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Preprint REVIEW | doi:10.20944/preprints202005.0234.v1

Epidemiological Challenges in Pandemic Coronavirus Disease (COVID-19): Role of Artificial Intelligence

Abhijit Dasgupta, Abhisek Bakshi, Srijani Mukherjee, Kuntal Das, Soumyajeet Talukdar, Pratyayee Chatterjee, Sagnik Mondal, Puspita Das, Subhrojit Ghosh, Archisman Som, Pritha Roy, Rima Kundu, Akash Sarkar, Arnab Biswas, Karnelia Paul, Sujit Basak, Krishnendu Manna, Chinmay Saha, Satinath Mukhopadhyay, Nitai P. Bhattacharyya, Rajat K. De

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: SIRD; Twitter; GHSI; Pre-symptomatic; EHR; Contact tracing; On-line survey; qRT-PCR; X-ray; CT/HRCT; CNN; Autoencoder; Drug affinity; CPI; and Inflation.

Online: 14 May 2020 (11:25:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0074.v1

Regulation of ERK and AKT Pathways by Hepatitis B Virus X Protein via Notch1 Pathway in Hepatocellular Carcinoma

Bo Liao, Hong-Hao Zhou, Hui-Fang Liang, Chang-Hai Li

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: hepatocellular carcinoma; hepatitis B virus X protein; Notch1 pathway; ERK; AKT

Online: 21 September 2016 (09:49:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0003.v6

Farey Sequences and the Riemann Hypothesis

Darrell Cox

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Riemann hypothesis, Farey sequence, Gauss sum associated with a Dirichlet character

Online: 10 August 2016 (11:35:25 CEST)

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Working Paper REVIEW

Review of Potential High-Leverage and Inexpensive Mitigations for Reducing Risk in Epidemics and Pandemics

David Manheim, David Denkenberger

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Mitigation; Risk Reduction; Global Catastrophic Biological Risk; Epidemics; Disease X; Literature Review; Pandemics; Value of Information; Existential Risk

Online: 28 February 2020 (12:32:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0027.v1

Impaired Adipose Tissue Expansion Caused by LXR Activation is Associated with Insulin Resistance in HFD Mice

Yueting Dong, Zhiye Xu, Ziyi Zhang, Xueyao Yin, Xihua Lin, Qianqian Pan, Hong Li, Fenping Zheng

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Liver X receptor (LXR); Peroxisome proliferator-activated receptor (PPARγ); Adipose expansion; Insulin resistance

Online: 10 October 2016 (07:56:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0234.v1

Sequence Properties of the MAAP Protein and of the VP1 Capsid Protein of Adeno-Associated Viruses

David G. Karlin

Subject: Biology And Life Sciences, Virology Keywords: adeno-associated virus; protein sequence analysis; overlapping genes; amino acid depletion; cysteine depletion; tyrosine depletion; capsid design; membrane-binding amphipathic helix

Online: 17 February 2020 (02:42:39 CET)

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Preprint ARTICLE | doi:10.3390/sci2020046

Portable XRF Quick-Scan Mapping for Potential Toxic Elements Pollutants in Sustainable Urban Drainage Systems: A Methodological Approach

Guri Venvik, Floris Boogaard

Subject: Environmental And Earth Sciences, Environmental Science Keywords: portable X-ray fluorescence spectrometer (pXRF); Potential Toxic Elements (PTE); lead (Pb), zinc (Zn); copper (Cu); topsoil; sustainable urban drainage systems; SuDS; LID; BMPs; WSUD; GI; SCMs

Online: 13 June 2020 (00:00:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0126.v1

Comments about Rietveld Analysis and Tolerance Factor: Y Doped BaTiO₃

I. A. Lira-Hernández, F. R. Barrientos-Hernández, M. Pérez-Labra, A. M. García-Mercado, J. A. Romero-Serrano

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: A. Ceramics; A. Oxides; C. X-ray diffraction; D. Crystal structure; D. Microstructure

Online: 28 October 2016 (08:09:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0137.v1

Contamination Characteristics and Assessment of Manganese, Zinc, Chrome, Lead, Copper and Nickel in Bus Station Dusts of Xifeng, Northwest China

Yongfu Wu, Xinwei Lu, Sukai Zhuang, Xiufeng Han, Yan Zhou

Subject: Environmental And Earth Sciences, Environmental Science Keywords: heavy metal; contamination assessment; X-ray fluorescence; bus station dusts

Online: 13 August 2016 (09:41:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0060.v1

Impact of Soft Tissue Pathophysiology in the Development and Maintenance of Bisphosphonate Related Osteonecrosis of the Jaw (BRONJ)

Thomas Ziebart, Sebastian Blatt, Junho Jung, Andreas Pabst, Christian Walter, Frank Halling, Paul Heymann, Andreas Neff, Leonardo Righesso

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: gingiva; bisphosphonate; soft tissue; fibroblasts; keratinocytes; bisphosphonate associated osteonecrosis of the jaws

Online: 15 October 2016 (08:03:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0001.v1

ESWT Enhances Expression of Pdia-3 which is a Key Factor of 1α,25-Dihydroxyvitamin D3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis Knee

Shan-Ling Hsu, Jai-Hong Cheng, Ching-Jen Wang, Jih-Yang Ko, Chih-Hsiang Hsu

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: protein-disulfide isomerase-associated 3; osteoarthritis; extracorporeal shockwave therapy; 1α,25-Dihydroxyvitamin D3 signaling pathway; two dimensional electrophoresis

Online: 1 September 2016 (10:47:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints201608.0043.v1

Arms Race between Enveloped Viruses and the Host ERAD Machinery

Dylan A. Frabutt, Yong-Hui Zheng

Subject: Biology And Life Sciences, Virology Keywords: enveloped viruses; viral glycoproteins; endoplasmic reticulum-associated degradation; ERAD; unfolded protein response; UPR; ER stress

Online: 4 August 2016 (11:44:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0010.v1

Impact of the Fused Deposition (FDM) Printing Process on Polylactic Acid (PLA) Chemistry and Structure

Michael Cuiffo, Jeffrey Snyder, Alicia Elliott, Nicholas Romero, Sandhiya Kannan, Gary Halada

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: PLA; fused deposition modeling (FDM); surface characterization; vibrational spectroscopy; laser confocal microscopy; X-ray photoelectron spectroscopy

Online: 3 April 2017 (17:34:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0074.v4

Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H2DAB)[Co(H2PO3)4]·2H2O

Najlaa Hamdi, Souad Chaouch, Ivan da Silva, Mohamed Ezahri, Mohammed Lachkar, Rama Alhasan, Ahmad Yaman Abdin, Claus Jacob, Brahim El Bali

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Hybrid phosphite; X-Ray crystal structure; FTIR; Thermal behavior; Biological activities; Antimi-crobial; micro-organisms

Online: 22 November 2021 (08:43:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0110.v1

The Synthesis and New Crystal Structures of Three Arylpiperazine Compounds

Jinhui Zhou, Maocai Yan, Maojian Shi, Jun Xu, Guoqiang Shangguan

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: arylpiperazine compound; X-ray crystal structure; characterization; triclinic

Online: 21 December 2016 (11:01:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0656.v1

