Preprint Article Version 1 This version not peer reviewed

Impaired skin barrier due to sebaceous gland atrophy in the latent stage of radiation-induced skin injury: application of non-invasive diagnostic methods

Version 1 : Received: 20 November 2017 / Approved: 23 November 2017 / Online: 23 November 2017 (08:33:29 CET)

A peer-reviewed article of this Preprint also exists.

Jang, H.; Myung, H.; Lee, J.; Myung, J.K.; Jang, W.-S.; Lee, S.-J.; Bae, C.-H.; Kim, H.; Park, S.; Shim, S. Impaired Skin Barrier Due to Sebaceous Gland Atrophy in the Latent Stage of Radiation-Induced Skin Injury: Application of Non-Invasive Diagnostic Methods. Int. J. Mol. Sci. 2018, 19, 185. Jang, H.; Myung, H.; Lee, J.; Myung, J.K.; Jang, W.-S.; Lee, S.-J.; Bae, C.-H.; Kim, H.; Park, S.; Shim, S. Impaired Skin Barrier Due to Sebaceous Gland Atrophy in the Latent Stage of Radiation-Induced Skin Injury: Application of Non-Invasive Diagnostic Methods. Int. J. Mol. Sci. 2018, 19, 185.

Journal reference: Int. J. Mol. Sci. 2018, 19, 185
DOI: 10.3390/ijms19010185

Abstract

Abstract: Radiation-induced skin injury can be a serious cutaneous damage and have specific characteristics. Asymptomatic periods are classified as the latent stage. The skin barrier plays a critical role in the modulation of skin permeability and hydration and protects the body against a harsh external environment. However, an analysis on the skin barrier dysfunction against radiation exposure in the latent stage has not been conducted. Thus, we investigated whether skin barrier is impaired by irradiation in the latent stage and aimed to identify the molecules involved in skin barrier dysfunction. We analyzed skin barrier function and its components in SKH-1 mice that received 20 and 40 Gy local irradiation. Increased transepidermal water loss and skin pH were observed in the latent stage of the irradiated skin. Skin barrier components, such as structural proteins and lipid synthesis enzymes in keratinocyte, increased in the irradiated group. Interestingly, we noted sebaceous gland atrophy and increased serine protease and inflammatory cytokines in the irradiated skin during the latent period. This finding indicates that the main factor of skin barrier dysfunction in the latent stage of radiation-induced skin injury is sebaceous gland deficiency, which could be an intervention target for skin barrier impairment.

Subject Areas

radiation; skin barrier; sebaceous gland; transepidermal water loss; skin pH

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