Background: New regional techniques can improve pain management after nephrectomy. Methods: This study was a randomized controlled trial conducted at two teaching hospitals. Patients undergoing elective open and laparoscopic nephrectomy were eligible to participate in the trial. A total of 100 patients were divided into a quadratus lumborum block (QLB) group and a control (CON) group. At the end of surgery, but while still under general anesthesia, unilateral QLB with ropivacaine was performed on the side of nephrectomy for patients in the QLB group. The main measured outcome of this study was oxycodone consumption via a patient-controlled anesthesia (PCA) pump during the first 24 hours following surgery; other measured outcomes included postoperative pain intensity assessment, patient satisfaction with pain management, and persistent pain evaluation. Results: Patients undergoing QLB needed less oxycodone than those in the CON group (34.5 mg [interquartile range 23–40 mg] vs. 47.5 mg [35–50 mg]; p<0.001). No difference between the groups was seen in postoperative pain intensity measured on the visual analog scale, except for the evaluation at hour 2, which was in favor of the QLB group (p=0.03). Patients who received QLB were more satisfied with postoperative pain management than the CON group. Persistent postoperative pain was assessed with the Neuropathic Pain Symptom Inventory (NPSI) at months 1, 3, and 6 and was found to be significantly lower in the QLB group at each evaluation (p<0.001). We also analyzed the impact of the surgery type on persistent pain severity, which was significantly lower after laparoscopic procedures than open procedures at months 1, 3, and 6. Conclusions: QLB reduces oxycodone consumption in patients undergoing open and laparoscopic nephrectomy and decreases persistent pain severity months after hospital discharge.

In the light of almost a century of struggle to make (common) sense of Quantum Mechanics and to reconcile it with General Relativity, it is proposed to (for some time) forget about quantizing gravity or striving for one Theory of Everything or “Weltformel”, which would describe the whole of reality without any joints or suture marks. Instead of one single monolithic formalism, a three-legged compound approach is argued for. Quantum Mechanics, Relativity and Thermodynamics are proposed as the main pillars of reality, each with its well-defined realm, specific features, and clearly marked interfaces between the three of them. Not only classical reality, which is rather directly accessible to us, is then comprehensively modelled by their encompassing combination. Quantum phenomena are understood as undoubtedly lying at the bottom of classical physics and at the same time, they become “fully real” only when embedded in classical frames between preparation and measurement in time. It is then where thermodynamics steps in and provides the mediating glue. The aim of this short contribution is not to deliver novel quantitative results but rather to propose a comprehensive research program and to coarsely lay out a very roughly coherent self-referential sketch starting from the beginning of the one universe, which we inhabit.

We show that Universe inflation occurs when Einstein's gravity couples to nonlinear electromagnetic fields with cosmic stochastic magnetic fields background. Nonlinear electrodynamics with two parameters is used. The strength of magnetic fields to have the Universe inflation is obtained. It is shown that singularities of the energy density and pressure are absent for any scale factors. At large scale factors one arrives at equation of state for ultra-relativistic case. It is demonstrated that the curvature invariants do not have singularities. By computing the deceleration parameter we show that graceful exit takes place with reasonable e-folding number. The duration of Universe inflation as a function of model parameters is obtained. The classical stability and causality are analyzed by calculating the speed of the sound.

The Standard Model (SM) of particle physics successfully describes electromagnetic, weak, and strong forces but omits gravity. We introduce the Kinematrix Field Theory (KFT), integrating gravity into this fundamental force framework through a novel particle, the kinematon. This gauge boson, existing in both massless and massive forms, advances the SM's scope to address enigmas like dark matter and neutrino masses. We detail the mathematical structure of the KFT and establish Feynman rules for kinematon interactions with fermions and gauge bosons. The KFT, synergizing with the Higgs mechanism and general relativity, aspires to a unified quantum theory of gravity. We explore the kinematon's phenomenological implications and potential experimental signatures, forecasting significant advancements in fundamental physics and setting a course for future explorations in the SM.

Our comprehension of fundamental cosmological principles hinges on a thorough understanding of the early universe. The Lambda Cold Dark Matter (ΛCDM) model has emerged as a valuable framework for elucidating various cosmic phenomena, uniting a cosmological constant (Λ) with cold dark matter (CDM). Nevertheless, recent observations, particularly data from the Planck, WMAP, and DES missions that probe the early universe, alongside local measurements of the Hubble constant, have unveiled significant inconsistencies. These inconsistencies have magnified the perplexing issue known as the Hubble Tension, thereby challenging our current understanding of the universe. To address this conundrum, we adopt a comprehensive approach encompassing a review of cosmological fundamentals, an exploration of the ΛCDM model, an examination of the cosmic microwave background (CMB), power spectrum, and perturbation theory, a thorough review of existing research, and finally, an investigation of real data. By undertaking these early universe processes, we aim to understand more about Hubble constant and its consequence in ΛCDM model.

The cyclic universe theory is a model of cosmic evolution according to which the universe undergoes endless cycles of expansion and cooling, each beginning with a big bang and ending in a big crunch. In this paper, the researcher finds a unique property of Space-time, this particular and marvelous nature of space shows us that space can shrink, expand, and stretch. This property of space is caused the size of the Universe changing over time: growing or shrinking. The observed accelerated expansion, which relates the stretching of Shrunk space for the new theory, is derived. This model is based on three underlying notions: First, the Big Bang was not the beginning of Space-time, but rather at the very beginning fraction of a second there was an infinite force of infinite Shrunk space in the cosmic singularity, that force gave rise to the big bang and caused the rapidly growing of space-time, and all other forms of energy are transformed into matter and radiation and a new period of expansion and cooling begins. Second, there was a previous phase leading up to it, with multiple cycles of contraction and expansion that repeat indefinitely. Third, the two principal long-range forces are the gravitational force and the repulsive force generated by shrunk space. They are the two most fundamental quantities in the universe that govern cosmic evolution. They may provide the clockwork mechanism that operates our eternal cyclic universe. The space will not continue to expand forever, no need however, for dark energy and dark matter. This model of Space-time and its unique properties enables us to describe a sequence of events from the Big Bang to the Big Crunch.

Under the big unified framework of quantum gravitational field and quantum repulsive field, the earlier in this series of work has comprehensively expanded the general relativity and loop quantum ring gravitation theory, set up the quantum repulsive field equation corresponding to the quantum gravitational field equation, and then established the quantum hedge-unified field equation describing the interaction of quantum gravitational field and quantum repulsive field; On this basis, the quantum repulsive universe equation corresponding to the quantum gravitational universe equation has be established, thus a set of new equations describing the expansive universe model under the condition of fully considering the hedge effect of quantum gravitational field and quantum repulsion field, which can be called the expansive universe equation of quantum hedge-unified field theory, has be established. Now, let's go deep into the arche-unified physics behind the creation of the universe. Although all kinds of inflationary universe models can solve cosmological problems to a certain extent, there is no natural and reasonable analysis and explanation for all cosmological and physical consequences. For example, it is impossible to predict a large tensor-scale ratio and a relatively large spectral index run at the same time. At present, string theory, membrane theory, loop quantum gravity theory, super-gravitational holography principle and M theory, which are the theoretical basis of cosmology, are basically established by simplification in the case of breaking away from the extreme background conditions of the universe. While cosmology, which is deficient in nature, cannot provide strong support for particle physics to further advance to a wider field and a deeper level. Due to the lack of new ideas, the construction of existing theoretical models is difficult. Therefore, the existing research can only be further promoted by new astronomical observation. Unlike existing studies, we concentrate on the emergence of the big rip-rebound clusters of quantum chaotic-reticulate distribution between the outwards-push of the universe as a whole (related to pseudo-vacuum energy, Higgs field, dark energy, etc.) and the inwards-pull of the universe in local scale (related to dark matter, quantum gravity and initial gravity separated from high-dimensional supergravity, and the initial strong force separated from the grand unified force subsequently). On the one hand, we find a great impetus to make the inflation of the universe into firstly-imposed suppression, then-imposed acceleration and finally-imposed deceleration, which really explains why the universe expands at a critical rate and has the same temperature in different regions, on the other hand, we find a fundamental unit of matter and its emerging clusters evolving in the big bang, inflation and expansion of the universe accompanied by the great rip-rebound clusters of quantum chaos-reticulate distribution, which can be reduced to an arche-pulsator of neither punctiform particle nor linear string. From these two aspects, it can been seen that the evolution of the early universe is much more complicated than people originally thought. The complexity of the super inflation of the universe is mainly reflected in the big rip-rebound cluster emerging behind the gravitational disturbance (the pressure and tensor disturbance related to dark matter), the repulsive disturbance (the pressure and scalar disturbance related to dark energy), the cosmological disturbance (related to the interaction between high-dimensional supergravity and high-dimensional superrepulsion). This is a system of nonlinear stochastic differential dynamics, or a quantum statistical physical process of nonlinear nonequilibrium state. In the new research paradigms established in this series, the arche-conjugation between the high-dimensional supergravity and the high-dimensional superrepulsion, as well as between the quantum gravity and the quantum repulsion, is higher than the supersymmetry, and then becomes the core concept of the new theory. In this series, cluster-inflating configuration, spin network space and cosmic paradigm vectors are proposed, so the model of the super-inflated universe with quantum chaos-reticulate distribution emerged under the great impetus. The new model reveals that the unified inflation of the universe as a whole and the local inflation of the universe emerge together in the great impetus of the big rip-rebound cluster of quantum chaos-reticulate distribution. As a spin network model variable, the spatiotemporal mode variable is a vector composed of a series of variables, which variables include: dimension, curvature, range, expansion speed, dynamics, quantization, chaotic-reticulate distribution (inhomogeneity, concentration, fluctuation), synergy, and so on. Between particle physics and cosmology, this series of papers proposes the cosmic quantum evolution mode, the physical-sphere distributing configuration and the interaction situation variables, organizes the concepts, variables and models of these three levels, and establishes a systematic super-synergy paradigm. In this paradigm, the general Langevan equation and the general Fokker-Planck equation are established. For the quantum cosmic-sphere, a series of trend parameters are introduced to establish the dynamics of quantum gravitational mode and its master equation, and then to establish the operator distribution function and its motion equation of the action mode. For the Tachyon of upheaval in the rip-rebound-inflating of the universe, the hypothesis on the bifurcate-chaos wave of quantum is given, the quantum theory of the early photons in upheaval is set up, and the analysis on the particles of the ultrahigh energy cosmic ray from the γ ray burst is made. Finally, using Wigner-Ville distribution as a nonlinear time-frequency distribution, we establish the ultra-synergistic field equation of quantum-classic unifying action-sphere.

In the quest for robust and efficient digital communication, this paper introduces cutting-edge key exchange protocols leveraging tropical semirings’ computational prowess and block matrices’ structural resilience. Moving away from the conventional use of finite fields, these protocols deliver markedly faster processing speeds and heightened security. We present two implementations of our concept, each utilizing a different platform for the set of commuting matrices: one employing tropical polynomials of matrices and the other employing Linde-de la Puente matrices. The inherent simplicity of tropical semirings leads to a decrease in operational complexity, and using block matrices enhances our protocols’ security profile. The security of these protocols relies on the Matrix Decomposition Problem. We also provide a comparative analysis of our protocols against existing matrix block-based protocols in finite fields. This research marks a significant shift in cryptographic protocol design, specifically tailored for demanding engineering applications, and sets a new standard in secure and efficient digital communication.

