NRF1 or NRF2: Emerging Role of Redox Homeostasis on PERK/NRF/Autophagy Mediated Antioxidant in Tumor and Patient Dependent Chemo Sensitivity

Sanaz Dastghaib; Seyed Mohammad Shafiee; Fatemeh Ramezani; Niloufar Ashtari; Farhad Tabasi; Javad Saffari-Chaleshtori; Omid Vakili; Morvarid Siri; Somayeh Igder; Mojdeh Zamani; Mahshid Moballegh Nasery; Fariba Kokabi; Emilia Wiechec; Zohreh Mostafavi-Pour; Pooneh Mokarram; Saeid Ghavami

doi:10.20944/preprints202401.0079.v1

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preprints.org > biology and life sciences > biochemistry and molecular biology > doi: 10.20944/preprints202401.0079.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

NRF1 or NRF2: Emerging Role of Redox Homeostasis on PERK/NRF/Autophagy Mediated Antioxidant in Tumor and Patient Dependent Chemo Sensitivity

Sanaz Dastghaib

Seyed Mohammad Shafiee

Fatemeh Ramezani

Niloufar Ashtari

Farhad Tabasi

Javad Saffari-Chaleshtori

Mahshid Moballegh Nasery

Fariba Kokabi

Emilia Wiechec

Zohreh Mostafavi-Pour

^* ,

Pooneh Mokarram

^* ,

Saeid Ghavami

Version 1 : Received: 31 December 2023 / Approved: 2 January 2024 / Online: 3 January 2024 (02:26:23 CET)

How to cite: Dastghaib, S.; Shafiee, S.M.; Ramezani, F.; Ashtari, N.; Tabasi, F.; Saffari-Chaleshtori, J.; Vakili, O.; Siri, M.; Igder, S.; Zamani, M.; Moballegh Nasery, M.; Kokabi, F.; Wiechec, E.; Mostafavi-Pour, Z.; Mokarram, P.; Ghavami, S. NRF1 or NRF2: Emerging Role of Redox Homeostasis on PERK/NRF/Autophagy Mediated Antioxidant in Tumor and Patient Dependent Chemo Sensitivity. Preprints 2024, 2024010079. https://doi.org/10.20944/preprints202401.0079.v1 Dastghaib, S.; Shafiee, S.M.; Ramezani, F.; Ashtari, N.; Tabasi, F.; Saffari-Chaleshtori, J.; Vakili, O.; Siri, M.; Igder, S.; Zamani, M.; Moballegh Nasery, M.; Kokabi, F.; Wiechec, E.; Mostafavi-Pour, Z.; Mokarram, P.; Ghavami, S. NRF1 or NRF2: Emerging Role of Redox Homeostasis on PERK/NRF/Autophagy Mediated Antioxidant in Tumor and Patient Dependent Chemo Sensitivity. Preprints 2024, 2024010079. https://doi.org/10.20944/preprints202401.0079.v1

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MDPI and ACS Style

Dastghaib, S.; Shafiee, S.M.; Ramezani, F.; Ashtari, N.; Tabasi, F.; Saffari-Chaleshtori, J.; Vakili, O.; Siri, M.; Igder, S.; Zamani, M.; Moballegh Nasery, M.; Kokabi, F.; Wiechec, E.; Mostafavi-Pour, Z.; Mokarram, P.; Ghavami, S. NRF1 or NRF2: Emerging Role of Redox Homeostasis on PERK/NRF/Autophagy Mediated Antioxidant in Tumor and Patient Dependent Chemo Sensitivity. Preprints 2024, 2024010079. https://doi.org/10.20944/preprints202401.0079.v1

APA Style

Dastghaib, S., Shafiee, S.M., Ramezani, F., Ashtari, N., Tabasi, F., Saffari-Chaleshtori, J., Vakili, O., Siri, M., Igder, S., Zamani, M., Moballegh Nasery, M., Kokabi, F., Wiechec, E., Mostafavi-Pour, Z., Mokarram, P., & Ghavami, S. (2024). NRF1 or NRF2: Emerging Role of Redox Homeostasis on PERK/NRF/Autophagy Mediated Antioxidant in Tumor and Patient Dependent Chemo Sensitivity. Preprints. https://doi.org/10.20944/preprints202401.0079.v1

Chicago/Turabian Style

Dastghaib, S., Pooneh Mokarram and Saeid Ghavami. 2024 "NRF1 or NRF2: Emerging Role of Redox Homeostasis on PERK/NRF/Autophagy Mediated Antioxidant in Tumor and Patient Dependent Chemo Sensitivity" Preprints. https://doi.org/10.20944/preprints202401.0079.v1

Abstract

Chemo-resistance is a substantial challenge in the realm of cancer treatment that requires exploring new therapeutic approaches for effective mitigation. Achieving this goal requires examination of the molecular mechanisms involved in both tumor growth and therapeutic interventions. The potential of NRF2 (Nuclear factor E2-related factor 2) in addressing resistance to chemotherapy across diverse cancer types highlights its value as a promising therapeutic approach based on cancer characteristics. Manipulating the NRF2 signaling pathway has a dual impact, offering promise for both preventing and treating cancer, as well as inhibiting carcinogenesis. The influence of the NRF2/KEAP1 pathway on the progression of tumor formation and resistance to drugs has been well-documented. The interplay between the NRF2 signaling pathway and processes such as endoplasmic reticulum (ER) stress, unfolded protein response (UPR), and autophagy plays a crucial protective role. A deeper understanding of NRF2's role in the modulating these pathways is necessary to develop novel approaches for improving chemotherapeutic efficacy. This article discusses the significance of the NRF2-KEAP1 pathway in preventing/promoting cancer and resistance mechanisms to various chemotherapeutic agents, with a focus on the complementary effects of antioxidants via NRF2-mediated signaling pathways. This study aims to provide a molecular basis for targeting NRF2 via inhibitors/activators as promising therapeutic strategies to overcome chemo-resistance.

Keywords

NF-E2-related factor 2; Drug resistance; Reactive oxygen species; Autophagy; Unfolded protein response

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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