One Shot Cluster Based Approach for the Detection of COVID-19 from Chest X-Ray Images

V.N. Manjunath Aradhya, Mufti Mahmud, Basant Agarwal, D.S. Guru, M. Shamim Kaiser

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19 infection; Chest X-ray image; generalized regression neural network; probabilistic neural network and detection accuracy

Online: 27 July 2020 (00:52:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints201702.0098.v1

MicroRNAs in the Communication between Cancer Associated Fibroblasts (CAF) and Cancer Cells

Maren Schoepp, Anda Jana Stroese, Joerg Haier

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: MicroRNA; cancer associated fibroblasts; cell-cell communication; transformation; epigenetic

Online: 28 February 2017 (10:29:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0383.v1

Achieving a Good Crystal System for Crystallographic X-ray Fragment Screening

Patrick M. Collins, Alice Douangamath, Romain Talon, Alexandre Dias, José Brandão-Neto, Tobias Krojer, Frank von Delft

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: fragment screening; XChem; protein crystallisation; X-ray crystallography; diamond light source; I04-1; structural genomics consortium

Online: 19 September 2018 (11:37:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0016.v1

A 14-bit Hybrid Incremental Sigma-Delta/Cyclic ADC for X-ray Linear Array Sensor

Yuze Niu, Yacong Zhang, Zhuo Zhang, Miaomiao Fan, Wengao Lu, Zhongjian Chen

Subject: Engineering, Electrical And Electronic Engineering Keywords: hybrid ADC; sigma-delta ADC; cyclic ADC; pseudo-differential OTA; X-ray sensor

Online: 2 March 2017 (08:37:48 CET)

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Preprint REVIEW | doi:10.20944/preprints201703.0095.v1

Melatonin as an Interventional Novel Candidate for the Individual with Autistic Fragile X Syndrome in Human

Jinyoung Won, Yunho Jin, Tae Ho Lee, Sang-Rae Lee, Kyu-Tae Chang, Yonggeun Hong

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: autism spectrum disorders; fragile X syndrome (FXS); sleep disorder; melatonin

Online: 15 March 2017 (07:40:49 CET)

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Working Paper ARTICLE

Open Problems on Computable Sets {${\mathcal X} \subseteq N$}, Which Require That a Known Integer $n$ Satisfies ${\rm card}({\mathcal X})=\omega \Leftrightarrow {\mathcal X} \cap (n,\infty) \neq \emptyset$, and Which Cannot Be Stated Formally as They Refer to Current Knowledge about ${\mathcal X}$}

Apoloniusz Tyszka

Subject: Computer Science And Mathematics, Logic Keywords: Alexander Zenkin's super-induction method; arithmetical operations on huge integers cannot be performed by any physical process; computable set {${\mathcal X} \subseteq N$} whose finiteness remains conjectured; computable set {${\mathcal X} \subseteq N$} whose infiniteness remains conjectured

Online: 25 February 2020 (10:06:45 CET)

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Let β= (((24!)!)!)!, and let {${\mathcal P}_{n^2+1}$} denote the set of all primes of the form {$n^2+1$}. Let ${\mathcal M}$ denote the set of all positive multiples of elements of the set {${\mathcal P}_{n^2+1} \cap (\beta,\infty)$}. The set {${\mathcal X}=\{0,\ldots,\beta\} \cup {\mathcal M}$} satisfies the following conditions: (1) ${\rm card}({\mathcal X})$ is greater than a huge positive integer and it is conjectured that ${\mathcal X}$ is infinite, (2)} we do not know any algorithm deciding the finiteness of ${\mathcal X}$, (3)~a~known and short algorithm for every {$n \in N$} decides whether or not {$n \in {\mathcal X}$}, (4) a known and short algorithm returns an integer~$n$ such that ${\mathcal X}$ is infinite if and only if ${\mathcal X}$ contains an element greater than $n$. The following problem is open: {\em simply define a set {${\mathcal X} \subseteq N$} such that ${\mathcal X}$ satisfies conditions (1)-(4), and \underline{we do not know any representation of~~${\mathcal X}$~~as a finite union of sets whose definitions are simpler than} \underline{the definition of ${\mathcal X}$}} {\tt (5)}. Let {$f(1)=2$}, {$f(2)=4$}, and let {$f(n+1)=f(n)!$} for every integer {$n \geqslant 2$}. For a positive integer $n$, let {$\Psi_n$} denote the following statement: {\em if a system of equations ${\mathcal S} \subseteq \Bigl\{x_i!=x_k: i,k \in \{1,\ldots,n\}\Bigr\} \cup \Bigl\{x_i \cdot x_j=x_k: i,j,k \in \{1,\ldots,n\}\Bigr\}$ has only finitely many solutions in positive integers \mbox{$x_1,\ldots,x_n$}, then each such solution \mbox{$(x_1,\ldots,x_n)$} satisfies {$x_1,\ldots,x_n \leqslant f(n)$}.} We prove that for every statement $\Psi_n$ the bound {$f(n)$} cannot be decreased. The author's guess is that the statements {$\Psi_1,\ldots,\Psi_9$} are true. We prove that the statement $\Psi_9$ implies that the set ${\mathcal X}$ of all {non-negative} integers $k$ whose number of digits belongs to {${\mathcal P}_{n^2+1}$} satisfies conditions {\tt (1)-(5)}.

Preprint TECHNICAL NOTE | doi:10.20944/preprints201710.0098.v1

Assessing Error Correlations in Remote Sensing-Based Estimates of Forest Attributes for Improved Composite Estimation

Sarah Ehlers, Svetlana Saarela, Nils Lindgren, Eva Lindberg, Mattias Nyström, Henrik J. Persson, Håkan Olsson, Göran Ståhl

Subject: Environmental And Earth Sciences, Environmental Science Keywords: airborne LiDAR; composite estimators; forest inventory; SPOT-5 HRG; TanDEM-X

Online: 16 October 2017 (04:30:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0155.v1

Cancer-associated Fibroblasts: Origins, Heterogeneity and Functions in Tumor Microenvironment

Kevin Dzobo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Tumor microenvironment; tumor stroma; cancer-associated fibroblasts; heterogeneity; biomarkers; cancer; The Cancer Genome Atlas; gene expression; computational biology

Online: 15 January 2020 (12:56:44 CET)

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Preprint REVIEW | doi:10.20944/preprints201907.0211.v2

HIV-1: Tackling the Obstacles that Limit the Effectiveness of CRISPR-Cas9 Gene Editing of the T Cell Co-receptor CCR5

Tatiana Hillman

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: HIV-1; CRISPR-Cas9; T-cells; lipid nanoparticles; gut-associated-lymphoid tissue; Co-receptors; Probiotics; GI Tract,; Gene Editing

Online: 13 April 2020 (10:57:52 CEST)

