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Preprint ARTICLE | doi:10.20944/preprints201810.0359.v1

Chlorpyrifos- and Dichorfos-Induced Oxidative and Neurogenic Damage Elicits Neuro-Cognitive Deficits and Increases Anxiety-Like Behaviors in Wild-Type Rats

Aminu Imam, Nafeesah Abdulkareem Sulaiman, Aboyeji Lukuman Oyewole, Samson Chengetanai, Victoria Williams, Musa Iyiola Ajibola, Royhaan Olamide Folarin, Asma'u Shehu Muhammad, Sheu-Tijani Toyin Shittu, Salihu Moyosore Ajao

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: oxidative damage; organophosphates; neurotoxicity; spatial working memory; anxiety-related behaviors

Online: 16 October 2018 (12:04:13 CEST)

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The mechanization of agricultural activities has led to indiscriminate deposition of toxic xenobiotics, including organophosphates in the biomes, and this has led to intoxication characterized with deleterious oxidative and neuronal changes. This study investigated the consequences of oxidative and neurogenic disruptions that follow exposure to two organophosphates, chlorpyrifos (CPF) and dichlorvos (DDVP) on neuro-cognitive performance and anxiety-like behaviors in rats Thirty-two adult male Wistar rats (150 – 170g) were randomly divided into 4 groups, orally exposed to normal saline (NS), DDVP (8.8mg/kg), CPF (14.9mg/kg) and DDVP+CPF for 14 consecutive days. On day 10 of exposures, anxiety-like behaviors and amygdala dependent fear learning were assessed using Open Field and Elevated Plus Maze paradigms respectively, while spatial working memory was assessed on day 14 in the Morris water maze paradigm, following 3 training trials each on days 11, 12 and 13. On day 15, the rats were euthanized, and their brains excised, hippocampus and amygdala removed, 5 of which were homogenized and centrifuged to analyze nitric oxide (NO) metabolites, total reactive oxygen species (ROS), and acetylcholinesterase (AChE) activity, and the other three processed for histology (cresyl violet stain) and proliferative marker (Ki67 immunohistochemistry). Marked (p≤0.05) loss in body weight, AChE depletion, and overproduction of both NO and ROS were observed after repeated exposure to individual and combined doses of CPF and DDVP. Insults from DDVP exposure appeared more severe owing to the observed greater losses in the body weights of exposed rats. There was also a significant (p≤0.05) effect on the cognitive behaviors recorded from the exposed rats, and these deficits were related to the oxidative damage and neurogenic cell loss in the hippocampus and the amygdala of the exposed rats. Taken together, these results provided an insight that oxidative and neurogenic damages are central to the severity of neuro-cognitive dysfunction and increased anxiety-like behaviors that follow organophosphate poisoning.

Preprint REVIEW | doi:10.20944/preprints202307.0304.v1

Lipofuscin, Its Origin, Properties, and Contribution to Retinal Fluorescence as a Potential Biomarker of Oxidative Damage to the Retina

Malgorzata B. Rozanowska

Subject: Medicine And Pharmacology, Ophthalmology Keywords: lipofuscin; retina; fundus autofluorescence; fluorescence imaging; oxidative stress; photooxida-tion; oxidation; biomarker; age-related macular degeneration

Online: 5 July 2023 (10:42:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0335.v1

Socio-Moral Development of Preschool Children: Aspects of Theory and Practice

Evgenia Korotaeva, Irina Chugaeva

Subject: Social Sciences, Psychology Keywords: social and moral education; preschool age; communitarian approach

Online: 27 November 2019 (08:46:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0565.v1

Aberrant Epigenetic Regulation in Head and Neck Cancer Due to Distinct EZH2 Overexpression and DNA Hypermethylation

Daiki Mochizuki, Yuki Misawa, Hideya Kawasaki, Atsushi Imai, Shiori Endo, Masato Mima, Satoshi Yamada, Takuya Nakagawa, Takeharu Kanazawa, Kiyoshi Misawa

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: EZH2; epigenetic regulation; DZNep; tumor-related genes; head and neck cancer

Online: 24 October 2018 (10:34:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0536.v1

“What a Mobility-Limited World”: Design Requirements of an Age-Friendly Playable City

Liliana Vale Costa, Ana Isabel Veloso, Michael Loizou, Sylvester Arnab, Richard Tomlins, Arun Sukumar

Subject: Social Sciences, Urban Studies And Planning Keywords: playable city; age-friendly environments; games; mobility; active ageing

Online: 23 October 2018 (10:11:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0015.v1

Knut Brockow, Katarzyna Plata-Nazar, Magdalena Lange, Bogusław Nedoszytko, Marek Niedoszytko, Peter Valent

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: mast cells; mastocytosis; mediator-related symptoms; anaphylaxis; children

Online: 1 February 2021 (11:36:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0029.v1

Gender, Age, Year of Course and Faculty: Factors Influencing the Risk of Eating Disorders

María-Camino Escolar-Llamazares, María-Ángeles Martínez-Martín, María-Begoña Medina-Gómez, María-Yolanda González-Alonso, Elvira Mercado-Val, Fernando Lara-Ortega

Subject: Social Sciences, Psychology Keywords: eating disorder; gender; age; university degree

Online: 1 February 2021 (12:58:08 CET)

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Working Paper ARTICLE

Where Freshness Matters in the Control Loop: Mixed Age-of-Information and Event-based Co-design for Multi-loop Networked Control Systems

Mohammad H. Mamduhi, Jaya Prakash Champati, James Gross, Karl H. Johansson

Subject: Engineering, Electrical And Electronic Engineering Keywords: networked control systems; age-of-information; event-triggered sampling; scheduling architecture; resource constraint; asymptotic performance; estimation error

Online: 12 July 2020 (11:36:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0121.v1

Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework

Laure-Alix Clerbaux, Maria Cristina Albertini, Núria Amigó, Anna Beronius, Gillina F.G. Bezemer, Sandra Coecke, Evangelos P. Daskalopoulos, Giusy Del Giudice, Dario Greco, Lucia Grenga, Alberto Mantovani, Amalia Muñoz, Elma Omeragic, Nikolaos Parissis, Mauro Petrillo, Laura A. Saarimäki, Helena Soares, Kristie Sullivan, Brigitte Landesmann

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: SARS-CoV-2 infection; COVID-19; modulating factors; Adverse Outcome Pathway; sex; age; co-morbidities; lifestyle; environment; pre-existing conditions

Online: 8 June 2022 (09:47:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0459.v1

User Monitoring in Autonomous Driving System Using Gamified Task: A Case for vr/AR in-Car Gaming

Joseph K. Muguro, Pringgo Widyo Laksono, Yuta Sasatake, Kojiro Matsushita, Minoru Sasaki

Subject: Engineering, Automotive Engineering Keywords: Autonomous Driving System; In-Car Gaming; Driver Behavior; Driving Related Tasks; 3D-VR/AR

Online: 17 June 2021 (12:29:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0589.v1

Compaction Model for Shale in Differences of Geological Ages Using A 3D Empirical Relationship in Northeastern Thailand

Avirut Puttiwongrak, Syukratun Nufus, Chaiyaphruk Bunprasert, Pham Huy Giao, Sakanann Vann, Thongchai Suteerasak, Nophea Sasaki

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Shale compaction; Geological age; Thailand shale; Compaction model; Standard curve

Online: 21 April 2021 (16:50:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0383.v1

Order Effects in the Perception and Production of New Words

Peter Richtsmeier, Michelle Moore

Subject: Social Sciences, Psychology Keywords: child speech; speech production; speech perception; learning; consonant age of acquisition

Online: 24 May 2020 (16:07:44 CEST)

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Purpose: Perceptual learning and production practice are basic mechanisms that children depend on to acquire adult levels of speech accuracy. In this study, we examined perceptual learning and production practice as they contributed to changes in speech accuracy in three- and four-year-old children. Our primary focus was manipulating the order of perceptual learning and baseline production practice to better understand when and how these learning mechanisms interact. Method: Sixty-five typically-developing children between the ages of three and four were included in the study. Children were asked to produce CVCCVC nonwords like /bozjəm/ and /tʌvtʃəp/ that were described as the names of make-believe animals. All children completed two separate experimental blocks: a baseline block in which participants heard each nonword once and repeated it, and a test block in which the perceptual input frequency of each nonword varied between 1 and 10. Half of the participants completed a baseline-test order; half completed a test-baseline order. Results: Greater accuracy was observed for nonwords produced in the second experimental block, reflecting a production practice effect. Perceptual learning resulted in greater accuracy during the test for nonwords that participants heard 3 or more times. However, perceptual learning did not carry over to baseline productions in the test-baseline design, suggesting that it reflects a kind of temporary priming. Finally, a post hoc analysis suggested that the size of the production practice effect depended on the age of acquisition of the consonants that comprised the nonwords. Conclusions: The study provides new details about how perceptual learning and production practice interact with each other and with phonological aspects of the nonwords, resulting in complex effects on speech accuracy and learning of form-referent pairs. These findings may ultimately help speech-language pathologists maximize their clients’ improvement in therapy.

