Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Design Techniques to Optimize the Scaffold Performance: Freeze-dried Bone Custom-made Allografts for Maxillary Alveolar Horizontal Ridge Augmentation

Felice Roberto Grassi
,
Roberta Grassi
,
Leonardo Vivarelli
ORCID logo ,
Dante Dallari
,
Marco Govoni
ORCID logo ,
Gianna Maria Nardi
,
Zamira Kalemaj
ORCID logo ,
Andrea Ballini
* ORCID logo
Version 1 : Received: 29 January 2020 / Approved: 3 February 2020 / Online: 3 February 2020 (09:46:05 CET)

A peer-reviewed article of this Preprint also exists.

Grassi, F.R.; Grassi, R.; Vivarelli, L.; Dallari, D.; Govoni, M.; Nardi, G.M.; Kalemaj, Z.; Ballini, A. Design Techniques to Optimize the Scaffold Performance: Freeze-dried Bone Custom-made Allografts for Maxillary Alveolar Horizontal Ridge Augmentation. Materials 2020, 13, 1393. Grassi, F.R.; Grassi, R.; Vivarelli, L.; Dallari, D.; Govoni, M.; Nardi, G.M.; Kalemaj, Z.; Ballini, A. Design Techniques to Optimize the Scaffold Performance: Freeze-dried Bone Custom-made Allografts for Maxillary Alveolar Horizontal Ridge Augmentation. Materials 2020, 13, 1393.

DOI: 10.3390/ma13061393

Abstract

Background: The aim of the present investigation was to evaluate the clinical success of horizontal ridge augmentation in the severely atrophic maxilla (Cawood and Howell class IV) using freeze-dried custom made bone harvested from cadaver donors tibial hemiplateau and to analyze the marginal bone level gain prior dental implants placement at 9 months after bone grafting and before prosthetic rehabilitation. Methods: A 52-year-old woman received custom made bone grafts. Patient underwent CT scans 2 weeks prior and 9 months after surgery for graft volume and density analysis. Results: The clinical and radiographic bone observations showed a very low rate of resorption after bone graft and implant placement. Conclusions: The custom-made allograft material was a highly effective modality for restoring the alveolar horizontal ridge, resulting in this way to reduce the need to obtain autogenous bone from a secondary site with predictable procedure. Further studies are needed to investigate its behavior at longer time points.

Keywords

Geometry optimization of scaffolds; allograft; block bone grafts; custom made bone; design techniques for scaffold; precision and translational medicine

Subject

MATERIALS SCIENCE, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (1)

Comment 1
Received: 28 March 2022
Commenter:
Leonardo Vivarelli
(Click to see Publons profile: )
The commenter has declared there is no conflict of interests.
Comment: Peer-reviewed published version available here: https://doi.org/10.3390/ma13061393
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