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Synchronized Oscillations in Double-Helix B-DNA Molecules with Mirror-Symmetric Codons
Version 1
: Received: 2 January 2021 / Approved: 4 January 2021 / Online: 4 January 2021 (16:35:40 CET)
A peer-reviewed article of this Preprint also exists.
Maciá, E. Synchronized Oscillations in Double-Helix B-DNA Molecules with Mirror-Symmetric Codons. Symmetry 2021, 13, 241. Maciá, E. Synchronized Oscillations in Double-Helix B-DNA Molecules with Mirror-Symmetric Codons. Symmetry 2021, 13, 241.
Abstract
A fully analytical treatment of the base-pair and codon dynamics in double-stranded DNA molecules is introduced, by means of a realistic treatment which considers different mass values for G, A, T, and C nucleotides and takes into account the intrinsic three-dimensional, helicoidal geometry of DNA in terms of a Hamitonian in cylindrical coordinates. Within the framework of the Peyrard-Dauxois-Bishop model we consider the coupling between stretching and stacking radial oscillations as well as the twisting motion of each base pair around the helix axis. By comparing the linearized dynamical equations for the angular and radial variables when going from the bp local scale to the longer triplet codon scale, we report an underlying hierarchical symmetry. The existence of synchronized collective oscillations of the base-pairs and their related codon triplet units are disclosed from the study of their coupled dynamical equations. The possible biological role of these correlated, long-range oscillation effects in double standed DNA molecules containing mirror-symmetric codons of the form XXX, XX’X, X’XX’, YXY, and XYX is discussed in terms of the dynamical equations solutions and their related dispersion relations.
Keywords
double-stranded DNA; DNA dynamical models; correlated oscillations in macromolecules; epigenetic changes
Subject
Biology and Life Sciences, Biophysics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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