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HIV-1 is a complicated and perplexing virus. It infects T cells, reverse transcribes its RNA into DNA, utilizes its host DNA machinery to replicate its HIV-DNA, translates the HIV-DNA into proteins, assembles itself for a budding escape from the T cell, and rapidly mutates its conformation. Partially, due to its complexity, there remains no cure for HIV or AIDs. However, recently with the discovery of TALENs, the use of zinc fingers, and most of all the applications of CRISPR-Cas9 technology, has given researchers new hope in finding alternative gene therapies and treatments for diseases. With more focus on CRISPR-Cas9, this new and novel technology uses a guiding RNA, sgRNA, to lead a Cas9 nuclease to its target for deletion or to change that DNA site. CRISPR-Cas9 can delete point mutations and multiple DNA sites. Because CRISPR can alter DNA sequences, several scientists have conducted research into CRISPR, possibly treating more diseases such as cancer, diabetes, and even HIV. HIV-1 drew the focus of a researcher named Dr. Ebina in 2013 when he was the first to design and apply CRISPR-Cas9 to genes found in the binding sites of HIV-1, inhibiting HIV-1 gene expression. Since 2013, several other researchers have blocked HIV replication and infection through CRISPR-Cas9 targeting the receptors of T cells called the CC chemokine receptor 5 or CCR5. HIV-1 binds to the CD4 receptor of T cells, which consists of co-receptors CCR5 and CXCR4. If CCR5 expression can be removed, the HIV virus cannot bind to T-cells, blocking the initial attachment stage, and discontinuing the infection. However, there remain obstacles and issues for the CRISPR deletion of CCR5 for treating HIV-1. The issues include: 1) finding new and safe methods of CRISPR-Cas9 delivery, 2) clearing the latent HIV reservoirs, 3) improving the sgRNA design to avoid off-target mutations or deletions, and 4) effectively analyze the viral escape of HIV from CRISPR-Cas9 modifications. Therefore, the purpose of this review is to discuss possible techniques for removing the obstacles that can lessen the potential of CRISPR to delete CCR5, repressing HIV-1 into long-term remission or a functional cure.

Preprint SHORT NOTE | doi:10.20944/preprints201703.0158.v1

Triphenylphosphine-(N,N-dimethyldithiocarbamato)-gold(I) Methanol Solvate

Nicolas Bélanger-Desmarais, Christian Reber

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: au(I) dithiocarbamate and phosphine complex; Raman spectroscopy; Single crystal X-ray diffraction; DFT calculations

Online: 20 March 2017 (10:00:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0108.v1

Neuropsychological Findings in Adults with Triple X Syndrome

Maarten Otter, Bea Campforts, Connie TRM Stumpel, Thérèse Van Amelsvoort, Claudia Vingerhoets, Marjan Drukker

Subject: Social Sciences, Cognitive Science Keywords: Triple X syndrome; Adults; Neurocognitive functioning; Sex Chromosomal Disorders; Attention; Psychomotor speed; Executive functioning

Online: 7 June 2022 (11:26:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0187.v1

Multidisciplinary Study of the Origin of the Painting From the Early 20TH Century Leads to Picasso

Marica Bakovic, Slobodanka Karapandza, Sajed Mcheik, Ana Pejovic Milic

Subject: Arts And Humanities, Art Keywords: historic pigments; colorants; nitrocellulose; X-ray radiography; X-ray fluorescence spectroscopy; infrared Fourier transform spectroscopy; Raman spectroscopy

Online: 13 May 2022 (09:44:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0016.v1

CSL Collapse Model Mapped with the Spontaneous Radiation

Kristian Piscicchia, Angelo Bassi, Catalina Curceanu, Raffaele Del Grande, Sandro Donadi, Beatrix Hiesmayr, Andreas Pichler

Subject: Physical Sciences, Quantum Science And Technology Keywords: quantum mechanics; the measurement problem; collapse models; X-rays

Online: 1 May 2017 (11:02:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0638.v1

Shugoshin: From a Perspective of Clinical Disorders

Ravinder Kumar, Meenakshi Agarwal

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Shugoshin; tumor suppressor; cancer; oncogene; tumour associated gene

Online: 25 March 2021 (15:31:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201706.0052.v1

Access to HIV Care and Resilience in a Long Term Conflict Setting. A Pilot Qualitative Assessment of the Experiences of Living with Diagnosed HIV in Mogadishu, Somali

Asli Kulane, John O. A. Owuor, Douglas Sematimba, Sacdia Abdisamad Abdulahi, Hamdi Moalim Yusuf, Lul M. Mohamed

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Somali; conflict; health system; resilience; fragile; access; government; NGO

Online: 12 June 2017 (06:26:20 CEST)

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Background: Human Immnodeficiency virus (HIV) continues to take a heavy toll on the lives of many people with worst impact on health and wellbeing for the affected individuals in fragile states. The HIV situation in Somalia is not clearly known and experiences of the people living with HIV in this war-torn region unexpressed. This pilot qualitative study sought to explore the experiences of people living with diagnosed HIV in Mogadishu and their resilience in access to care and social support. Method: Face-to-face in-depth interviews were conducted in Somali in May 2013 among patients who were receiving Antiretroviral therapy (ART) from the HIV clinic in Mogadishu. Participants were recruited through drug dispensers at the HIV clinic in Benader Hospital. These were tape recorded, transcribed and translated for content analysis. Results: Three women and four men who were living with HIV shared the following narratives. Their perception was that they had either got HIV from their spouces or through health care contamination. They were very knowledgable about the realities of HIV, how the medication works, nutritional requirements and drug adherence. They were always willing to go an extra mile to secure a good life for themselves. However the external HIV stigma impacted their access to care. They faced challenges in their homes and at work which compelled them to seek support from non-governmental organisations (NGOs) or close family members. This stigma often affected their disclosure to the wider community due to the uncertainity of the repercussions, leading to a life of extreme loneliness and financial difficulties. The participants’ coping mechansms included living together and starting their own NGO for support with very strong optimism about their prognosis. Conclusions: The people living with diagnosed HIV in Mogadishu are highly knowledgeable about HIV transmission, the realities of living with diagnosed HIV infection and efficacy of HIV treatment. Our small sample suggests adequate access to ART through NGOs. However, widespread HIV stigma limits HIV status disclosure to the families and communities which creates a risk of self isolation and ill health. But affected individuals have developed resilient mechanisms of managing the risks. They strive to remain employed for economic security, adhere to HIV treatment, engage in support groups and maintain utmost optimism about their prognosis.

Preprint REVIEW | doi:10.20944/preprints201703.0093.v1

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

Vibeke Andersen, Axel Kornerup Hansen, Berit Lilienthal Heitmann

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: lifestyle factors; chronic inflammatory diseases; treatment result; treatment response; diet; meat intake; dietary pattern; food; mucosa associated bacteria; epithelium-associated bacteria; microbiome; fibre intake; personalized medicine; mucus; sulphate-reducing bacteria; mucin-degrading bacteria; Western style diet; anti-TNF

Online: 15 March 2017 (07:29:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0244.v1

Coatings Thickness Determination Using X-ray Fluorescence Spectroscopy: Monte Carlo Simulations as an Alternative to the Use of Standards

Walter Giurlani, Enrico Berretti, Massimo Innocenti, Alessandro Lavacchi

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: XRF; X-ray fluorescence; thickness determination; thin film; simulation; XMI-MSIM; electrodeposition; Monte Carlo; galvanic industry; electroplating

Online: 24 January 2019 (08:09:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0535.v1

Metal Body Armour: Biomimetic Engineering of Lattice Structures ^†

Anton du Plessis, C. Broeckhoven

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: biomimicry; biomimetic engineering; energy absorption; lattice structure; additive manufacturing; powder bed fusion; X-ray tomography; microCT; non-destructive testing; 3D image analysis