Preprint REVIEW | doi:10.20944/preprints201901.0039.v1

Prevention of Hearing Loss by Alteration of the Systemic Immune System

Hiroshi Iwai, Muneo Inaba

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: autoimmune sensorineural hearing loss; age-related sensorineural hearing loss; inflammation, immune senescence; interleukin 1 receptor type II -positive T cells; naturally occurring regulatory T cells; immune rejuvenation; thymus

Online: 4 January 2019 (11:37:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0532.v3

Examining the Role of the Noradrenergic Locus Coeruleus for 2 Predicting Attention and Brain Maintenance in Healthy Old Age 3 and Disease: An MRI Structural Study for the Alzheimer’s Disease 4 Neuroimaging Initiative

Emanuele Raffaele Giuliano Plini, Erik O'Hanlon, Rory Boyle, Francesca Sibilia, Gaia Rikhye, Joanne Kenney, Robert Whelan, Michael Christopher Melnychuk, Ian Hamilton Robertson, Paul Michael Dockree

Subject: Social Sciences, Psychology Keywords: Locus Coeruleus; Reserve; Brain Age; Visual Attention; Alzheimer’s Disease; Mild Cognitive Impairment; normal Aging; Neuroimaging; Voxel Based Morphometry

Online: 21 June 2021 (11:41:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0209.v1

Green and Healthy —Age Effects in Use and Perception of Urban Green Spaces and their Impact on Personal Health and Well-being during COVID-19 Pandemic

Karolina Taczanowska, Donna Tansil, Jacqueline Wilfer, Alexandra Jiricka-Pürrer

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Urban green areas; health; urban health; emotional health; physical health; well-being; nature; environmental medicine; COVID-19; SARS-CoV-2 pandemic; Vienna; Austria, environmental perception; pandemic; human nature relationship; recreation; age

Online: 14 September 2022 (12:08:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0208.v1

Educating Digital Citizens on Sustainable Development Goals

Antonia Lozano-Díaz, Juan S. Fernández-Prados

Subject: Social Sciences, Education Keywords: Sustainable Development Goals; 2030 Agenda; digital citizenship; cyberactivism; syllabus-related sustainability; social justice

Online: 8 August 2020 (17:22:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0332.v1

Malnutrition in Infants Aged under 6 Months Attending Community Health Centres: A Cross Sectional Survey

Carlos S. Grijalva-Eternod, Emma Beaumont, Ritu Rana, Nahom Abate, Hatty Barthorp, Marie McGrath, Ayenew Negesse, Mubarek Abera, Alemseged Abdissa, Tsinuel Girma, Elizabeth Allen, Marko Kerac, Melkamu Berhane

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Anthropometric deficit; infants under 6 months; malnutrition; weight-for-age; the Composite Index of Anthropometric Failure; MAMI; Ethiopia

Online: 14 June 2021 (08:31:54 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201810.0527.v1

Cross-Modal Priming Effect of Rhythm on Visual Word Recognition and Its Relationships to Music Aptitude and Reading Achievement

Tess S. Fotidzis, Heechun Moon, Jessica R. Steele, Cyrille L. Magne

Subject: Social Sciences, Cognitive Science Keywords: implicit prosody; rhythm sensitivity; event related potentials; reading achievement; musical aptitude

Online: 23 October 2018 (08:30:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0379.v1

Post-Transplant Lymphoproliferative Diseases in the Elderly after Cardiac Transplantation: The Diagnostic Role of [18f] FDG-PET With Co-Registered CT and the Effect of Sports Activity Rehabilitation Program

Antonello Sica, Maria Luisa de Rimini, Beniamino Casale, Caterina Sagnelli, Alessandro Spada, Alfonso Reginelli, Armando Calogero, Cristiano Amarelli, Ciro Maiello, Evangelista Sagnelli, Maria Paola Belfiore, Salvatore Cappabianca

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: post-transplant lymphoproliferative disorder; FDG-PET/CT; elder age; physical activity

Online: 29 December 2019 (10:37:20 CET)

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Working Paper REVIEW

Effectiveness of Chitosan as a Dietary Supplement in Lowering Cholesterol in Murine Models: A Meta-analysis

Sung-Il Ahn, Sangbuem Cho, Nag-Jin Choi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: meta-analysis; chitosan; lifestyle-related disease; cholesterol lowering

Online: 18 November 2020 (10:59:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0283.v1

Concentrations of C-Reative Protein and Leukocytes as Predictors of Adverse Health Factors in the Period of 30 Days Post-Hospital Discharge

Nayara Araújo dos Reis, Rosalina Aparecida Partezani Rodrigues, Darlene Mara dos Santos Tavares, Jack Roberto Silva Fhon, Jair Sindra Virtuoso Júnior

Subject: Medicine And Pharmacology, Hematology Keywords: chronic inflammation; biomarker panels; leukocyte count; C-reactive protein; related syndromes and pathologies; risk assessment; screening programmes; ageing; elderly's health

Online: 25 October 2019 (04:16:43 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202011.0720.v1

Aline Rangel-Pozzo, Tinuccia Dettori, Daniela Virginia Frau, John Gartner, Garbor Fisher, Roberta Vanni, Sabine Mai, Paola Caria

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Papillary thyroid cancer; noninvasive follicular thyroid neoplasm with papillary-like nuclear features; follicular adenoma; telomere-related genomic instability

Online: 30 November 2020 (11:37:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0289.v1

Latitudinal and Cross-Shelf Patterns of Size, Growth and Mortality of a Tropical Damselfish Acanthochromis polyacanthus on the Great Barrier Reef

Michael Kingsford, David Welch, Mark O'Callaghan

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: reef fish, age, growth, mortality, Great Barrier Reef, Pomacentridae, cross-shelf, MPA, latitudinal gradients.

Online: 24 December 2018 (15:36:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0255.v1

Canopy Top, Height and Photosynthetic Pigment Estimation Using Parrot Sequoia Multispectral Imagery and the Unmanned Aerial Vehicle (UAV): Norway Spruce Forest Case Study

Veronika Kopačková-Strnadová, Lucie Koucká, Jan Jelenek, Zuzana Lhotakova, Filip Oulehle

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: UAV; Parrot Sequoia multispectral camera; photosynthetic pigments; Norway spruce; forest; linear models; ground truth; needle age; crown detection

Online: 13 January 2021 (14:52:06 CET)

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Remote sensing is one of the modern methods that have significantly developed over the last two decades and nowadays provides a new means for forest monitoring. High spatial and temporal resolutions are demanded for accurate and timely monitoring of forests. In this study multi-spectral Unmanned Aerial Vehicle (UAV) images were used to estimate canopy parameters (definition of crown extent, top and height as well as photosynthetic pigment contents). The UAV images in Green, Red, Red-Edge and NIR bands were acquired by Parrot Sequoia camera over selected sites in two small catchments (Czech Republic) covered dominantly by Norway spruce monocultures. Individual tree extents, together with tree tops and heights, were derived from the Canopy Height Model (CHM). In addition, the following were tested i) to what extent can the linear relationship be established between selected vegetation indexes (NDVI and NDVIred edge) derived for individual trees and the corresponding ground truth (e.g., biochemically assessed needle photosynthetic pigment contents), and ii) whether needle age selection as a ground truth and crown light conditions affect the validity of linear models. The results of the conducted statistical analysis show that the two vegetation indexes (NDVI and NDVIred edge) tested here have a potential to assess photosynthetic pigments in Norway spruce forests at a semi-quantitative level, however the needle-age selection as a ground truth was revealed to be a very important factor. The only usable results were obtained for linear models when using the 2nd year needle pigment contents as a ground truth. On the other hand, the illumination conditions of the crown proved to have very little effect on the model’s validity. No study was found to directly compare these results conducted on coniferous forest stands. This shows that there is a further need for studies dealing with a quantitative estimation of the biochemical variables of nature coniferous forests when employing spectral data acquired by the UAV platform at a very high spatial resolution.

