Version 1
: Received: 20 December 2016 / Approved: 21 December 2016 / Online: 21 December 2016 (11:01:58 CET)
How to cite:
Zhou, J.; Yan, M.; Shi, M.; Xu, J.; Shangguan, G. The Synthesis and New Crystal Structures of Three Arylpiperazine Compounds. Preprints2016, 2016120110. https://doi.org/10.20944/preprints201612.0110.v1.
Zhou, J.; Yan, M.; Shi, M.; Xu, J.; Shangguan, G. The Synthesis and New Crystal Structures of Three Arylpiperazine Compounds. Preprints 2016, 2016120110. https://doi.org/10.20944/preprints201612.0110.v1.
Cite as:
Zhou, J.; Yan, M.; Shi, M.; Xu, J.; Shangguan, G. The Synthesis and New Crystal Structures of Three Arylpiperazine Compounds. Preprints2016, 2016120110. https://doi.org/10.20944/preprints201612.0110.v1.
Zhou, J.; Yan, M.; Shi, M.; Xu, J.; Shangguan, G. The Synthesis and New Crystal Structures of Three Arylpiperazine Compounds. Preprints 2016, 2016120110. https://doi.org/10.20944/preprints201612.0110.v1.
Abstract
The structure of arylpiperazine moieties as an important pharmacophore could generate wide pharmacological activities．Arylpiperazine derivatives referred in this paper possessed antitumor activity. The title compounds were crystallized by slow evaporation. 2-(4-(2-(4-Phenylpiperazin-1-yl)ethyl)benzyl)isoindoline-1,3-dione(1), 2-(4-(2-(4-(4-Bromophenyl)piperazin-1-yl)ethyl)benzyl)isoindoline-1,3-dione (2) and 2-(4-(2-(4-(4-Chlorophenyl)piperazin-1-yl)ethyl)benzyl)isoindoline-1,3-dione (3) crystallizes in the triclinic space group P-1 with two molecules in the unit cell. The unit cell parameters for 1 are a = 6.9159(14) Å, b = 9.999(2) Å, c = 16.925(3) Å, α = 88.25(3)°, β = 85.14(3) °, γ = 79.22(3) °. The unit cell parameters for 2 are a = 6.9995(14) Å, b = 9.919(2) Å, c = 17.671(4) Å, α= 97.55(3)°, β = 92.19(3) °, γ = 102.23(3) °. The unit cell parameters for 1 are a = 6.9872(14) Å, b = 9.863(2) Å, c = 17.557(4) Å, α=96.81(3)°, β = 91.89(3) °, γ = 101.74(3) °. Pi-pi interactions were observed between molecules, and compound 2 and 3 showed halogen interactions between molecules nearby, which was different from compound 1.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
