Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Post Vaccination Titers of Serum Anti-Diphtheria in Indonesian Young and Middle-Aged Adults

Version 1 : Received: 11 July 2021 / Approved: 12 July 2021 / Online: 12 July 2021 (11:33:20 CEST)

How to cite: Soegiarto, G.; Novritasari, D.; Baskoro, A.; Fetarayani, D.; Nurani, W.K. Post Vaccination Titers of Serum Anti-Diphtheria in Indonesian Young and Middle-Aged Adults. Preprints 2021, 2021070245 (doi: 10.20944/preprints202107.0245.v1). Soegiarto, G.; Novritasari, D.; Baskoro, A.; Fetarayani, D.; Nurani, W.K. Post Vaccination Titers of Serum Anti-Diphtheria in Indonesian Young and Middle-Aged Adults. Preprints 2021, 2021070245 (doi: 10.20944/preprints202107.0245.v1).

Abstract

Objective: This study aimed to evaluate the antibody responses in two adult age groups after diphtheria vaccination. Study Design: An observational analytic study was carried out to determine the difference in serum titer of anti-diphtheria antibody. Methods: Serum antibody titers were measured just before and 3 months after injection of Diphtheria toxoid vaccine. Vaccine was given to two adult age groups of health care personnel in hospital: the young (< 40 years) and the middle-aged (≥ 40 years). Data were analyzed using the Mann-Whitney test (p < 0.05). Results: Significant increase in serum anti-diphtheria antibody titers were recorded after vaccination in both age group (p < 0.001 in young adult and p = 0.001 in middle-aged adult, respectively). There were no substantial differences between the two groups in terms of antibody titer before vaccination (p = 0.741), 3 months after vaccination (p = 0.317) and in the increase of antibody titer (p = 0.479). Conclusions: This study showed that there was no significant difference in the increase of anti-diphtheria antibody titers between the two age groups, proving that both young and middle-aged adults had an equal immune response to a given diphtheria vaccine.

Keywords

Age; Antibody titers; Diphtheria; Immunosenescence; Vaccine

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