springer, Rob Armstrong

Subject: Medicine And Pharmacology, Dermatology Keywords: pruritus; 3D-accellerometer; monitoring; allergic skin disease; canine atopic dermatitis

Online: 5 June 2023 (10:13:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0257.v1

Ciprofloxacin-Loaded Polyvinylpyrrolidone Foils for the Topical Treatment of Wound Infections with Methicillin-Resistant Staphylococcus aureus (MRSA)

Fiorenza Rancan, Jana Jurisch, Sabrina Hadam, Annika Vogt, Ulrike Blume-Peytavi, Ilker S. Bayer, Marco Contardi, Christoph Schaudinn

Subject: Medicine And Pharmacology, Dermatology Keywords: wound dressing; drug delivery; organ culture, infection models, ciprofloxacin, infected wounds

Online: 5 June 2023 (08:09:29 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0016.v1

The IFIH1/MDA5 rs1990760 Gene Variant (946Thr) Differentiates Early Versus Late-Onset Skin Disease and Increased the Risk of Arthritis in a Spanish Cohort of Psoriatic Disease

Pablo Coto-Segura, Daniel Vazquez-Coto, Lucinda Velazquez-Cuervo, Claudia García-Lago, Eliecer Coto, Rubén Queiro

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; psoriatic arthritis; IFIH1; MDA5; polymorphism; genetic association

Online: 1 June 2023 (03:40:11 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202305.2058.v1

Super-high Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions

Vittoria Cioppa, Giulio Cortonesi, Linda Tognetti, Jean Luc Perrot, Renato Rossi, Matteo Gnone, Alessandra Cartocci, Pietro Rubegni, Elisa Cinotti

Subject: Medicine And Pharmacology, Dermatology Keywords: Dermoscopy; high magnification; super-high magnification; keratinocyte; melanocyte; melanoma.

Online: 30 May 2023 (06:04:10 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1369.v1

Protective Effect of Amaranthus cruentus Seed Oil on the UVA Radiation-Induced Apoptosis in Human Skin Fibroblasts

Katarzyna Wolosik, Magda Chalecka, Jerzy Palka, Arkadiusz Surazynski

Subject: Medicine And Pharmacology, Dermatology Keywords: UVA radiation; oxidative stress; dermal fibroblasts; apoptosis; antioxidant; Amaranthus cruentus seed oil; sun-protective substance; pharmacy; cosmetology

Online: 19 May 2023 (03:49:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1290.v1

Is Cutaneous T-Cell Lymphoma Caused by Ultraviolet Radiation? Comparison of UV Mutational Signatures Between Malignant Melanoma and Mycosis Fungoides.

Robert Gniadecki, Sandra O’Keefe, Dylan Hennessey, Aishwarya Iyer

Subject: Medicine And Pharmacology, Dermatology Keywords: cutaneous T-cell lymphoma; ultraviolet; mutation signatures; malignant melanoma, whole exome sequencing

Online: 18 May 2023 (07:36:55 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202305.0628.v1

Nanotechnology-Based Topical Delivery of Natural Products for the Management of Atopic Dermatitis

Mário Pedro Marques, Carla Varela, Laura Mendonça, Célia Cabral

Subject: Medicine And Pharmacology, Dermatology Keywords: atopic dermatitis; skin inflammation; natural products; nanotechnology; topical delivery

Online: 9 May 2023 (09:45:26 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0461.v1

Polymorphisms of the GCLC Gene Are Novel Genetic Markers For Susceptibility To Psoriasis Associated With Alcohol Abuse And Cigarette Smoking

Ekaterina Efanova, Olga Bushueva, Roman Saranyuk, Anna Surovtseva, Mikhail Churnosov, Maria Solodilova, Alexey Polonikov

Subject: Medicine And Pharmacology, Dermatology Keywords: Psoriasis; genetic susceptibility; oxidative stress; glutathione; glutamate cysteine ligase; GCLC; single nucleotide polymorphism; cigarette smoking; alcohol abuse; gene–environment interactions

