Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies

María Folgueras; Luis Miguel Gonzalez; Julio Collazos; Mercedes Rodríguez-Pérez; Laura Pérez-ls; Javier Diaz-Arias; María Meana; Belen Revuelta; Estrella Montero; Víctor Asensi

doi:10.20944/preprints202401.1739.v2

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preprints.org > biology and life sciences > immunology and microbiology > doi: 10.20944/preprints202401.1739.v2

Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies

María Folgueras

Luis Miguel Gonzalez

Julio Collazos

Mercedes Rodríguez-Pérez

^* ,

Version 1 : Received: 23 January 2024 / Approved: 24 January 2024 / Online: 24 January 2024 (21:16:09 CET)
Version 2 : Received: 27 February 2024 / Approved: 20 March 2024 / Online: 21 March 2024 (12:17:31 CET)

How to cite: Folgueras, M.; Gonzalez, L.M.; Collazos, J.; Rodríguez-Pérez, M.; Pérez-ls, L.; Diaz-Arias, J.; Meana, M.; Revuelta, B.; Montero, E.; Asensi, V. Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies. Preprints 2024, 2024011739. https://doi.org/10.20944/preprints202401.1739.v2 Folgueras, M.; Gonzalez, L.M.; Collazos, J.; Rodríguez-Pérez, M.; Pérez-ls, L.; Diaz-Arias, J.; Meana, M.; Revuelta, B.; Montero, E.; Asensi, V. Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies. Preprints 2024, 2024011739. https://doi.org/10.20944/preprints202401.1739.v2

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MDPI and ACS Style

Folgueras, M.; Gonzalez, L.M.; Collazos, J.; Rodríguez-Pérez, M.; Pérez-ls, L.; Diaz-Arias, J.; Meana, M.; Revuelta, B.; Montero, E.; Asensi, V. Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies. Preprints 2024, 2024011739. https://doi.org/10.20944/preprints202401.1739.v2

APA Style

Folgueras, M., Gonzalez, L.M., Collazos, J., Rodríguez-Pérez, M., Pérez-ls, L., Diaz-Arias, J., Meana, M., Revuelta, B., Montero, E., & Asensi, V. (2024). Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies. Preprints. https://doi.org/10.20944/preprints202401.1739.v2

Chicago/Turabian Style

Folgueras, M., Estrella Montero and Víctor Asensi. 2024 "Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies" Preprints. https://doi.org/10.20944/preprints202401.1739.v2

Abstract

Clinical and analytical differences between adult patients monoinfected with Borrelia burgdorferi sensu lato (s.l.) and patients infected with B. burgdorferi s.l. who also had IgG antibodies against Babesia divergens have not been reported so far. Both Lyme disease caused by B. burgdorferi and babesiosis caused by B. divergens, endemic in Asturias, Northwestern Spain, are transmitted by Ixodes tick bites. Clinical, laboratory and other diagnostic tests characteristics (imaging, electro-cardiographic-ECG) of 120 residents of Asturias with confirmed B. burgdorferi s.l. infection, di-agnosed during 2015-2017, of whom 47 (39.2%) had B. divergens IgG antibodies, were retrospec-tively compared. Cardiorespiratory symptoms were reported in 9/47 (19.2%) patients with Lyme disease and B. divergens IgG antibodies compared to 4/73 (5.5%) patients with B. burgdorferi s.l. monoinfection (P=0.02). Dyspnea was recorded in 4/47 (8.5%) patients with Lyme disease and B. divergens IgG antibodies compared to 1/73 (1.4%) monoinfected (P=0.07). In addition ECG atri-oventricular (AV) block, mostly 1st degree, was detected in 5/47 (15.6%) patients with Lyme dis-ease and B. divergens IgG antibodies compared to 1/73 (2.6%) B. burgdorferi s.l. monoinfected (P=0.09). No other clinical, laboratory or other tests differences were observed between B. burgdorferi and B. divergens IgG antibodies carriers and B. burgdorferi monoinfected. We con-cluded that patients with Lyme disease and B. divergens IgG antibodies had more frequent car-diorespiratory symptoms, mainly dyspnea, compared to B. burgdorferi monoinfected patients. These symptoms were unrelated to anemia. ECG AV block, perhaps induced by summative myo-cardial damage due to either infections or B. divergens induced lung microcirculation slow-ing-down, might play a role in the cardiorespiratory dysfunction.

Keywords

Babesia divergens, babesiosis; Borrelia burgdorferi sensu lato; cardiorespiratory simptoms; electrocardiographic (EGC) atrioventricular (AV) block; Lyme disease; myocardial damage

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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