Synchronous electrical cardioversion is a relatively common procedure in the emergency department (ED), often performed for unstable supraventricular tachycardia (SVT) or unstable ventricular tachycardia (VT). However, it is also used for stable cases resistant to drug therapy, which carry a risk of deterioration. In addition to the inherent risks linked with procedural sedation, there is a possibility of malignant arrhythmias or bradycardia, which could potentially result in cardiac arrest following this procedure. Here, we present a case of complete heart block unresponsive to transcutaneous pacing and positive inotropic and chronotropic drugs for 90 minutes, resulting in multiple cardiac arrests. The repositioning of the transcutaneous cardio-stimulation electrodes, one of them placed in the left latero-sternal position and the other at the level of the apex, led to immediate stabilization of the patient. Extubation of the patient was performed the following day, while full recovery and discharge within 7 days, after insertion of a permanent pacemaker.

Up to 56% of patients develop chronic postsurgical pain (CPSP) after coronary artery bypass grafting (CABG). CPSP can affect patients’ moods and decrease daily activities. The primary aim of this study was to investigate CPSP severity in patients following off-pump (OP)-CABG using the Neuropathic Pain Symptom Inventory (NPSI). This was a prospective cohort study conducted in a cardiac surgery department of a teaching hospital. Patients undergoing OP-CABG were enrolled in an erector spinae plane block (ESPB) group (n = 27) or a control (CON) group (n = 24). Before the induction of general anesthesia, ESPB was performed on both sides under ultrasound guidance using 0.375% ropivacaine. The secondary outcomes included cumulative oxycodone consumption, acute pain intensity, mechanical ventilation time, hospital length of stay, and postoperative complications. CPSP intensity was lower in the ESPB group than in the CON group 1, 3, and 6 months postsurgery (p < 0.001). Significant between-group differences were also observed in other outcomes, including postoperative pain severity, opioid consumption, mechanical ventilation time, and hospital length of stay in favor of the ESPB group. Preemptive ESPB appears to decrease the risk of CPSP development in patients undergoing OP-CABG. Reduced acute pain severity and shorter mechanical ventilation times and hospital stays should improve patients’ satisfaction and reduce perioperative complications.

Star block-copolymers (SBCs) are macromolecules formed by a number of diblock copolymers anchored to a common central core, being the internal monomers solvophilic and the end monomers solvophobic. Recent studies have demonstrated that SBCs constitute a self-assembling building blocks with specific softness, functionalization, shape, and flexibility. Depending on different physical and chemical parameters the SBCs can behave as flexible patchy particles. In this paper, we study the rotational dynamics of isolated SBCs using a hybrid mesoscale simulation technique. We compare three different approaches to analyse the dynamics: the laboratory frame, the non-inertial Eckart's frame, and a geometrical approximation relating the conformation of the SBC to the velocity profile of the solvent. We find that the geometrical approach is adequate when dealing with very soft systems while in the opposite extreme, the dynamics is best explained using the laboratory frame. On the other hand, the Eckart frame is found to be very general and to reproduced well both extreme cases. We also compare the rotational frequency and the kinetic energy with the definitions of the angular momentum and inertia tensor different from recent publications.

Based on recent progress in cosmological thermodynamics, we are presenting a new ther- modynamic formulation of the Friedmann equations, as well as for other similar equations put forward in the literature from different solutions to Einstein’s field equation. Since the CMB temperature has been measured much more accurately than the Hubble constant, we demonstrate that the thermodynamic formulation of the Friedmann equation dramatically narrows down the acceptable range for the mass-energy density in the universe.

A persistent idea in cosmology is that the universe originated and then continued to evolve as a black hole. While the notion of a black hole universe has generally been framed within the standard cosmological model, the latter has had numerous problems related to dark matter, dark energy and other issues. To avoid such problems an alternative is proposed which omits cosmic expansion, dark matter and dark energy. The observable universe is cast instead as primarily a thin spherical shell of cold (~29 K) baryonic matter situated near the Hubble radius. This shell of plasma holds 95% of the observable universe’s mass, the remaining 5% existing in the interior galaxies and gas clouds. A key premise of the model is that spacetime is fundamentally photonic in nature. This allows photon energy to be transferred to spacetime in the Hubble redshift and to be transferred back to photons in a novel blueshift. These exchanges together drive a cosmic energy cycle for gravity and the cosmological constant, Λ. Photons of the cosmic microwave background originating in the plasma shell lose energy to ‘cooler’ regions of spacetime in interior zones via the Hubble redshift. This gives rise to gravity through the optical gravity approach. The depleted photons moving back towards the shell are then reenergized in ‘hotter’ spacetime regions via the Hubble blueshift. These photons eventually exert outward pressures on the shell which perfectly balance the inward forces of gravity, in this manner functioning as Einstein’s cosmological constant. The observable universe behaves as a closed system in thermodynamic equilibrium with constant energy and entropy and indeterminate age. Black holes are suggested to have analogous plasma shell structures and gravity/Λ cycles.

Albert Einstein, shortly after publishing his General Relativity Theory (GRT) applied it to the entire universe in a paper of 1917. Einstein assumed that such a universe was static in time and possessed a uniform distribution of matter on the largest scales, obtaining a static and finite universe of spherical spatial curvature of radius R. Although this model was refuted by Edwin Hubble's discovery of the expansion of the universe, it is still often studied as a theoretical framework for some problems, such as the twin paradox. This paper will show that Einstein's static universe model leads to a privileged frame of reference, so that any observer moving at the speed v will be able to measure speeds of light other than c depending on the direction of beam transmission. The above will refute the validity of the application to this closed and static universe of the Special Relativity Theory (SRT) proposed by Einstein in 1905 in his article . In addition, a new synchronization convention and new coordinate transformations will be deduced, the "generic" transformations, which will replace those of Lorentz. Finally, the twin paradox in this universe will be solved by making use of them.

Recently, some authors have claimed that we may live in one of a pair of universes in which one is expanding receding from the Big Bang and its partner is contracting and moving towards the Big Bang. We show that near a black hole binary system, this event may be occurring. If we suppose that there is a N dimensional brane which contains many smaller k dimensional branes and black holes, there is a possibility that the curved space times near black holes act like mirrors. This is because these space-times contain two regions such that the branes in the one region have opposite quantum numbers with respect to the branes in the other region. Also, if branes in one region are expanding and go away from a point state and the Big Bang, anti-branes in the other region are contracting and moving towards the point state and the Big Bang. If black holes join and form a binary system, then their states become similar to two mirrors that are facing each other and producing many images themselves of smaller branes and even black holes in the binary system. Summing over all branes and images give the CPT system. Dark energy could be a result of the images of observed matter. Comparing the masses of the observed objects and dark energy, the angle between cosmic mirrors like black hole binary systems could be determined.

In a bid to resolve lingering problems in cosmology, more focus is being tilted towards cosmological models in which physical constants of nature are not necessarily real constants, but varying with cosmic time. In this paper we have study cosmology in nonlinear electrodynamics with the Newton's gravitational constant $G$ not a constant but vary in form of power-law of the scale factor of the universe. The evolution of the scale factor $a (t)$ is studied in this model which depends on nonlinear electrodynamics fine tuning term of $\alpha$. Then we check the stability of the model using the speed of sound.

The origins of the stellar mass neutron black holes and supermassive dark matter black holes without the singularities are reported based on the 4-D Euclidean space. The neutron black holes with the mass of m_BH = 5 – 15 m_sun are made by the 6-quark merged states (N_6q) of two neutrons with the mass (m(N_6q) = 10 m(n)) of 9.4 GeV/c² that gives the black hole mass gap of m_BH = 3 – 5 m_sun. Also, the supermassive black holes with the mass of m_SMBH = 10⁶ – 10¹¹ msun are made by the merged 3-D states (J(B1B2B3)₃ particles) of the dark matters. The supermassive black hole at the center of the Milky way galaxy has the mass of mSMBH = 4.1 10⁶ m_sun that is consistent with m_SMBH = 2.08 - 6.23 10⁶ m_sun calculated from the 3-D states (J(B1B2B3)₃ particles) of the dark matters with the mass of m(J) = 1.95 10¹⁵ eV/c². In other words, this supports the existence of the B1, B2 and B3 dark matters with the proposed masses. The first dark matter black hole (primary black hole) was created at the big bang. This first dark matter black hole decayed to the supermassive dark matter black holes through the secondary dark matter black holes that are explained by the merged states of the J(B1B2B3)₃ particles. The universe evolution is closely connected to the decaying process of the dark matter black holes since the big bang. The dark matter cloud states are proposed at the intermediate mass black hole range of m_IMBH = 10² – 10⁵ msun. This can explain why the dark matter black holes are not observed at the intermediate mass black hole range of m_IMBH = 10² – 10⁵ m_sun.

Unification point of view, quantum cosmology must be given a priority and one should make a note that, Spin is a basic property of quantum physics and rotation is a very common experience. In this context, we have developed a quantum model of cosmology associated with Machian universe having Planck scale origin, total dark matter, light speed rotation and equality of gravitational self energy density and thermal energy density. We would like to appeal that, observed cosmic radius and age seem to be shortened by 146.3 times their actual magnitudes.

In 1922, Albert Einstein visited Paris and interacted extensively with an illustrious section of the French academia. In overfilled sessions at the Coll\`{e}ge de France and the Sorbonne, Einstein explained his theories of relativity, and prominent physicists, mathematicians and philosophers listened, debated, questioned and explored facets of relativity. The 1922 visit had its echoes in the life and works of many who participated, particularly decisive for Einstein and the philosopher Henri Bergson. This essay examines that eventful visit, focusing on the physical and logical aspects of Bergson's critique, with physics commentaries, linking prominent French physicists and mathematicians Langevin, Painlev\'{e}, Hadamard, Becquerel, Sagnac, and Kastler. I give particular attention to the logical and empirical accuracy of the physics issues involved, delineating Bergson's exact reasoning for his philosophical enthusiasm in Einstein's theory and for the ensuing critique. Bergson's philosophical stand on duration and simultaneity is reassessed in the context of later developments in cosmological physics as well as the wealth of empirical data involving comparison of atomic clocks. Finally we are led naturally to a surprising completion of the philosopher's program on universal time, duration and simultaneity, in harmony with the time of the physicist. In the appendices after the main text I also give the physics background and easily verifiable proofs for the assertions made in the text, pertaining to relativity, simultaneity and time dilation, clearly distinguishing beliefs and facts.

Utilizing unmanned aerial vehicles (UAVs) to facilitate wireless communication has emerged as a viable and promising strategy aimed at enhancing both current and prospective wireless systems. This approach offers many advantages by establishing line-of-sight connections, optimizing operational efficiency, and enabling flexible deployment capabilities in various terrains. Thus, in this paper, we investigate UAV communication in a relaying network in which a UAV helps communication between a source and two destination users while flying to a location. To have a complete view of our proposed system, we consider both orthogonal multiple access as OFDM and non-orthogonal multiple access (NOMA) scenarios. Moreover, we apply successive convex optimization (SCO) and the Block-coordinate gradient descent (BCGD) for the sum-rate optimization problems to improve the system performance under constraints of total bandwidth and total power at the ground base station and UAV. The experimental results validate that the achievable secrecy rates are notably enhanced by using our proposed algorithms and show optimal trends for critical parameters, such as transmit powers, the flight trajectory and speed of UAV, and resource allocation of OFDM and NOMA.