Preprint ARTICLE | doi:10.20944/preprints202010.0052.v1

Predicting SARS-CoV-2 Weather-Induced Seasonal Virulence from Atmospheric Air Enthalpy

Angelo Spena, Leonardo Palombi, Massimo Corcione, Alessandro Quintino, Mariachiara Carestia, Vincenzo Andrea Spena

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: weather-related SARS-CoV-2 virulence; specific enthalpy of atmospheric moist air; temperature and humidity effects on COVID-19 outbreak; correlating equation; COVID-19 spread prediction risk scale

Online: 5 October 2020 (08:10:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0478.v1

Quality of Life: Changes in Self Perception in People with DS who Participate in Laliga Genuine Santander. Self Reports and External Reports

Rocío Camacho, Cristina Castejón-Riber, Francisco Requena, Julio Camacho, Arturo Gallego, Roberto Espejo, Amaranta De Miguel-Rubio, Begoña M. Escribano, Estrella I. Agüera

Subject: Social Sciences, Psychology Keywords: Down's Syndrome; perception; quality of life; sport; age; gender; scale

Online: 18 December 2020 (16:17:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0627.v2

Engineering Properties of New-age (Nano) Modified Emulsion (NME) Stabilised Naturally Available Granular Road Pavement Materials Explained using Basic Chemistry

Gerrit Jordaan, Wynand J vdM Steyn

Subject: Engineering, Civil Engineering Keywords: nanotechnology in pavement engineering; stabilisations of naturally available materials; road pavement engineering; mineralogy; chemistry in emulsions; organofunctional silanes; anionic emulsion; cationic emulsion; New-age (Nano) Modified Emulsions (NME)

Online: 14 September 2021 (15:20:44 CEST)

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Nano-scale organofunctional silanes have been developed, tested and successfully applied to protect stone buildings in Europe against climatic effects since the 1860s. The same nanotechnologies can also be used in pavement engineering to create strong chemical bonds between a stabilising agent and the material substrata. The attachment of the organofunctional silane to a material also makes the surface of the material hydrophobic, reducing future chemical weathering. These properties allow naturally available materials to be used in any pavement layer at a low risk. In the built environment, scientists soon determined that the successful use of an organo-silane depends on the type and condition of the stone to be treated. The same principles apply to the implementation of applicable nanotechnologies in pavement engineering. Understanding the basic chemistry determining the properties of the stabilising agent and the organofunctional modifying agent and the chemical interaction with the primary and secondary minerals of the material are essential for the successful application of these technologies in pavement engineering. This paper explains some basic chemistry which fundamentally influences engineering outputs that can be achieved using New-age (Nano) Modified Emulsions (NME) stabilising agents with naturally available material in all road pavement TRANSLATE with x English ArabicHebrewPolish BulgarianHindiPortuguese CatalanHmong DawRomanian Chinese SimplifiedHungarianRussian Chinese TraditionalIndonesianSlovak CzechItalianSlovenian DanishJapaneseSpanish DutchKlingonSwedish EnglishKoreanThai EstonianLatvianTurkish FinnishLithuanianUkrainian FrenchMalayUrdu GermanMalteseVietnamese GreekNorwegianWelsh Haitian CreolePersian TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back TRANSLATE with x English ArabicHebrewPolish BulgarianHindiPortuguese CatalanHmong DawRomanian Chinese SimplifiedHungarianRussian Chinese TraditionalIndonesianSlovak CzechItalianSlovenian DanishJapaneseSpanish DutchKlingonSwedish EnglishKoreanThai EstonianLatvianTurkish FinnishLithuanianUkrainian FrenchMalayUrdu GermanMalteseVietnamese GreekNorwegianWelsh Haitian CreolePersian TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back TRANSLATE with x English ArabicHebrewPolish BulgarianHindiPortuguese CatalanHmong DawRomanian Chinese SimplifiedHungarianRussian Chinese TraditionalIndonesianSlovak CzechItalianSlovenian DanishJapaneseSpanish DutchKlingonSwedish EnglishKoreanThai EstonianLatvianTurkish FinnishLithuanianUkrainian FrenchMalayUrdu GermanMalteseVietnamese GreekNorwegianWelsh Haitian CreolePersian TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back

Preprint ARTICLE | doi:10.20944/preprints202103.0787.v1

Psychosocial Resources and Diet-Related Lifestyle in Overweight and Obesity: A Cluster-Based Study

Débora Godoy-Izquierdo, Raquel Lara, Adelaida Ogallar, Alejandra Rodríguez-Tadeo, María J. Ramírez, Estefanía Navarrón, Félix Arbinaga

Subject: Social Sciences, Psychology Keywords: body image; healthy diet; weight-related stigma; subjective well-being; excessive weight; cluster analysis

Online: 31 March 2021 (17:35:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0585.v1

Topical Triamcinolone Acetonide-Loaded Liposomes Formulation Used as an Adjuvant to Intravitreal Ranibizumab Therapy for Neovascular Age Related Macular Degeneration

Jose Navarro-Partida, Juan Carlos Altamirano-Vallejo, Luis Abraham Aceves Franco, Jesús Gonzalez-Cortes, Sergio Hernandez Da Mota, Jose Gerardo García-Aguirre, Carlos David Azuara-Galindo, Carlos Rodrigo Castro-Castaneda, Juan Armendariz-Borunda, Arturo Santos

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Triamcinolone acetonide; Liposomes; Neovascular age related macular degeneration; Wet macular degeneration; Adjuvant therapy; Ranibizumab

Online: 23 June 2021 (12:56:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0473.v1

Temporal Dynamics of Event-Related Potentials During Inhibitory Control Characterize Age-Related Neural Compensation

Elizabeth R Paitel, Kristy A Nielson

Subject: Social Sciences, Behavior Sciences Keywords: inhibitory control; executive function; event-related potentials; electroencephalography; N200; P300; cognitive aging; neural recruitment

Online: 20 May 2021 (10:18:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0237.v1

Confounding Factors Influencing the Kinetic and the Magnitude of Serological Response Following Administration of BNT162b2

Jean-Louis Bayart, Laure Morimont, Mélanie Closset, Grégoire Wieërs, Tatiana Roy, Vincent Gerin, Marc Elsen, Christelle Eucher, Sandrine Van Eeckhoudt, Nathalie Ausselet, Clara David, François Mullier, Jean-Michel Dogné, Julien Favresse, Jonathan Douxfils

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; vaccine; BNT162b2; antibody, serology; kinetic; age; gender; BMI; blood-group.

