Version 1
: Received: 11 July 2021 / Approved: 12 July 2021 / Online: 12 July 2021 (11:33:20 CEST)
How to cite:
Soegiarto, G.; Novritasari, D.; Baskoro, A.; Fetarayani, D.; Nurani, W.K. Post Vaccination Titers of Serum Anti-Diphtheria in Indonesian Young and Middle-Aged Adults. Preprints2021, 2021070245. https://doi.org/10.20944/preprints202107.0245.v1
Soegiarto, G.; Novritasari, D.; Baskoro, A.; Fetarayani, D.; Nurani, W.K. Post Vaccination Titers of Serum Anti-Diphtheria in Indonesian Young and Middle-Aged Adults. Preprints 2021, 2021070245. https://doi.org/10.20944/preprints202107.0245.v1
Soegiarto, G.; Novritasari, D.; Baskoro, A.; Fetarayani, D.; Nurani, W.K. Post Vaccination Titers of Serum Anti-Diphtheria in Indonesian Young and Middle-Aged Adults. Preprints2021, 2021070245. https://doi.org/10.20944/preprints202107.0245.v1
APA Style
Soegiarto, G., Novritasari, D., Baskoro, A., Fetarayani, D., & Nurani, W.K. (2021). Post Vaccination Titers of Serum Anti-Diphtheria in Indonesian Young and Middle-Aged Adults. Preprints. https://doi.org/10.20944/preprints202107.0245.v1
Chicago/Turabian Style
Soegiarto, G., Deasy Fetarayani and Wita Kartika Nurani. 2021 "Post Vaccination Titers of Serum Anti-Diphtheria in Indonesian Young and Middle-Aged Adults" Preprints. https://doi.org/10.20944/preprints202107.0245.v1
Abstract
Objective: This study aimed to evaluate the antibody responses in two adult age groups after diphtheria vaccination.
Study Design: An observational analytic study was carried out to determine the difference in serum titer of anti-diphtheria antibody.
Methods: Serum antibody titers were measured just before and 3 months after injection of Diphtheria toxoid vaccine. Vaccine was given to two adult age groups of health care personnel in hospital: the young (< 40 years) and the middle-aged (≥ 40 years). Data were analyzed using the Mann-Whitney test (p < 0.05).
Results: Significant increase in serum anti-diphtheria antibody titers were recorded after vaccination in both age group (p < 0.001 in young adult and p = 0.001 in middle-aged adult, respectively). There were no substantial differences between the two groups in terms of antibody titer before vaccination (p = 0.741), 3 months after vaccination (p = 0.317) and in the increase of antibody titer (p = 0.479).
Conclusions: This study showed that there was no significant difference in the increase of anti-diphtheria antibody titers between the two age groups, proving that both young and middle-aged adults had an equal immune response to a given diphtheria vaccine.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