Research on image-inpainting tasks has mainly focused on enhancing performance by augmenting various stages and modules. However, this trend does not consider the increase in the number of model parameters and operational memory, which increases the burden on computational resources. To solve this problem, we propose a Parametric Efficient Image InPainting Network (PEIPNet) for efficient and effective image-inpainting. Unlike other state-of-the-art methods, the proposed model has a one-stage inpainting framework in which depthwise and pointwise convolutions are adopted to reduce the number of parameters and computational costs. To generate semantically appealing results, we selected three unique components: spatially-adaptive denormalization (SPADE), dense dilated convolution module (DDCM), and efficient self-attention (ESA). The SPADE was adopted to conditionally normalize activations according to the mask to distinguish between damaged and undamaged regions. The DDCM was employed at every scale to overcome the gradient-vanishing obstacle and gradually fill-in pixels by capturing global information along the feature maps. The ESA was utilized to obtain clues from unmasked areas by extracting long-range information. In terms of efficiency, our model has the lowest operational memory compared with other state-of-the-art methods. Both qualitative and quantitative experiments demonstrate the generalized inpainting of our method on three public datasets: Paris StreetView, CelebA, and Places2.

This study presents the solution of the second type of a two-dimensional nonlinear integral equation in Banach space. Also, the existence and uniqueness of this equation’s solution are discussed. We utilize a numerical approach involving hybrid and block-pulse functions to obtain the approximate solution of a two-dimensional nonlinear integral equation. Nonlinear integral equation in two dimensions is reduced numerically to a system of nonlinear algebraic equations that can be solved using numerical methods. This study focuses on showing the convergence analysis for the numerical approach and obtaining an error estimate. Some numerical examples have been provided to demonstrate the approach’s viability and efficacy

This paper presents results on tribological characteristics for polymer blends made of polybutylene terephthalate (PBT) and polytetrafluoroethylene (PTFE). This blend is relatively new in research as PBT has restricted processability because of its processing temperature near the degradation one. Tests were done block-on-ring tribotester, in dry regime, the variables being the PTFE concentration (0%, 5%, 10% and 15%wt) and the sliding regime parameters (load: 1 N, 2.5 N and 5 N, the sliding speed: 0.25 m/s, 0.5 m/s and 0.75 m/s, and the sliding distance: 2500 m, 5000 m and 7500 m). Results are encouraging as PBT as neat polymer has very good tribological characteristics in terms of friction coefficient and wear rate. SEM investigation reveals a quite uniform dispersion of PTFE drops in the PBT matrix.

Proteins are the workhorses of the cell that perform biological functions by interacting with other proteins. Many statistical methods for protein-protein interaction (PPI) have been studied without considering time-dependent changes in networks and the functionalities. I introduced a novel method that models PPI networks as being dynamic in nature and evolving time-varying multivariate distribution with Conditional Random Fields (CRF). This research is directed towards implementing this new combinatorial algorithm on massively parallel architectures such as Graphics Processing Units (GPUs) for efficient computations for large scale bioinformatics datasets. I compared Conditional Random Fields (CRF) and the proposed novel method using CRF combined with the Block Coordinate Descent algorithm for human protein-protein interaction data set. Both are implemented on GPU-Accelerated Computing Architecture and the proposed novel method showed the advantages in predicting protein-protein interaction sites. I also show that the proposed approach is more efficient in 6.13% than standalone CRF++ in predicting protein-protein interaction sites.

We review time expansion wave theory and refine our model showing it to accurately match observed cosmological luminosity data. The theory augments general relativity to create a container within which quantum effects can be explained by treating time as an artefact of a fourth spatial dimension that we observe as the expansion of the universe. This leads us to explain mass creation, the speed of light limit, gravity, black holes without singularities and other macroscopic effects. Our model leads to an expansion velocity of 6.87 0.36 × 106 ms-1, which results in a Hubble expansion rate constant of 71.3 3.7 km/s/Mpc. Because of the finite window of time in which we exist, an extra a degree of freedom is available leading to interesting interpretations at the subatomic level. At this size range, then a spin is allowed within the time dimension explaining why wave particle duality occurs and explains the electromagnetic force and other quantum mechanical properties. It provides a solution to the double slit conundrum and can explain how quantum entangled partners can behave in a quantum way and pass seemingly time-defying information. The potential quantitative origin of the fine structure constant which governs the size of the electromagnetic force is also strongly indicated by this theory.

A teoria diz que as primeiras coisas a existir no universo e no momento atual foram impulsionadas pela necessidade imperiosa; ou seja, os espaços físicos influenciam a existência de elementos e fatos a partir das inúmeras observações nos espaços físicos em relação a elementos e fatos. A existência de elementos obrigatórios no espaço é motivada pelas características dos espaços que oferecem condições para tal obrigação. A teoria afirma que o universo não surgiu por acaso; Ou seja, o universo surgiu por determinação influenciada pelo que o rodeia. O objetivo do estudo é ajudar a explicar os elementos e fatos do universo desde a origem até o presente.

Physics lacks a confirmed description of dark matter, has yet to develop an adequate understanding of dark energy, and includes unverified conjectures regarding new elementary particles. This essay features modeling that addresses those problems and explains otherwise unexplained data. Our modeling starts from five bases – multipole expansions for the electromagnetic and gravitational fields associated with an object, the list of known elementary particles, some aspects of mathematics for isotropic harmonic oscillators, concordance cosmology, and a conjecture that the universe includes six isomers of most elementary particles. The multipole expansions – which have use in conjunction with Newtonian kinematics modeling, special relativity, and general relativity – lead to a catalog of kinematics properties such as charge, magnetic moment, mass, and repulsive gravitational pressure. The multipole expansions also point to all known elementary particles, some properties of those particles, and properties of some would-be elementary bosons and elementary fermions. The harmonic-oscillator mathematics points to Gauge symmetries regarding some elementary bosons. The would-be elementary fermions lack charge and would measure as dark matter. The conjecture regarding six isomers of most elementary particles rounds out and dominates our specification for dark matter. Five of the isomers form the basis for most dark matter. Our modeling explains ranges of observed ratios of dark matter effects to ordinary matter effects – for the universe, galaxy clusters, two sets of galaxies observed at high redshifts, three sets of galaxies observed at modest redshifts, and one type of depletion of cosmic microwave background radiation. Our description of repulsive gravitational pressure points toward resolution for tensions – between data and modeling – regarding the recent rate of expansion of the universe, resolution for possible tensions regarding large-scale clumping, and resolution for possible tensions regarding interactions between neighboring galaxies. Our work regarding gravity, dark matter, and elementary particles suggests characterizations for eras that might precede the inflationary epoch, a mechanism that might have produced baryon asymmetry, mechanisms that govern the rate of expansion of the universe, and insight about galaxy formation and evolution.

In 1982, MIT physicist Frank Wilczek predicted and named ANYONS, quasiparticles (particle-like formations) that are confined to 2 dimensions and were discovered in 2020. The name might come from Prof. Wilczek's lighthearted comment "anything goes". This article's main goal is to show that anyons could be another name for 1) virtual particles, 2) Mobius strips, and 3) figure-8 Klein bottles. Along the way, we'll see the picture painted by the article confirm that Einstein's dream of gravitational-electromagnetic unity fits in with anyons being Mobius strips. The topological hypothesis offers an explanation of dark matter and dark energy. We'll also have encounters with intergalactic travel and imaginary computers. They really could exist but are imaginary in the sense that they use imaginary time (as well as space-time warping).

Specifically this work is based on the concept of ‘dark energy’ as a phenomenal effect of expansion through which a theoretical value of Hubble’s constant has been introduced. It is a constant that is based on a postulate that the square root of ratio of the Siva’s constant ‘K’ and Hubble’s constant ‘H’ is exactly equal to the diameter of the neutral hydrogen atom. That is the, exact theoretical value of Hubble’s constant. This is always constant .However, space-time conversions and the changes in the velocity of light will affect the distance and velocity in Hubble’s equation. Deviation factors in velocity, distance and the Hubble’s constant have been calculated separately which are affected by change of velocity of light with expansion of space time. The observations are related to red shift. So the change factor in terms of Hubble’s constant has been calculated with respect to red shift. Thus a factor which affects the theoretical Hubble’s constant has been calculated to find the exact value of Hubble’s constant that satisfies the experimental results. The present theoretical value of Hubble’s constant has been calculated. The experimental results by plank, ACT (Atacama Cosmology Telescope), WMAP (Wilkinson Microwave Anisotropy Probe) etc. experiments are at par with the theoretical result. Thus the ontology of space time introduced in this theoretical work supposed to be correct and leads to a new theory of origin of universe for which a brief description has been provided.

Insulator defect detection is of great significance to compromise the stability of the power transmission line. The state-of-the-art network of object detection, YOLOv5, has been widely used on insulator and defect detection. However, YOLOv5 network has some limitations like poor detection rate and high computational loads in detecting small insulator defects. To solve these problems, we proposed a light-weight network for insulator and defect detection. In this network, we introduced Ghost module into YOLOv5 backbone and neck to reduce the parameters and model size to enhance the performance in unmanned aerial vehicles (UAVs). Besides, we added small object detection anchors and layers for small defect detection. In addition, we optimized the backbone of YOLOv5 by applying convolutional block attention module (CBAM) to focus on critical information for insulator and defect detection and suppress uncritical information. The experiment result shows the mean average precision (mAP) 0.5 and the mAP0.5:0.95 of our model can reach 99.4% and 91.7%, the parameters and model weight are reduced to 3807372 and 8.79M, which can easily deploy to embedded devices like UAVs. And the speed of detection can reach 10.9ms/image, which can meet the real-time detection requirement.

Abstract: Ambulatory cancer centers face fluctuating patient demand and deploy specialized personnel who have variable availability. This undermines operational stability through misa-lignment of resources to patient needs, resulting in overscheduled clinics, budget deficits, and wait times exceeding provincial targets. We describe deployment of a Learning Health System framework for operational improvements within the entire ambulatory center. Known methods of value stream mapping, operations research and statistical process control were applied to achieve organizational high performance that is data-informed, agile and adaptive. We transitioned from a fixed template model by individual physician to a caseload management by disease site model that is realigned quarterly. We adapted a block schedule model for the ambulatory oncology clinic to align the regional demand for specialized services with optimized human and physical resources. We demonstrated improved utilization of clinical space, increased weekly consistency and im-proved distribution of activity across the workweek. Increased value, represented as the ratio of monthly encounters per nursing worked hours, and increased percentage of services delivered by full-time nurses were benefits realized in our cancer system. The creation of a data-informed demand capacity model enables application of predictive analytics and business intelligence tools that will further enhance clinical responsiveness..

The article suggests methods that allow creating the most complicated type of polygonal masonry found in Peru. This masonry type consists of large stone blocks weighing from several hundred kilograms to several tons fitted close to each other almost without a gap between complicated curved surfaces over a large area. The work provides a description of techniques, which apparently were used by builders who arrived from Europe. The techniques under discussion are based on the use of a reduced clay model, 3D-pantograph, topography translator and replicas. The use of the topography translator, reduced clay model and pantograph provides not only the unique appearance and high quality of masonry of large blocks, but also allows to increase the productivity of the builders significantly. As machines coping-scaling three-dimensional objects are known since the beginning of the 18th century, the stone structures under consideration should be approximately dated by this time. The remaining simpler types of polygonal masonry, when the stones are small or the fitted surfaces are almost flat, or the stones contact each other over a small area, or there are significant gaps between the stones, are quite consistent with the well-known methods of stone processing at that time or earlier, and, therefore, they do not require any additional explanations. The Fortress Sacsayhuaman is considered as an example of early star fortresses that has survived to our time. The polygonal structures in Peru, the polygonal Face Towers and polygonal bas-reliefs in Cambodia, symmetrical statues of pharaohs in Egypt are based on the same construction technologies, working methods, tools and technical contrivances. Therefore, with a high probability one can state that all these monuments were created by the same group of architects, sculptors, builders, and could not have appeared before the 17th century.

