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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0350.v2

Recent Advances in Proteomic-based Approaches to Study Age-related Macular Degeneration: A Systematic Review

Laura García-Quintanilla, Lorena Rodríguez-Martínez, Enrique Bandín-Vilar, María Gil-Martinez, Miguel González-Barcia, Cristina Mondelo-García, Anxo Fernández-Ferreiro, Jesús Mateos

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Proteomics, Age-related macular degeneration, inflammation, biomarker, oxidative stress.

Online: 21 November 2022 (02:35:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0278.v1

Association between Knowledge about Anemia, Food Consumption Behaviors, and Hematocrit Level among School-Age Children in Nakhon Si Thammarat Province, Thailand

Pastraporn Kaewpawong, Kiatkamjorn Kusol, Onuma Bunkarn, Sirigran Sutthisompohn

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: knowledge; food consumption behaviors; hematocrit level; school-age children

Online: 19 October 2022 (10:06:28 CEST)

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Anemia is a significant public health problem among children, especially school-age children because their body quickly produces red blood cells to provide sufficient blood volume with plasma expansion to maintain blood concentration. This research aimed to study the anemia situation, knowledge about anemia, food consumption behaviors, and the association between knowledge, food consumption behaviors, and hematocrit level among school-age children in primary school, in Thasala district, Nakhon Si Thammarat Province. This is a descriptive study among 408 students, Grades 4 to 6, aged 9-12 years. Research instruments included the demographic data of the children and their knowledge about anemia, food consumption behaviors, and hematocrit assessment. Data were analyzed using descriptive, Spearman’s rank correlation coefficient, and logistic regression statistics. The results revealed that 23.2% of the samples had anemia, whereas 22.22% had mild anemia and 0.98% had moderate anemia. The children knew about anemia, where the mean score was at a moderate level (Mean= 6.63; SD= 2.51) out of 10. The mean score on food consumption behaviors was in the moderate level (Mean= 17.49; SD= 3.68) out of 24. There were significantly positive correlations between the knowledge about anemia and the hematocrit level at a moderate level (r= 0.45, p< 0.001). Correlation analysis revealed moderate food consumption behaviors with the hematocrit level (r= 0.40, p< 0.001). When confirm with Logistic regression found that knowledge about anemia (OR = 9.15, 95% CI: 4.57-18.34), and food consumption behaviors (OR = 19.09, 95% CI: 9.71-37.53) were significantly associated with the hematocrit level. Conclusions: This study showed that knowledge and appropriate food consumption behaviors are associated with hematocrit levels. Enhancing knowledge about anemia and food consumption behaviors may be reduced the prevalence of anemia in school-age children. The health care providers in primary care should be encouraged children to have health education and eat sufficient food.

Preprint ARTICLE | doi:10.20944/preprints202308.0198.v1

The Hatching Time of Broiler Chickens Modifies Not Only the Production Traits, but Also the Early Bacteriota Development of the Ceca

Nikoletta Such, Kornél Schermann, László Pál, Laszlo Menyhart, Valéria Farkas, Gábor Csitári, Brigitta Kiss, Kesete Goitom Tewelde, Károly Dublecz

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: broiler chickens; parent flock age; hatching time; production traits; bacteriota composition; ceca

Online: 3 August 2023 (08:15:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0109.v1

Effects of Altered Dietary Fiber on the Gut Microbiota, Short-Chain Fatty Acids and Cecum of Chickens during Different Growth Periods

Baosheng Sun, Linyue Hou, Yu Yang

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: dietary fiber; SCFA; growth period; chickens; gut microbiota; microbiotal diversity; age; cecum

Online: 9 February 2020 (16:24:29 CET)

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Increasing numbers of researchers are interested in the importance of dietary fiber for the gut microbiota, microbiotal metabolite SCFA, energy metabolism and gut health of the host. However, studies have demonstrated that long-term and longitudinal observation may be needed to evaluate the effect of dietary fiber better, and few such works have been made in chickens. Therefore, we successively fed low-fiber, high--fiber and low-fiber diets to two breeds of chickens during different growth periods (1—8, 9—20 and 21—50 weeks), aiming to longitudinally observe the long-term effect of altered dietary fiber on the gut microbiota, SCFA and development of cecum of chickens with age. The results showed that the composition and function of the gut microbiota, SCFA and the development of the cecum were different during different periods, which was largly affected by dietary fiber. However, the causes of some effects were different during the different periods. For example, compared with that in low-fiber chickens at 8 weeks, dominant fiber-degradation bacteria such as Bacteroidetes, Alloprevotella and SCFA-producing bacteria such as Faecalibacterium increased due to a high-fiber diet at 20 weeks, while due to a high feed intake in 50 weeks. Moreover, the concentration of SCFA in 20 weeks was significantly higher than in 8 weeks and 50 weeks, but the causes of this difference were also distinct. It was proposed that a long-term observation was needed to evaluate the effect of dietary fiber better on chickens. The metabolite pathways of ATP-binding cassette (ABC) transporters encoded by Firmicutes were enriched in 8 weeks, while a two-component system and β–glucosidase encoded by Bacteroidetes were enriched in 20 and 50 weeks. The trend was the same in two breeds of chickens except for Alloprevotella. In addition, the total content of SCFA in the contents of cecum was also affected by the size of the cecum. Surprisingly, the length of the cecum shortened from 20—50 weeks, maybe due to reduced dietary fiber.

Preprint ARTICLE | doi:10.20944/preprints202201.0218.v3

Landscape and Settlement over 4 Millennia on the South Side of Lake Issyk kul, Kyrgyzstan: Preliminary Results of Survey Research in 2019-2021

Claudia Chang, Sergei Sergievich .Ivanov, Perry Alan Tourtellotte

Subject: Arts And Humanities, Archaeology Keywords: Archaeological survey; Inner Tian Shan Mountain region; Iron Age; Medieval period; agropastoralism

Online: 3 March 2022 (07:44:09 CET)

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Preprint REVIEW | doi:10.20944/preprints201609.0096.v1

Quantum Cosmology vs. Observational Cosmology (A Simple, Curious and Advanced Approach)

U. V. S. Seshavatharam, S. Lakshminarayana

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: big bang; planck scale Hubble parameter; quantum cosmology; Mach’s principle; observational cosmology; super luminal expansion speed; super luminal rotation speed; dark energy; cosmic rota-tional kinetic energy; cosmic age and scale factor

Online: 27 September 2016 (05:24:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202302.0147.v1

Optical Coherence Tomography Angiography (OCTA): A Review of the Current Literature

Ahmed Javed, Aishwarya Khanna, Eleanor Palmer, Craig Wilde, Anwar Zaman, Gavin Orr, Dharmalingam Kumudhan, Arun Lakshmanan, Georgios D Panos

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Ophthalmic imaging; Optical coherence tomography; Age-related macular degeneration; Glaucoma; Retinal conditions

Online: 8 February 2023 (11:28:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0237.v1

Confounding Factors Influencing the Kinetic and the Magnitude of Serological Response Following Administration of BNT162b2

Jean-Louis Bayart, Laure Morimont, Mélanie Closset, Grégoire Wieërs, Tatiana Roy, Vincent Gerin, Marc Elsen, Christelle Eucher, Sandrine Van Eeckhoudt, Nathalie Ausselet, Clara David, François Mullier, Jean-Michel Dogné, Julien Favresse, Jonathan Douxfils

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; vaccine; BNT162b2; antibody, serology; kinetic; age; gender; BMI; blood-group.

Online: 8 June 2021 (13:48:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0525.v1

Association of gut microbiota with age-related macular degeneration and glaucoma: a bidirectional Mendelian randomization study

Chen Li, Peirong Lu

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Age-related macular degeneration; Glaucoma; Gut microbiota; Mendelian randomization; Gut-retina axis

Online: 9 October 2023 (14:55:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1197.v1

Writing in the Digital Era: The Amazing Evolution of Pen and Paper to Screens and Keyboards

Edgar Eslit

Subject: Social Sciences, Education Keywords: Digital Age; Digital Era; Evolution of Pen and Paper; Screens and Keyboards

Online: 17 May 2023 (05:39:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0517.v1

Effects of Neurofeedback in the Working Memory of Children with Learning Disorders: An EEG Power-Spectrum Analysis

Benito Javier Martínez-Briones, Jorge Bosch-Bayard, Rolando Jose Biscay-Lirio, Lucero Albarrán-Cárdenas, Juan Silva-Pereyra, Thalía Fernández

Subject: Social Sciences, Psychology Keywords: Neurofeedback; Learning Disorders; Working Memory; School-age Children; EEG Power Spectrum; Source Localization

Online: 21 May 2021 (09:53:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0349.v1

Integrating Geomorphological Data, Geochronology, and Archaeological Evidence for Coastal Landscape Reconstruction. The Case of Ammoudara Beach, Crete

George Alexandrakis, Stelios Petrakis, Nikolaos Kampanis

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Sea level changes; Luminescence dating; coastal archaeology; landscape reconstruction; Bronze age; Crete

Online: 13 April 2021 (11:42:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0333.v1

Employing Machine Learning to Estimate Hallmark Measures of Physical Activities from Wrist-worn Devices Across Age Groups

Mamoun T. Mardini, Chen Bai, Amal A. Wanigatunga, Santiago Saldana, Ramon Casanova, Todd M. Manini

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: wrist; accelerometer; physical activity; energy expenditure; machine learning; random forest, age groups

