Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Confounding Factors Influencing the Kinetic and the Magnitude of Serological Response Following Administration of BNT162b2

Version 1 : Received: 7 June 2021 / Approved: 8 June 2021 / Online: 8 June 2021 (13:48:34 CEST)

How to cite: Bayart, J.; Morimont, L.; Closset, M.; Wieërs, G.; Roy, T.; Gerin, V.; Elsen, M.; Eucher, C.; Van Eeckhoudt, S.; Ausselet, N.; David, C.; Mullier, F.; Dogné, J.; Favresse, J.; Douxfils, J. Confounding Factors Influencing the Kinetic and the Magnitude of Serological Response Following Administration of BNT162b2. Preprints 2021, 2021060237 (doi: 10.20944/preprints202106.0237.v1). Bayart, J.; Morimont, L.; Closset, M.; Wieërs, G.; Roy, T.; Gerin, V.; Elsen, M.; Eucher, C.; Van Eeckhoudt, S.; Ausselet, N.; David, C.; Mullier, F.; Dogné, J.; Favresse, J.; Douxfils, J. Confounding Factors Influencing the Kinetic and the Magnitude of Serological Response Following Administration of BNT162b2. Preprints 2021, 2021060237 (doi: 10.20944/preprints202106.0237.v1).

Abstract

Background: Little is known about potential confounding factors influencing the humoral response in individuals having received the BNT162b2 vaccine. Methods: Blood samples from 231 subjects were collected before and 14, 28 and 42 days following COVID-19 vaccination with BNT162b2. Anti-Spike Receptor-Binding-Domain protein (anti-Spike/RBD) immunoglobulin G (IgG) antibodies were measured at each time-point. Impact of age, sex, childbearing age status, hormonal therapy, blood group, body mass index and past-history of SARS-CoV-2 infection were assessed by multivariable analyses. Results and Conclusions: In naïve subjects, the level of anti-Spike/RBD antibodies gradually increased following administration of the first dose to reach the maximal response at day 28 and then plateauing at day 42. In vaccinated subjects with previous SARS-CoV-2 infection, the plateau was reached sooner (i.e. at day 14). In the naïve population, age had a significant negative impact on anti-Spike/RBD titers at day 14 and 28 while lower levels were observed for males at day 42, when corrected for other confounding factors. BMI as well as B and AB blood groups had a significant impact in various subgroups on the early response at day 14 but no longer after. No significant confounding factors were highlighted in the previously infected group.

Subject Areas

SARS-CoV-2; vaccine; BNT162b2; antibody, serology; kinetic; age; gender; BMI; blood-group.

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