Online: 8 June 2021 (13:48:34 CEST)

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Working Paper ARTICLE

Behavioral, Emotional and Social Apathy in Alcohol-Related Cognitive Disorders

Maud E.G. van Dorst, Yvonne C.M. Rensen, Masud Husain, Roy P.C. Kessels

Subject: Social Sciences, Psychology Keywords: apathy; neuropsychology; Korsakoff’s syndrome; alcohol use disorder; alcohol-related cognitive disorders

Online: 8 April 2021 (10:12:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0198.v1

Psychosocial and Diet-Related Lifestyle Clusters in Overweight and Obesity

Débora Godoy-Izquierdo, Raquel Lara, Adelaida Ogallar, Alejandra Rodríguez-Tadeo, María J. Ramírez, Estefanía Navarrón, Félix Arbinaga

Subject: Social Sciences, Psychology Keywords: body image; healthy diet; weight-related stigma; subjective well-being; excessive weight; cluster analysis

Online: 5 March 2021 (21:27:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1716.v1

AI-Powered Innovation in Digital Transformation: Key Pillars and Industry Impact

Abdulaziz Aldoseri, Khalifa Al-Khalifa, Abdel Magid Hamouda

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Technology disruptions, digital transformation, DT, Artificial intelligence, Innovation ecosystem, digital age, Industry 5.0.

Online: 24 January 2024 (09:49:59 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202002.0280.v1

Novel Morphological Alteration and Neural Pathway of NADPH Diaphorase Positivity in the Spinal Cord with Disc Herniation of Aged Dog: A Case Report

Yinhua Li, Yunge Jia, Wei Hou, Huibing Tan

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: spinal disc herniation, dog, NADPH diaphorase, the aging-related NADPH diaphorase body, megaloneurite, homogeneous formazan globule, intermedial collateral pathway

Online: 19 February 2020 (11:47:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0209.v1

Low-order Spherical Harmonic HRTF Restoration using a Neural Network Approach

Benjamin Tsui, William A. P. Smith, Gavin Kearney

Subject: Engineering, Control And Systems Engineering Keywords: Deep learning; Head Related Transfer Function (HRTF); Restoration; Ambisonics; Spatial Audio; Spherical harmonic; Audio signal processing; Denoising; Auto-Encoder; Neural Network

Online: 10 July 2020 (08:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0219.v1

Ancient Agricultural and Pastoral Landscapes on the South Side of Lake Issyk-Kul: Preliminary Surveys of the Juuku Valley and Lower Kizil Suu Valley, Archaeobotanical Results of Three Stratigraphic Profiles, and GIS Modeling of Iron Age in Lower Kizil Suu

Claudia . Chang, Sergeo Sergievich Ivanov, Perry Alan Tourtellotte, Robert N. Spengler III, Basira Mir-Makhamad, David Kramar

Subject: Arts And Humanities, Archaeology Keywords: archaeological landscapes; Iron Age; Medieval period; agriculture; pastoralism; vertical zonation, Issyk-Kul Lake; archaeobotany; GIS mapping

Online: 17 May 2022 (03:29:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0182.v1

p53-Mediated Oxidative Stress Enhances Indirubin-3′-Monoxime-induced Apoptosis in HCT116 Colon Cancer Cells by Upregulating Death Receptor 5 and TNF-related Apoptosis-inducing Ligand Expression

Matharage Gayani Dilshara, Ilandarage Menu Neelaka Molagoda, Rajapaksha Gedara Prasad Tharanga Jayasooriya, Yung Hyun Choi, Cheol Park, Kyoung Tae Lee, Seungheon Lee, Gi-Young Kim

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: indirubin-3′-monoxime; p53; death receptor 5; TNF-related apoptosis-inducing ligand; transcription factor C/EBP homologous protein

Online: 17 August 2019 (04:19:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0120.v1

Too Committed to Switch off – Capturing and Organizing the Full Range of Work-Related Rumination from Detachment to Overcommitment

Oliver Weigelt, J. Charlotte Seidel, Lucy Erber, Johannes Wendsche, Yasemin Z. Varol, Gerald M. Weiher, Petra Gierer, Claudia Sciannimanica, Richard Janzen, Christine J. Syrek

Subject: Social Sciences, Psychology Keywords: work-related rumination; overcommitment; psychological detachment; burnout; irritation; problem-solving pondering; positive work reflection; negative work reflection; affective rumination; satisfaction with life

Online: 6 January 2023 (09:36:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0589.v1

Evaluation of cost-effective thin modified binder seals on Nano-Modified Emulsion (NME) stabilised base layers using Accelerated Pavement Testing (APT)

Gerrit J Jordaan, Wynand J VdM Steyn, Andre Broekman

Subject: Engineering, Civil Engineering Keywords: nanotechnology in pavement engineering; thin surfacings for New-age (Nano) Modified Emulsion stabilised base layers; applicable modified binders for chip seals; Cape seals using anionic New-age Modified Emulsion slurries; Sasobit-M® modified binders for chip seals.

Online: 28 January 2021 (15:35:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0271.v1

The Effect of Health-Related Behaviors on Disease Progression and Mortality in Early Stages of Chronic Kidney Disease: A Nationwide Population-Based Study

Yookyung Lee, SuYeon Kwon, JongJoo Moon, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; disease progression; end stage renal disease; mortality; health-related behaviors; physical activity; smoking; alcohol

Online: 26 June 2019 (15:38:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0245.v1

Sexual Abuse vs Sexual Freedom? A Legal Approach to the Age of Sexual Consent in Adolescents in Spanish-Speaking Countries

Sandra M. Parra-Barrera, María del Mar Sánchez-Fuentes, Carlos Fuertes-Iglesias, Miguel Ángel Boldova

Subject: Social Sciences, Law Keywords: child sexual abuse; age of sexual consent; Romeo and Juliet clause; sexual freedom; sexual indemnity; comparative law.

Online: 11 August 2021 (10:29:19 CEST)

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Working Paper REVIEW

Does the Prevalence of Fabella Vary in Knee Osteoarthritis and Age-Related Degeneration? A Meta-Analysis of over 11,000 Knees

Adil Asghar, Shagufta Naaz, Ravi Kant Narayan, Anup Kumar

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Odds Ratio; Prevalence; Knee Joints; Osteoarthritis (OA); Age-related degeneration (ARD)

Online: 7 July 2020 (03:01:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0084.v1

Incidence, Mortality, Disability-Adjusted Life Years, and Trends of Prostate Cancer in Mexico from 2000 to 2019: Results from the Global Burden of Disease Study 2019

Saul A. Beltran-Ontiveros, Martha A. Fernandez-Galindo, Jose M. Moreno-Ortiz, Jose A. Contreras-Gutierrez, Jesus Madueña-Molina, Elyakim Arambula-Meraz, Emir Leal-Leon, Delia M. Becerril-Camacho, Veronica J. Picos-Cardenas, Carla Angulo-Rojo, Diana Z. Velazquez, Francisco Jimenez-Trejo, Francisco Gallardo-Vera, Daniel Diaz

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Age-standardized rate; Burden of disease; Cancer epidemiology; Malign neoplasm; Sociodemographic index; Subnational heterogeneity

Online: 6 May 2022 (14:47:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0413.v3

Hybrid HCNN-KNN Model Enhances Age Estimation Accuracy in Orthopantomography

Fatemeh Sharifonnasabi, Noor Jhanjhi, Jacob John, Peyman Obeidy, Shahab Shamshirband, Hamid Alinejad Rokny, Mohammed Baz

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dental Age Measurement; Dental Radiography; Orthopantomogram; Convolutional Neural Network; K-Nearest Neighbour; Health Data Analytics; Biomedical Machine Learning

Online: 12 April 2022 (10:12:48 CEST)

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Age estimation in dental radiographs Orthopantomography (OPG) is a medical imaging technique that physicians and pathologists utilise for disease identification and legal matters. For example, for estimating post-mortem interval, detecting child abuse, drug trafficking, and identifying an unknown body. Recent development in automated image processing models improved the age estimation's limited precision to an approximate range of +/- one year. While this estimation is often accepted as accurate measurement, age estimation should be as precise as possible in most serious matters, such as homicide. Current age estimation techniques are highly dependent on manual and time-consuming image processing. Age estimation is often a time-sensitive matter in which the image processing time is vital. Recent development in Machine learning-based data processing methods has decreased the imaging time processing; however, the accuracy of these techniques remains to be further improved. We proposed an ensemble method of image classifiers and transfer learning techniques to enhance the accuracy of age estimation using OPGs from one year to a couple of months (1-3-6). This hybrid model is based on convolutional neural networks (CNN) and K nearest neighbours (KNN). The hybrid (HCNN-KNN) model was used to investigate 1,922 panoramic dental radiographs of patients aged 15 to 23. These OPGs were obtained from the various teaching institutes and private dental clinics in Malaysia. To minimise the chance of overfitting in our model, we used the principal component analysis (PCA) algorithm and eliminated the features with high correlation. To further enhance the performance of our hybrid model, we performed systematic image pre-processing. We applied a series of classifications to train our model. We have successfully demonstrated that combining these innovative approaches has improved the classification and segmentation and thus the age-estimation outcome of the model. Our findings suggest that our innovative model, for the first time, to the best of our knowledge, successfully estimated the age in classified studies of one year old, six months, three months and one-month-old cases with accuracies of 99.98, 99.96, 99.87, and 98.78 respectively.