Natural systems of units $\{U_i\}$ need to be overhauled to include the dimensionless coupling constants $\{\upalpha_{U_i}\}$ of the natural forces. Otherwise, they cannot quantify all forces of nature in a unified manner. Thus, each force must furnish a system of units with at least one dimensional and one dimensionless constant. We revisit three natural systems of units (atomic, cosmological, and Planck). The Planck system is easier to rectify, and we do so in this work. The atomic system discounts $\{ G, \upalpha_G \}$, thus it cannot account for gravitation. The cosmological system discounts $\{ \slashed{h}, \upalpha_\slashed{h} \}$, thus it cannot account for quantum physics. Here, the symbols have their usual meanings; in particular, $\upalpha_G$ is the gravitational coupling constant and $\upalpha_\slashed{h}$ is Dirac's fine-structure constant. The speed of light $c$ and the impedance of free space $Z_0$ are resistive properties imposed by the vacuum itself, thus they must be present in all systems of units. The upgraded Planck system with fundamental units $${\rm UPS} \,:=\,\{ c, Z_0, G, \upalpha_G, \slashed{h}, \upalpha_\slashed{h}, \,\dots\,\!\},$$ describes all physical scales in the universe---it is nature's system of units. As such, it reveals a number of properties, most of which have been encountered previously in seemingly disjoint parts of physics, and some of which have been designated as mere coincidences. Based on the UPS results, that relate (sub)atomic scales to the Planck scale and the fine-structure constant to the Higgs field, we can state with confidence that no observed/measured physical properties are coincidental in this universe. Furthermore, we derive from first principles Koide's $K=2/3$ enigmatic constant and additional analogous quark and vector boson constants. These are formal mathematical proofs that justify a posteriori the use of geometric means in deriving the quark/boson mass ladder. This ladder allows us to also calculate the Higgs couplings to the vector bosons and the Weinberg angle in terms of only $K$.

We argue that the problem of time is not a crucial issue inherent in the quantum picture of the universe evolution. On the minisuperspace model example with the massless scalar field, we demonstrate four approaches to the description of quantum evolution, which give similar results explicitly. The relevance of these approaches to building a quantum theory of gravity is discussed.

The properties of the charged dark matters are discussed in terms of the new three-dimensional quantized space model. Because of the graviton evaporations, the very small Coulomb’s constant (k(dd)) of 10 ⁻⁴⁸ k and large gravitation constant (G_N(dd)) of 10⁶ G_N for the charged dark matters at the present time are expected. The tentative values of G and k are used for the explanation purpose. Therefore, F_c(mm) > F_g(dd) > F_g(mm) > F_g(dm) > F_c(dd) > F_c(dm) = F_c(lq) = 0 for the proton-like particle. Also, the gravitation constant has been changed with increasing of the time because of the graviton evaporation. In the present work, the B1, B2 and B3 bastons with the condition of k(mm) = k >> k(dd) > k(dm) = 0 are explained as the good candidates of the dark matters. Also, the particle creation, dark matters and dark energy could be deeply associated with the changing gravitation constants (G). It is expected that the changing process of the gravitation constant between the matters from G_N(mm) ≈ 10³⁶ G_N to G_N(mm) = G_N happened mostly near the inflation period. Therefore, during most of the universe evolution the gravitation constant could be taken as G_N(mm) = G_N. And the effective charges and effective rest masses of the particles are defined in terms of the fixed Coulomb’s constant (k) and fixed gravitation constant (G_N). Then, the effective charge of the B1 dark matter with EC = −2/3 e is (EC)_eff = −2/3·10⁻²⁴ e. It is concluded that the photons, gravitons and dark matters are the first particles created since the big bang. The particles can be created from the decay of the matter universe and the pair production of the particle and anti-particle with decreasing of the gravitation constant (G_N(mm)). Also, the weak force, strong force and dark matter force bosons are created from the interactions of the elementary particles with the T fluctuations of the vacuum energy.

Clinical and analytical differences between adult patients monoinfected with Borrelia burgdorferi sensu lato (s.l.) and patients infected with B. burgdorferi s.l. who also had IgG antibodies against Babesia divergens have not been reported so far. Both Lyme disease caused by B. burgdorferi and babesiosis caused by B. divergens, endemic in Asturias, Northwestern Spain, are transmitted by Ixodes tick bites. Clinical, laboratory and other diagnostic tests characteristics (imaging, electro-cardiographic-ECG) of 120 residents of Asturias with confirmed B. burgdorferi s.l. infection, di-agnosed during 2015-2017, of whom 47 (39.2%) had B. divergens IgG antibodies, were retrospec-tively compared. Cardiorespiratory symptoms were reported in 9/47 (19.2%) patients with Lyme disease and B. divergens IgG antibodies compared to 4/73 (5.5%) patients with B. burgdorferi s.l. monoinfection (P=0.02). Dyspnea was recorded in 4/47 (8.5%) patients with Lyme disease and B. divergens IgG antibodies compared to 1/73 (1.4%) monoinfected (P=0.07). In addition ECG atri-oventricular (AV) block, mostly 1st degree, was detected in 5/47 (15.6%) patients with Lyme dis-ease and B. divergens IgG antibodies compared to 1/73 (2.6%) B. burgdorferi s.l. monoinfected (P=0.09). No other clinical, laboratory or other tests differences were observed between B. burgdorferi and B. divergens IgG antibodies carriers and B. burgdorferi monoinfected. We con-cluded that patients with Lyme disease and B. divergens IgG antibodies had more frequent car-diorespiratory symptoms, mainly dyspnea, compared to B. burgdorferi monoinfected patients. These symptoms were unrelated to anemia. ECG AV block, perhaps induced by summative myo-cardial damage due to either infections or B. divergens induced lung microcirculation slow-ing-down, might play a role in the cardiorespiratory dysfunction.

The final assembly of appliances and automotive industries is a rigorous process, that has limited capabilities of full traceability associated with: (1) the parts installed, (2) their fabrication processes, and (3) the assembly work. This is also the case for each of its sub-assemblies The many parts and sub-assemblies that compose the final assembly, make full traceability a challenging fit, that is almost unsurmountable. Such full traceability along the entire supply-chain is not existent today and must be based on documentation of most assembled parts, assembly tasks, and inspection tasks that compose the full assembled product. In addition, security measures are needed to prevent hostile hacking and unauthorized approach to the assembly documentation throughout the entire supply chain. The related documentation and repeated verifications require considerable effort and have many chances for human errors. So, automating these processes has a great value. This article expounds a framework that harnesses block-chain and smart-contract technology to offer traceable and protected documentation of the assembly process. We expand the concept of a Bill-Of-Assembly (BOA) to incorporate data from the bill of materials (BOM), the associated assembly activities, the associated activities’ specification parameters and materials, and the associated assembly resources (machines and/or operators). The paper defines the operation of the BOA with blockchain and smart-contract technology, for attaining full traceability, safety, and security, for the entire assembled product. Future research could extend the proposed approach to facilitate the usage of the BOA data structure in constructing a digital twin of the entire simulated system.

The article presents the results and conclusions of a series of tests of wedge-shaped blocks armoring carried out on a new experimental facility (‘Hydraulic Experimentation Facility - Luis Ruano’) in quasi-prototype conditions. The article describes the singular testing facility that was built at the inlet channel of the Acequia de Sora channel, immediately upstream of the Laverné reservoir (Zaragoza, Spain). The inflow of the testing facility has a maximum discharge of 9 m³s^-1. The aim is to perform experimental research on technologies to protect embankment dams and dikes against overflowing erosion under quasi-prototype conditions. The results of the tests showed the ability of the WSBs to withstand high unit discharges under extremely negative conditions. Furthermore, conclusions were drawn about potential threats to the sound behavior of the armor.

Reverse-order laws for generalized inverses of matrix products is a classic object of study in the theory of generalized inverses. One of the well-known reverse-order laws for a matrix product AB is (AB)^(i,...,j) = B^(i,...,j)A^(i,...,j), where (·)^i,...,j denotes an {i,...,j}-generalized inverse of matrix. Because {i,...,j}-generalized inverse of a general matrix is not necessarily unique, the relationships between both sides of the reverse-order law can be divided into four situations for consideration. In this article, we first introduce a linear mixed model y = ABβ + Aγ + ε, present two least-squares methodologies to estimate the fixed parameter vector  in the model, and describe the connections between the two least-squares estimators and the reverse-order laws for generalized inverses of the matrix product AB. We then prepare some valued matrix analysis tools, including a general theory on linear or nonlinear matrix identities, a group of expansion formulas for calculating ranks of block matrices, two groups of explicit formulas for calculating the maximum and minimum ranks of B^(i,...,j)A^(i,...,j), as well as necessary and sufficient conditions for B^(i,...,j)A^(i,...,j) to be invariant with respect to the choice of A^(i,...,j) and B^(i,...,j). We then present a unied approach to the 512 set inclusion problems {(AB)^(i,...,j) ⊇ {B^(i,...,j)A^(i,...,j)}for the eight commonly-used types of generalized inverses of A, B, and AB using the block matrix representation method (BMRM), matrix equation method (MEM), and matrix rank method (MRM), where {(·)^(i,...,j)} denotes the collection of all {i,...,j}-generalized inverse of a matrix.

The Universe is treated as an unbound thermodynamic system in which two forces of Nature compete: Attractive gravity loss and repulsive entropic gain. Entropic gain, although not presently considered a force of Nature, is otherwise well known and can be expressed with the gas laws. The Universe at the time of last scattering was all gas. Its instant gain is expressed as gas pressure. When the Gibbs equation is properly applied to this unbound gas, the resulting atomic Hubble parameter is found to be exclusively dependent on baryon density, giving a constant and perpetual two-to-one gain/loss ratio. Instant loss to gravity cannot offset gas pressure in this “thermal equation”. By contrast, the Friedmann equation, a ΛCDM foundation, treats baryon mass as accreted, having little if any entropic gain. These two equations are actually equivalent. Expanding accreted matter at its comoving critical density is herein shown to behave exactly like a freely expanding gas. However, neither equation includes all of today’s Universal kinetic energy, and cannot by themselves fully account for observed stellar movement. The present paper proposes the plausible existence of highly energetic or “suprathermal” free electrons which comprise about half of the intergalactic medium’s kinetic total. It is this suprathermal energy which Λ expresses. The fluid equation, another ΛCDM foundation, eliminates entropic gain from the Gibbs equation. Additionally, rest mass’s Einstein energy E=Mc² is treated as a thermal variable. These two assumptions, isoentropy and energy conflation, led astronomers to populate Λ as they followed the prior art.