Online: 12 March 2021 (08:41:44 CET)

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Wrist-worn fitness trackers and smartwatches are proliferating with an incessant attention towards health tracking. Given the growing popularity of wrist-worn devices across all age groups, a rigorous evaluation for recognizing hallmark measures of physical activities and estimating energy expenditure is needed to compare their accuracy across the lifespan. The goal of the study was to build machine learning models to recognize physical activity type (sedentary, locomotion, and lifestyle) and intensity (low, light, and moderate), identify individual physical activities, and estimate energy expenditure. The primary aim of this study was to build and compare models for different age groups: young [20-50 years], middle (50-70 years], and old (70-89 years]. Participants (n = 253, 62% women, aged 20-89 years old) performed a battery of 33 daily activities in a standardized laboratory setting while wearing a portable metabolic unit to measure energy expenditure that was used to gauge metabolic intensity. Tri-axial accelerometer collected data at 80-100 Hz from the right wrist that was processed for 49 features. Results from random forests algorithm were quite accurate in recognizing physical activity type, the F1-Score range across age groups was: sedentary [0.955 – 0.973], locomotion [0.942 – 0.964], and lifestyle [0.913 – 0.949]. Recognizing physical activity intensity resulted in lower performance, the F1-Score range across age groups was: sedentary [0.919 – 0.947], light [0.813 – 0.828], and moderate [0.846 – 0.875]. The root mean square error range was [0.835 – 1.009] for the estimation of energy expenditure. The F1-Score range for recognizing individual physical activities was [0.263 – 0.784]. Performances were relatively similar and the accelerometer data features were ranked similarly between age groups. In conclusion, data features derived from wrist worn accelerometers lead to high-moderate accuracy estimating physical activity type, intensity and energy expenditure and are robust to potential age-differences.

Preprint REVIEW | doi:10.20944/preprints202312.1789.v1

Unveiling the Enigma: Exploring the Influences of Sexual Hormones in Adpkd Women and the Urgency for Novel Insight

Micaela Petrone, Martina Catania, Liliana Italia De Rosa, Rebecca S. Degliuomini, Kristiana Kola, Chiara Lupi, Matteo Brambilla Pisoni, Stefano Salvatore, Massimo Candiani, Giuseppe Vezzoli, Maria Teresa Sciarrone Alibrandi

Subject: Public Health And Healthcare, Primary Health Care Keywords: ADPKD; CKD; RAAS; female sexual hormones; hepatomegaly; childbearing age; postmenopausal; contraception; HRT

Online: 26 December 2023 (01:32:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1497.v1

Ethnic Representation Matters: Investigating Bias in Facial Age Prediction Models

Nenad Panić, Marina Marjanović, Timea Bezdan

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Facial recognition; Age prediction; Convolutional Neural Network (CNN); Ethnicity bias

Online: 26 March 2024 (08:15:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0350.v1

Human Age Estimation from Face Images with Deep Convolutional Neural Networks Using Transfer Learning

Gilbert George, Chandrashekhar Uppin, Usman Abubakar Bello

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Convolution neural network; Deep Learning; Facial Age; Regression; Transfer learning

Online: 4 January 2024 (07:41:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1081.v1

Splenic Stiffness Measured by 3-Tesla Magnetic Resonance Elastography Is Correlated with Age in Healthy Individuals

Süheyl Poçan, Levent Karakaş

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: 3 tesla magnetic resonance; age, healty volunteers; elastography; splenic stiffness

Online: 17 October 2023 (11:20:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1069.v1

Splenic Stiffness Measured by 3-Tesla Magnetic Resonance Elastography Is Correlated with Age in Healthy Individuals

Süheyl Poçan, Levent Karakaş

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: 3 tesla magnetic resonance; age; healty volunteers; elastography; splenic stiffness

Online: 17 October 2023 (11:11:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0409.v1

Are There Sex Differences in Self-Reported Childhood Maltreatment in Major Depressive and Bipolar Disorders? A Retrospective Cross-Sectional Study

Daniela Caldirola, Tatiana Torti, Francesco Cuniberti, Silvia Daccò, Alessandra Alciati, Koen Schruers, Giovanni Martinotti, Domenico De Berardis, Giampaolo Perna

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: childhood trauma; major depressive disorder; bipolar disorder; sex difference; age

Online: 31 May 2022 (03:39:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0446.v1

Non-Modifiable Risk Factors (Age and Sex), Stroke Types, and Outcomes in Rivers State, Nigeria: A Retrospective Hospital-Based Study

Osborne Ikechuckwu Osuegbu, Foluke Olukemi Adeniji, Golden Chukwuemaka Owhonda, Rogers Bariture Kanee, M Alblihed, Gaber El-Saber Batiha, Eric Osamudiamwen Aigbogun

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Age; Sex; Stroke Types; Outcomes; SEM; Tertiary Hospitals; Rivers State

Online: 20 July 2021 (11:45:13 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202005.0005.v1

Age-Adaptive and Gender-Balanced Social Interventions Might Be Stepping Stones to the Next ‘New Normal’ in COVID-19 Outbreak

Carlo Vittorio Cannistraci, Ilaria Capua

Subject: Biology And Life Sciences, Virology Keywords: social intervention; COVID-19; health policy; public health; age; gender

Online: 2 May 2020 (12:04:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0380.v1

Physical Activity in Elderly Kidney Transplant Patients with Multiple Renal Arteries

Armando Calogero, Caterina Sagnelli, Gaia Peluso, Antonello Sica, Maria Candida, Silvia Campanile, Gianluca Minieri, Paola Incollingo, Massimiliano Creta, Luigi Pelosio, Vincenzo Tammaro, Alessandro Scotti, Akbar Jamshidi, Marcello Caggiano, Evangelista Sagnelli, Concetta Anna Dodaro, Nicola Carlomagno, Michele Santangelo

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: physical activity; kidney transplantation; elder age; vascular anomalies; marginal kidneys

Online: 29 December 2019 (11:06:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0236.v1

Growth Opportunities and Earnings Quality from Emerging Economies

Jerry Danjuma kwarbai, Rufus Ishola Akintoye, Festus Fola Adegbie, Apollos Nwabuisi Nwaobia

Subject: Business, Economics And Management, Accounting And Taxation Keywords: earnings quality; growth opportunities; discretionary accruals; corporate age; corporate size

Online: 23 August 2019 (04:40:37 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202101.0499.v1

Integrated Machian Model of a Light Speed Rotating Universe

Satya Seshavatharam U.V, Lakshminarayana S

Subject: Physical Sciences, Acoustics Keywords: Mach's Universe; Planck scale; Cosmic Angular velocity; Galactic applications; shortened radius; shortened age;

Online: 25 January 2021 (13:46:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.2019.v1

Prognostic Impact of Guidelines-oriented Age Cut-off in Intermediate-to-low Risk Patients Undergoing Transcatheter Aortic Valve Implantation in a Large Real-world Multicenter Registry

Stefano Benenati, Francesco Gallo, Won-keun Kim, Arif A Khokhar, Tobias Zeus, Stefan Toggweiler, Roberto Galea, Federico De Marco, Antonio Mangieri, Damiano Regazzoli, Bernhard Reimers, Luis Nombela-Franco, Marco Barbanti, Ander Regueiro, Tommaso Piva, Josep Rodes-Cabau, Italo Porto, Antonio Colombo, Francesco Giannini, Alessandro Sticchi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: aortic stenosis; transcatheter aortic valve replacement; age; surgical risk; low-intermediate risk

Online: 29 May 2023 (14:36:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0424.v1

Social Networking in Adolescents: Time, Type and Motives of Using, Social Desirability and Communication Choices

Marta Tremolada, Lucio Silingardi, Livia Taverna

Subject: Social Sciences, Psychology Keywords: Social networking; adolescents; communication; motives of use; social desirability; gender differences; age differences

Online: 27 December 2021 (11:24:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0383.v1

Payment Behavioral Response Mechanisms for All-Age Retrofitting of Older Communities: A Study Among Chinese Residents

Yang Zhang, Lei Dong

Subject: Social Sciences, Behavior Sciences Keywords: older community renovation; all-age retrofitting; anxiety; PLS-SEM; payment behavioral response mechanisms

Online: 6 September 2023 (09:25:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0213.v2

Analysis of the Quantity and Average Age of Copper in-Use Stock in the U.S. from 1985 to 2014

Minxi Wang, Yanan Liang, Wu Chen, Xin Li

Subject: Business, Economics And Management, Business And Management Keywords: copper; in-use stock; average age; average use life method; fixed assets depreciation method

Online: 2 June 2017 (07:36:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1503.v1

Characteristics of Preoperative Arteriosclerosis Evaluated by Cardio-Ankle Vascular Index in Patients With Osteoarthritis Before Total Knee Arthroplasty

Yoshinori Ishii, HIdeo Noguchi, Junko Sato, Ikuko Takahashi, Hana Ishii, Ryo Ishii, Kei Ishii, Kai Ishii, Shin-ichi Toyabe

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: osteoarthritis; arteriosclerosis; cardio-ankle vascular index; total knee arthroplasty; age; body mass index

Online: 21 June 2023 (08:28:00 CEST)

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Working Paper ARTICLE

A Study to Establish Local Healthcare Projects in the with-COVID-19 Age : Based on Health Recognition of Local Residents in the Korea

Bo-Woo Lee

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; with- COVID-19 age; infectious disease; local healthcare projects; healthcare systems

Online: 16 September 2021 (14:59:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0502.v1