Preprint REVIEW | doi:10.20944/preprints202110.0197.v1

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Duc Le, Lindsay Brown, Kundan Malik, Shin Murakami

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: AGING; Age-related comorbidities; Angiotensin-Converting Enzyme; Amyloid-degrading enzyme; Alzheimer’s disease; Dementia; Hypertension; Life extension; Stress resistance

Online: 13 October 2021 (11:04:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0729.v1

Sergey Sudakov, Elena Alekseeva, Galina Nazarova, Valentina Bashkatova

Subject: Social Sciences, Psychology Keywords: age; behaviour; open field; physical activity; anxiety; Wistar rat.

Online: 30 June 2021 (10:57:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0175.v2

Quantum Mechanical Explanation for Dark energy, Cosmic Coincidence, Flatness, Age and Size of Universe

Biswaranjan Dikshit

Subject: Physical Sciences, Mathematical Physics Keywords: Dark energy, Cosmological constant problem, Cosmic coincidence problem, Flatness problem, Hubble’s law, Age of universe, Radius of universe

Online: 29 March 2019 (12:21:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0349.v1

Integrating Geomorphological Data, Geochronology, and Archaeological Evidence for Coastal Landscape Reconstruction. The Case of Ammoudara Beach, Crete

George Alexandrakis, Stelios Petrakis, Nikolaos Kampanis

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Sea level changes; Luminescence dating; coastal archaeology; landscape reconstruction; Bronze age; Crete

Online: 13 April 2021 (11:42:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0282.v1

The Deficit of Multimodal Perception of Congruent and Non-congruent Fearful Expressions in Patients with Schizophrenia: The ERP Study

Galina V Portnova, Aleksandra Maslennikova, Natalia Zakharova, Olga V Martynova

Subject: Social Sciences, Psychology Keywords: EEG; event-related potentials; schizophrenia; fearful expressions; perception; non-congruent sounds

Online: 11 December 2020 (12:58:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0034.v1

Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain

János Tajti, Délia Szok, Anett Csáti, Ágnes Szabó, Masaru Tanaka, And László Vécsei

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: migraine; neuropathic pain; calcitonin gene-related peptide (CGRP); kynurenine; glia; cytokines; neuroinflammation; transient receptor potential (TRP) ion channels; endocannabinoids

Online: 4 January 2023 (01:53:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0245.v1

Post Vaccination Titers of Serum Anti-Diphtheria in Indonesian Young and Middle-Aged Adults

Gatot Soegiarto, Diksi Novritasari, Ari Baskoro, Deasy Fetarayani, Wita Kartika Nurani

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Age; Antibody titers; Diphtheria; Immunosenescence; Vaccine

Online: 12 July 2021 (11:33:20 CEST)

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Working Paper ARTICLE

Does Urban Landscape Composition and Configuration Regulate Heat-Related Health Risk? A Spatial Regression-Based Study in World’s Dense City Delhi, India

Suvamoy Pramanik, Milap Punia, Saurav Chakraborty

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Urban Heat Island; Heat-Related Health Risk (HRHR); Urban Landscape Metrics (ULM); Local Indicators of Spatial Autocorrelation (LISA); Spatial Error (SE) Regression; NCT-Delhi.

Online: 2 November 2020 (13:53:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0028.v1

Association of Maternal Observation and Motivation (MOM) Program with M-Health Support on Maternal and Newborn Health

Premalatha Paulsamy, Vigneshwaran Easwaran, Rizwan Ashraf, Krishnaraju Venkatesan, Mervat Moustafa, Absar Ahmed Qureshi, Kousalya Prabahar, Kalaiselvi Periannan, Rajalakshimi Vasudevan, Geetha Kandasamy, Kumarappan Chidambaram, Ester Mary Pappiya, Kumar Venkatesan, Vani Manoharan

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: pregnant mothers, physical activity; maternal wellbeing; antenatal mothers; newborn outcomes; m-health; low birth weight; small for gestation; gestation age; hemoglobin

Online: 1 November 2021 (17:50:14 CET)

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Maternal and child nutrition has been a critical component of health, sustainable development, and progress in low- and middle-income countries (LMIC). While a decrement in maternal mortality is an important indicator, simply surviving pregnancy and childbirth does not imply better maternal health. One of the fundamental obligations of nations under international human rights law is to enable mothers and teenage girls to endure pregnancy and delivery as an aspect of their enjoyment of reproductive and sexual health and rights and live a dignified life. The aim of this study was to discover the correlation between the Maternal Observation and Motivation (MOM) program and m-Health support for maternal and newborn health. A Comparative study was done among 109 pregnant mothers (study group-94; control group-102 mothers) with not less than 20 weeks of gestation. Maternal outcomes such as Hb, weight gain and newborn results like birth weight and crown- heel length was obtained on the baseline, 28 and 36 weeks of gestation. Other secondary data collected were abortion, stillbirth, low birth weight, major congenital malformations, twin or triplet pregnancies, physical activity and maternal wellbeing. The MOM intervention included initial face to face education, three in-person visits and eight virtual health coaching by WhatsApp. The baseline data on Hb of the mothers show that 31(32.98%) vs 27(28.72%) of the study and control group had anaemia, which improved to 27.66% and 14.98% among study group mothers at 28 and 36 weeks of gestation (p<0.001). The weight gain (p< 0.001), level of physical activity (p< 0.001), and maternal wellbeing (p< 0.01) also had significant differences after the Intervention. Even after controlling for potentially confounding variables, the maternal food practices regression model revealed that birth weight was directly correlated with consumption of milk (p 0.001), fruits (p 0.01), and green vegetables (p 0.05).As per the physical activity and maternal wellbeing regression model, the birth weight and crown heel length were strongly related with the physical activity and maternal wellbeing of mothers at 36 weeks of gestation (p <0.05). Combining the MOM intervention with standard antenatal care is a safe and effective way to improve maternal welfare while upholding pregnant mothers' human rights.

