Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies

María Folgueras; Luis Miguel Gonzalez; Julio Collazos; Mercedes Rodríguez-Pérez; Laura Pérez-ls; Javier Diaz-Arias; María Meana; Belen Revuelta; Estrella Montero; Víctor Asensi

doi:10.20944/preprints202401.1739.v1

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preprints.org > biology and life sciences > parasitology > doi: 10.20944/preprints202401.1739.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies

María Folgueras

Luis Miguel Gonzalez

Julio Collazos

Mercedes Rodríguez-Pérez

^* ,

Version 1 : Received: 23 January 2024 / Approved: 24 January 2024 / Online: 24 January 2024 (21:16:09 CET)
Version 2 : Received: 27 February 2024 / Approved: 20 March 2024 / Online: 21 March 2024 (12:17:31 CET)

How to cite: Folgueras, M.; Gonzalez, L. M.; Collazos, J.; Rodríguez-Pérez, M.; Pérez-ls, L.; Diaz-Arias, J.; Meana, M.; Revuelta, B.; Montero, E.; Asensi, V. Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies. Preprints 2024, 2024011739. https://doi.org/10.20944/preprints202401.1739.v1 Folgueras, M.; Gonzalez, L. M.; Collazos, J.; Rodríguez-Pérez, M.; Pérez-ls, L.; Diaz-Arias, J.; Meana, M.; Revuelta, B.; Montero, E.; Asensi, V. Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies. Preprints 2024, 2024011739. https://doi.org/10.20944/preprints202401.1739.v1

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MDPI and ACS Style

Folgueras, M.; Gonzalez, L. M.; Collazos, J.; Rodríguez-Pérez, M.; Pérez-ls, L.; Diaz-Arias, J.; Meana, M.; Revuelta, B.; Montero, E.; Asensi, V. Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies. Preprints 2024, 2024011739. https://doi.org/10.20944/preprints202401.1739.v1

APA Style

Folgueras, M., Gonzalez, L. M., Collazos, J., Rodríguez-Pérez, M., Pérez-ls, L., Diaz-Arias, J., Meana, M., Revuelta, B., Montero, E., & Asensi, V. (2024). Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies. Preprints. https://doi.org/10.20944/preprints202401.1739.v1

Chicago/Turabian Style

Folgueras, M., Estrella Montero and Víctor Asensi. 2024 "Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies" Preprints. https://doi.org/10.20944/preprints202401.1739.v1

Abstract

Clinical and diagnostic tests differences between adult patients monoinfected with Borrelia burgdorferi sensu lato (s.l.) and patients infected with B. burgdorferi s.l. who also had IgG antigens against Babesia divergens have not been reported so far. Both Lyme disease caused by B. burgdorferi and babesiosis caused by B. divergens, endemic in Northwestern Spain, are transmitted by Ixodes tick bites. Clinical, laboratory and other diagnostic tests characteristics (imaging, electrocardiographic-ECG) of 120 residents of Northwestern Spain with B. burgdorferi s.l. infection, diagnosed during 2015-2017, of whom 47 (39.2%) had B. divergens IgG antibodies, were retrospectively compared. Cardiorespiratory symptoms were reported in 9/47 (19.2%) patients with Lyme disease and B. divergens IgG antibodies compared to 4/73 (5.5%) patients with B. burgdorferi s.l. monoinfection (P=0.02). Dyspnea was recorded in 4/47 (8.5%) patients with Lyme disease and B. divergens IgG antibodies compared to 1/73 (1.4%) monoinfected patients (P=0.07). In addition ECG atrioventricular (AV) block was detected in 5/47 (15.6%) patients with Lyme disease and B. divergens IgG antibodies compared to 1/73 (2.6%) monoinfected individuals (P=0.09). No other clinical, laboratory or other tests differences were observed between doubly infected and monoinfected patients. We conclude that patients with Lyme disease and B. divergens IgG antibodies had more frequently cardiorespiratory symptoms, mostly dyspnea, compared to monoinfected individuals. These symptoms were unrelated to anemia. ECG AV block perhaps induced by summative myocardial damage due to both infections might play some role in the cardiorespiratory dysfunction.

Keywords

babesia divergens; babesiosis; borrelia burgdorferi sensu lato; cardiorespiratory simptoms; electrocardiographic (EGC) atrioventricular (AV) block; Lyme disease; myocardial damage

Subject

Biology and Life Sciences, Parasitology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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