Online: 23 October 2018 (10:10:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0166.v1

Bile acid detoxifying enzymes limit susceptibility to liver fibrosis in female SHRSP5/Dmcr rats fed with a high-fat-cholesterol diet

Husna Yetti, Hisao Naito, Yuan Yuan, Xiaofang Jia, Yumi Hayashi, Hazuki Tamada, Kazuya Kitamori, Katsumi Ikeda, Yukio Yamori, Tamie Nakajima

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: constitutive androstene receptor; cytochrome P450, fibrosis; gender difference; high-fat-cholesterol (HFC) diet; necrosis; stroke-prone spontaneously hypertensive 5/Dmcr rats; sulfotransferase, pregnane X receptor; UGP-glucuronosyltransferase

Online: 23 May 2017 (07:54:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints201706.0068.v1

Human MAP tau based targeted cytolytic fusion proteins

Olusiji Akinrinmade, Sandra Jordaan, Dmitrij Hristodorov, Radoslav Mladenov, Neelakshi Mungra, Shivan Chetty, Stefan Barth

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: human cytolytic fusion proteins; immunotherapy; microtubule associated protein tau (MAP); cancer; inflammatory diseases

Online: 15 June 2017 (12:02:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0260.v1

Synthesis, X-ray Crystal Structures, Computational Studies and Catechol Oxidase Activity of New Acylhydrazone Derivatives

Khalid Karrouchi, Smaail Radi, Yousfi El Bekkaye, Nada Kheira Sebbar, Jamal Taoufi Taoufik, Younes Ouzidan, Hazem A. Ghabbour, Yahia Mabkhot, Salim Al-Showiman, Seham Alterary, M’hammed Ansar

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Acylhydrazone; Pyrazole; X-ray crystallography; DFT/B3LYP; Catecholase activity

Online: 28 January 2018 (12:44:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0059.v1

Sequestration Effect on the Open-Cyclic Switchable Property of Warfarin by Cyclodextrin: Ultrafast Dynamical Study

Naji Al-Dubaili, Na'il Saleh

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: open-cyclic tautomers; molecular switching; decay-associated spectra; warfarin; excited-state lifetime; cyclodextrins

Online: 21 July 2017 (04:56:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0299.v1

Green Synthesis, Structural, In Vitro and Vivo Bioactivity Properties of ZnO Nanoparticles for Biomedical Applications

Essam H. Ibrahim, Obaid Albulym, Omer Kaygili, Mona Kilany, Mohd Shkir, Mai S.A. Hussien, Niyazi Bulut, I.S. Yahia

Subject: Chemistry And Materials Science, Biomaterials Keywords: X-ray diffraction; bioactivities; cytotoxicity test; Anti-cancer activities

Online: 26 April 2019 (11:00:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0110.v1

Multi Component Reactions under Increased Pressure: On the Mechanism of Formation of Pyridazino[5,4,3-de][1,6]naphthyridine Derivatives from Reaction of Malononitrile, Aldehyde and 2-Oxoglyoxalarylhydrazones in Q-Tubes

Majdah A. AL-Johani, Khadijah M. Al-Zaydi, Sameera M. Mousally, Norah F. Alqahtani, Mohamed H. Elnagdi

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: X-ray; arylhydrazones; 2-amino-1,1,3-propenetricarbonitrile; pyridazines; rate enhance under pressure

Online: 17 October 2017 (04:13:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0028.v2

Comparative Study of the Reactivity of the Tungsten Oxides WO₂and WO₃with Beryllium at Temperatures up to 1273 K

Martin Köppen

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: X-ray photoelectron spectroscopy; physical vapor deposition; X-ray diffraction; tungsten oxide; tungsten dioxide; tungsten trioxide; beryllium; tungstate; tungsten bronze

Online: 10 September 2019 (08:09:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0171.v1

Fracture Reconstruction and Analysis of Low Permeability Carbonates using x-ray Tomography for Comparison with Outcrop Data

Stephanie G. Zihms, Helen Lewis, Tiago Siqueira de Miranda, Stephen A. Hall, James M. Somerville

Subject: Environmental And Earth Sciences, Geography Keywords: geomechanics; fractures; multi-scale; x-ray tomography; carbonates

Online: 10 May 2018 (16:24:06 CEST)

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Working Paper ARTICLE

COVID19 Detection from Radiographs: Is Deep Learning Able to Handle the Crisis?

Muhammad Saqib, Saeed Anwar, Abbas Anwar, Lars Petersson, Nabin Sharma, Michael Blumenstein

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: COVID-19; Deep learning; Convolutional neural network; Computed Tomography; X-Rays; Classification; Detection

Online: 14 June 2020 (17:51:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0061.v1

Quantitative Imaging of the Stress/Strain Fields and Generation of Macroscopic Cracks from Indents in Silicon

Brian K. Tanner, David Allen, Jochen Wittge, Andreas N. Danilewsky, Jorge Garagorri, Eider Gorostegui-Colinas, Reyes M. Elizalde, Patrick J. McNally

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: X-ray diffraction imaging; Raman spectroscopy; indentation geometry; plastic deformation; crack generation; plastic deformation strain imaging

Online: 10 October 2017 (11:46:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints201709.0027.v1

Insights into the Diagnostic Potential of Extracellular Vesicles and their miRNA Signature from Liquid Biopsy as Early Biomarkers of Diabetic Micro/Macrovascular Complications

Valeria La Marca, Alessandra Fierabracci

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: EVs; endothelial-derived microparticles; platelet-derived microparticles; non-invasive biomarkers; miRNAs signature; diabetes associated complications; micro-macrovascular damage; diabetic nephropathy

Online: 8 September 2017 (09:38:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0021.v1

In Vitro Antibacterial Activities of Aniline Dithiocarbamate Crystals with its Corresponding Oxovanadium(IV) and Zinc(II) Coordination Compounds

Ayodele Odularu, Peter Adewale Ajibade, Albert Bolhuis

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Keywords: one-pot synthesis; single crystal x-ray crystallography; oxovanadium(IV); zinc(II); spectroscopic studies; in vitro antibacterial studies.