Preprint ARTICLE | doi:10.20944/preprints202212.0565.v1

Operationalizing Digitainability: Encouraging mindfulness to harness the power of digitalization for sustainable development

Shivam Gupta, Jazmin Campos Zeballos, Gema Del Río Castro, Ana Tomičić, Sergio Andrés Morales, Maya Mahfouz, Isimemen Osemwegie, Vicky Phemia Comlan Sessi, Marina Schmitz, Nady Mahmoud, Mnena Inyaregh

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Digitainability; Digitalization; Sustainability; Artificial Intelligence; Blockchain; Smart homes; Big data; Sustainable Development; SDGs; Technology Assessment Framework; Agenda 2030; Digital Age

Online: 30 December 2022 (01:32:00 CET)

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Digitalization is globally transforming the world with profound implications. It has enormous potential to foster progress toward sustainability. However, in its current form, digitalization also continues to enable and encourage practices with numerous unsustainable impacts affecting our environment, ingraining inequality, and degrading quality of life. There is an urgent need to identify such multifaceted impacts holistically. Impact assessment of digital interventions (DIs) leading to digitalization is important specifically for Sustainable Development Goals(SDGs). Action is required to understand the pursuit of short-term gains toward achieving long-term value-driven sustainable development. We need to understand the impact of DIs on various actors and in diverse contexts. A holistic understanding of the impact it creates will help us align it with visions of sustainable development and identify potential measures to mitigate negative short and long-term impacts. The recently developed Digitainability Assessment Framework (DAF) unveils the impact of DIs with an in-depth context-aware assessment and offers an evidence-based impact profile of SDGs at the indicator level. We performed the impact assessment of diverse technologies using DAF. This paper summarizes the insights from the Digitainable Spring School 2022 on "Sustainability with Digitalization and Artificial Intelligence," one of whose goals was to operationalize the DAF as a tool in the action learning process with diverse professionals in the field of digitalization and sustainability. The DAF guides a holistic context-aware process formulation for a given DI. An evidence-based evaluation within the DAF protocol benchmarks a specific DI’s impact against the SDG indicators framework. The operationalization of the DAF was carried out by looking at four different DIs: smart home technologies (SHT) for energy efficiency, blockchain for food security, artificial intelligence for land use cover and changes (LUCC), and big data for international law. Each of the four studies addresses different DIs for digitainability assessment using different techniques for a diverse group of indicators, demonstrating the potential of the DAF but also outlining the existing data gaps that limit a comprehensive analysis.

Preprint ARTICLE | doi:10.20944/preprints202108.0425.v1

Nanotechnology Incorporation into Road Pavement Design based on Scientific Principles of Materials Chemistry and Engineering Physics

Gerrit J Jordaan, Wynand J vdM Steyn

Subject: Engineering, Civil Engineering Keywords: road pavement design; design based on materials science; material mineralogy; New-age (Nano) Modified Emulsions (NME); naturally available materials; material stabilisation; basic engineering requirements; Unconfined Compressive Strengths (UCS); Indirect Tensile Strengths (ITS); Retained Compressive Strengths (RCT) and; Retained Tensile Strengths (RTS)

Online: 23 August 2021 (10:38:52 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202109.0148.v1

Epigenetic Programming of Cancer-Related Inflammation byncRNA Rheostat: Impact on Tumor Directed Immune Therapies

Roshan Roy, Uttam Sharma, Rakhi Yadav, Manjit Kaur Rana, Ashok Sharma, Pranay Tanwar, Aklank Jain, Hridayesh Prakash

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Cancer related Inflammation; miRNA; LncRNA; Epigenetics, immune polarization

Online: 8 September 2021 (12:07:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0214.v1

Lung-Heart Toxicity in a Randomized Clinical Trial of Hypofractionated Image Guided Radiation Therapy for Breast Cancer

Hilde Van Parijs, Elsa Cecilia-Joseph, Olena Gorobets, Guy Storme, Nele Adriaenssens, Benedicte Heyndrickx, Claire Verschraegen, Nam P. Nguyen, Mark De Ridder, Vincent Vinh-Hung

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast; Targeted Radiotherapy; Lung injury; Heart injuries; Health-Related Quality Of Life; Irradiation toxicity.

Online: 13 December 2022 (01:17:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1257.v1

Pharmacological Treatments of Sleep-Wake Disorders: Update 2023

Marcel S Kallweit, Nayeli P Kallweit, Ulf Kallweit

Subject: Medicine And Pharmacology, Other Keywords: Pharmacotherapy; Sleep-Wake Disorders; Hypersomnolence; Restless Legs Syndroms; Parasomnias; Sleep-related breathing disorders; Insomnia; Circadian Disorders

Online: 20 October 2023 (03:52:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1956.v1

Characteristics of Mental Toughness in Young Basketball Players of Different Age Groups

Eimantas Pocius, Romualdas Malinauskas

Subject: Social Sciences, Psychology Keywords: mental toughness skills; young athletes; age groups

Online: 29 May 2023 (04:04:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0199.v1

Is Smart Working Beneficial for Workers' Well-being? A Longitudinal Investigation of Smart Working, Workload and Hair Cortisol/Dehydroepiandrosterone Sulfate during the COVID-19 Pandemic

Alessandra Falco, Damiano Girardi, Achim Elfering, Tanja Peric, Isabella Pividori, Laura Dal Corso

Subject: Social Sciences, Psychology Keywords: smart working; COVID-19; workload; hair cortisol; Dehydroepiandrosterone Sulfate; biomarker; work-related stress; organizational well-being

Online: 10 March 2023 (14:03:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0091.v1

Assessing the Effectiveness of Tobacco 21 Laws to Reduce Underage Access to Tobacco: Protocol for a Repeated Multi-Site Study

Mary Hrywna, Amanda Kong, Christopher Ackerman, Shawna Hudson, Cristine Delnevo

Subject: Public Health And Healthcare, Health Policy And Services Keywords: tobacco age of sale; tobacco policy; youth; young adults

Online: 7 June 2022 (03:44:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0392.v1

Prevalence of Controlled Systemic Hypertension and Its Associated Risk Factors among Hypertensive Patients at Mbeya Zonal Referral Hospital, Tanzania.

Samson Peter Mvandal, Victor Jastin Mwinuka

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Age; adherence; anti-hypertensive; Controlled hypertension; clinic; hypertension; Prevalence; Systemic

Online: 17 May 2021 (15:57:01 CEST)

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Working Paper REVIEW

A Systematic Review of Neuroimaging and Acute Cannabis Exposure in Age-of-Risk for Psychosis

Lani Cupo, Eric Plitman, Elisa Guma, M Mallar Chakravarty

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: systematic review; cannabis; neuroimaging; age-of-onset psychosis; psychosis; schizophrenia

Online: 14 May 2021 (09:58:14 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202101.0499.v1

Integrated Machian Model of a Light Speed Rotating Universe

Satya Seshavatharam U.V, Lakshminarayana S

Subject: Physical Sciences, Acoustics Keywords: Mach's Universe; Planck scale; Cosmic Angular velocity; Galactic applications; shortened radius; shortened age;

Online: 25 January 2021 (13:46:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0257.v1

Cautionary Observations Concerning the Introduction of Psychophysiological Biomarkers into Neuropsychiatric Practice

Paul E. Rapp, Christopher Cellucci, David Darmon, David Keyser

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: biomarkers; electroencephalography; event related potentials; heart rate variability; diagnosis; sensitivity; specificity

Online: 17 March 2022 (15:19:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0603.v1

Investigation of Attributes for Identifying Homogeneous Flood Regions for Regional Flood Frequency Analysis in Canada

Ziyang Zhang, Tricia A. Stadnyk

Subject: Engineering, Civil Engineering Keywords: regional flood frequency analysis; flood-related attribute; region of influence; flood region revision process; Canadian annual maximum flow

Online: 25 July 2020 (11:12:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0066.v1

Grapevine – Downy Mildew Rendez-Vous: Proteome Analysis of the First Hours of an Incompatible Interaction

Rita B. Santos, Rui Nascimento, Ana V. Coelho, Andreia Figueiredo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Vitis vinifera; Plasmopara viticola; plant-pathogen interaction; proteomics; defence-related proteins, ETS, ETI

Online: 5 October 2020 (10:58:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0353.v1

Chromothripsis and DNA-repair Disorders

Lusine Nazaryan-Petersen, Victoria Alexandra Bjerregaard, Finn Cilius Nielsen, Niels Tommerup, Zeynep Tümer

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chromothripsis; structural variants; DNA-repair; DNA-repair disorders; DNA-double strand breaks (DSBs); ataxia telangiectasia mutated (ATM); ataxia-telangiectasia and Rad3-related (ATR); TP53; micronuclei; chromosome pulverization.