This article presents a new theory on redshift of light from celestial bodies. Lately it has been found that the Hubble constant calculated from different methods discord so much that calls arise for new physics to explain. Also, in addition to many unsolved puzzles like dark matter and source of expansion force, we shall show in this article that the current theory of redshift implies a few hidden, unreasonale assumptions. By assuming photon has temperature and its thermal energy is fully converted to wave energy, this article shows that photon can have a new redshift called Temperature Redshift, which not only is more significant for remote stars or galaxies, but also better fits the observational data, including those used in Hubble constant calculation. As such, if true, this new theory not only adds to our new understanding of photons, but may totally change our current understanding of the Universe, i.e., the Big Bang theory.

A cosmological model was developed using the equation of state of photon gas, as well as cosmic time. The primary objective of this model is to see if determining the observed rotation speed of galactic matter is possible, without using dark matter (halo) as a parameter. To do so, a numerical application of the evolution of variables in accordance with cosmic time and a new state equation was developed to determine precise, realistic values for a number of cosmological parameters, such as energy of the universe , cosmological constant Λ, curvature of space k, energy density , age of the universe etc. Some assumptions were put forth in order to solve these equations. The current version of the model partially explains several of the observed phenomena that raise questions. Numerical application of the model has yielded the following results, among others: Initially, during the Planck era, at the very beginning of Planck time, , the universe contained a single photon at Planck temperature Planck energy in the Planck volume. During the photon inflation phase (before characteristic time ~10^-9 ), the number of original photons (alphatons) increased at each unit of Planck time and geometrical progression ~n³, where n is the quotient of cosmic time over Planck time . Then, the primordial number of photons reached a maximum of N~10⁸⁹, where it remained constant. It's primordial photons (alphatons) are still present today and represents the essential of the energy contained in the universe via the cosmological constante . Such geometric growth in the number of photons can bring a solution to the horizon problem through exchange and a photon energy volume that is in phase with that of the the volume energy of the universe. The age of the universe in cosmic time that is in line with positive energy conservation (in terms of conventional thermodynamics) and the creation of proton, neutron, electron, and neutrino masses, is ~76 [Gy] (observed . The predicted total mass (p, n, e and n), based on the Maxwell-Juttner relativistic statistical distribution, is ~7x10⁵⁰ . The predicted cosmic neutrino mass is ≤ 8.69x10^-32 (≤ 48.7 ) if based on observations of SN1987A. The temperature variation of the cosmic microwave background (CMB), as measured by Planck, can be said to be partially due to energy variations in the universe (DU/U) during the primordial baryon synthesis (energy jump from the creation of protons and neutrons). In this model, what is usually referred to as dark energy actually corresponds to the energy of the universe that has not been converted to mass, and which acts on the mass created by the energy-mass equivalence principle and the cosmological gravity field, , associated with the cosmological constant, which is high during primordial formation of the galaxies (<1 [Gy]). A look at the Casimir effect makes it possible to estimate a minimum Casimir pressure and thus determine our possible relative position in the universe at cosmic time 0,1813 (t₀/t_W=13,8 /76,1 ). Therefore, from the observed age of 13,8 [Gy], we can derive a possible cosmic age of 76,1 [Gy]. That energy of the universe, when taken into consideration during the formation of the first galaxies (< 1 [Gy]), provides a relatively adequate explanation of the non-Keplerian rotation of galactic masses. Indeed, such residual, non-baryonic energy, when considered in Newton’s gravity equation, adds the term , which can partially explain, without recourse to dark matter, the rotations of some galaxies, such as M33, UGC12591, UGC2885, NGC3198, NGC253, DDO161, UDG44, the MW and the Coma cluster. Today, in the MW, that cosmological gravity force is in the order of 10²⁶ times smaller than the conventional gravity force. The model predicts an acceleration of the mass in the universe (q~ 0,986); the energy associated with curvature is the driving force behind the expansion of the universe, rather than the energy associated with the cosmological constant . An equation to determine expansion is obtained using the energy form of the Friedmann equation relative to Planck power and cosmic time or Planck force acting at the frontier of the universe moving at c. This constant Planck force, from unknown sources, acts everywhere to the expansion of the universe as a stretching effect on the volume. Finally, the model partly explains the value a₀ of the MOND theory. Indeed, a₀ is not a true constant, but depends on the cosmological constant at the time the great structures were formed (~1 [Gy]), as well as an adjustment of the typical mass and dimension of those great structures, such as galaxies. The constant a₀ is a different expression of the cosmological gravity force as expressed by the cosmological constant, Λ, acting through the energy-mass equivalent during the formation of the structures. It does not put in question the value of G.

Fetuses of pregnant women affected by anti-Ro/anti La antibodies are at risk to develop complete atrioventricular heart block (CAVB) and other potentially life-threatening cardiac affections. CAVB can develop in less than 24 hours. Treatment with anti-inflammatory drugs and immuno-globulins (IVIG) can restore normal rhythm if applied in the transition period. Routine weekly echocardiography as often recommended will seldomly detect emergent AVB. Surveillance of these pregnancies is controversial. To obtain an overview of the current practice in Germany we have developed a web-based survey sent by the DEGUM (German Society of Ultrasound in Med-icine) to ultrasound specialists. Home-monitoring by hand-held Doppler is a promising new approach. With the intention to evaluate practicability, we instructed pregnant women at risk to use hand-held Doppler in the vulnerable period between 18-26 weeks at our university center.

Post-training quantization is pivotal in deploying convolutional neural networks for mobile applications. Block-wise reconstruction with adaptive rounding, as employed in prior works like BrecQ and Qdrop, facilitates acceptable 4-bit quantization accuracy. However, adaptive rounding is time-intensive, and its constraint on weight optimization space curtails the potential for quantization performance. The optimality of block-wise reconstruction hinges on the quantization status of subsequent network blocks. In this investigation, we delve into the theoretical underpinnings of the limitations inherent in adaptive rounding and block-wise reconstruction. Our exploration leads to the development of a post-training quantization methodology, designated as AE-Qdrop. This algorithm operates in two distinct phases: block-wise reconstruction and global fine-tuning. The block-wise reconstruction phase introduces a progressive optimization strategy, superseding adaptive rounding, which not only augments quantization precision but also significantly improves quantization efficiency. To mitigate the risk of overfitting, we introduce a random weighted quantized activation mechanism. During the global fine-tuning phase, we account for interdependencies among quantized network blocks. The weight of each network block will be corrected with logit matching and feature matching. Extensive experiments validate that AE-Qdrop achieves high-precision and efficient quantization. For instance, in the case of 2-bit MobileNetV2, AE-Qdrop outperforms Qdrop by achieving a 6.26% enhancement in quantization accuracy and quintupling the quantization efficiency.

In order to study the collapse failure of shaft wall of high depth inclined ore-pass under ore impact wear behavior, 25 ore-passes in a deep mine in Yunnan, China were investigated. Considering the ore-pass structural characteristics and the impact wear effect of ore on shaft wall, the shaft wall damage model of high depth inclined ore-pass is constructed based on the contact mechanics theory. Furthermore, No. 1#, 2#, 3# and 9# ore-passes of the mine are taken as examples for analysis, and the three results of theoretical analysis, numerical simulation and engineering case are used for comparison and verification. The shaft wall damage degree is predicted, and the damage mechanism between total shaft wall damage volume Qtol and ore-pass depth H, ore-pass dip angle θ, inclined angle of chute α, shaft diameter D and ore block size P is quantitatively investigated. The results show that the rationality of the proposed model is verified by numerical analysis and field engineering situations. Moreover, the deeper ore-pass depth H, the more shaft wall damage volume Qtol with the increase of collision frequency. Qtol increases exponentially with P and increases gradually with D. With the increase of θ or α, Qtol increases generally first and then decreases. Therefore, Qtol can be effectively reduced by selecting the appropriate structure parameters of ore-pass and adopting the technology of drilling straight ore-pass. This work provides technical support for long period safe operation of high depth inclined ore-pass.

Craters are the most prominent geomorphological features on the surface of celestial bodies, which is playing a crucial role in studying the formation and evolution of celestial bodies, as well as in landing and planning for surface exploration. Currently, the main automatic crater detection models and datasets focus on the detection of large and medium craters. In this paper, we created 23 small lunar crater datasets for model training based on the Chang’E-2 (CE-2) DOM, DEM, Slope, and integrated data with 7 kinds of visualization stretching methods. And then, we proposed the YOLO-Crater model for Lunar and Martian small crater detection by replacing EioU and VariFocal loss to solve the crater samples imbalance problem and introducing a CBAM attention mechanism to mitigate interference from the complex extraterrestrial environment. The results show that the accuracy (P = 87.86%, R = 66.04%, and F1 = 75.41%) of the Lunar YOLO-Crater model based on the DOM-MMS (Maximum-Minimum Stretching) dataset is the highest and better than that of YOLOX model. And the Martian YOLO-Crater, trained by the Martian dataset from the 2022 GeoAI Martian Challenge, achieves good performance with P = 88.37%, R = 69.25%, and F1 = 77.65%. It indicates that the YOLO-Crater model has a strong transferability and generalization capability, which can be applied to detect small craters on the Moon and other celestial bodies.

Traditional soil characterization methods are time consuming, laborious and invasive and do not allow long-term repeatability of measurements. The overall aim of this paper was to assess and model spatial variability of the soil in an olive grove in south Italy by using data from two sensors of different type: a multi-spectral on-board drone radiometer and a hyperspectral visible-near infrared-shortwave infrared (VIS-NIR-SWIR) reflectance radiometer as well as sample data, to arrive at a delineation of homogeneous areas. The hyperspectral data were processed using continuum removal methodology to obtain information about the content and composition of clay. Differently, the multispectral data were firstly upscaled to the support of soil data using geostatistics and taking into account change of support. Secondly, the two-sensor data were integrated with soil granulometric properties by using the multivariate geostatistical techniques of multi-collocated cokriging and factor cokriging, in order to achieve a more exhaustive and finer-scale soil characterisation. The paper shows the impact of change of support on the uncertainty of soil prediction that can have a significant effect on decision making in Precision Agriculture. Moreover, four regionalised factors at two different scales (two per each scale) were retained and mapped. Each factor provided a different delineation of the field with areas characterised by different granulometry and clay composition. The applied method is sufficiently flexible and could be applied to any number and type of sensors.

Background: The aim of the present investigation was to evaluate the clinical success of horizontal ridge augmentation in the severely atrophic maxilla (Cawood and Howell class IV) using freeze-dried custom made bone harvested from cadaver donors tibial hemiplateau and to analyze the marginal bone level gain prior dental implants placement at 9 months after bone grafting and before prosthetic rehabilitation. Methods: A 52-year-old woman received custom made bone grafts. Patient underwent CT scans 2 weeks prior and 9 months after surgery for graft volume and density analysis. Results: The clinical and radiographic bone observations showed a very low rate of resorption after bone graft and implant placement. Conclusions: The custom-made allograft material was a highly effective modality for restoring the alveolar horizontal ridge, resulting in this way to reduce the need to obtain autogenous bone from a secondary site with predictable procedure. Further studies are needed to investigate its behavior at longer time points.

HU is the Hypergeometrical Universe Theory (HU)[1-8], proposed in 2006, where the Universe is a Lightspeed Expanding Hyperspherical Hypersurface and Gravitation is an absolute-velocity-dependent, epoch-dependent force. Here we introduce the Big Pop Cosmogenesis and show our calculations associated with the Equation of State of the Universe. This article is the first in a series of articles[9-22] supporting the paradigm shift.