Online: 2 February 2018 (16:00:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0259.v1

Bio-Functionalization of a Novel Biocompatible High Entropy Alloy Used For Bone Implants

Mirela Maria Codescu, Alina Vladescu, Victor Geanta, Ionelia Voiculescu, Iulian Pana, Mihaela Dinu, Adrian Emil Kiss, Viorel Braic, Delia PATROI, Virgil E MARINESCU, Iordoc Mihai

Subject: Chemistry And Materials Science, Biomaterials Keywords: VAR alloy obtaining; Biomedical applications; Apatite films; Corrosion, X-ray method, Electron microscopy; Hardness

Online: 9 April 2021 (13:24:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0564.v1

Fischer-Tropsch Synthesis as Key for a Decentralized Sustainable Kerosene Production

Andreas Meurer, Jürgen Kern

Subject: Engineering, Automotive Engineering Keywords: alternative fuels; power-to-liquid; synthetic fuel; synthetic kerosene; aviation fuel; sustainable fuel; power-to-x; e-fuel; fischer-tropsch; renewable fuel

Online: 27 January 2021 (15:04:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0096.v1

Multifractal Comparison of Reflectivity and Polarimetric Rainfall Data from C- and X-Band Radars and Respective Hydrological Responses of a Complex Catchment Model

Igor Paz, Bernard Willinger, Auguste Gires, Laurent Monier, Christophe Zobrist, Bruno Tisserand, Ioulia Tchiguirinskaia, Daniel Schertzer

Subject: Environmental And Earth Sciences, Environmental Science Keywords: complex catchment; weather X-band radars; flash floods; multifractals; spatio-temporal variability

Online: 14 October 2017 (03:10:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0166.v1

High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-Acyl-β-D-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors

Thomas Fischer, Symeon M. Koulas, Anastasia S. Tsagkarakou, Efthimios Kyriakis, George A. Stravodimos, Vassiliki T. Skamnaki, Panagiota G.V. Liggri, Spyros E. Zographos, Rainer Riedl, Demetres D. Leonidas

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Structure-based design; glycogen phosphorylase inhibitor; glycogen metabolism; type 2 diabetes; X-ray crystallography; N-acyl-β-D-glucopyranosylamine

Online: 15 March 2019 (14:06:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202006.0147.v1

Novel Therapeutic Targets and Biomarkers for the Treatment of Progressive Supranuclear Palsy

Imogen Tyer, Alison Hill

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: PSP; Progressive Supranuclear Palsy; 4R-tau; four-repeat tau; MAPT; Microtubule-associated ligand; PET; Positron Emission Tomography

Online: 12 June 2020 (09:41:06 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints201711.0029.v1

Di-Silicate Dental Ceramic Surface Preparation by 1070 nm Fiber Laser: Thermal and Ultrastructural Analysis

Carlo Fornaini, Federica Poli, Elisabetta Merigo, Nathalie Brulat-Bouchard, Ahmed El Gamal, Jean-Paul Rocca, Stefano Selleri, Annamaria Cucinotta

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: di-silicate ceramics; fiber lasers; Fiber Bragg Grating; Energy Dispersive X-ray Spectroscopy

Online: 5 November 2017 (11:47:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0423.v1

Is “Cellular Senescence” a Misnomer?

David Gems, Carina Kern

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Aging; cellular senescence; fibroblast; osteoarthritis; remodeling-associated secretory phenotype (RASP); remodeling activation

Online: 27 July 2022 (13:38:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0024.v1

Isolation and Purification of an Antibiotic Polyketide JBIR-99 from the Marine Fungus Meyerozyma guilliermondii by High-Speed Counter-Current Chromatography

Hankui Wu, Jianmin Liu, Ninghui Duan, Ru Han, Xinxin Zhang, Xiaoyu Leng, Wenjie Liu, Liwen Han, Xiaobin Li, Shu Xing, Yongchun Zhang, Mingyang Zhou

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: JBIR-99; high-speed counter-current chromatography; polyketide; NMR spectroscopy; mass spectroscopy; X-ray crystallography; Meyerozyma guilliermondii

Online: 2 September 2019 (11:20:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0118.v1

Chiral Dirhodium(II) Carboxylates: New Insights into the Effect of Ligand Stereo-Purity on Catalyst Structure and Enantioselectivity

Frady Gouany, Hannah Bollard, Michael Gardiner, Ashraf Ghanem

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Dirhodium(II) complexes; Rh2(S-PTTL)4; Asymmetric Catalysis; Cyclopropanation; X-Ray Crystallography; Chiral Catalysis

Online: 7 May 2018 (14:56:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202101.0181.v2

Lignins Isolated via Catalyst-free Organosolv Pulping from Miscanthus x giganteus, M. sinensis, M. robustus and M. nagara: A Comparative Study

Michel Bergs, Yulia Monakhova, Bernd Diehl, Christopher Konow, Goerg Völkering, Ralf Pude, Margit Schulze

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Miscanthus x giganteus; Miscanthus sinensis; Miscanthus robustus; Miscanthus nagara; lignin; monolignol ratio; low-input crops

Online: 25 January 2021 (14:51:06 CET)

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Abstract: As a low-input crop, Miscanthus offers numerous advantages that, in addition to agricultural applications, permits its exploitation for energy, fuel, and material production. Depending on the Miscanthus genotype, season, and harvest time as well as plant component (leaf versus stem), correlations between structure and properties of the corresponding isolated lignins differ. Here, a comparative study is presented between lignins isolated from M. x giganteus, M. sinensis, M. robustus and M. nagara using a catalyst-free organosolv pulping process. The lignins from different plant constituents are also compared regarding their similarities and differences regarding monolignol ratio and important linkages. Results showed that the plant genotype has the weakest influence on monolignol content and interunit linkages. In contrast, structural differences are more significant among lignins of different harvest time and/or season. Analyses were performed using fast and simple methods such as nuclear magnetic resonance (NMR) spectroscopy. Data was assigned to four different linkages (A: b-O-4 linkage, B: phenylcoumaran, C: resinol, D: b-unsaturated ester). In conclusion, A content is particularly high in leaf-derived lignins at just under 70 % and significantly lower in stem and mixture lignins at around 60 % and almost 65 %. The second most common linkage pattern is D in all isolated lignins, the proportion of which is also strongly dependent on the crop portion. Both stem and mixture lignins, have a relatively high share of approximately 20 % or more (maximum is M. sinensis Sin2 with over 30 %). In the leaf-derived lignins, the proportions are significantly lower on average. Stem samples should be chosen if the highest possible lignin content is desired, specifically from the M. x giganteus genotype, which revealed lignin contents up to 27 %. Due to the better frost resistance and higher stem stability, M. nagara offers some advantages compared to M. x giganteus. Miscanthus crops are shown to be very attractive lignocellulose feedstock (LCF) for second generation biorefineries and lignin generation in Europe.

Preprint REVIEW | doi:10.20944/preprints202110.0083.v1

Multilayer Reflective Coatings for BEUV Lithography: A Review

Paul C. Uzhoma, Salman Shabir, Huan Hu, Paul C. Okonkwo, Oleksiy V. Penkov

Subject: Physical Sciences, Condensed Matter Physics Keywords: BEUV lithography; Multilayer mirrors; X-ray optics; reflectivity

Online: 5 October 2021 (12:44:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0038.v1

Miscanthus x giganteus Stem versus Leaf-derived Lignins Differing in Monolignol Ratio and Linkage

Michel Bergs, Georg Völkering, Thorsten Kraska, Ralf Pude, Xuan Tung Do, Peter Kusch, Yulia Monakhova, Christopher Konow, Margit Schulze

Subject: Engineering, Bioengineering Keywords: biomass; chemometrics, genotype; HSQC NMR; lignin; Miscanthus X giganteus; monolignol ratio; principal component analysis

Online: 4 March 2019 (10:30:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201711.0003.v1

Wetland Mapping Using SAR Data from Sentinel-1A and TanDEM-X Missions: Comparative Study in the Biebrza Floodplain (Poland)

Magdalena Mleczko, Marek Mróz

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Sentinel-1A; TanDEM-X science phase; wetlands mapping

Online: 1 November 2017 (04:37:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0140.v1