Online: 29 January 2020 (11:58:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0079.v1

NRF1 or NRF2: Emerging Role of Redox Homeostasis on PERK/NRF/Autophagy Mediated Antioxidant in Tumor and Patient Dependent Chemo Sensitivity

Sanaz Dastghaib, Seyed Mohammad Shafiee, Fatemeh Ramezani, Niloufar Ashtari, Farhad Tabasi, Javad Saffari-Chaleshtori, Omid Vakili, Morvarid Siri, Somayeh Igder, Mojdeh Zamani, Mahshid Moballegh Nasery, Fariba Kokabi, Emilia Wiechec, Zohreh Mostafavi-Pour, Pooneh Mokarram, Saeid Ghavami

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: NF-E2-related factor 2; Drug resistance; Reactive oxygen species; Autophagy; Unfolded protein response

Online: 3 January 2024 (02:26:23 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202107.0075.v1

Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops Truncatus), an Essential Step in the Conservation of at-Risk Dolphins.

Ashley Barratclough, Cynthia R. Smith, Forrest M. Gomez, Theoni Photopoulou, Ryan Takeshita, Enrico Pirotta, Len Thomas, Abby M. McClain, Celeste Parry, Joseph A Zoller, Steve Horvath, Lori H Schwacke

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: DNA methylation; epigenetic aging; bottlenose dolphin; chronological age

Online: 5 July 2021 (07:59:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0434.v1

Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Hye-Young Kim, Ha Young Jo, Seong Heon Kim

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Kikuchi-Fujimoto disease; histiocytic necrotizing lymphadenitis; prognosis; children; age

Online: 20 July 2021 (09:37:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0285.v1

Comparing Measurement Properties of the English EQ-5D-Y Three-Level Version with the Five-Level Version in South Africa

Janine Verstraete, Razia Amien, Des Scott

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Health Related Quality of Life, EQ-5D-Y-3L, EQ-5D-Y-5L, Youth, children, orthopaedic

Online: 20 January 2022 (07:23:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0696.v1

Revealed Preferences of Fourth Graders When Requesting Face-to-Face Help While Doing Math Exercises Online

Roberto Araya, Raúl Gormaz

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Help Seeking; Same-age Peer Tutoring; Revealed Preferences; Data analytics

Online: 29 June 2021 (11:36:26 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202212.0579.v3

Known Modifiable Risk Factors of Cancer

Angel Justiz-Vaillant, Darren Gopaul

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Lifestyle; diet; carcinogenesis; tobacco; alcohol; cancer-related microorganisms

Online: 3 March 2023 (10:19:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0066.v1

Comparison of Antioxidant Properties of Dehydrolutein with Lutein and Zeaxanthin, and their Effects on Retinal Pigment Epithelial Cells

Malgorzata Rozanowska, Barbara Czuba-Pelech, John T. Landrum, Bartosz Rozanowski

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: carotenoid; lutein; zexanthin; dehydrolutein; retina; retinal pigment epithelium; singlet oxygen; photosensitized oxidation; age-related macular degeneration.

Online: 2 April 2021 (14:04:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0501.v1

Age-dependent Non-silent Somatic Mutation with Transcriptomic Landscape and Prognosis of Lower Grade Glioma

YoungJoon Park, JeongMan Park, Ju Won Ahn, JeongMin Sim, Su Jung Kang, Suwan Kim, Sojung Hwang, Kyoung Su Sung, Jaejoon Lim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: age; glioma; mutation; TCGA; transcriptomic analysis

Online: 23 February 2021 (08:16:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0374.v1

Fetal Growth Acceleration – Current Approach to the Big Baby Issue

Jan Modzelewski, Anna Kajdy, Katarzyna Muzyka-Placzyńska, Dorota Sys, Michał Rabijewski

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Diabetes; Gestational; Diagnostic Techniques; Obstetrical and Gynecological; Fetal growth acceleration; Fetal Macrosomia; Large-for-gestational-age; Obstetrics; Pregnancy Complications; Stillbirth

Online: 19 January 2021 (11:42:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1529.v1

Brain Wearables: Validation Toolkit for Ear-Level EEG Sensors

Guilherme Correia, Michael J Crosse, Alejandro Lopez Valdes

Subject: Engineering, Bioengineering Keywords: Wearable Electroencephalography; Ear-EEG; Validation; Toolkit; EEG Phantom; Event-Related Potentials

Online: 20 December 2023 (10:23:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0222.v1

Physiological and Medico-Social Research Trends of the Wave P300 and More Late Components of Visual Event-Related Potentials

Sergey Lytaev, Irina Vatamaniuk

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: event-related potentials; visual evoked potentials; component P300; brain-computer interface; speller; oddball paradigm; categorization of images.

Online: 9 December 2020 (11:56:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.1115.v1

A Paradigm Shift in the Entertainment Industry in the Digital Age: A Critical Review

Dr. Bharat Dhiman

Subject: Arts And Humanities, Film, Radio And Television Keywords: media; digital media; entertainment; paradigm shift; digital age

Online: 15 June 2023 (09:40:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0743.v1

Factors Associated with Success of Switching to Faricimab for Neovascular Age-Related Macular Degeneration Refractory to Intravitreal Aflibercept

Akira Machida, Akio Oishi, Junichiro Ikeda, Junko Kurihara, Ai Yoneda, Eiko Tsuiki, Yuki Hirata, Ryuya Murakami, Takashi Kitaoka

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Age-related macular degeneration (AMD); Anti-vascular endothelial growth factor (VEGF) treatment; Drug switch; Intravitreal aflibercept (IVA); Intravitreal faricimab (IVF); Macular neovascularization (MNV); Polypoidal choroidal vasculopathy (PCV); Real-world date; Refractory cases; Treat-and-extend (TAE) regimen

Online: 9 January 2024 (15:53:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0186.v1

Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study

Arturo Cuomo, Marco Cascella, Cira Antonietta Forte, Sabrina Bimonte, Gennaro Esposito, Stefano De Santis, Luigi Cavanna, Flavio Fusco, Mario Dauri, Silvia Natoli, Marco Maltoni, Alessandro Morabito, Rocco Domenico Mediati, Vito Lorusso, Sandro Barni, Giampiero Porzio, Sebastiano Mercadante, Anna Crispo

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: breakthrough cancer pain; cancer-associated pain; cancer; health-related quality of life; sleep disorders; transmucosal fentanyl

Online: 14 February 2020 (03:36:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0192.v1

Inequalities in Temporal Effects on Cervical Cancer Mortality in States in Different Geographic Regions of Brazil: An Ecological Study

Karina Cardoso Meira, Carinne Magnago, Angelo Braga Mendonça, Stephane Fernanda Soares Duarte, Pedro Henrique Oliveira de Freitas, Juliano dos Santos, Dyego Leando Bezerra de Souza, Taynãna César Simões

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: uterine cervical neoplasms; mortality; age-period-cohort analysis; forecasting; Brazil

Online: 16 February 2022 (05:03:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0019.v1

Glacier Recession in Altay Mountains after the LIA Maximum

Dmitry Ganyushkin, Kirill Chistyakov, Ekaterina Derkach, Dmitriy Bantcev, Elena Kunaeva, Anton Terekhov, Valeriia Rasputina

Subject: Environmental And Earth Sciences, Environmental Science Keywords: glaciers; Little Ice Age; reconstruction; retreat; Altai

Online: 4 January 2022 (20:30:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0644.v1

Novel Method to Analytically Obtain the Asymptotic Stable Equilibria States of Extended SIR-type Epidemiological Models

Teddy Lazebnik, Svetlana Bunimovich-Mendrazitsky, Leonid Shaikhet

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Markov chain; random variable transformation technique; asymptotic stable equilibria state; three age group SIIRD model

Online: 26 May 2021 (14:29:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0244.v1

Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice

Dolors Puigoriol-Illamola, Mirna Martínez-Damas, Christian Griñán-Ferré, Mercè Pallàs

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Stress; epigenetics; senescence; cognition; age-related cognitive decline; Alzheimer’s disease; SAMP8; SAMR1; oxidative stress; inflammation; autophagy

Online: 21 January 2020 (11:44:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0081.v2