Online: 8 May 2023 (08:03:11 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202305.0357.v1

Kinetics of Wound Development and Healing Suggests a Skin-Stabilizing Effect of Allogeneic ABCB5+ Mesenchymal Stromal Cell Treatment in Recessive Dystrophic Epidermolysis Bullosa

Elke Niebergall-Roth, Kathrin Dieter, Cristina Daniele, Silvia Fluhr, Maria Khokhrina, Ines Silva, Christoph Ganss, Markus H. Frank, Mark A. Kluth

Subject: Medicine And Pharmacology, Dermatology Keywords: ABCB5; cell therapy; mesenchymal stromal cells; recessive dystrophic epidermolysis bullosa; wound healing

Online: 5 May 2023 (10:49:57 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202304.1261.v1

Sharp Resection of Hypergranulation Tissue from Only One Sulcus in a Bilateral Stage 3 Onychocryptosis: A Case Report

Ian Reilly

Subject: Medicine And Pharmacology, Dermatology Keywords: Ingrown toenail; onychocryptosis; hypergranulation tissue; proud flesh; sharp resection

Online: 30 April 2023 (04:48:26 CEST)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints202304.0775.v1

Guided Superficial Enhanced Fluid Fat Injection (SEFFI) Procedures for Facial Rejuvenation: An Italian Multicenter Retrospective Case Reports

Gennai Alessandro, Monica Baldessin, Fabrizio Melfa, Bruno Bovani, Alessandra Camporese, Barbara Claysset, Mattia Colli, Alberto Diaspro, Rosalba Russo, Placido Strano, Daniele Bollero, Guido Capparè, Alessandro Casadei, Giovanni Gallo, Domenico Piccolo, Giovanni Salti, Piero Tesauro

Subject: Medicine And Pharmacology, Dermatology Keywords: facial rejuvenation; Stromal Vascular Fraction; adipose derived mesenchymal stem cells; autologous adipose tissue graft; Superficial Enhanced Fluid Fat Injection; clinical regeneration applications

Online: 23 April 2023 (05:01:28 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202304.0630.v1

Clinical‑Epidemiological Characteristics of Hidradenitis Suppurativa: A Retrospective Cohort Study

Anan Hammud, Emily Avitan-Hersh, Ziad Khamaysi

Subject: Medicine And Pharmacology, Dermatology Keywords: Hidradenitis Suppurativa; Adalimumab (Humira); Hurley Stages; Arabs and Jews

Online: 20 April 2023 (08:14:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202304.0617.v1

Plaque Psoriasis: Effectiveness and Therapeutic Safety Using a Topical Cream of Natural Origin Quasi–experimental Clinical Trial

Elizabeth Maria Benites, Esmeralda Carrillo, Martha Heras

Subject: Medicine And Pharmacology, Dermatology Keywords: Psoriasis; erythema; infiltration; desquamation; itching; PASI; SBA

Online: 20 April 2023 (07:34:29 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202304.0545.v1

Potential Use of Guarana-Loaded Liposomes in Topical Applica-Tions: Toxicity Profile Assessment Using Different Skin Cell Lines

Isabel Roggia, Patrícia Gomes, Ana Julia Figueiro Dalcin, Aline Ferreira Ourique, Ivana Beatrice Mânica Da Cruz, Euler Esteves Ribeiro, Montserrat Mitjans, Maria Pilar Vinardell

Subject: Medicine And Pharmacology, Dermatology Keywords: Paullinia cupana; natural products; nanoparticles; stability; cytotoxicity; cell culture

Online: 19 April 2023 (04:52:31 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202304.0395.v1

An Investigation into The Acute and Subacute Toxicity of Extracts of Cassipourea Flanaganii Stem Bark in vivo