Influence of Alkali Metal Substitution on the Phase Transition Behavior of CsGaQ2 (Q = S, Se)

Daniel Friedrich, Marc Schlosser, Martin Etter, Arno Pfitzner

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: chalcogenogallates; polymorphism; solid solutions; in situ X-ray diffraction; synchrotron radiation; rietveld refinement

Online: 20 October 2017 (12:53:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0331.v1

Coronavirus 2019 Infection in People with Associated Co-Morbidities: Case Fatality and ACE2 Inhibitors Treatment Concerns

Maryam Honardoost, Rokhsareh Aghili, Mohammad E. Khamseh

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; associated comorbidities; treatment; ACE2 inhibitors; Type 2 diabetes

Online: 19 April 2020 (05:42:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0164.v1

A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome

Pedram Shokouh, Per Bendix Jeppesen, Kjeld Hermansen, Natalja Nørskov, Christoffer Laustsen, Stephen Jacques Hamilton-Dutoit, Haiyun Qi, Hans Stødkilde-Jørgensen, Søren Gregersen

Subject: Biology And Life Sciences, Food Science And Technology Keywords: coffee; dietary supplements; metabolic syndrome X; non-alcoholic fatty liver disease; adiponectin; hyperpolarized magnetic resonance spectroscopy

Online: 27 October 2017 (02:32:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints201804.0063.v1

Probing Molecular Insights of Zika Virus-Host Interactions

Ina Lee, Sandra Bos, Ge Li, Shusheng Wang, Gilles Gadea, Philippe Despres, Richard Y. Zhao

Subject: Biology And Life Sciences, Virology Keywords: Zika virus; ZIKV-host interactions; viral pathogenesis; cell surface receptors; antiviral responses; viral counteraction; cytopathic effects; microcephaly; ZIKV-associated neurologic disorders

Online: 5 April 2018 (05:34:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0616.v2

Mechanical Properties and In-Situ Deformation Imaging of Micro-Lattices Manufactured by Laser Based Powder Bed Fusion

Anton du Plessis, Dean-Paul Kouprianoff, Ina Yadroitsava, Igor Yadroitsev

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: laser powder bed fusion; additive manufacturing; X-ray tomography; in-situ imaging; Ti6Al4V; lattice structures

Online: 30 August 2018 (06:12:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0081.v1

Relative Velocity Measurement with Spectrometer and Its Integrated Navigation

Zhonghua Wang, Yiming Peng, Jiu Liu

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: navigation; velocity measurement; X-ray pulsar; Mars explorer; formation flight

Online: 11 February 2018 (06:46:14 CET)

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Preprint REVIEW | doi:10.20944/preprints201806.0036.v1

Molecular Aspects of Varicella-Zoster Virus Latency

Daniel P. Depledge, Tomohiko Sadaoka, Werner J. D. Ouwendijk

Subject: Biology And Life Sciences, Virology Keywords: varicella-zoster virus; latency; reactivation; sensory ganglia; VZV latency-associated transcript; open reading frame 63; RNA-sequencing; epigenetics; immunity

Online: 4 June 2018 (11:49:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0236.v2

Specificity of Escherichia coli Heat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and Crystallography

Julie E. Heggelund, Joel B. Heim, Gregor Bajc, Vesna Hodnik, Gregor Anderluh, Ute Krengel

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: bacterial toxin; cholera toxin; Escherichia coli heat-labile enterotoxin; lectin; N-acetyllactosamine binding; neutral glycosphingolipids; protein-carbohydrate interactions; surface plasmon resonance spectroscopy; X-ray crystal structure

Online: 28 January 2019 (15:23:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201903.0097.v1

Synthesis and Characterization of Te Nanotubes Decorated with Pt Nanoparticles for Fuel Cell Anode/Cathode Working at Neutral pH

Maria Rachele Guascito, Daniela Chirizzi, Emanuela Filippo, Francesco Milano, Antonio Tepore

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Te nanotubes decorated with Pt nanoparticles; fuel cell neutral pH; oxygen reduction reaction; methanol oxidation reaction; X-ray photoelectron spectroscopy.

Online: 7 March 2019 (13:49:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0591.v1

A CNN Classification Model For Diagnosis Covid19

Ahmed Abdullah Farid, hatem khater, gamal selim

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Bacterial -Viral Pneumonia; COVID-19; X-ray Image; Deep Learning; Convolution Neural Network

Online: 24 July 2020 (14:02:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0204.v1

Formation of Deformation-Induced Products in a Metastable β-titanium Alloy during High Temperature Compression

Alireza Samiee, Gilberto Casillas, Mansur Ahmed, Dmytro G. Savvakin, Ryan Naseri, Elena Pereloma

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: metastable Ti alloy; high temperature deformation; stress-induced ω; stress-induced α˝ martensite; transmission electron microscopy; slip; X-ray diffraction.

Online: 22 January 2018 (17:17:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0149.v1

Supramolecular Organogels Based on N-Benzyl, N’-Acylbispidinols

Alexey Medved'ko, Alexander Dalinger, Vyacheslav Nuriev, Vera Semashko, Andrei Filatov, Alexander Ezhov, Andrei Churakov, Judith A. K. Howard, Andrey Shiryaev, Alexander Baranchikov, Vladimir Ivanov, Sergey Vatsadze

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Organic nanomaterials, bispidines; supramolecular gels; SEM, TEM, AFM study; X-ray diffraction; FT IR-spectroscopy; ATR-spectroscopy; SAXS

Online: 12 December 2018 (13:06:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0085.v1

Synthesis, Characterization, and Crystal Structure Determination of a New Lithium Zinc Iodate Polymorph LiZn(IO₃)₃

Zoulikha Hebboul, Christine Galez, Djamal Benbertal, Sandrine Beauquis, Yannick Mugnier, Abdelnour Benmakhlouf, Mohamed Bouchenafa, Daniel Errandonea

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: iodate; crystal structure; x-ray diffraction; density functional theory; infrared absorption

Online: 7 August 2019 (03:42:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0500.v1

Clinical and Structural Biological Studies of Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines

Mei-Yun Cheng, Hsuan-Chen Ho, Jung-Lung Hsu, Yi Wang, Lin-Yi Chen, Ming-Feng Liao, Long-Sun Ro

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Acute disseminated encephalomyelitis; Central nervous system inflammatory demyelinating diseases; COVID-19 vaccines; Myelin oligodendrocyte glycoprotein antibody-associated disease; Neuromyelitis optica spectrum disorders; Transverse myelitis

Online: 8 February 2024 (08:43:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0139.v1

CD15 and CD15s in The Anticancer Therapy

Wojciech Szlasa, Karol Wilk, Klaudia Knecht-Gurwin, Adam Gurwin, Anita Froń, Natalia Sauer, Jolanta Saczko, Tomasz Szydełko, Julita Kulbacka, Bartosz Małkiewicz

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CD15; Lewis X; Lex; Cancer; Therapy

Online: 10 March 2022 (04:15:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0443.v1

Welding of Copper to Aluminium With Laser Beam Wavelength of 515 nm

Karthik Mathivanan, Peter Plapper

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Laser welding; Cu-Al welding; green laser; Micro-structure analysis; Energy dispersive X-ray spectroscopy (EDS))

Online: 23 August 2021 (13:28:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0225.v1