Correlation Between the Bilingual Status and the Onset Age of AD and MCI Subjects: Evidence from the ADNI Dataset

Jason Li, Yang Han, Jacqueline Lam, Victor Li, Stephen Matthews, Lawrence Cheung, Virginia Yip, Jocelyn Downey, Danny Chan, Illana Gozes

Subject: Social Sciences, Language And Linguistics Keywords: Alzheimer's Disease; Onset Age; Bilingualism; Cognitive Reserve; Dementia; Mild Cognitive Impairment; ADNI database

Online: 23 February 2021 (09:20:19 CET)

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Background: This paper investigates the statistical relationship between bilingualism and the Onset Age (OA) of AD and MCI across a clinical sample, consisting of 580 Alzheimer's Disease (AD) subjects and 1264 Mild Cognitive Impairment (MCI) subjects, via a statistical analysis conducted on the sample retrieved from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. Method: To investigate whether bilingualism has any correlation with the OAs of AD or MCI subjects, our study leverages the full potential of the ADNI dataset, a dataset that covers both the OA and the bilingualism status of both the AD and MCI subjects. Prior to performing any meaningful statistical analysis, a regression model and a probabilistic model were developed in parallel to fill in the missing OA and bilingualism values. A simple least-square regression model that consists of an independent variable of registered age for Mini-Mental State Examination (MMSE) score was used to estimate the OA of the AD and MCI subjects in the ADNI dataset. After filling in the missing OA values, the number of subjects relevant for the statistical analysis increased from 816 (AD: 371, MCI: 445) to 1844 (AD: 580, MCI: 1264), which greatly enlarged the representation of the AD and MCI sample in the ADNI population. With increased sample size, a novel probabilistic classification model was introduced to infer an ADNI subject’s bilingualism when relevant demographic information and deterministic outcome were not readily available from the ADNI dataset. The weighted average OA for the bilinguals and the monolinguals was then computed, where the weights for the probabilistic labels were assigned based on the percentage of bilingualism in the general US population. Finally, a statistical analysis was performed to test whether any statistically significant correlation exists between the OA and the bilingualism of the AD and MCI subjects within the ADNI dataset. Findings: Our preliminary study demonstrates no significant statistical difference between the OA of the bilinguals and the monolinguals within the ADNI dataset. Thus, the monolingual speakers within the ADNI dataset do not statistically manifest earlier onset, as compared to the bilingual speakers, which is slightly inconsistent with some earlier statistical findings that bilingual speakers enjoy certain distinctive advantages, such as late onset of AD, as compared to monolingual counterparts.

Preprint ARTICLE | doi:10.20944/preprints201812.0289.v1

Latitudinal and Cross-Shelf Patterns of Size, Growth and Mortality of a Tropical Damselfish Acanthochromis polyacanthus on the Great Barrier Reef

Michael Kingsford, David Welch, Mark O'Callaghan

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: reef fish, age, growth, mortality, Great Barrier Reef, Pomacentridae, cross-shelf, MPA, latitudinal gradients.

Online: 24 December 2018 (15:36:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201706.0081.v3

Developing and Validating an Age-Independent Equation Using Multi-Frequency Bioelectrical Impedance Analysis for Estimation of Appendicular Skeletal Muscle Mass and Establishing a Cutoff for Sarcopenia

Yosuke Yamada, Miyuki Nishizawa, Tomoka Uchiyama, Yasuhiro Kasahara, Mikio Shindo, Motohiko Miyachi, Shigeho Tanaka

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: age-related skeletal muscle loss; sarcopenia; malnutrition risk assessment; DXA; multi-frequency BIA; aging

Online: 23 August 2017 (17:57:14 CEST)

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Background: Appendicular skeletal muscle (or lean) mass (ALM) estimated using dual-energy X-ray absorptiometry (DXA) is considered to be a preferred method for sarcopenia studies. However, DXA is expensive, has limited portability, and requires radiation exposure. Bioelectrical impedance analysis (BIA) is inexpensive, easy to use, and portable; thus BIA might be useful in sarcopenia investigations. However, a large variety of models have been commercially supplied by different companies, and for most consumer products, the equations estimating ALM are not disclosed. It is therefore difficult to use these equations for research purposes. In particular, the BIA equation is often age-dependent, which leads to fundamental difficulty in examining age-related ALM loss. The aims of the current study were as follows: (1) to develop and validate an equation to estimate ALM using multi-frequency BIA (MF-BIA) based on theoretical models, and (2) to establish sarcopenia cutoff values using the equation for the Japanese population. Methods: We measured height (Ht), weight, and ALM obtained using DXA and a standing-posture 8-electrode MF-BIA (5, 50, 250 kHz) in 756 Japanese individuals aged 18 to 86-years-old (222 men and 301 women as developing equation group and 97 men and 136 women as a cross validation group). The traditional impedance index (Ht²/Z₅₀) and impedance ratio of high and low frequency (Z₂₅₀/Z₅) of hand to foot values were calculated. Multiple regression analyses were conducted with ALM as dependent variable in men and women separately. Results: We created the following equations: ALM = (0.6947 × (Ht²/Z₅₀)) + (−55.24 × (Z₂₅₀/Z₅)) + (−10,940 × (1/Z₅₀)) + 51.33 for men, and ALM = (0.6144 × (Ht²/Z₅₀)) + (−36.61 × (Z₂₅₀/Z₅)) + (−9332 × (1/Z₅₀)) + 37.91 for women. Additionally, we conducted measurements in 1624 men and 1368 women aged 18 to 40 years to establish sarcopenia cutoff values in the Japanese population. The mean values minus 2 standard deviations of the skeletal muscle mass index (ALM/Ht²) in these participants were 6.8 and 5.7 kg/m² in men and women, respectively. Conclusion: The current study established and validated a theoretical and age-independent equation using MF-BIA to estimate ALM and provided reasonable sarcopenia cutoff values.

Preprint REVIEW | doi:10.20944/preprints202403.0545.v1

Telomere Length as a Biomarker of Smoking-Induced Cellular Damage

Mohammad Odah

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Smoking; telomere atrophy; cellular aging; disease risk; molecular mechanisms; gender disparities; age disparities. ;

Online: 10 March 2024 (16:55:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1003.v1

Bacterial Profile, Antibiotic Susceptibility Pattern and Associated Risk Factors of Urinary Tract Infection among Reproductive Age Females Attending the Logbaba District Hospital, Douala, Cameroon

Ngwa Fabrice Ambe, Pride Bobga Tanyi, Ekwi Damian Nsongmayi, Ebai Christabel Ashu, Sangwe Bertrand Ngwa, Ngong Judith Nyeme

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Bacterial profile; Antibiotic susceptibility; reproductive age females; risk factors; Urinary tract infection (UTI)

Online: 18 September 2023 (14:36:21 CEST)

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Background: Urinary tract infection (UTI) is one of the commonest bacterial infections among reproductive age females. Untreated UTI in reproductive age female is associated with sexual dysfunction, cystitis, pyelonephritis and Pelvic inflammatory disease. At present, the antimicrobial resistance emergency has quadrupled worldwide and poses a serious threat to the treatment of patients. Thus, this study aimed to determine bacterial profile, antibiotic susceptibility pattern and associated risk factors of urinary tract infection among reproductive age females attending the Logbaba District Hospital Methods: A hospital-based cross-sectional study was conducted from January – July, 2023. Convenient sampling was employed to recruit 259 reproductive age females. Sociodemographic and risk factors information were obtained using a well-structured questionnaire. Mid-stream urine was collected and inoculated on cystine lactose electrolyte deficient media. Isolates were identified using API 20. Antibiotic sensitivity testing was performed using modified kirby-bauer susceptibility testing technique. Multivariate logistic regression model was used to assessed risk factors. A p-value < 0.05 was considered as statistically significant. Results: The overall prevalence of UTI among reproductive age females was 82/259 (31.66%). Symptomatic and asymptomatic patients reported a prevalence of 50/121(41.32%) and 32/138 (23.19%), respectively. Ages ranging from 21-30 years (AOR: 2.53 ,95% CI 1.32 – 4.43, p=0.006) and 31 – 40 years (AOR: 0.19 , 95% CI: 0.14- 0.54; p <0.0001), student (AOR: 1.8, 95% CI: 1.21 - 2.75; p = 0.010), history of UTI (5.34, 95% CI = 1.86 - 18.15; p = 0.03), symptomatic (AOR = 2.86, 95% CI1.78 - 4.67, p <0.0001) and secondary education (AOR: 0.13, 95% CI 0.08 - 0.32; p<0.0001) were predictors to UTI. Klebsiella Pneumoniae was the most frequent species 27 (32.9%), follow by E coli 22(26.8%), Staphylococcus aureus 16 (19.5%), CONS 8 (9.8%), Proteus mirabilis 6 (7.3 %) and Pseudomonas aeruginosa 3(3.7%). Majority of the isolates were sensitive to cefotaxime (87.80%), imipenem (85.7%), vancomycin (79.27%), Ofloxacillin (76.83%), Ceftriaxone (75.61%), Ciprofloxacin (74.39%), Gentamicin (71.95%) and Doxycycline (69.51%), and resistant to Amoxicillin (51.22%), cotrimoxazole (47.56%) and Azithromycin (31.71%) , All the isolates were multidrug drug resistant (100%) and Klebsiella Pneumoniae and E coli were the most multidrug drug resistant species Conclusion: In the present study, the prevalence of urinary tract infection among reproductive age females was high and considerably a high proportion of multidrug resistance was observed. This result will have a significant impact on the selection of appropriate antimicrobial agents for the treatment of urinary tract infection in the study area.

