Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs

Roopa Thapar

doi:10.20944/preprints201810.0500.v3

Preprint Review Version 3 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 22 October 2018 / Approved: 22 October 2018 / Online: 22 October 2018 (13:14:33 CEST)
Version 2 : Received: 23 October 2018 / Approved: 24 October 2018 / Online: 24 October 2018 (09:55:26 CEST)
Version 3 : Received: 25 October 2018 / Approved: 26 October 2018 / Online: 26 October 2018 (10:22:45 CEST)

DNA double-strand breaks (DSBs) are deleterious lesions that are generated in response to ionizing radiation or replication fork collapse that can lead to genomic instability and cancer. Eukaryotes have evolved two major pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ) to repair DSBs. Whereas the roles of protein-DNA interactions in HR and NHEJ have been fairly well defined, the functions of small and long non-coding RNAs and RNA-DNA hybrids in the DNA damage response is just beginning to be elucidated. This review summarizes recent discoveries on the identification of non-coding RNAs and RNA-mediated regulation of DSB repair

DNA repair; long non-coding RNA; microRNA; DNA damage; double-strand breaks; NHEJ; HR

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Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs

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