In cosmology dark energy and dark matter are included in the ΛCDM model, but they are still completely unknown. Because in black holes Lorentz invariance seems not to be applicable for curved space-time, we introduce a model for a reduced speed of light in black holes due to quantum gravity effects and the Heisenberg uncertainty relation. Then black holes are a source for a scalar field with dark energy characteristics. This model has no information paradox for black holes because particles / radiation entering the black hole are redshifted in their wavelength that far that the wavelength has the size of the Schwarzschild radius and thus they are in some way "frozen" in the black hole. We show that the scalar field also has characteristics of dark matter shortly after Planck time, when we use a Big Bounce model. This model also presents an alternative to cosmological inflation with the possibility to solve the flatness and horizon problem and the problem of density fluctuations.

We suggest progress regarding the following six physics opportunities. List all elementary particles. Describe dark matter. Explain ratios of dark matter to ordinary matter. Explain eras in the history of the universe. Link properties of objects. Interrelate physics models. We use models based on Diophantine equations.

According to the Cosmological Principle the Universe is isotropic and no preferred direction would be seen by an observer that might be stationary with respect to the expanding cosmic fluid. However, because of observer’s partaking in the solar system peculiar motion, there would appear in some of the observed properties of the Cosmos a dipole anisotropy, which could in turn be exploited to determine the peculiar motion of the solar system. The dipole anisotropy in the Cosmic Microwave Background Radiation (CMBR) has given a peculiar velocity vector 370 km s−1 along l=264∘,b=48∘. However, some other dipoles, for instance, from the number counts, sky brightness or redshift distributions in large samples of distant Active Galactic Nuclei (AGNs), have yielded values of the peculiar velocity many times larger than that from the CMBR, though surprisingly, in all cases the directions agreed with the CMBR dipole. Here we determine our peculiar motion from a sample of 0.28 million AGNs, selected from the Mid Infra Red Active Galactic Nuclei (MIRAGN) sample comprising more than a million sources. From this, we find a peculiar velocity, which is more than four times the CMBR value, although the direction seems to be within ∼2σ of the CMBR dipole. A genuine value of the solar peculiar velocity should be the same irrespective of the data or the technique employed to estimate it. Therefore, such discordant dipole amplitudes, might mean that the explanation for these dipoles, including that of the CMBR, might in fact be something else. But, the observed fact that the direction in all cases, is the same, though obtained from completely independent surveys using different instruments and techniques, by different sets of people employing different computing routines, might nonetheless indicate that these dipoles are not merely due to some systematics, otherwise why would they all be pointing along the same direction. It might instead suggest a preferred direction in the Universe, implying a genuine anisotropy, which would violate the Cosmological Principle, the core of the modern cosmology.

We present a model of space that considers it to be a quantized dynamical entity which is a component of the universe along with matter and radiation. The theory is used together with thermodynamic data to provide a new view of cosmic evolution and an insight into the nature of dark energy and dark matter. Space is made up of energy quanta. The universe started from an atomic size volume at very high temperature and pressure near the Planck epoch. Upon expansion and cooling, phase transitions occurred resulting in the formation of radiation, fundamental particles, and matter. These nucleate and grow into stars, galaxies, and clusters. From a phase diagram of cosmic composition, we obtained a correlation between dark energy and the energy of space. Using the Friedmann equations, data from WMAP studies of the composition of the universe at 3.0 x 10⁵ (a=5.25 x 10^-2) years and at present (a=1), are well fitted by our model with an equation of state parameter, w= -0.7. The accelerated expansion of the universe, starting at about 7 billion years, determined by BOSS measurements, also correlates well with the dominance of dark energy at 7.25 x 10⁹ years ( a= 0.65). The expansion can be attributed to Quintessence with a space force arising from a quantum space field. From our phase diagram, we also find a correlation suggesting that dark matter is a plasma form of matter similar to that which existed during the photon epoch immediately prior to recombination. Our Quantum Space Model leads to a universe which is homogeneous and isotropic without the need for inflation. The thermodynamics of expansion is consistent with BOSS data that show the process to be adiabatic and the rate of expansion decelerating during the first 6 billion years after the Big Bang. However, it became non-adiabatic and accelerating thereafter. This implies an influx of energy from a source outside the universe; it warrants consideration as a possible factor in the accelerated expansion of the universe.

We appeal the science community to review the basic definition of wavelength dependent cosmic red shift. We would like to emphasize the point that, the true cosmic red shift must be defined as the ratio of loss in energy of photon to the energy of photon at galaxy. In terms of wavelength, photon red shift must be defined as the ratio of change in wavelength to the observed wavelength of photon. Considering the recent paper pertaining to cosmic halt authored by Cosmin Andrei, Anna Ijjas, and Paul J. Steinhardt and reviewed by Saul Perlmutter, in this paper we propose a very simple model of the universe having early stage light radius of proton seems to be equal to half the product of reduced Planck’s constant and current speed expansion and current stage quantum halt accompanied by continuous light speed rotation. In this context, representing early cosmic expansion and rotation as an outward spiral, it seems possible to consider Hubble’s law as a representation of current cosmic light speed rotation having no further expansion. To understand the current cosmic halt, we are proposing very simple and very strange atomic and nuclear relations that constitute Hubble parameter and gravitational constant. Qualitatively and quantitatively, gravitational potential energy of proton and electron separated by a distance of root mean square radius of proton. Based on uncertainty condition, it needs further study, observations and analysis. We have extended our analysis towards the microscopic coupling constants. Thus, instead of considering the cosmological variable nature of elementary physical constants, we consider the case of current or nearby cosmic halt by means of considering the equality of current cosmic variable physical constants having similar dimensions of fixed elementary physical constants and their combinations. In this connection, it is very interesting to note that, our estimated cosmic age of (2/H0) is matching with recent estimates proposed by Rajendra P Gupta and published in MNRAS.

Based on four major cosmological and astrophysical coincidences, it seems possible to develop a new model of Hubble-Hawking Universe having light speed expansion. Considering the analysis of 740 super novae data, it is possible to consider a constant rate of cosmic expansion. As there is no physical reasoning for the observed speed of light and all the cosmological observations are completely based on speed of light-by considering ‘light speed expansion’ as a characteristic nature of the universe, big bang, inflation, dark energy, quintessence and lambda term like ideal and unidentified concepts can be reviewed and relinquished at fundamental level and a practical model of expanding universe can be developed with ease and clarity. In this context, we would like to emphasize the point that, traditional definition of cosmic red shift is absolutely wrong. In terms of energy of photon, true cosmic red shift must be defined as - ratio of loss of energy in photon to the energy of photon at galaxy. We encourage the reader to see Figure 1 and Table 1 pertaining to light travel distances prepared with $\left(\frac{z}{1+z}\right)\left(\frac{c}{H_0}\right)\cong z_{new}\left(\frac{c}{H_0}\right)$. For data comparison, readers are encouraged to visit https://cosmocalc.icrar.org/ and http://www.atlasoftheuniverse.com/cosmodis.c. It may be noted that, considering 200 million solar masses as a cut off for ordinary gravity, dark matter can be considered as an effect of power law based super gravity of galactic baryonic mass. It is well believed that, Hawking’s findings about black holes are the most important contributions to physics in recent decades. Hence, we appeal the science community to recommend our Hubble-Hawking model for further research and study.

We present a Machian model of Quantum Cosmology with full dark matter and light speed expansion and rotation. During galaxy formation and evolution, fraction of dark matter transforms to visual matter with a relation of the form, m_vis = constant * (m_dark)^2/3. Using this relation and replacing MOND’s ‘critical acceleration’ with “current cosmic maximum angular acceleration”, galactic flat rotation speed range of (50 to 500) km/sec can be fitted well. Estimated flat rotation speeds of DD168, Milky Way and UGC12591 are 49.96 km/sec, 199.66 km/sec and 521.75 km/sec respectively. Based on these striking coincidences, it is possible to say that, MOND’s approach is implicitly connected with cosmological estimation of 95% invisible matter. Considering galactic total matter and current cosmic maximum angular acceleration, galactic working radii, angular velocity and visual matter density can be estimated. Even though, this model is free from ‘big bang’, ‘inflation’, ‘dark energy’, ‘flatness’ and ‘red shift’ issues, at 2.722 K, estimated present Hubble parameter is 66.24 km/sec/Mpc, cosmic radius is 146.3 times the Hubble radius, angular velocity is 146.3 times lower than the Hubble parameter and cosmic age is 146.3 times the Hubble age. With future observations and advanced telescopes, it may be possible to see far distant galaxies and very old stars far beyond the current observable cosmic radius.

Understanding and predicting damage progression within thin plain-woven CFRP components is an essential issue for scheduling maintenance intervals and structural inspections, and typically require extensive test series. However, uncertainties always remain and result in conservative design and unnecessary downtimes due to the repeated inspections of a healthy structure. SHM can be used to reduce these uncertainties, as it allows to evaluate the condition of a mechanical structure during operation. Numerous SHM methods are developed , that achieve different levels of damage identification but are often investigated at small coupons with non-realistic structural damages and loading conditions on both, structure and sensor. The present research investigates the electrical impedance tomography (EIT) featuring an elastoresistive thin-film sensor to evaluate damage that propagates from a circular hole in a large plate under cyclic tensile-tensile multi-block loading. Applied fatigue loads were increased multiple times up to a total number of two million cycles. During the loading damage initiated at the hole and continuously propagated into the plate. Repeated EIT evaluations of the applied sensor and validating evaluations by means of digital image correlation clearly revealed the robustness of the hardware and the potential of the SHM method for damage evaluation of plain-woven CFRP components.

Due to the special characteristics of the shooting distance and angle of remote sensing satellites, the pixel area ratio of ship targets is small and the feature expression is insufficient, which leads to unsatisfactory ship detection performance and even situations such as missed detection and false detection. In this study, we propose an improved-YOLOv5 algorithm. The improvement strategies mainly include: (1) Add the Convolutional Block Attention Module (CBAM) into the Backbone to enhance the extraction of target-adaptive optimal features; (2) Introduce cross-layer connection channel and lightweight GSConv structure into the Neck to achieve higher-level multi-scale feature fusion and reduce the number of model parameters; (3) The Wise-IoU loss function is used to cal-culate the localization loss in the Output, and assign reasonable gradient gains to cope with dif-ferences in image quality. In addition, during the preprocessing stage of experimental data, a me-dian and bilateral filter method is used for noise reduction to reduce interference from ripples and waves and highlight the information of ship features. The experimental results show that Im-proved-YOLOv5 has a significant improvement in recognition accuracy compared to various mainstream target detection algorithms; Compared to the original YOLOv5s, the mean Average Precision (mAP) has improved by 3.2% and the Frames Per Second (FPN) has accelerated by 8.7%.