Preprint REVIEW | doi:10.20944/preprints202309.1738.v1

Zebrafish as an Emerging Model for Sarcopenia: Considerations, Current Insights, and Future Directions

Santiago Callegari, Foad Mirzaei, Lila Agbaria, Sanobar Shariff, Burhan Kantawala, Desmond Moronge, Brian M. O. Ogendi

Subject: Biology And Life Sciences, Aging Keywords: Sarcopenia; Zebrafish; Age-related muscle deficits; Aging; Biomarkers; Electrical Impedance Myography

Online: 26 September 2023 (13:38:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1318.v1

Wet and Dry Age-Related Macular Degeneration Induced by Polyethylene Glycol

Reece Mitchell, Connor Logan, Valeriy V. Lyzogubov, Nalini S. Bora, Puran S. Bora

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Age-related macular degeneration, Choroidal neovascularization, Retinal pigmented epithelium, Fluorescein isothiocyanate

Online: 19 July 2023 (09:24:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0102.v1

Age-Related Diseases as Vicious Cycles

Aleksey V. Belikov

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: aging; age-related disease; mortality rate; positive feedback loop; vicious cycle

Online: 18 April 2017 (02:45:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0313.v1

Age Estimation in Brazilian Adult Subpopulation by Calculating the Pulp/Tooth Ratio of the Maxillary Canine and Mandibular Second Premolar in Panoramic and Periapical Radiographs

Ismar Nery-Neto, Orlando Aguirre Guedes, Lucas Rodrigues de Araújo Estrela, Luciano Tavares Angelo Cintra, Cyntia Rodrigues de Araújo Estrela, Carlos Estrela

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: human identification; age estimation by teeth; forensic dental radiography; forensic science; forensic dentistry

Online: 6 February 2024 (09:17:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0314.v1

Mindful Application of Digitalization for Sustainable Development: The Digitainability Assessment Framework

Shivam Gupta, Jakob Rhyner

Subject: Engineering, Control And Systems Engineering Keywords: Digitalization; Sustainable digitalization; Artificial Intelligence; Sustainable Development; SDGs; Assessment Framework; Mindful; Digital Age; Digitainability

Online: 24 February 2022 (11:03:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1262.v1

Association of Maternal Age and Blood Markers for Metabolic Disease in Newborns

Yuhan Xie, Gang Peng, Hongyu Zhao, Curt Scharfe

Subject: Biology And Life Sciences, Other Keywords: maternal age; newborn metabolites; inborn errors of metabolism; public health; newborn screening; precision medicine

Online: 21 November 2023 (09:34:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0443.v1

EEG Power Spectrum Correlates of Working Memory in Children with Learning Disorders

Benito Javier Martínez Briones, Thalia Fernandez Harmony, Nicolás Garófalo Gómez, Rolando Jose Biscay Lirio, Jorge Bosch-Bayard

Subject: Social Sciences, Cognitive Science Keywords: learning disorders; working memory; school-age children; EEG power spectral density; source localization; sLORETA

Online: 18 September 2020 (18:54:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0458.v1

Coronavirus Disease (COVID-19) Dynamics: Age and Gender-based Analysis of Surveillance Variables

Malik Khizar Hayat, Ali Daud, Rabeeh Ayaz Abbasi, Tehmina Amjad, Xiuzhen Jenny Zhang

Subject: Computer Science And Mathematics, Analysis Keywords: Coronavirus disease (COVID-19); Correlation and analysis; Age and Gender; Hospitalization; Tests performed; Recovery

Online: 20 August 2020 (13:02:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0366.v1

The Power of First Impressions: Can Influenza Imprinting during Infancy Inform Vaccine Design?

Melissa Rioux, Mara McNeil, Magen Francis, Nicholas Dawe, Mary Foley, Joanne Langley, Alyson Kelvin

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: vaccine; age; pneumonia; influenza virus; seasonal influenza; influenza imprinting; infant; infant immunity; immune response

Online: 17 August 2020 (12:04:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1702.v1

Dividing Time – An Absolute Chronological Study of Material Culture from Early Iron Age Urnfields in Denmark

Helene Rose, John Meadows

Subject: Arts And Humanities, Archaeology Keywords: Archaeology; Early Iron Age; typology; cremated bone; radiocarbon dating; Bayesian chronological modelling

Online: 28 November 2023 (02:02:39 CET)

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Chronological frameworks based on artefact typologies are essential for interpreting the archaeological record, but they inadvertently treat transitions between phases as abrupt events and disregard the temporality of transformation processes within and between individual phases. This study presents an absolute chronological investigation of a dynamic material culture from Early Iron Age urnfields in Denmark. The chronological framework of Early Iron Age in Southern Scandinavia is largely unconstrained by absolute dating, primarily due to it coinciding with the so-called ‘Hallstatt calibration plateau’ (c.750 to 400 cal BC), and it is difficult to correlate it with Central European chronologies due to a lack of imported artefacts. This study applies recent methodological advances in radiocarbon dating and Bayesian chronological modelling, specifically a statistical model for wood-age offsets in cremated bone and presents the first large-scale radiocarbon investigation of regional material culture from Early Iron Age in Southern Jutland, Denmark. Dated material is primarily cremated bone from 111 cremation burials from three urnfields. The study presents absolute date ranges for 16 types of pottery and 15 types of metalwork, which include most of the recognised metalwork types from the period. This provides new insights into gradual change in material culture, when certain artefact types were in production and primary use, how quickly types were taken up and later abandoned, and distinguishing periods of faster and slower change. The study also provides the first absolute chronology for the period, enabling correlation with chronologies from other regions. Urnfields were introduced at the Bronze-Iron Age transformation, which is often assumed to have occurred c.530-500 BC. We demonstrate that this transformation took place in the 7^th century BC, however, which revives the discussion of whether the final Bronze Age period VI should be interpreted as a transitional phase to the Iron Age.

Preprint ARTICLE | doi:10.20944/preprints202309.0159.v1

The Impact of Reading Modalities and Text Types on Reading in School-Age Children: An Eye-tracking Study

Wi-Jiwoon Kim, Seo Rin Yoon, Seohyun Nam, Yunjin Lee, Dongsun Yim

Subject: Social Sciences, Education Keywords: eye-tracking; reading modality; audio-assisted reading; text type; reading comprehension; school-age children

Online: 5 September 2023 (02:26:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0405.v1

Regional Precipitation Trends Since 1500 Ce, Reconstructed from Calcite Sublayers of a Varved Mediterranean Lake Record (Central Pyrenees)

Teresa Vegas-Vilarrúbia, Juan Pablo Corella, Javier Sigró, Valentí Rull, Isabel Dorado, Blas Valero, Emilia Gutiérrez

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Authigenic varves; Autumn precipitation; Climate warming; Little Ice Age; Transfer function model; Water resources

Online: 22 November 2021 (14:21:49 CET)

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The Mediterranean is one of the regions of the world where human-induced climate warming is expected to have large impacts on water and environmental resources. To predict shifts in the current climate system, more regional climate records, including seasonal-to-century scale variability spanning longer than the instrumental periods, are needed. To help fill this gap, we provide a reconstruction of autumn precipitation variations for the Central Pyrenees range since 1500 Common Era (CE) using the varved sediments of Lake Montcortès. To assess the suitability of the calcite sublayer width of the sediments of this lake as a proxy for precipitation anomalies, we performed an analysis and smoothing of the temporal structure of the width series, calibration of the new series with the available instrumental climate records, calculation of a transfer function and testing and comparison of the reconstructed series against available empirical data.The prediction model was statistically robust and showed that the climatic signal was captured in the calcite sublayers. The reconstruction provides the first estimations of regional autumn precipitation shifts in the Central Pyrenees at annual resolution, since 1500 CE. Pronounced interdecadal shifts in precipitation were noticeable; no increasing nor decreasing linear trends or periods of extreme precipitation events were identified. The reconstructed precipitation anomalies suggest a decrease in rainfall during the coldest phase within the coldest period of the Little Ice Age and also during the 20^th century, probably associated to current Global Warming. Correlations between autumn precipitation and the North Atlantic Oscillation, Western Mediterranean Oscillation and Southern Oscillation indices were weak to moderate. A potential relationship with the Atlantic Multidecadal Oscillation pattern is suggested. The reconstructed autumn precipitation trends are coherent with other palaeohydrological reconstructions in similar Mediterranean settings, and consistent at a regional level.

Preprint ARTICLE | doi:10.20944/preprints202306.0061.v1

Visual Outcomes of Anti-VEGF Treatment on Neovascular Age-Related Macular Degeneration: A Real-World Popula-Tion-Based Cohort Study

Ida Korva-Gurung, Anna-Maria Kubin, Pasi Ohtonen, Nina Hautala

Subject: Medicine And Pharmacology, Ophthalmology Keywords: neovascular age-related macular degeneration; visual outcomes; anti-VEGF; visual impairment; population-based cohort

Online: 1 June 2023 (08:10:15 CEST)

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Working Paper ARTICLE

U-Pb Age and Hf Isotope Systematics of Zircon from Eclogite Xenoliths in Devonian Kimberlites: The Neoarchaean Roots of the Central Belarus Suture Zone

Leonid Shumlyanskyy, Stepan Tsymbal, Monika A. Kusiak, Simon A. Wilde, Alexander A. Nemchin, Iryna Tarasko, Liudmyla Shumlianska, Mandy Hofmann

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: Eclogite xenolith; kimberlite; zircon; U-Pb age; Hf isotopes; Ukrainian Shield; Devonian; East European Platform.