Use of GeneXpert and the Role of an Expert Panel in Improving Clinical Diagnosis of Smear-Negative Tuberculosis Cases

Jovilia Abong, Victoria Dalay, Ivor Langley, Ewan Tomeny, Danaida Marcelo, Victor Mendoza, Anna Marie Celina Garfin, S. Bertel Squire, Charles Yu

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: GeneXpert; TB Expert Panel; Smear Negatives; Clinically Diagnosed TB; TB DOTS; Chest X-ray

Online: 17 May 2019 (11:18:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0163.v1

Shaping Light in Backward-Wave Nonlinear Hyperbolic Metamaterials

Alexander K. Popov, Sergey A. Myslivets, Vitaly V. Slabko, Victor A. Tkachenko, Thomas F. George

Subject: Physical Sciences, Optics And Photonics Keywords: optical metamaterials; fundamental concepts in photonics; light-matter interactions at the subwavelength and nanoscale; fundamental understanding of linear and nonlinear optical processes in novel metamaterials underpinning photonic devices and components; advancing the frontier of nanophotonics with the associated nanoscience and nanotechnology; nanostructures that can serve as building blocks for nano-optical systems; use of nanotechnology in photonics; nonlinear nanophotonics, plasmonics and excitonics; subwavelength components and negative index materials; slowing, store, and processing light pulses; materials with such capabilities that could be used for optical sensing, tunable optical delay lines, optical buffers, high extinction optical switches, novel image processing hardware, and highly-efficient wavelength converters

Online: 26 February 2018 (11:24:39 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202109.0015.v1

HIV Prevalence and Risk Factors for Infants Born to Mothers on Arv Treatment at CHUB/Rwanda

Bernard Nsengimana, Francois Nkurunziza, Wivine Mudahigwa Ntaganira, Ruth Uzayisenga, Gad Rutayisire

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Rwanda; Risk associated MTCT; HIV-exposed infants

Online: 1 September 2021 (12:18:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0022.v1

Facile Low Temperature Hydrothermal Synthesis of BaTiO₃ Nanoparticles Studied by In Situ X-ray Diffraction

Ola Gjoennes Grendal, Anders Bank Blichfeld, Susanne Linn Skjarvø, Wouter van Beek, Sverre Magnus Selbach, Tor Grande, Mari-Ann Einarsrud

Subject: Chemistry And Materials Science, Nanotechnology Keywords: BaTiO3; hydrothermal synthesis; in situ; X-ray diffraction; nanoparticles

Online: 2 May 2018 (11:25:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0029.v2

Incidence and Determinants of Health Care Associated Blood Stream Infection at a Neonatal Intensive Care Unit in Ujjain, India: A Prospective Cohort Study

Mamta Dhaneria, Sachin Jain, Poonam Singh, Aditya Mathur, Cecilia Stålsby Lundborg, Ashish Pathak

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: blood stream health care associated infections; neonates; risk factors, antibiotic use, antibiotic resistance; neonatal intensive care unit; India

Online: 30 January 2018 (08:03:04 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0281.v1

The Role of Apoptotic Signaling in Axon Guidance

Riley Kellermeyer, Leah M. Heydman, Grant S. Mastick, Thomas Kidd

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: axon guidance; growth cone; cytoskeleton; caspases; apoptosis; signal integration; basal level of caspase activity; death associated inhibitor of apoptosis; axon branching; Netrin; DCC; frazzled; slit; robo; Drosophila

Online: 16 September 2018 (09:43:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0274.v1

Effect of Recycled Ceramic Waste Content on the Properties of Unsaturated Polyester Resin

Mohamed Farsane, Abdellah Anouar, Souad Chah, Miloudi Bouzziri

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: ceramic waste particles; unsaturated polyester resin; X-ray diffraction; water absorption; thermal degradation; curing process

Online: 20 December 2019 (11:08:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202001.0203.v1

Mechanisms and Regulation of Nonsense-Mediated mRNA Decay and Nonsense-Associated Altered Splicing in Lymphoid Cells

Jean-Marie Lambert, Mohamad Omar Ashi, Nivine Srour, Laurent Delpy, Jérôme Saulière

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: immunoglobulin (Ig); nonsense-mediated mRNA decay (NMD); nonsense-associated altered splicing (NAS); B lymphocytes; plasma cells

Online: 18 January 2020 (10:21:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0710.v1

Virtual Asphalt to Predict Roads’ Air Voids and Hydraulic Conductivity

Mustafa Aboufoul, Andrea Chiarelli, Isaac Triguero, Alvaro Garcia

Subject: Engineering, Civil Engineering Keywords: computational design; optimisation; porosity; pore networks; X-ray CT; 3D printing

Online: 30 October 2018 (07:27:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0271.v1

Blackcurrant Leaf Chlorosis Associated Virus: Next-Generation Sequencing Reveals an Extraordinary Virus with Multiple Genomic Components Including Evidence of Circular RNA

Delano James, James Phelan, Daniel Sanderson

Subject: Biology And Life Sciences, Plant Sciences Keywords: Idaeovirus; Blackcurrant leaf chlorosis associated virus; next-generation sequencing (NGS); bridge reads; abutting primers; RNase R digestion; circular RNA; concatenated RNA

Online: 30 March 2018 (11:40:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0374.v1

Preclinical Evidence of STAT3 Inhibitor, Pacritinib, Overcomes Temozolomide Resistance via Down-Regulating miR-21-enriched Exosomes from M2 Glioblastoma-Associated Macrophages

Hao-Yu Chuang, Yu-kai Su, Heng-Wei Liu, Chao-Hsuan Chen, Shao-Chih Chiu, Der-Yang Cho, Shinn-Zong Lin, Yueh-Sheng Chen, Chien-Min Lin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Keywords: Tumor microenvironment (TME), glioblastoma multiforme (GBM), GBM- associated macrophages (GAMs), exosomes, oncomiR-21, STAT3 inhibitor.

Online: 31 May 2019 (08:18:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0110.v1

In Situ SAXS Measurement and Molecular Dynamics Simulation of Magnetic Alignment of Hexagonal LLC Nanostructures

Weiwei Cong, Weimin Gao, Christopher Garvey, Ludo Dumee, Juan Zhang, Ben Kent, Guang Wang, Fenghua She, Lingxue Kong

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Alignment, Magnetic field, Hexagonal, Lyotropic liquid crystals, Nanofiltration, in situ small angle X-ray scattering (SAXS)

Online: 5 October 2018 (16:33:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0156.v1

Strain and Grain Size of CeO₂ and TiO₂ Nanoparticles: Comparing Structural and Morphological Methods

Yamerson Canchanya-Huaman, Angie F. Mayta-Armas, Jemina Pomalaya-Velasco, Yéssica Bendezú-Roca, Jorge Andres Guerra, Juan A. Ramos-Guivar

Subject: Chemistry And Materials Science, Biomaterials Keywords: X-ray diffraction; CeO2; TiO2; crystallite size; strain; TEM; μ-Raman

Online: 7 June 2021 (09:25:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0182.v1

Physiological and Agronomic Strategies to Increase Mungbean Yield in Climatically Variable Environments of Northern Australia

