Version 1
: Received: 16 May 2023 / Approved: 16 May 2023 / Online: 16 May 2023 (08:39:53 CEST)
How to cite:
Soda, K. Basic Knowledge of Polyamines That Researchers Must Know before Starting Research, and the Relationship of Polyamines to Aging, Health and Disease. Preprints2023, 2023051128. https://doi.org/10.20944/preprints202305.1128.v1
Soda, K. Basic Knowledge of Polyamines That Researchers Must Know before Starting Research, and the Relationship of Polyamines to Aging, Health and Disease. Preprints 2023, 2023051128. https://doi.org/10.20944/preprints202305.1128.v1
Soda, K. Basic Knowledge of Polyamines That Researchers Must Know before Starting Research, and the Relationship of Polyamines to Aging, Health and Disease. Preprints2023, 2023051128. https://doi.org/10.20944/preprints202305.1128.v1
APA Style
Soda, K. (2023). Basic Knowledge of Polyamines That Researchers Must Know before Starting Research, and the Relationship of Polyamines to Aging, Health and Disease. Preprints. https://doi.org/10.20944/preprints202305.1128.v1
Chicago/Turabian Style
Soda, K. 2023 "Basic Knowledge of Polyamines That Researchers Must Know before Starting Research, and the Relationship of Polyamines to Aging, Health and Disease" Preprints. https://doi.org/10.20944/preprints202305.1128.v1
Abstract
The human polyamines spermine and spermidine are essential for cell function, and their properties have been extensively studied. However, research results of experiments conducted without understanding the properties of polyamines have been evaluated and published by reviewers who appear to have little knowledge of the properties of polyamines. It is sad that some studies repeat what was done more than half a century ago before polyamines were characterized. First, I explain the basic properties of polyamines that researchers need to know. Then, the relationship between changes in polyamine levels in the body and age- and lifestyle-related diseases is discussed. In addition, the epigenetic mechanism of action of polyamines in relation to healthy longevity and, conversely, age- and lifestyle-related diseases and the progression of senescence are discussed. Spermine, which increases with a polyamine-rich diet, acts to suppress aberrant gene methylation and proinflammatory status associated with aging. Meanwhile, chronic inflammation associated with aging induces the enzyme activity of spermine oxidase, which breaks down spermine and produces acrolein, resulting in reduced spermine levels. Acrolein, a toxic aldehyde that increases with age- and lifestyle-related diseases, is thought to accelerate these diseases.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
