Ramírez-Lozada, T.; Pérez-Serna, C.E.; Pinto-Almazán, R.; Pérez-Serna, C.E.; Ramírez-Magaña, X.; García-Salazar, E.; Cruz-Tovar, E. Candida Vaginal Colonization in Pregnancy and Its Perinatal Impact: Cause, Effect or Coincidence?. Preprints2023, 2023051003. https://doi.org/10.20944/preprints202305.1003.v1
APA Style
Ramírez-Lozada, T., Pérez-Serna, C.E., Pinto-Almazán, R., Pérez-Serna, C.E., Ramírez-Magaña, X., García-Salazar, E., & Cruz-Tovar, E. (2023). Candida Vaginal Colonization in Pregnancy and Its Perinatal Impact: Cause, Effect or Coincidence?. Preprints. https://doi.org/10.20944/preprints202305.1003.v1
Chicago/Turabian Style
Ramírez-Lozada, T., Eduardo García-Salazar and Estefani Cruz-Tovar. 2023 "Candida Vaginal Colonization in Pregnancy and Its Perinatal Impact: Cause, Effect or Coincidence?" Preprints. https://doi.org/10.20944/preprints202305.1003.v1
Abstract
In the vaginal ecosystem there is a symbiotic relationship between the microbiota and the host, particularly Candida spp., which are considered commensals of the vaginal mucosa. During pregnancy there is an increase in hormonal secretion that alters the vaginal microbiota and favors the development of Candida infection. Several studies have shown the increased prevalence of Candida during pregnancy, as well as its association with perinatal complications and current clinical practice guidelines recommend fluconazole as the treatment of choice during pregnancy in case of infection by Candida albicans and non-albicans Candida. However, in the Mexican population, this association has not been studied. So in this study, an intentional search for colonization by Candida spp. in pregnant women who attended the obstetric triage of the Hospital Regional de Alta Especialidad de Ixtapaluca during the period from May to October 2019, and they were followed up until the end of the pregnancy. Data on age, number of pregnancies, gestational age, body mass index, and perinatal outcomes were analyzed. Of 83 patients included in the study, yeasts corre-sponding to C. albicans (12) and C. glabrata (4) were isolated in 16. In the group of patients with Candida, the maternal age range was from 15 to 36 years old, of which 7 were adolescents and 2 with advanced maternal age, with an average of 2 gestations, the range of body mass index was from 19.3 to 42.4, of which 4 were overweight and 7 obese. Perinatal complications were observed in three patients, one presented chorioamnionitis and in two the neonates were small for gestational age. No association was found between colonization by Candida spp. and the number of preg-nancies, gestational age, body mass index or perinatal results. However, it was found that age (adolescence) may be a risk factor for the development of vulvovaginitis during pregnancy.
Keywords
Candida albicans; preterm delivery; premature rupture of membranes; small for gestational age; perinatal mortality
Subject
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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