Yashvir S. Chauhan, Rex Williams

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Vigna radiata (L.) Wilczek; G x E interaction; Improvement; Model; Yield; Yield traits

Online: 11 May 2018 (15:46:43 CEST)

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Mungbean [Vigna radiata (L.) Wilczek] in Australia has been transformed from a niche opportunistic crop into a major summer cropping option for dryland growers in the summer-dominant rainfall regions of Queensland and New South Wales. This transformation followed stepwise genetic improvements in both grain yields and disease resistance. For example, more recent cultivars such as ‘Crystal’, ‘Satin II’ and ‘Jade-AU‘ have provided up to a 20% yield advantage over initial introductions. Improved agronomic management to enable mechanised management and cultivation in narrow (<50 cm) rows has further promised to increase yields. Nevertheless, average yields achieved by growers for their mungbean crops remain less than 1 t/ha, and are much more variable than other broad acre crops. Further increases in yield and crop resilience in mungbean are vital. In this review, opportunities to improve mungbean have been analysed at four key levels including phenology, leaf area development, dry matter accumulation and its partitioning into grain yield. Improving the prediction of phenology in mungbean may provide further scope for genetic improvements that better match crop duration to the characteristics of target environments. There is also scope to improve grain yields by increasing dry matter production through the development of more efficient leaf canopies. This may introduce additional production risks as dry matter production depends on the amount of available water, which varies considerably within and across growing regions in Australia. Improving crop yields by exploiting photo-thermal sensitivities to increase dry matter is likely a less risky strategy for these variable environments. Improved characterisation of growing environments using modelling approaches could also better define and identify the risks of major abiotic constraints. This would assist in optimising breeding and management strategies to increase grain yield and crop resilience in mungbean for the benefit of growers and industry.

Preprint ARTICLE | doi:10.20944/preprints202107.0566.v2

Degradation Analysis of Thin Mg-xAg Wires Using X-Ray Near-Field Holotomography

Sebastian Meyer, Andreas Wolf, Daniela Sanders, Kamila Iskhakova, Hanna Ćwieka, Stefan Bruns, Silja Flenner, Imke Greving, Johannes Hagemann, Regine Willumeit-Römer, Björn Wiese, Berit Zeller-Plumhoff

Subject: Chemistry And Materials Science, Biomaterials Keywords: X-ray computed tomography; magnesium-silver alloy; wire; degradation; near-field holotomography

Online: 8 December 2021 (14:26:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0340.v1

Dialectical GAN for SAR Image Translation: From Sentinel-1 to TerraSAR-X

Dongyang Ao, Corneliu Octavian Dumitru, Gottfried Schwarz, Mihai Datcu

Subject: Engineering, Electrical And Electronic Engineering Keywords: dialectical generative adversarial network; image translation; Sentinel-1; TerraSAR-X

Online: 19 July 2018 (04:46:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0314.v1

Comprehensive Analysis of Hepatitis B Virus Promoter Region Mutations

Vanessa Meier-Stephenson, William T.R. Bremner, Chimone S. Dalton, Guido van Merle, Carla Coffin, Trushar R. Patel

Subject: Biology And Life Sciences, Virology Keywords: hepatitis B virus (HBV); cccDNA; basal core promoter; X promoter; single nucleotide polymorphisms; logo analyses; genotype alignments

Online: 15 October 2018 (13:03:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0095.v1

Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin

Suresh Banjara, Gareth Shimmon, Linda Dixon, Christopher Netherton, Mark Hinds, Marc Kvansakul

Subject: Biology And Life Sciences, Virology Keywords: Autophagy, Bcl-2, Beclin, ASFV, X-ray crystallography

Online: 7 August 2019 (10:10:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0196.v1

TiO_2-x/TiO₂-Structure Based ‘Self-Heated’ Sensor for the Determination of Some Reducing Gases

Simonas Ramanavicius, Alla Tereshchenko, Renata Karpic, Vilma Ratautate, Urte Bubniene, Andrius Maneikis, Arunas Jagminas, Arunas Ramanavicius

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: nonstoichiometric titanium oxides; TiO2-x/TiO2; Ti3O5/TiO2; photoluminescence; anatase; rutile; sensor for reducing gases

Online: 15 December 2019 (15:22:14 CET)

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Preprint REVIEW | doi:10.20944/preprints201904.0209.v1

The Immunosuppressive Microenvironment of Classic Hodgkin Lymphoma and Therapeutic Approaches to Counter It

Donatella Aldinucci, Cinzia Borghese, Naike Casagrande

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Hodgkin lymphoma; tumor microenvironment; immune escape; tumor-associated macrophages

Online: 18 April 2019 (08:14:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0168.v1

An Affordable Image Detector and a Low-Cost Evaluation System for Computed Tomography Using Neutrons, X-Rays or Visible Light

Burkhard Schillinger

Subject: Physical Sciences, Radiation And Radiography Keywords: neutron imaging; neutron detector; X-ray detector; CCD camera; CMOS camera; collimator; X-rays; image processing; computed tomography; CT reconstruction

Online: 15 October 2019 (11:15:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0186.v1

Roles of Extracellular Vesicles (EVs) Carrying HSPs in Cancer Biomarkers, Immune Surveillance, and Immune Evasion

Eman Taha, Kisho Ono, Takanori Eguchi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: heat shock protein (HSP); extracellular vesicle (EV); exosome; oncosome; immune evasion; resistance-associated secretory phenotype (RASP); EMT; hypoxia; biomarker; liquid biopsy

Online: 17 August 2019 (16:15:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0294.v1

P^N bridged Cu(I) Dimers Featuring both TADF and Phosphorescence. From Overview Towards Detailed Case Study of the Excited Singlet and Triplet States.

Thomas Hofbeck, Thomas A. Niehaus, Michel Fleck, Uwe Monkowius, Hartmut Yersin

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Dimeric copper(I) complexes; PN phosphine ligands; X-ray structures; Combined thermally activated delayed fluorescence (TADF) and phosphorescence; Combined singlet and triplet harvesting; High emission quantum yields; Tunability of photophysical properties; Zero-field splitting (ZFS), Spin-lattice relaxation (SLR); Triplet substate decay components.

Online: 12 April 2021 (12:41:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0542.v1

Effect of Heat Stress on Yield, Monoterpene Content and Antibacterial Activity of Essential Oils of Mentha X Piperita Var. Mitcham and Mentha Arvensis Var. Piperascens

Milad Heydari, Anna Zanfardino, Alireza Taleei, Ali Akbar Shah-NejatBoushehri, Javad Hadian, Viviana Maresca, Sergio Sorbo, Michela Di Napoli, Mario Varcamonti, Adriana Basile, Daniela Rigano

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Mentha x piperita; Mentha x arvensis; essential oils; heat stress; antibacterial activity; monoterpenes

Online: 27 July 2018 (14:04:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0380.v1

A Model for Characteristic X-Ray Emission in Electron Probe Microanalysis based on the Spherical Harmonic (PN) Method for Electron Transport

Jonas Buenger, Silvia Richter, Manuel Torrilhon

Subject: Chemistry And Materials Science, Biomaterials Keywords: EPMA; deterministic electron transport; k-ratio; moment method; spherical harmonic (PN) approximation; characteristic X-Ray emission

Online: 19 January 2021 (13:20:53 CET)

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