Preprint Review Version 3 This version is not peer-reviewed

Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs

Version 1 : Received: 22 October 2018 / Approved: 22 October 2018 / Online: 22 October 2018 (13:14:33 CEST)
Version 2 : Received: 23 October 2018 / Approved: 24 October 2018 / Online: 24 October 2018 (09:55:26 CEST)
Version 3 : Received: 25 October 2018 / Approved: 26 October 2018 / Online: 26 October 2018 (10:22:45 CEST)

A peer-reviewed article of this Preprint also exists.

Thapar, R. Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs. Molecules 2018, 23, 2789. Thapar, R. Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs. Molecules 2018, 23, 2789.

Journal reference: Molecules 2018, 23, 2789
DOI: 10.3390/molecules23112789

Abstract

DNA double-strand breaks (DSBs) are deleterious lesions that are generated in response to ionizing radiation or replication fork collapse that can lead to genomic instability and cancer.  Eukaryotes have evolved two major pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ) to repair DSBs.  Whereas the roles of protein-DNA interactions in HR and NHEJ have been fairly well defined, the functions of small and long non-coding RNAs and RNA-DNA hybrids in the DNA damage response is just beginning to be elucidated.  This review summarizes recent discoveries on the identification of non-coding RNAs and RNA-mediated regulation of DSB repair

Subject Areas

DNA repair; long non-coding RNA; microRNA; DNA damage; double-strand breaks; NHEJ; HR

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