We present a thermodynamic approach in modeling the evolution of the universe based on a theory that space consists of energy quanta, the spaceons. From wave-particle duality, they can be treated as an ideal gas. The model is similar to the Big Bang but without Inflation. It provides an insight into the nature of dark energy and dark matter, and an explanation for the accelerated expansion of the universe. The universe started from an atomic size volume of spaceons at very high temperature and pressure. Upon expansion and cooling, phase transitions occurred resulting in the formation of fundamental particles, and matter. These nucleate and grow into stars, galaxies, and clusters due to the action of gravity. From the cooling curve of the universe we constructed a thermodynamic phase diagram of cosmic composition, from which we obtained the correlation between dark energy and the energy of space. Using Friedmann’s equations, our model fits well the WMAP data on cosmic composition with an equation of state parameter, w= -0.7. The dominance of dark energy started at 7.25 x 10⁹ years, in good agreement with BOSS measurements. The expansion of space is attributed to a scalar quantum space field. Dark Matter is identified as a plasma form of matter similar to that which existed during the photon epoch, prior to recombination. The thermodynamics of expansion of the universe was adiabatic and decelerating during the first 7 billion years after the Big Bang; it accelerated thereafter. A negative pressure for Dark Energy is required to sustain the latter. This is consistent with the theory of General Relativity and the law of conservation of energy. We propose a mechanism for the acceleration as due to consolidation of matter forming Dark Energy Stars (DES) and other compact objects. The resulting reduction in gravitational potential energy feeds back energy for the expansion. Space will continue to expand and dark energy will undergo phase transition to a Bose-Einstein condensate, a superfluid form of matter. Self-gravitation can cause a bounce and start a new Big Bang. We show how the interplay of gravitational and space forces leads to a cyclic, maybe eternal, universe.

The main foundations of the standard $\Lambda $CDM model of cosmology are that: 1) The redshifts of the galaxies are due to the expansion of the Universe plus peculiar motions; 2) The cosmic microwave background radiation and its anisotropies derive from the high energy primordial Universe when matter and radiation became decoupled; 3) The abundance pattern of the light elements is explained in terms of primordial nucleosynthesis; and 4) The formation and evolution of galaxies can be explained only in terms of gravitation within a inflation+dark matter+dark energy scenario. Numerous tests have been carried out on these ideas and, although the standard model works pretty well in fitting many observations, there are also many data that present apparent caveats to be understood with it. In this paper, I offer a review of these tests and problems, as well as some examples of alternative models.

Quaking aspen (Populus tremuloides Michx.) is an important deciduous species in western U.S. forests. Existing maps of aspen distribution are based on Landsat imagery and often miss small stands (&lt;0.09 ha or 30 m²), which rapidly regrow when managed or following disturbance. In this study, we present methods for deriving a new regional map of aspen forests using one year of Sentinel-1 (S1) and Sentinel-2 (S2) imagery in Google Earth Engine. We assessed the annual phenology of aspen in the Southern Rockies and leveraged the frequent temporal resolution of S1 and S2 to create ecologically relevant seasonal composites. Additionally, we derived spectral indices and radar textural features targeting the canopy structure, moisture, and chlorophyll content. Using spatial block cross-validation and Random Forests, we assessed the accuracy of different scenarios and selected the best performing set of features for classification. Comparisons were then made with existing landcover products across the study region. The resulting map improves on existing landcover products in both accuracy (average F1-score = 93.1%) and detection of smaller forest patches. These methods enable accurate mapping at spatial and temporal scales relevant to forest management for one of the most widely distributed tree species in North America.

A plenty of theories on the origin of genetic codes have been proposed so far, yet all ignored the energetic driving force, its relation to the biochemical system, and most importantly, the missing “matchmaker” between proteins and nucleic acids. Here, a new hypothesis is proposed, according to which ATP is at the origin of the primordial genetic code by driving the coevolution of the genetic code with the pristine biochemical system. This hypothesis aims to show how the genetic code was produced e.g. by photochemical reactions in a protocell that derived from a lipid vesicle enclosing various life’s building blocks (e.g. nucleotides and peptides). At extant cell, ATP is the only energetic product of photosynthesis, and is at the energetic heart of the biochemical systems. ATP could energetically form and elongate chains of both polynucleotides and polypeptides, thus acting a “matchmaker” between these two bio-polymers and eventually mediating precellular biochemical innovation from energy transformation to informatization. ATP was not the only one that could drive the formation of polynucleotides and polypeptides, but favored by precellular selection. The protocell innovated a photosynthesis system to produce ATP efficiently and regularly with the aids of proteins and RNA/DNA. The completion of permanently recording the genetic information by DNA marked the dawn of cellular life operated by Darwinian evolution. The ATP hypothesis assumes or supports the photochemical origin of life, shedding light on the origins of both photosynthetic and biochemical systems, which remains largely unknown thus far. Based on ATP hypothesis, virus (like the new coronavirus) could not be the earliest life on Earth, as it has neither biochemical systems nor lipid bilayer membrane that provided relatively isolated environment for the development of protobiochemical reactions, although it owns the genetic code of a cellular life. Virus could not be a bridge between life and non-life, but is an anti-life substance, as it depletes cellular material for its own replication, and then spreads by destroying the host cells. It can be imagined that if cellular life are completely wiped out by the virus, the complete destruction of life on Earth would be inevitable.

Space-time evolution is briefly explained by using the 3-dimensional quantized space model (TQSM) based on the 4-dimensional (4-D) Euclidean space. The energy (mass), charges and absolute time are newly defined based on the 4-D Euclidean space. The photons and gravitons are understood as the 2-D space fluctuations along the space axes and 1-D time fluctuations along the time axis, respectively. This indicates that the electromagnetic (EM) and gravitational (G) waves can be unified into the so called gravityelectromagnetic (GEM) wave which has both space and time fluctuations. The photon with zero force fields is the 2EM wave because an EM wave corresponds to a charged fermion. The dark matter bosons, weak force bosons, strong force bosons are the 1-D time fluctuations which can be expressed by the G waves. This indicates that all five forces are unified by the GEM wave. It is called as the super unification theory in the present work. And the force carrying bosons and mesons are, for the first time, proposed as the possible candidates of the magnetic monopoles like the fermions and baryons are the electric monopoles. The signs of the magnetic charges quantized as q_m=cq are newly defined. The big bang is understood by the space-time evolution of the 4-D Euclidean space but not by the sudden 4-D Minkowski space-time creation. The big bang process created the matter universe with the positive energy and the partner anti-matter universe with the negative energy from the CPT symmetry.

Alzheimer’s Disease (AD) has no cure. Earlier, we showed that partial inhibition of mitochondrial complex I (MCI) with small molecule CP2 induces adaptive stress response activating multiple neuroprotective mechanisms. Chronic treatment reduced inflammation, improved synaptic and mitochondrial functions, and blocked neurodegeneration in symptomatic APP/PS1 mice, a translational model of AD. Here, using serial block-face scanning electron microscopy (SBFSEM) and three-dimensional (3D) EM reconstructions combined with Western blot analysis and next-generation RNA sequencing, we demonstrate that CP2 treatment also restores mitochondrial morphology and mitochondria-endoplasmic reticulum (ER) communication in the APP/PS1 mouse brain. Using 3D EM volume reconstructions, we show that mitochondria in AD dendrites exist primarily as mitochondria-on-a-string (MOAS). Compared to other morphological phenotypes, MOAS are extensively enveloped in the ER membranes forming multiple mitochondria-ER contact sites (MERCS) known to contribute to abnormal lipid and calcium homeostasis. CP2 treatment specifically reduced MOAS formation, consistent with improved energy homeostasis in the brain, with concomitant reduction in MERCS, ER stress, and improved lipid homeostasis. These data provide novel information on the role MOAS play in AD and additional support for further development of partial MCI inhibitors as disease modifying strategy for AD.

We try to solve three decades-old physics challenges. List all elementary particles. Describe dark matter. Describe mechanisms that govern the rate of expansion of the universe. We propose new modeling. The modeling uses extensions to harmonic oscillator mathematics. The modeling points to all known elementary particles. The modeling suggests new particles. Based on those results, we do the following. We explain observed ratios of dark matter amounts to ordinary matter amounts. We suggest details about galaxy formation. We suggest details about inflation. We suggest aspects regarding changes in the rate of expansion of the universe. We interrelate the masses of some elementary particles. We interrelate the strengths of electromagnetism and gravity. Our work seems to offer new insight regarding applications of harmonic oscillator mathematics. Our work seems to offer new insight regarding three branches of physics. The branches are elementary particles, astrophysics, and cosmology.

We develop and apply new physics theory. The theory suggests specific unfound elementary particles. The theory suggests specific constituents of dark matter. We apply those results. We explain ratios of dark matter amounts to ordinary matter amounts. We suggest details about galaxy formation. We suggest details about inflation. We suggest aspects regarding changes in the rate of expansion of the universe. The theory points to relationships between masses of elementary particles. We show a relationship between the strength of electromagnetism and the strength of gravity. The mathematics basis for matching known and suggesting new elementary particles extends mathematics for harmonic oscillators.

Space-time evolution of our universe is explained by using the 3-dimensional quantized space model (TQSM) based on the 4-dimensional (4-D) Euclidean space. The energy (E = cDtDV), charges and energy density (|q| = r = cDt) and absolute time (ct) are newly defined based on the 4-D Euclidean space. The photon flat space with the constant energy density of r = cDt_q is proposed as the dark energy (DE). The dark energy is separated into the n DE and photon DE which create the new photon spaces with the constant energy density of r = cDt_q. The v DE is from the n pair production by the CPT symmetry and the photon DE is from the photon space pair production by the T symmetry. The vacuum energy crisis and Hubble’s constant puzzle are explained by the photon space with the n DE and photon DE. The big bang and inflation of the primary black hole is connected to the accelerated space expansion and big collapse of the photon space through the universe evolution. The big bang from the nothing is the pair production of the matter universe with the positive energy and the partner anti-matter universe with the negative energy from the CPT symmetry. Our universe is the matter universe with the negative charges of electric charge (EC), lepton charge (LC) and color charge (CC). This first universe is made of dark matter -, lepton -, and quark - primary black holes with the huge negative charges which cause the Coulomb repulsive forces much bigger than the gravitational forces. The huge Coulomb forces induce the inflation of the primary black holes, that decay to the super-massive black holes and particles.

Paving blocks are concrete pieces placed in exposed places to the weather, which are sub-jected to loads and wear. Hence, quality control in the manufacture of paving blocks is es-sential to guarantee the properties and durability of the product in construction projects. In Ecuador, the requirements are described in the Ecuadorian technical standard "NTE INEN 3040", and tensile splitting strength is a fundamental requirement to guarantee product quality. It is analyzed using quality control measurements such as dimensions, the weight of the fresh paving block in the vibro-compacted process, and the percentage of water absorption in order to know how the variables influence and manage to predict the tensile splitting strength to avoid product non-conformity in advance, having a timely and better control of the manufacturing process. The data was obtained from a company that can produce 30 000 units per day of rectangular paving blocks with 6 cm thickness. Mul-tivariate models such as multiple linear regression, regression trees, random forests and neural networks are performed to predict the tensile splitting strength variable through two groups of predictors; the first group is the thickness mm, width mm, length mm, mass of fresh paving block g and percentage of water absorption %. The second group of pre-dictor variables is the density of the fresh paving block kg/m3 and the percentage of water absorption %. It is concluded that the multiple linear regression method performs better in predicting the first group of predictor variables with a mean square error (MSE) of 0.110086, followed by the neural network without hidden layers resulting in an MSE of 0.112198. The best method for the second set of predictors was the neural network with-out hidden layers with a mean square error ( MSE ) of 0.112402, closely followed by the multiple linear regression model with an MSE of 0.115044.