Online: 5 October 2021 (15:43:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0634.v1

Factors Impacting The Readiness, Acceptance, and Adoption of A.I.'s Involvement in Religious Education: Result Across Generations and Religious Orientation in Vietnam.

Khoa Tran, Tuyet Nguyen

Subject: Social Sciences, Anthropology Keywords: Age; Artificial intelligence; Christianity; Religious Orientation; Unified Theory of Acceptance and Use of Technology

Online: 29 January 2021 (15:55:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0011.v1

Trace Elements of Cu-(Fe)-Sulphide Inclusions in Bronze Age Copper Slags from South Urals and Kazakhstan: Ore Sources and Alloying Additions

Dmitry A. Artemyev, Maksim N. Ankushev

Subject: Arts And Humanities, Archaeology Keywords: copper slag; sulphide; chalcocite; сovellite; bornite; LA-ICP-MS; South Ural; Kazakhstan; Bronze Age

Online: 2 October 2019 (03:32:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0010.v1

Age Analysis of Status Updating System with Probabilistic Packet Preemption

Jixiang Zhang, Yinfei Xu

Subject: Engineering, Control And Systems Engineering Keywords: age of information; discrete time status updating system; probabilistic preemption; probability generation function; stationary distribution

Online: 4 May 2022 (13:15:56 CEST)

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The age of information (AoI) metric was proposed to measure the freshness of messages obtained at the terminal node of a status updating system. In this paper, the AoI of discrete time status updating system with probabilistic packet preemption is investigated by analyzing the steady state of a three-dimensional discrete stochastic process. Assuming the queue used in system is Ber/Geo/1/2*/η, which represents that the system size is 2 and the packet in buffer can be preempted by fresher packet with probability η. Instead of considering system’s AoI separately, we use a three-dimensional state vector (n,m,l) to simultaneously track the real time changes of the AoI, the age of packet in server, and the age of packet waiting in buffer. We give the explicit expression of system’s average AoI, and show that the average AoI of system without packet preemption is obtained by letting η=0. When η is set to 1, the mean of AoI of system having Ber/Geo/1/2* queue is obtained as well. Combining the results we have obtained and comparing them with corresponding average continuous AoIs, we propose a possible relationship between average discrete AoI with Ber/Geo/1/c queue and the average continuous AoI with M/M/1/c queue. For each of two extreme cases where η=0 and η=1, we also determine the stationary distribution of AoI using the probability generation function (PGF) method. The relations between average AoI and the packet preemption probability η, as well as AoI’s distribution curves in two extreme cases are illustrated by numerical simulations. Notice that the probabilistic packet preemption may occur, for example, in an energy harvest (EH) node of wireless sensor network, where the packet in buffer can be replaced only when the node collects enough energy. In particular, to exhibit the usefulness of our idea and methods and highlight the merits of considering discrete time systems, in this paper we give much more explanations showing that how the results about continuous AoI is derived by analyzing the corresponding discrete time system, and how the discrete age analysis is generalized to the system with multiple sources. In terms of packet service process, we also propose our idea to analyze system’s AoI when the service time distribution is relaxed to be arbitrary.

Preprint ARTICLE | doi:10.20944/preprints202306.1896.v2

Relationship of Maternal Age and Adverse Childhood Experiences (ACEs) with Traumatic Sequelae in Commercially Sexually Exploited Youth

Kirsten Byrnes, HaeSung Han, Kie Fujii

Subject: Social Sciences, Psychiatry And Mental Health Keywords: trafficked youth and trauma; ACEs; early maternal age; teen pregnancy; exploitation and trauma; self-harm; psychological trauma

Online: 18 August 2023 (07:25:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0111.v1

Mineralogical Characterization of Slags from Oiola Site (Biscay) to Assess the Development in Bloomery Iron Smelting Technology from the Roman Period to the Early Middle Ages

Haizea Portillo-Blanco, Maria Cruz Zuluaga, Luis Angel Ortega, Ainhoa Alonso-Olazabal, Juanjo Cepeda-Ocampo, Ana Martínez Salcedo

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: smelting slags; multianalytical study; furnace operating conditions; Roman Period; Early Middle Age; North Spain

Online: 11 January 2020 (14:24:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.2088.v1

Unpacking Demographics Based Impediments to Professionalization in the South African Built Environment.

Molusiwa Ramabodu, Tholang Nena

Subject: Engineering, Architecture, Building And Construction Keywords: Demographics; Diversity; Gender; Race; Age; Professionals; Built Environment; Construction Industry; South Africa

Online: 27 December 2023 (10:35:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0789.v1

Extended Duration Anti-VEGF Therapy for Chorioretinal Vascular Diseases: Successes, Failures and Challenges

Azeem Hasan, Darby D Miller, Michael W. Stewart

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Angiogenesis; Age-related macular degeneration; diabetic retinopathy; intravitreal injections; retinal vein occlusions

Online: 13 November 2023 (10:37:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0264.v1

Timothy Gustavo Cavazzotto, Natã Gomes de Lima Stavinski, Marcos Roberto Queiroga, Michael Pereira da Silva, Edilson Serpeloni Cyrino, Helio Serassuelo Junior, Edgar Ramos Vieira

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: exercise; marriage; sedentary behavior; gender; age groups; behavioral risk factors surveillance system

Online: 15 November 2021 (13:44:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0141.v1

Kazburun I Barrow Burial Ground: Barrow Complex of and Alakul Population of Bashkir Transurals Archeological Microdistrict: The Southern Urals Barrow Burial Ground of the Late Bronze Age: The Complex of Alakul and Srubnaya Crosscultural Actions

I. Shuteleva, Nikolai Shcherbakov, T. Leonova, K. Gorshkov

Subject: Arts And Humanities, Archaeology Keywords: the Late Bronze Age; Bashkir Transurals; Srubnaya-Alacul type of monuments; interdisciplinary methods in archaeological investigation

Online: 15 February 2019 (11:16:37 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0320.v1

Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan

Arastu Sharma, Sophie Chabloz, Elisabeth M. Roider, Collin Y. Ewald

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; longevity; supplements; geroprotectors; SIRT1; NAD+; NMN; resveratrol; nutraceuticals; age-related diseases; flavonoids; senolytics; healthspan

Online: 17 November 2022 (02:51:11 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.1538.v2

Is the Myasthenia Gravis (MG) the Result of Age and Sex/Gender? A Narrative Review for Identifying Genetic and Epigenetic Biomarkers for a Differential MG Management in Old and Young Women

Giuseppe Schirò, Tiziana Colletti, tommaso piccoli, paolo ragonese, giuseppe salemi, Carmela Rita Balistreri, marco d'amelio

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: Myasthenia gravis (MG); age and sex/gender; two different forms; genetic and epigenetic factors

Online: 30 April 2024 (11:46:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0219.v1

Ancient Agricultural and Pastoral Landscapes on the South Side of Lake Issyk-Kul: Preliminary Surveys of the Juuku Valley and Lower Kizil Suu Valley, Archaeobotanical Results of Three Stratigraphic Profiles, and GIS Modeling of Iron Age in Lower Kizil Suu

Claudia . Chang, Sergeo Sergievich Ivanov, Perry Alan Tourtellotte, Robert N. Spengler III, Basira Mir-Makhamad, David Kramar

Subject: Arts And Humanities, Archaeology Keywords: archaeological landscapes; Iron Age; Medieval period; agriculture; pastoralism; vertical zonation, Issyk-Kul Lake; archaeobotany; GIS mapping

Online: 17 May 2022 (03:29:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0066.v1

Comparison of Antioxidant Properties of Dehydrolutein with Lutein and Zeaxanthin, and their Effects on Retinal Pigment Epithelial Cells

Malgorzata Rozanowska, Barbara Czuba-Pelech, John T. Landrum, Bartosz Rozanowski

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: carotenoid; lutein; zexanthin; dehydrolutein; retina; retinal pigment epithelium; singlet oxygen; photosensitized oxidation; age-related macular degeneration.