Nomakhosi Mpofana, John Kudakwashe Chipangura, Michael Paulse, Bert Mohr, Nceba Gqaleni, Celenkosini Thembelenkosini Nxumalo, Ncoza Cordelia Dlova, Ahmed A. Hussein, Neil R. Crouch

Subject: Medicine And Pharmacology, Dermatology Keywords: cassipourea flanaganii; hypermelanosis; melasma; toxicity

Online: 17 April 2023 (04:11:14 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202303.0164.v1

Role of the Gut Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence

Maria Consiglia Bragazzi, Rosanna Venere, Anthony Vignone, Domenico Alvaro, Vincenzo Cardinale

Subject: Medicine And Pharmacology, Dermatology Keywords: mucosal barrier; cholangiocarcinoma; gut-liver-axis; primay biliary cholangitis; primay sclerosing cholangitis

Online: 9 March 2023 (03:12:39 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202303.0110.v1

The Current Role and Future Applications of Machine Perfusion in Liver Transplantation

Sebastian Manuel Staubli, Carlo D. L. Ceresa, Jörg-Matthias Pollok

Subject: Medicine And Pharmacology, Dermatology Keywords: Liver transplantation; organ perfusion

Online: 6 March 2023 (15:23:52 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202303.0039.v1

The Impact of Ultraviolet Radiation on Energy Metabolism and Metabolic Disorders in Mice: Mechanisms and Implications

Qing-Ling Quan, Kyeong-No Yoon, Ji Su Lee, Eun Ju Kim, Dong Hun Lee

Subject: Medicine And Pharmacology, Dermatology Keywords: metabolic disorders; nitric oxide; obesity; ultraviolet; vitamin D

Online: 2 March 2023 (09:44:53 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202303.0035.v1

Clinical Assessment of Specifically Formulated Creams for Oncology: Case Series

Jordi Esquirol Caussa, José Luis Ribes Bernal

Subject: Medicine And Pharmacology, Dermatology Keywords: breast cancer; radiodermatitis; radiotherapy; primary prevention

Online: 2 March 2023 (06:33:07 CET)

Show abstract| Download PDF| Supplementary Files| Share

INTRODUCTION: Radiation dermatitis is a common sequela of radiotherapy (RT) that can affect up to 95% of patients, developing moderate to severe skin reactions in up to 30% of them. Variation in fractionation or administration methods may reduce the incidence and severity of radiation dermatitis. It is considered that topical use of preparations holding certain preservatives, surfactants, additives, oils, and impurities should be avoided in cancer patients. In clinical practice, creams of different compositions are used, with and without Epidermal Growth Factor (EFG). OBJECTIVE: To analyze the effectiveness of three creams of different compositions for the control of symptoms and skin side effects of RT.METHODS: A pilot study comparing three treatment groups (HR, HU, and RS creams) during the RT program and with a follow-up of 2 weeks thereafter. Study variables: fractionation, Patient-Observer scale, Maxidex (elasticity, hydration, melanin, erythema).RESULTS: The pilot study sample included 15 patients (5 for each group), so the results were not statistically significant. There were no undesirable side effects to the application of the creams under study and compliance and tolerance were excellent.Regardless of fractionation, RS cream appears to be more effective in controlling symptoms during RT, while HU cream may control them more effectively after the RT regimen is completed.During RT, in hypofractionated therapies, the RS cream seems to preserve elasticity, hydration, and hyperpigmentation allowing erythema that could increase skin repair processes. After the RT is finished, the HR cream further improves elasticity and allows the appearance of erythema.In normofractionated therapies during RT all creams seem to have comparable results in the four cutaneous components analyzed; after completion of RT, HR cream appears to better control hydration and hyperpigmentation.CONCLUSIONS: All the creams analyzed have good control of symptoms and the appearance of the skin during and after RT. The prescription of one or another composition should be done individually according to the cutaneous and clinical particularities of each patient. A study with experimental design is needed to analyze the statistical significance of the differences between the creams analyzed.