Measuring Independent and Controlled Effects of Age at Marriage and Age at First Birth on Completed Family Size among women aged 45-59 in Zambia

Nkuye Moyo, Tina Nanyangwe-Moyo, Xiaochun Qiao, Jilei Wu, Xiaoying Zheng

Subject: Social Sciences, Demography Keywords: age at first marriage; age at first birth; completed family size; fertility

Online: 13 October 2020 (14:17:28 CEST)

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Background The link between age at marriage and first birth in explaining completed family size is not always direct, due to heterogeneity in circumstances, that compel individual women to marry or initiate childbearing at a particular age. We analyzed data for 1020 women aged 45-49 in 2014 of the 1965-1969 birth cohort from the 2013-14 Zambia Demographic and Health Survey (ZDHS). Methods We fitted a bivariate and multivariate multinomial logistic regression to establish the relationship between a mother’s age at first marriage and at first birth on completed family size (CFS). Chi-square test of proportions measuring differences in proportions and relative risk ratios (RRR) with confidence intervals at 95% are reported. Results Our results show that the average CFS was 6.7 (95% CI: 6.5 – 6.9) among women completing their reproductive span in 2014 with mean age at first marriage and birth being 18.3 years (95% CI: 18.0 – 18.5) and 18.9 years (95% CI: 18.7 – 19.1) respectively. Women marrying at younger ages and having their first birth at younger ages were more likely (RRR: 1.187; 95% CI: 1.138-1.239 and RRR: 0.195; 95% CI: 0.074-0.511 respectively) to have higher CFS than their compatriots that initiated both marriage and childbearing at or after age 22 controlling for covariates as presented in the controlled model. The independent effects model shows that the risk of having 1-3 children compared to 6 or more children was lower (RRR: 0.073; 95% CI: 0.009-0.611; RRR: 0.136; 95% CI: 0,046-0.402 and RRR: 0.421; 05% CI: 0.135-1.312) for women whose ages at first marriage were <15, 15-18 and 19-21 respectively relative to 22+. Women with 1-3 children were 2.5 times more likely to use contraception than women with 6 or more children. Conclusion Having no education, being a rural resident and having a medium household wealth all increase the risk of having higher CFS. Women that marry before age 19 have a higher likelihood of having 6 or more children by the end of their reproductive period. The study concludes that apart from a woman’s age at first marriage and first birth, a complex network of factors interact to determined CFS.

Preprint ARTICLE | doi:10.20944/preprints202008.0314.v1

The Early Silurian Gabbro in the Eastern Kunlun Orogenic Belt, Northeast Tibet: Constraints on the Proto-Tethyan Ocean Closure

Wenxiao Zhou, Haiquan Li, Feng Chang, Xinbiao Lv

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: northeast Tibet; Proto-Tethyan ocean; early silurian; eastern Kunlun orogenic belt; gabbro; zircons U-Pb age

Online: 14 August 2020 (09:02:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0504.v1

Development and Validation of UPLC-Qtof-MS Method for Blood Analysis of Amphetamine-Related Drug Isomers

Ahmad Alamir, James Watterson, Ibraheem Attafi

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Amphetamine-related drugs; Forensic Toxicology; blood; UPLC-qTOF-MS; MMSPE; Validation; SWGTOX

Online: 30 August 2022 (04:09:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0670.v1

Comparing the Loading Dose between Aflibercept and Faricimab for Neovascular Age-Related Macular Degeneration

Chikako Hara, Masaki Suzue, Satoko Fujimoto, Yoko Fukushima, Kaori Sayanagi, Kentaro Nishida, Kazuichi Maruyama, Shigeru Sato, Kohji Nishida

Subject: Medicine And Pharmacology, Ophthalmology Keywords: age-related macular degeneration; aflibercept; faricimab; anti-vascular endothelial growth factor therapy; exudative change

Online: 10 November 2023 (07:30:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0179.v1

“Animal-style art,” and special finds at Iron Age settlements in Southeastern Kazakhstan: Commodity Production, Trade, and Pathways during the Iron Age

Claudia Chang, Sergei Sergievich Ivanov

Subject: Arts And Humanities, Archaeology Keywords: zoomorphic art; Saka nomadic tradition; horse and weaponry gear; etched carnelian beads; Iron Age agropastoral settlements; world-systems analysis

Online: 9 December 2022 (10:20:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0147.v1

Optical Coherence Tomography Angiography (OCTA): A Review of the Current Literature

Ahmed Javed, Aishwarya Khanna, Eleanor Palmer, Craig Wilde, Anwar Zaman, Gavin Orr, Dharmalingam Kumudhan, Arun Lakshmanan, Georgios D Panos

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Ophthalmic imaging; Optical coherence tomography; Age-related macular degeneration; Glaucoma; Retinal conditions

Online: 8 February 2023 (11:28:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0224.v1

SIG-1451, A Novel, Non-Steroidal Anti-Inflammatory Compound, Attenuates Light-Induced Photoreceptor Degeneration by Inhibiting Microglial Activation

Yuki Kikuchi, Eriko Sugano, Shiori Yuki, Kitako Tabata, Yuka Endo, Yuya Takita, Reina Onoguchi, Taku Ozaki, Tomokazu Fukuda, Yoshihiro Takai, Takahiro Kurose, Koichi Tanaka, Yoichi Honma, Eduardo Perez, Maxwell Stock, Jose Fernandez, Masanori Tamura, Michael Voronkov, Jeffry B Stock, Hiroshi Tomita

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: age-related macular degeneration; light-induced photoreceptor degeneration; anti-inflammatory drug; toll-like receptor 4

Online: 17 May 2022 (08:03:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0030.v1

Practical Application of Nanotechnology Solutions in Pavement Engineering: Addressing Practical Road Construction Related Problems Using Marginal Materials Stabilised With New-Age (Nano) Modified Emulsions (Nme) Towards Sustainable Roads

Gerrit J Jordaan, Wynand J vdM Steyn

Subject: Engineering, Civil Engineering Keywords: New-age (Nano) Modified Emulsion (NME) stabilisation; identifying construction problems; preventing construction related problems; material related problems; constructability using nanotechnology applications; nano-silane stabilisation of granular materials; construction quality control problems; construction equipment problems; practical implementation of nano-silane stabilisation.

Online: 11 January 2022 (10:37:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0243.v2

Morphological and Molecular Status of Daphne Wolongensis Brickell et Mathew as Genetic Resource for Horticulture

Vojtěch Holubec, Leona Leišová-Svobodová

Subject: Biology And Life Sciences, Horticulture Keywords: Daphne wolongensis; distribution; morphology; relationships; genetics; AFLP; related species; Rehdera section

Online: 16 September 2020 (03:12:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1585.v1

First Correction by Prime Editing of a Mutation in the RYR1 Gene Responsible for a Myopathy

Kelly Godbout, Joël Rousseau, Jacques P. Tremblay

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: prime editing; CRISPR/Cas9; gene editing; gene therapy; RYR1-related diseases; neuromuscular diseases; RYR1 gene; mutations

Online: 24 November 2023 (08:51:01 CET)

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Working Paper ARTICLE

National Versus Local Sustainable Development Plans and Island Priorities in Sanitation: Examples From the Kingdom of Tonga

Ian White, Tony Falkland, Taaniela Kula

Subject: Engineering, Automotive Engineering Keywords: sustainable development strategies; community development plans; small island developing states; governance; sanitation; water supply; hygiene; WASH; census results; top-down versus bottom-up; gender and age; SDG6

Online: 23 October 2020 (12:13:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0351.v1

Almamy Amara Touré, Aboubacar Sidiki Magassouba, Gnoume Camara, Abdoulaye Doumbouya, Diao Cissé, Ibrahima Barry, Lansana Mady Camara, Abdoul Habib Béavogui, Alexandre Delamou, Vanessa Veronese, Corinne Simone Merle, Hugues Asken Traoré, Adama Marie Bangoura

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Tuberculosis; Health-related quality of life; COVID-19; Guinea

Online: 25 July 2022 (05:37:10 CEST)

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