Online: 2 April 2021 (14:04:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0644.v1

Novel Method to Analytically Obtain the Asymptotic Stable Equilibria States of Extended SIR-type Epidemiological Models

Teddy Lazebnik, Svetlana Bunimovich-Mendrazitsky, Leonid Shaikhet

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Markov chain; random variable transformation technique; asymptotic stable equilibria state; three age group SIIRD model

Online: 26 May 2021 (14:29:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0165.v1

Impact of Age-Adjusted Charlson Comorbidity on Hospital Survival and Short-Term Outcome of Patients with Extracorporeal Cardiopulmonary Resuscitation

Li-Jung Tseng, Hsi-Yu Yu, Chih-Hsien Wang, Nai-Hsin Chi, Shu-Chien Huang, Heng-Wen Chou, Nai-Kwoun Chou, Hsin-Chin Shih, Yih-Sharng Chen

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: extracorporeal membrane oxygenation; cardiopulmonary resuscitation; extracorporeal cardiopulmonary resuscitation; Charlson comorbidity index; age-adjusted Charlson comorbidity index

Online: 10 September 2018 (10:12:11 CEST)

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Background: Extracorporeal cardiopulmonary resuscitation (ECPR) has gradually come to be regarded as an effective therapy, but the hospital mortality rate after ECPR is still high and unpredictable. The present study tested whether age-adjusted Charlson comorbidity index (ACCI) can be used as an objective selection criterion to ensure the most efficient utilization of medical resources. Methods: Adult patients (age ³ 18 years) receiving ECPR at our institution between 2006 and 2015 were included. Data regarding ECPR events and ACCI characteristics were collected immediately after extracorporeal membrane oxygenation (ECMO) setup. Adverse events during hospitalization were also prospectively collected. The primary endpoint was survival to hospital discharge. The second endpoint was short-term (2-year) follow-up outcome. Results: A total of 461 patients included in the study were grouped into low ACCI (ACCI 0–3) (240, 52.1%) and high ACCI (ACCI 4–13) (221, 47.9%) groups. The median ACCI was 2 (IQR: 1–3) and 5 (IQR: 4–7) for the low and high ACCI groups, respectively (P < 0.001). Cardiopulmonary resuscitation (CPR)-to-ECMO duration was comparable between the groups (42.1 ± 25.6 and 41.3 ± 20.7 min in the low and high ACCI groups, respectively; P = 0.754). Regarding hospital survival rate, 256 patients (55.5%) died on ECMO support. A total of 205 patients (44.5%) were successfully weaned off ECMO, but only 138 patients (29.9%) survived to hospital discharge (32.1% and 27.6% in low and high ACCI group, P = 0.291). Multivariate logistic regression analysis revealed CPR-to-ECMO duration and CPR cause of septic shock as significant risk factors for hospital survival after ECPR (P = 0.043 and 0.014, respectively), whereas age and ACCI were not (P = 0.334 and 0.164, respectively). The 2-year survival rate after hospital discharge for the 138 hospital survivors was 96% and 74% in the low and high ACCI groups, respectively (P = 0.002.)Conclusions: High ACCI before ECPR does not predict poor outcome of hospital survival. Therefore, ECPR should not be rejected solely due to high ACCI. However, high ACCI in hospital survivors is associated with a higher 2-year mortality rate than low ACCI, and patients with high ACCI should be closely followed up.

Preprint ARTICLE | doi:10.20944/preprints202307.0057.v1

The Ratio of cf-mtDNA vs cf-nDNA in the Follicular Fluid of Women Undergoing IVF Is Positively Correlated with Age

Georgia Tsirka, Athanasios Zikopoulos, Kyriaki Papageorgiou, Charilaos Kostoulas, Ioannis Tsigkas, Efthalia Moustakli, Aris Kaltsas, Eleftheria Sarafi, Theologos M Michaelidis, Ioannis Georgiou

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: follicular fluid (FF); mitochondria; cf-mtDNA/cf-nDNA; age; cf-mtDNA; cf-nDNA; IVF; ART; PCOS

Online: 4 July 2023 (03:03:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1128.v1

Basic Knowledge of Polyamines That Researchers Must Know before Starting Research, and the Relationship of Polyamines to Aging, Health and Disease

Kuniyasu Soda

Subject: Biology And Life Sciences, Aging Keywords: Polyamine; Spermine; Spermidine; Lifespan extension; Polyamine-rich food; age-related disease; Inflammation; Gene methylation; LFA-1

Online: 16 May 2023 (08:39:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0418.v1

Analyzing academic stress in adolescence and their relationship with students’ psychological and physical well-being: Development and validation of the Questionnaire of Academic Stress in Secondary Education

Rafael García-Ros, Francisco Pérez-González, José M. Tomás

Subject: Social Sciences, Psychology Keywords: academic stress; psychological and physical well-being; adolescence; secondary education; validity; reliability; gender and age differences

Online: 23 August 2018 (15:32:43 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202003.0295.v1

DNA Methylation Analysis of the COVID-19 Host Cell Receptor, Angiotensin I Converting Enzyme 2 Gene (ACE2) in the Respiratory System Reveal Age and Gender Differences

Michael J. Corley, Lishomwa C. Ndhlovu

Subject: Biology And Life Sciences, Virology Keywords: Wuhan 2019-nCoV; ACE2; DNA methylation; epigenetics; profiling; lung tissue; age; gender; COVID-19; coronavirus

Online: 19 March 2020 (02:51:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1218.v1

Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

Ludmila Müller, Svetlana Di Benedetto

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: aging; immunosenescence; cytomegalovirus; inflammaging; CMV latency; COVID-19; SARS-CoV-2; long COVID; age-related diseases

Online: 20 November 2023 (05:14:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0408.v1

A Hint on the COVID-19 Risk: Population Disparities in Gene Expression of Three Receptors of SARS-CoV

Guoshuai Cai, Xiang Cui, Xia Zhu, Jun Zhou

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Wuhan SARS-CoV-2; ACE2; DC-SIGN; L-SIGN; expression; susceptibility; race; age; gender; smoking; single cell

Online: 27 February 2020 (12:45:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1716.v1

AI-Powered Innovation in Digital Transformation: Key Pillars and Industry Impact

Abdulaziz Aldoseri, Khalifa Al-Khalifa, Abdel Magid Hamouda

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Technology disruptions, digital transformation, DT, Artificial intelligence, Innovation ecosystem, digital age, Industry 5.0.

Online: 24 January 2024 (09:49:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1259.v1

AI in Orthodontics: Revolutionizing Diagnostics and Treatment Planning

Natalia Kazimierczak, Wojciech Kazimierczak, Zbigniew Serafin, Pawel Nowicki, Jakub Nożewski, Joanna Janiszewska

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: orthodontics; artificial intelligence; deep learning; cephalometric analysis; radiology; CBCT; skeletal age; treatment planning

Online: 18 December 2023 (10:30:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0063.v2

Exploring the Future Design Approach to Ageing Based on the Double Diamond Model

Xiaochun Wang, Zihan Huang, Tongfei Xu, Yuting Li, Xiangang Qin

Subject: Arts And Humanities, Art Keywords: Double Diamond Model; Future Studies; Future Cone; IDEO Method Cards; age-appropriate design

Online: 7 August 2023 (11:41:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1384.v1

Biomass Allocation, Foliar And Root Production in Boreal Drained Downy Birch (Betula pubescens Ehrh.) Dominated Peatland Sites

Md Rezaul Karim, Katja T. Rinne-Garmston, Sakari Sarkkola

Subject: Biology And Life Sciences, Forestry Keywords: downy birch; biomass allocation; above-ground biomass; stand age; tree diameter; forest peatland.

Online: 20 July 2023 (09:54:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1283.v1

Understanding the Relationship between Extraversion and Life Satisfaction, with Special Emphasis on the Interaction with Age

Felix Bittmann

Subject: Social Sciences, Psychology Keywords: extraversion; age; life satisfaction; happiness; well being; correlation analysis; regression analysis; functional form

Online: 19 June 2023 (04:16:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0870.v1

Paleoproterozoic U Mineralization in Huayangchuan Deposit, Xiaoqinling Area: Evidence From the U-Rich Granitic Pegmatite

Putao Li, Yongjun Li, Pingyang Gu, Shiping He, Yujun Zhuang, Ruiming Chen

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: Southern Margin of North China Craton; Xiaoqinling; Huayangchuan; Uranium; Pegmatite; Paleoproterozoic; Mineralization age

Online: 13 June 2023 (03:31:13 CEST)

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The Huayangchuan uranium deposit, located in the west of the Xiaoqinling belt on the southern margin of the North China Craton, is a polymetallic deposit dominated by U, Nb, Pb, and rare earth elements. The Huayangchuan uranium deposit, discovered in the 1950s, has long been known as a carbonatite-type uranium deposit. Recently, new geological work has found uranium mineralisation in many granitic pegmatite veins in the Huayangchuan deposit and adjacent areas. Here, we report a systematic investigation of the petrography, whole-rock geochemistry, zircon U-Pb ages, and in situ Lu-Hf isotopic characteristics of newly discovered U-rich granitic pegmatite veins in the west of Huayangchuan deposit. The petrological results showed that the lithology of the samples is equivalent to that of granite. The U-Pb ages of zircon were 1826.3 ± 7.9 and 1829 ± 11 Ma. Microscopically, the symbiotic characteristics of zircon, betafite, and uraninite exist in the intergranular fissures of K-feldspar and quartz, reflecting metallogenic phenomena in the rock formation process. Almost all whole-rock samples were rich in SiO2 (64.37–70.69 wt.%), total alkalis (K2O+Na2O = 8.50–10.30 wt.%), and Al2O3 (12.20–14.41 wt.%), but poor in Ti2O (0.23–0.73 wt.%), MgO (0.38–0.90 wt.%), P2O5 (0.14–0.83 wt.%), MnO (0.04–0.57 wt.%). Additionally, they showed enrichment of LILEs (such as Rb, Ba, Th, U, and K), depletion of HFSEs (such as Ta, Nb, P, Ti, and Hf), no alkaline dark minerals, and the characteristics are typical of intraplate A1-type granite. The A1-type granite displayed low zircon εHf(t) values (-19.42– -15.02) with zircon two-stage Hf model aged 3.10–2.76 Ga, indicating that the U-rich granitic pegmatite was derived predominantly from partial melting of the ancient continental crust (such as the early Taihua group formed in Archean-Neoarchean). Combined with the above results and regional geological data, the U-rich granitic pegmatite discovered in the Huayangchuan deposit was related to granite magma activity that formed in a post-collisional regime after the Luliang movement in the late Palaeoproterozoic. This study suggests that future uranium prospecting work in this area should focus on late Palaeoproterozoic U-rich granitic pegmatites.