Preprint REVIEW | doi:10.20944/preprints202302.0458.v1

Pathophysiology of Atopic Dermatitis in Different Ethnic Groups

Andrea Chiricozzi, Martina Maurelli, Laura Calabrese, Ketty Peris, Giampiero Girolomoni

Subject: Medicine And Pharmacology, Dermatology Keywords: atopic eczema; dermatitis; allergy; itch; skin disease; treatment; prevention; epidemiology; ethnic differences; cellular; molecular; immunological; physiological therapeutic

Online: 27 February 2023 (08:30:54 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202302.0429.v1

The Dawning of a New Enterprise: RNA Therapeutics for the Skin

Rachel Kieser, Shaheerah Khan, Nada Bejar, Daniel Kiss

Subject: Medicine And Pharmacology, Dermatology Keywords: RNA therapeutics; skin; mRNA therapeutics; siRNA therapeutics; antisense oligonucleotide ther-apeutics; ASO; melanoma; hypertrophic scars; wound healing; dermatology

Online: 27 February 2023 (01:53:06 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202302.0351.v1

Bile Duct Double Ligation and Microdialysis in Rats: An Animal Model of Liver Fibrosis

Giuliana Scarpati, Marco Corona, Ornella Piazza

Subject: Medicine And Pharmacology, Dermatology Keywords: liver fibrosis; liver cirrhosis; bile duct ligation; animal model

Online: 21 February 2023 (04:21:07 CET)

Show abstract| Download PDF| Share

Preprint CONCEPT PAPER | doi:10.20944/preprints202302.0297.v1

Novel Data Analyses Address the African Enigma and Controversies Surrounding the Roles of Helicobacter pylori in Peptic Ulcers

Simon Xin Min Dong

Subject: Medicine And Pharmacology, Dermatology Keywords: Helicobacter pylori; peptic ulcer; etiology; illusion; philosophy; African enigma

Online: 17 February 2023 (06:33:15 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202302.0271.v1

Novel Data Analyses Explain the Seasonal Variation of Peptic Ulcers

Simon Xin Min Dong

Subject: Medicine And Pharmacology, Dermatology Keywords: peptic ulcer; seasonal variation; superposition mechanism; climate; work; vacation; psychosomatic disease; psychological stress

Online: 16 February 2023 (04:52:59 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202302.0193.v1

Novel Data Analyses Explain the Birth-Cohort Phenomenon of Peptic Ulcers

Simon Xin Min Dong

Subject: Medicine And Pharmacology, Dermatology Keywords: peptic ulcers; birth-cohort phenomenon; superposition mechanism; psychosomatic disease; psy-chological stress; crucial events

Online: 13 February 2023 (02:06:22 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202212.0364.v1

Efﬁcacy and Safety of Phaseolus angularis L for. as Anti-aging Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

Sarang Oh, Jeehaeng Jeong, Xiangji Jin, Myeongju Kim, Shengdao Zheng, Tae-Hoo Yi

Subject: Medicine And Pharmacology, Dermatology Keywords: Phaseolus angularis seed extract (PASE); anti-aging; health skin, cosmetic products

Online: 20 December 2022 (09:03:36 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202212.0315.v1

Treatment of Melasma on Darker Skin Types: a Scoping Review

Nomakhosi Mpofana, Buyisile Chibi, Tronel Visser, Michael Paulse, Avenal Jane Finlayson, Shanaz Ghuman, Nceba Gqaleni, Ahmed Mohammed Hussain, Ncoza Cordelia Dlova

Subject: Medicine And Pharmacology, Dermatology Keywords: Melasma; Treatment; Darker skin types; Fitzpatrick skin types IV-VI; mapping review

Online: 19 December 2022 (03:45:26 CET)

Show abstract| Download PDF| Share

Medicine and Pharmacology