Preprint Review Version 1 This version is not peer-reviewed

Elucidating Role of Bacteria in Psoriatic Disease: From Skin and Gut Perspectives

Version 1 : Received: 12 September 2018 / Approved: 12 September 2018 / Online: 12 September 2018 (07:49:33 CEST)

How to cite: Yermekbayeva, B.; Algazina, T.; Razbekova, M.; Pinhasov, A.; Batpenova, G.; Kushugulova, A. Elucidating Role of Bacteria in Psoriatic Disease: From Skin and Gut Perspectives. Preprints 2018, 2018090215 (doi: 10.20944/preprints201809.0215.v1). Yermekbayeva, B.; Algazina, T.; Razbekova, M.; Pinhasov, A.; Batpenova, G.; Kushugulova, A. Elucidating Role of Bacteria in Psoriatic Disease: From Skin and Gut Perspectives. Preprints 2018, 2018090215 (doi: 10.20944/preprints201809.0215.v1).

Abstract

Psoriasis is a chronic inflammatory disease characterized by skin lesions. Psoriasis development has been associated both with genetic and environmental factors. Though skin and gut microbiota has been implicated in number of pathologies including atopic dermatitis, inflammatory bowel disease, Crohn’s disease, allergy, obesity, its role has been poorly studied in psoriatic disease, which incorporates both psoriasis and psoriatic arthritis. This literature review summarizes the most recent and major findings on microbiota features in psoriatic disease as well as gives immune system role in the given condition. Despite conflicting findings, psoriasis patients were frequently found to have distinct microbial composition in both skin and guts especially in the major bacterial phyla, Firmicutes, Bacteroidetes, and Akkermansia. Furthermore, bacterial DNA has been found in psoriatic patients both locally and systemically, and altogether suggesting role of bacteria in the chronic disease and future studies in this field.

Subject Areas

gut microbiota; skin microbiota; inflammation; psoriasis; psoriatic arthritis; dysbiosis

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