Preprint BRIEF REPORT | doi:10.20944/preprints202209.0063.v1

SARS-CoV-2 Infection in Unvaccinated High Risk Pregnant Women in the Bronx, NY is Associated with Placental Abnormalities, Shorter Gestation and Lower Apgar Scores

Sandra Reznik, Patricia Vuguin, Rasha Khoury, Olivier Loudig, Ridin Balakrashnian, Susan Fineberg, Francine Hughes, Malini Harigopal, Maureen J. Charron

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; Placental Pathology; Apgar Scores; Gestational Age; Under-resourced Patient Population

Online: 5 September 2022 (13:17:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0304.v1

Lipofuscin, Its Origin, Properties, and Contribution to Retinal Fluorescence as a Potential Biomarker of Oxidative Damage to the Retina

Malgorzata B. Rozanowska

Subject: Medicine And Pharmacology, Ophthalmology Keywords: lipofuscin; retina; fundus autofluorescence; fluorescence imaging; oxidative stress; photooxida-tion; oxidation; biomarker; age-related macular degeneration

Online: 5 July 2023 (10:42:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2031.v1

The Impact of Hormesis, Neuronal Stress Response, and Reproduction, Upon Clinical Ageing: A Narrative Review

Marios Kyriazis, Lama Sawas, Tatiana Orlova

Subject: Biology And Life Sciences, Aging Keywords: Hormesis; neuronal stress response; neuron-germline communication; neuron-germline conflict; cognitive challenges; enriched environment; age-related degeneration.

Online: 29 June 2023 (02:42:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0197.v1

Modernization of Arab Linguistic Sciences in Modern Age

Salahuddin Mohd. Shamsuddin, Siti Sara Binti Hj. Ahmad

Subject: Arts And Humanities, Humanities Keywords: Arab Sciences; Greek Logic; Islamic Philosophy; Heretical Books; Modernization of Arab Rhetorical Linguistic Sciences in the contemporary age

Online: 22 January 2018 (10:07:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1268.v1

Prevention of Delayed Graft Function in Kidney Transplant Recipients by Continuous Infusion of Prostaglandin-Analogue Iloprost: A Single-Center Prospective Study

Massimiliano Veroux*, Floriana Sanfilippo, Giuseppe Roscitano, Martina Maria Giambra, Alessia Giaquinta, Giordana Riccioli, Domenico Zerbo, Daniela Corona, Massimiliano Sorbello, Pierfrancesco Veroux

Subject: Medicine And Pharmacology, Transplantation Keywords: Kidney transplantation; Marginal Donor; Cold Ischemia Time; Donor Age; Acute kidney Injury; Deceased Donor; Graft Survival; Patient Survival

Online: 18 December 2023 (06:07:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0246.v1

Higher Virulence of Diplodia seriata on Vines of cv. Cabernet Sauvignon Associated with 10-Year-Old Wood Compared to Young Tissue

Alejandra Larach, Paulina Vega-Celedón, Eduardo Salgado, Aldo Salinas, Natalia Riquelme, Diyanira Castillo-Novales, Paulina Sanhueza, Michael Seeger, Ximena Besoain

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Keywords: Plant–pathogen interactions; Grape trunk diseases; GTD; Botryosphaeria dieback; Pathogenicity; Tissue age, Virulence, Vitis vinifera; Cabernet Sauvignon.

Online: 4 July 2023 (14:05:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0670.v1

Comparing the Loading Dose between Aflibercept and Faricimab for Neovascular Age-Related Macular Degeneration

Chikako Hara, Masaki Suzue, Satoko Fujimoto, Yoko Fukushima, Kaori Sayanagi, Kentaro Nishida, Kazuichi Maruyama, Shigeru Sato, Kohji Nishida

Subject: Medicine And Pharmacology, Ophthalmology Keywords: age-related macular degeneration; aflibercept; faricimab; anti-vascular endothelial growth factor therapy; exudative change

Online: 10 November 2023 (07:30:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0209.v1

Inflammation Indexes PLR, SII, AISI, MLR, and MCVL in Peripartum Treated Thrombophilia Peripartum Patients Undergoing Cesarean Section at Term

Catalina Filip, Roxana Covali, Demetra Socolov, Ingrid Andrada Vasilache, Alexandru Carauleanu, Mona Akad, Ioana Sadyie Scripcariu, Tudor Butureanu, Ioana Pavaleanu, Gabriela Dumachita-Sargu, Lucian Vasile Boiculese, Alina Melinte, Razvan Socolov

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: thrombophilia; pregnancy; postpartum uterine ultrasonographic scale; SII; AISI; MLR; PLR; MCVL; Rh factor; age.

Online: 3 November 2023 (05:05:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1184.v1

Frontotemporal-TDP and LATE Neurocognitive Disorders: A Pathophysiological and Genetic Approach

Genaro Gabriel Ortiz, Javier Ramírez-Jirano, Raul L. Arizaga, Daniela L.C. Delgado-Lara, Erandis D. Torres-Sánchez

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: frontotemporal lobar degeneration; transactive response DNA‐binding protein 43; limbic age related encephalopathy; progranulin

Online: 19 September 2023 (07:39:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1676.v1

Montane Ecoclines as Social Aggregation Zones in Ancient Central Asia: Agropastoral economies in Jukuu, Kyrgyzstan

Claudia Chang, Sergei S. Ivanov, Robert N. Spengler III, Basira Mir-Makhamad, Perry Alan Tourtellotte

Subject: Environmental And Earth Sciences, Ecology Keywords: Agropastoralism; Central Asia; Archaeology; Archaeobotany; Turkic burial mound; Iron Age settlement; Ecotones; Mountainous ecoclines

Online: 24 May 2023 (03:17:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1003.v1

Candida Vaginal Colonization in Pregnancy and Its Perinatal Impact: Cause, Effect or Coincidence?

Tito Ramírez-Lozada, Carlos Enrique Pérez-Serna, Rodolfo Pinto-Almazán, Carlos Enrique Pérez-Serna, Xóchitl Ramírez-Magaña, Eduardo García-Salazar, Estefani Cruz-Tovar

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Candida albicans; preterm delivery; premature rupture of membranes; small for gestational age; perinatal mortality

Online: 15 May 2023 (08:50:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0585.v1

Topical Triamcinolone Acetonide-Loaded Liposomes Formulation Used as an Adjuvant to Intravitreal Ranibizumab Therapy for Neovascular Age Related Macular Degeneration

Jose Navarro-Partida, Juan Carlos Altamirano-Vallejo, Luis Abraham Aceves Franco, Jesús Gonzalez-Cortes, Sergio Hernandez Da Mota, Jose Gerardo García-Aguirre, Carlos David Azuara-Galindo, Carlos Rodrigo Castro-Castaneda, Juan Armendariz-Borunda, Arturo Santos

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Triamcinolone acetonide; Liposomes; Neovascular age related macular degeneration; Wet macular degeneration; Adjuvant therapy; Ranibizumab

Online: 23 June 2021 (12:56:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0361.v1

Granites and Pegmatites of the Collisional and Intra-Plate Magmatism of the Baikal Area: Age, Mineralogical and Geochemical Types and Genesis Peculiarities

Viktor Antipin, Natalya Sheptyakova, Larisa Kushch, Valentina Makrygina

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Paleozoic granitoids; pegmatites; age; collisional; intra-plate; magmatism; mineralogical and geochemical types; mineralization; minerals; post-collisinal; amazonite; genesis

Online: 18 January 2021 (16:14:03 CET)

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The paper presents new data on mineralogical-geochemical peculiarities of the granites and pegmatites of the Baikal area (Olkhon Region) with implications for the age, generation conditions and geodynamic settings of magmatism. The early Paleozoic granitoids of the Olkhon region are syncollisional formations produced from the gneiss-schistose substratum of the Olkhon metamorphic sequences. Pegmatoid granites and pegmatites of the Region were generated within a wide age range (458-390 Ma) and include different mineralogical and geochemical types. Amongst the Early Paleozoic granitoids, pegmatoid rocks are products of the collisional magmatism evolution and are similar to granites in terms of the mineral composition and distribution patterns of rare and rare earth elements. On the Olkhon island (Baikal lake) the pegmatite of the Tashkiney vein belong to the Be-Nb-Ta mineralogical-geochemical type demonstrating high contents of W, Sn U, Th and very low concentrations of Li and volatile components (F, B). In the Pryolkhonye area, vein pegmatite Iliksin is with Li, Be, Nb, Ta mineralization (lepidolite, vorobyevite, samarskite et al). The studied pegmatite veins are similar both by the profound negative Ba, Sr, Eu, and Zr anomalies. The zircons from the Tashkiney vein (390±5.0 Ma) and of the Iliksin vein (430.1±2.2 Ma, U-Pb isotope LA ICP MS metod) indicate the formation of pegmatite at the late post-collisional stage of magmatism in the Olkhon Region. As regard to mineralogical and geochemical characteristics, vein pegmatites with amazonite (Ainsky and Ulan-Nur) belong to the Li-F type. The tantalum mineralization, represented by microlites and minerals of the columbite-tantalite group is associated with the Ainsky amazonite pegmatite. As opposed to the Early Paleozoic syncollisional granitoids and pegmatoid formations, the middle Paleozoic vein bodies of pegmatites (Tashkiney, Iliksin, Ainsky, Ulan-Nur) are regarded as rare-metal pegmatites. In terms of geochemical characteristics, they are similar to the rare-metal pegmatoid granites and pegmatites of the intra-plate setting widespread in Mongolia and Transbaikalia. The rare-metal mineralization in the Olkhon region may be genetically related to the evolution of Be-Nb-Ta and Li-F types of the post-collisional granites and pegmatites.