Physics theory has yet to settle on specific descriptions for new elementary particles, for dark matter, and for dark energy forces. Our work extrapolates from the known elementary particles. The work suggests well-specified candidate descriptions for new elementary particles, dark matter, and dark energy forces. This part of the work does not depend on theories of motion. This work embraces symmetries that correlate with motion-centric conservation laws. The candidate descriptions seem to explain data that prior physics theory seems not to explain. Some of that data pertains to elementary particles. Our theory suggests relationships between masses of elementary particles. Our theory suggests a relationship between the strengths of electromagnetism and gravity. Some of that data pertains to astrophysics. Our theory seems to explain ratios of dark matter effects to ordinary matter effects. Our theory seems to explain aspects of galaxy formation. Some of that data pertains to cosmology. Our theory suggests bases for inflation and for changes in the rate of expansion of the universe. Generally, our work proposes extensions to theory in three fields. The fields are elementary particles, astrophysics, and cosmology. Our work suggests new elementary particles and seems to explain otherwise unexplained data.

Space-time evolution is briefly explained by using the 3-dimensional quantized space model (TQSM) based on the 4-dimensional (4-D) Euclidean space. The energy (E=cDtDV), charges (|q|= cDt) and absolute time (ct) are newly defined based on the 4-D Euclidean space. The big bang is understood by the space-time evolution of the 4-D Euclidean space but not by the sudden 4-D Minkowski space-time creation. The big bang process created the matter universe with the positive energy and the partner anti-matter universe with the negative energy from the CPT symmetry. Our universe is the matter universe with the negative charges of electric charge (EC), lepton charge (LC) and color charge (CC). This first universe is made of three dark matter -, lepton -, and quark - primary black holes with the huge negative charges which cause the Coulomb repulsive forces much bigger than the gravitational forces. The huge Coulomb forces induce the inflation of the primary black holes, that decay to the super-massive black holes. The dark matter super-massive black holes surrounded by the normal matters and dark matters make the galaxies and galaxy clusters. The spiral arms of galaxies are closely related to the decay of the 3-D charged normal matter black holes to the 1-D charged normal matter black holes. The elementary leptons and quarks are created by the decay of the normal matter charged black holes, that is caused by the Coulomb forces much stronger than the gravitational forces. The Coulomb forces are very weak with the very small Coulomb constants (k₁(EC) = k_dd(EC) ) for the dark matters and very strong with the very big Coulomb constants (k₂(EC) = k_nn(EC)) for the normal matters because of the non-communication of the photons between the dark matters and normal matters. The photons are charge dependent and mass independent. But the dark matters and normal matters have the similar and very weak gravitational forces because of the communication of the gravitons between the dark matters and normal matters. The gravitons are charge independent and mass dependent. Note that the three kinds of charges (EC, LC and CC) and one kind of mass (m) exist in our matter universe. The dark matters, leptons and quarks have the charge configurations of (EC), (EC,LC) and (EC,LC,CC), respectively. Partial masses of elementary fermions are calculated, and the proton spin crisis is explained. The charged black holes are not the singularities.

The part of this article dealing with topological insulators and topological superconductors was first written about two years ago - the ideas in the part about the topological universe originated six years ago or more. It’s rather strange that I never put the two parts together in writing before. My belief in unification is unshakeable - I’ve been convinced for years that the universe must be composed of topology. Since Earth is part of the cosmos, entanglement means it must have topological materials. The reverse is also true: topological materials on Earth are well known to science - so in a unification, space and time inevitably possess topological composition. Topological materials (topological insulators, topological superconductors) can be less mystifying if they’re related to the paradigm-shifting deterministic view of quantum mechanics which is described in the universal topology (the “rubber-sheet geometry” of the cosmos): see my previous submission “Hypothesis of Quantum Gravity - Resulting from a Static, Topological Universe Resulting from the Positives and Negatives of the Steady State and Big Bang Theories" at https://www.preprints.org/manuscript/202105.0239/v1 (the first section of this present article is a quick summary of the relevant parts).

Dirac's Large Number Hypothesis (LNH), proposed in 1937, has captivated the scientific community with its exploration of profound correlations between cosmic and atomic scales. This hypothesis delves into the intricate interplay between the infinitesimally small and the vastly large, offering potential insights into the fundamental nature of the universe. As we continue to uncover the mysteries of the cosmos, the LNH oscillates on the precipice of scientific acceptance—neither fully validated nor entirely dismissed. In this review paper, we embark on a comprehensive journey through Dirac's LNH, shedding light on its theoretical underpinnings, its implications for universe models, and its resonance with the Anthropic Principle. We delve into the possibilities of variable gravitational constants and continuous mass creation, inviting further exploration into the intricacies of our cosmic symphony. By embracing the ongoing quest for understanding, we endeavor to unravel the profound harmonies that connect the infinitesimal with the infinite, contributing to the symphony of knowledge in theoretical physics and cosmology.

Here we mathematically model black holes and the early universe following dynamics similar to RLC electrical models, focusing on their similarities at the singularity. We use this mathematically modelling to hypothesize the evolution of an expanding universe as the result of a black hole collapse followed by its evaporation. Or model consists of several steps defined by: (1) the formation of a black hole following general relativity equations; (2) growth of the black hole modelled as a resistance-capacitance-like electrical circuit; (3) expansion of space-time following the disintegration of the black hole, modelled by RLC-like dynamics. In updating this article, version 2, we will expand by presenting three additional examples related to the theory of the generalization Boltzmann's constant in curved space-time and the theory of general and especial relativity. We will calculate the critical mass to produce a black hole in the LHC, the existence of a high temperature Bose-Einstein condensate and finally we will demonstrate the existence of a tangential force to the repulsion force in the disintegration of subatomic particles. In the update of this article, version 3, we will expand to develop two examples. First, we will present the relationship between M-theory, extra dimensions with the theory of the generalization of Boltzmann's constant in curved space-time. Secondly, we will propose the idea of ​​updating the Lambda-CDM model, considering the primordial gravitational waves to correctly describe the evolution of the universe.

Here, using the theory of electrical-quantum modelling of the neutron and proton as a three-phase alternating current electrical generator, we will analyse the proton decay and the inverse neutron decay and determine the following subatomic particles, Dproton, Protoniu, Dneutron and Neutroniumd.

Here we will electrically-quantum model the neutron and proton as a three-phase alternating current electric generator, for this, we will use the theory of three-phase electric generators and vector or phasor diagrams. We will use this model to hypothesize how the quarks that form neutrons and protons with a combined mass of 10 MeV/c², can generate, through quarks-antiquarks-gluon interactions, a mass of 939.56 MeV/c² for the neutron and a mass of 938.27 MeV/c² for the proton. Using quantum mechanics and the theory of the generalization of the Boltzmann constant in curved space-time we will calculate the number of quarks-antiquarks-gluons and gravitons inside a neutron. We will also analyse βˉ decay using vector diagrams, we will calculate the tension of the string T₀ and the length of the string ℓs between quarks-antiquark and finally, we will model a black hole using a neutron equivalent model. In version 2 of this article, we will update the vector diagrams of the βˉ decay and theoretically calculate the energy of the W⁻ boson, the Z⁰ boson, and the Θ angle, Θ = arc cos (W⁻/Z⁰). We will demonstrate, through vector diagrams, that quarks-antiquarks-gluon interactions are the cause of the origin of the W⁻ boson and the Z⁰ boson. We will also demonstrate how the fine structure constant α originates. It is important to make clear, in future updates, we will describe the relationship that exists between the theory described in this paper and the Isospin theory, flavour and colour theory

Here, applying the theory of the generalization of the Boltzmann constant in curved space-time, we will model the mechanism by which elementary particles are formed. We will determine the relationship between gravity and each of the elementary particles that form the standard model following analogies to that of stellar bodies. In order to achieve our goal, we will propose new models for photons, quarks and gluons; with this, we will demonstrate why there are stable and unstable elementary particles; why the first family of elementary particles forms hadrons and why the second and third families cannot form hadrons; why the fermions comply with the Pauli exclusion principle and why the bosons do not comply with the Pauli exclusion principle, etc. Finally, we will analyse the generalization of the ADS/CFT correspondence and propose a theory of everything (T.O.E.).

The paper discusses the 2022 Nobel Prize in physics for experiments of entanglement “establishing the violation of Bell inequalities and pioneering quantum information science” in a much wider, including philosophical context legitimizing by the authority of the Nobel Prize a new scientific area out of “classical” quantum mechanics relevant to Pauli’s “particle” paradigm of energy conservation and thus to the Standard model obeying it. One justifies the eventual future theory of quantum gravitation as belonging to the newly established quantum information science. Entanglement, involving non-Hermitian operators for its rigorous description, non-unitarity as well as nonlocal and superluminal physical signals “spookily” (by Einstein’s flowery epithet) synchronizing and transferring some nonzero action at a distance, can be considered to be quantum gravity so that its local counterpart to be Einstein’s gravitation according to general relativity therefore pioneering an alternative pathway to quantum gravitation different from the “secondary quantization” of the Standard model. So, the experiments of entanglement once they have been awarded by the Nobel Prize launch particularly the relevant theory of quantum gravitation grounded on “quantum information science” thus granted to be nonclassical quantum mechanics in the shared framework of the generalized quantum mechanics obeying rather quantum-information conservation than only energy conservation. The concept of “dark phase” of the universe naturally linked to the very well confirmed “dark matter” and “dark energy” and opposed to its “light phase” inherent to classical quantum mechanics and the Standard model obeys quantum-information conservation, after which reversible causality or the mutual transformation of energy and information are valid. The mythical Big Bang after which energy conservation holds universally is to be replaced by an omnipresent and omnitemporal medium of decoherence of the dark and nonlocal phase into the light and local phase. The former is only an integral image of the latter and borrowed in fact rather from religion than from science. Physical, methodological and proper philosophical conclusions follow from that paradigm shift heralded by the 2022 Nobel Prize in physics. For example, the scientific theory of thinking should originate from the dark phase of the universe, as well: probably only approximately modeled by neural networks physically belonging to the light phase thoroughly. A few crucial philosophical sequences follow from the break of Pauli’s paradigm: (1) the establishment of the “dark” phase of the universe as opposed to its “light” phase, only to which the Cartesian dichotomy of “body” and “mind” is valid; (2) quantum information conservation as relevant to the dark phase, furthermore generalizing energy conservation as to its light phase, productively allowing for physical entities to appear “ex nihilo”, i.e., from the dark phase, in which energy and time are yet inseparable from each other; (3) reversible causality as inherent to the dark phase; (4) the interpretation of gravitation only mathematically: as an interpretation of the incompleteness of finiteness to infinity, for example, following the Gödel dichotomy (“either contradiction or incompleteness”) about the relation of arithmetic to set theory; (5) the restriction of the concept of hierarchy only to the light phase; (6) the commensurability of both physical extremes of a quantum and the universe as a whole in the dark phase obeying quantum information conservation and akin to Nicholas of Cusa’s philosophical and theological worldview.

SARS-CoV-2 Omicron variant spike RBD epitopes in complex with spike (S) -protein D614G mutations now predominate globally and increase infectivity by assembling more functional S proteins into the virion. On average, homeopathic medicine contains less than one molecule per dose on average. Single variable SphericalHarmonicY, LaguerreL, WhittakerM, SphericalBesselJ, LegendreP, LegendreQ, LaguerreL, ChebyshevT, and Hypergeometric1F1 Functions pFqarise in connection with the power series solution of the Schrodinger equation or in the summation of perturbation expansions in quantum mechanics. A quantum interpretation of the homeopathic method is presented here through a novel algebraic topology approach to supersymmetry and symmetry breaking in quantum fields and quantum gravity theory with the aim of developing a wide range of physical-based drug design applications in a Small Molecule Quantized Water Memory Network suggesting that the Hidden Black Hole Paradox of Information Loss might be solved under suitable conditions.