Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Characteristics of Preoperative Arteriosclerosis Evaluated by Cardio-Ankle Vascular Index in Patients With Osteoarthritis Before Total Knee Arthroplasty

Yoshinori Ishii
* ORCID logo ,
HIdeo Noguchi
,
Junko Sato
,
Ikuko Takahashi
,
Hana Ishii
,
Ryo Ishii
,
Kei Ishii
,
Kai Ishii
,
Shin-ichi Toyabe
Version 1 : Received: 21 June 2023 / Approved: 21 June 2023 / Online: 21 June 2023 (08:28:00 CEST)

A peer-reviewed article of this Preprint also exists.

Ishii, Y.; Noguchi, H.; Sato, J.; Takahashi, I.; Ishii, H.; Ishii, R.; Ishii, K.; Ishii, K.; Toyabe, S.-I. Characteristics of Preoperative Arteriosclerosis Evaluated by Cardio-Ankle Vascular Index in Patients with Osteoarthritis before Total Knee Arthroplasty. J. Clin. Med. 2023, 12, 4685. Ishii, Y.; Noguchi, H.; Sato, J.; Takahashi, I.; Ishii, H.; Ishii, R.; Ishii, K.; Ishii, K.; Toyabe, S.-I. Characteristics of Preoperative Arteriosclerosis Evaluated by Cardio-Ankle Vascular Index in Patients with Osteoarthritis before Total Knee Arthroplasty. J. Clin. Med. 2023, 12, 4685.

Abstract

Purpose: Cardiovascular disease (CVD) is a major risk factor for mortality in patients with osteoarthritis, and comorbidities increase postoperative complications after total knee arthroplasty (TKA). Arteriosclerosis plays a major role in hemodynamic dysfunction and CVD; however, arteriosclerosis has not been preoperatively evaluated before TKA using the cardio–ankle vascular index (CAVI). In this study, we evaluated the degree of preoperative arteriosclerosis using the CAVI in patients undergoing TKA, as well as its correlations with several preoperative patient factors. Methods: Arteriosclerosis was evaluated in 209 consecutive patients (251 knees) with osteoarthritis who underwent TKA at our institution between May 2011 and June 2022. The CAVI was measured in the supine position 1 day before TKA, and the correlations between the CAVI and several clinical factors were analyzed. A p value of <0.05 was considered statistically significant. Results: The CAVI was normal in 62 knees (25%), borderline in 71 knees (28%), and abnormal in 118 knees (47%). Univariate analysis revealed a moderate positive correlation between preoperative CAVI and age (r = 0.451, p < 0.001) and a weak negative correlation between preoperative CAVI and body weight (r = −0.306, p < 0.001) and body mass index (BMI) (r = −0.319, p < 0.001). Multivariate analysis showed that age (β = 0.349, p < 0.001) and BMI (β = −0.235, p < 0.001) were significantly correlated with preoperative CAVI. Conclusion: Arteriosclerosis should be carefully managed intraoperatively and postoperatively in patients with osteoarthritis undergoing TKA, particularly in older patients and patients with a low BMI.

Keywords

osteoarthritis; arteriosclerosis; cardio-ankle vascular index; total knee arthroplasty; age; body mass index

Subject

Medicine and Pharmacology, Orthopedics and Sports Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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