Preprint REVIEW | doi:10.20944/preprints202401.1524.v1

New Generation of Gene Therapies as the Future of Wet AMD Treatment

Janusz Blasiak, Elzbieta Pawlowska, Justyna Ciupinska, Marcin Derwich, Joanna Szczepanska, Kai Kaarniranta

Subject: Medicine And Pharmacology, Ophthalmology Keywords: age-related macular degeneration; AMD; vascular endothelial growth factor; VEGF; anti-VEGF therapy; gene therapy; clinical trials; gene editing

Online: 22 January 2024 (10:11:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1148.v1

Perceptions, Barriers, and Facilitators of Maternal Health Service Utilization in Southern Ethiopia: A Qualitative Exploration of Community Members’ and Health Care Providers’ Views

Amanuel Yoseph, Wondwosen Teklesilasie, Francisco Guillen-Grima, Ayalew Astatkie

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: antenatal care; health facility delivery; postnatal care; utilization; women of reproductive age; perceptions; barriers; facilitators; phenomenological study; Ethiopia

Online: 15 December 2023 (11:39:01 CET)

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AbstractBackground: Maternal health service (MHS) use is a key strategy to reduce maternal mortality. However, the existing evidence is scarce to design efficient intervention strategies in Ethiopia. Thus, we aimed to explore community members and health care providers' perceptions of MHS, and barriers, and facilitators of MHS use in southern Ethiopia. Methods: A phenomenological qualitative study was conducted from November 14-30, 2022, in the northern zone of the Sidama region. Sixteen in-depth interviews, nine focus group discussions, and 15 key informant interviews were done with 112 study participants. A maximum variance sampling method was used to select study participants. Data coding and analysis were done using MAXQAD 2020 software and presented in narratives. Results: Communities have positive perceptions and good practices of skilled antenatal care (ANC) and health facility delivery (HFD), but lack awareness of postnatal care (PNC) services and schedules. Some have experienced negative interactions with health care providers, health facilities, and ambulance drivers. The main identified barriers to ANC use were lack of awareness of ANC benefits, distance from a health facility, costs associated with ANC use, long waiting time, lack of access to road, and women being busy with different household chores. Distance from health facility, costs associated with HFD use, unpredicted labour, lack of an ANC visit, lack of a birth preparedness plan, and non-dignified care were the main barriers to HFD. The major identified barriers to PNC use were home delivery, lack of awareness of PNC service and schedule, and socio-cultural beliefs. The main identified facilitators of MHS use were previous experience and fear of obstetric complications, health extension workers and women’s development teams, and pregnant women's forum.Conclusions: Rural women still encounter several challenges when using MHS, even though communities have positive perceptions and good practices of skilled MHS. Bad experiences mothers faced in health facilities, challenges associated with the costs of MHS use, poor awareness of service, and unpredictable labour continued to be basic barriers to MHS use. Intervention approaches should consider inter-sectoral collaboration to address barriers at the community and health facility levels. The programs must emphasize the transportation arrangements during unpredictable labour, the needs of poor mothers, and women who have poor awareness of MHS at the community level.

Preprint ARTICLE | doi:10.20944/preprints202108.0245.v1

Sexual Abuse vs Sexual Freedom? A Legal Approach to the Age of Sexual Consent in Adolescents in Spanish-Speaking Countries

Sandra M. Parra-Barrera, María del Mar Sánchez-Fuentes, Carlos Fuertes-Iglesias, Miguel Ángel Boldova

Subject: Social Sciences, Law Keywords: child sexual abuse; age of sexual consent; Romeo and Juliet clause; sexual freedom; sexual indemnity; comparative law.

Online: 11 August 2021 (10:29:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0248.v1

Effect of Age, Sex, and COVID-19 Vaccination History on All-Cause Mortality: Unexpected Outcomes in a Complex Biological and Social System

Rodney P Jones, Andrey Ponomarenko

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID–19; vaccination; all-cause mortality; age; gender; complex system; pathogen interference; seasonality; miRNAs; nonspecific vaccine effects

Online: 12 April 2023 (07:06:23 CEST)

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Working Paper ARTICLE

Where Freshness Matters in the Control Loop: Mixed Age-of-Information and Event-based Co-design for Multi-loop Networked Control Systems

Mohammad H. Mamduhi, Jaya Prakash Champati, James Gross, Karl H. Johansson

Subject: Engineering, Electrical And Electronic Engineering Keywords: networked control systems; age-of-information; event-triggered sampling; scheduling architecture; resource constraint; asymptotic performance; estimation error

Online: 12 July 2020 (11:36:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0589.v1

Evaluation of cost-effective thin modified binder seals on Nano-Modified Emulsion (NME) stabilised base layers using Accelerated Pavement Testing (APT)

Gerrit J Jordaan, Wynand J VdM Steyn, Andre Broekman

Subject: Engineering, Civil Engineering Keywords: nanotechnology in pavement engineering; thin surfacings for New-age (Nano) Modified Emulsion stabilised base layers; applicable modified binders for chip seals; Cape seals using anionic New-age Modified Emulsion slurries; Sasobit-M® modified binders for chip seals.

Online: 28 January 2021 (15:35:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0911.v1

Age Profiles for SARS-CoV-2 Variants in England and Wales and States of the USA (2020 to 2022): Impact on All-Cause Mor-Tality

Rodney P Jones, Andrey Ponomarenko

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID–19; all-cause mortality; single year of age; gender; complex system; pathogen interference; seasonality; small RNAs

Online: 12 May 2023 (09:01:29 CEST)

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Since 2020 COVID-19 has caused serious mortality around the world. Given the ambiguity in es-tablishing COVID-19 as the direct cause of death we first investigate the effects of age and sex upon all-cause mortality during 2020 and 2021 in England and Wales. Since infectious agents have their own unique age profile for death, we explore several methods to adjust single year of age deaths in England and Wales during 2019 (the pre-COVID-19 base year) to a pathogen-neutral single year of age baseline. This adjusted base year is then used to confirm the widely reported higher deaths in males for most ages above 43 years in both 2020 and 2021. During 2020 (+ COVID-19 but no vac-cination) both male and female population-adjusted deaths were significantly increased above age 35. A significant reduction in all-cause mortality among both males and females aged 75+ could be demonstrated in 2021 during widespread COVID–19 vaccination, however, below age 75 deaths progressively increased. This finding arises from a mix of vaccination and year of age profiles of deaths for the different SARS-CoV-2 variants. In addition, specific effects for age around puberty were demonstrated where females had higher deaths rather than males. There is evidence that year-of-birth cohorts may also be involved, indicating that immune priming to specific pathogen outbreaks in the past may lead to lower deaths for some birth cohorts. To specifically identify the age profile for the COVID-19 variants in 2020 to 2023, we employ the proportion of total deaths at each age which are potentially due to or ‘with’ COVID-19. The original Wuhan strain, and the Alpha variant show somewhat limited divergence in the age profile with the Alpha variant shifted to a moderately higher proportion of deaths below age 84. The Delta variant specifically targeted persons below age 65. The Omicron variants showed significantly lower proportion of overall mortality, with markedly higher relative proportion of deaths above age 65 steeply increasing with age to a maximum around 100 years of age. A similar age profile for the variants can be seen in the age-banded deaths in US states – although slightly obscured by using age bands rather than single year of age. However, the US data shows that higher male deaths are greatly dependent on age and the COVID-variant. Deaths determined as ‘due to’ COVID-19 (as opposed to ‘involving’ COVID-19) in England and Wales were especially over-estimated in 2021 relative to the change in all-cause mortality. This arose as a by-product of an increase in COVID-19 testing capacity in late 2020. Potential structure-function mechanisms for the year of age specificity of SARS-CoV-2 var-iants are discussed. The question is posed as to whether vaccines based on different variants carry the specific age profile through into the vaccine.

Preprint REVIEW | doi:10.20944/preprints202110.0197.v1

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Duc Le, Lindsay Brown, Kundan Malik, Shin Murakami

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: AGING; Age-related comorbidities; Angiotensin-Converting Enzyme; Amyloid-degrading enzyme; Alzheimer’s disease; Dementia; Hypertension; Life extension; Stress resistance

Online: 13 October 2021 (11:04:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0175.v2

Quantum Mechanical Explanation for Dark energy, Cosmic Coincidence, Flatness, Age and Size of Universe

Biswaranjan Dikshit

Subject: Physical Sciences, Mathematical Physics Keywords: Dark energy, Cosmological constant problem, Cosmic coincidence problem, Flatness problem, Hubble’s law, Age of universe, Radius of universe

Online: 29 March 2019 (12:21:37 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1772.v1

Identification of Putative Causal Relationships Between Blood-Based Biomarkers and Prediabetes-Induced Senescence: A Comprehensive Review

Nonkululeko Avril Mbatha, Aganze Gloire-Aime Mushebenge, Andile Khathi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: prediabetes; senescence; blood-based biomarkers; aging; age-related diseases; inflammation; oxidative stress; vascular dynamics; metabolic disorders; chronic inflammation

Online: 29 November 2023 (04:48:13 CET)

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