Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Incidence, Mortality, Disability-Adjusted Life Years, and Trends of Prostate Cancer in Mexico from 2000 to 2019: Results from the Global Burden of Disease Study 2019

Saul A. Beltran-Ontiveros
ORCID logo ,
Martha A. Fernandez-Galindo
* ORCID logo ,
Jose M. Moreno-Ortiz
,
Jose A. Contreras-Gutierrez
,
Jesus Madueña-Molina
,
Elyakim Arambula-Meraz
,
Emir Leal-Leon
ORCID logo ,
Delia M. Becerril-Camacho
,
Veronica J. Picos-Cardenas
,
Carla Angulo-Rojo
,
Diana Z. Velazquez
,
Francisco Jimenez-Trejo
,
Francisco Gallardo-Vera
,
Daniel Diaz
* ORCID logo
Version 1 : Received: 3 May 2022 / Approved: 6 May 2022 / Online: 6 May 2022 (14:47:04 CEST)

A peer-reviewed article of this Preprint also exists.

Beltran-Ontiveros, S.A.; Fernandez-Galindo, M.A.; Moreno-Ortiz, J.M.; Contreras-Gutierrez, J.A.; Madueña-Molina, J.; Arambula-Meraz, E.; Leal-Leon, E.; Becerril-Camacho, D.M.; Picos-Cardenas, V.J.; Angulo-Rojo, C.; Velazquez, D.Z.; Jimenez-Trejo, F.; Gallardo-Vera, F.; Diaz, D. Incidence, Mortality, and Trends of Prostate Cancer in Mexico from 2000 to 2019: Results from the Global Burden of Disease Study 2019. Cancers 2022, 14, 3184. Beltran-Ontiveros, S.A.; Fernandez-Galindo, M.A.; Moreno-Ortiz, J.M.; Contreras-Gutierrez, J.A.; Madueña-Molina, J.; Arambula-Meraz, E.; Leal-Leon, E.; Becerril-Camacho, D.M.; Picos-Cardenas, V.J.; Angulo-Rojo, C.; Velazquez, D.Z.; Jimenez-Trejo, F.; Gallardo-Vera, F.; Diaz, D. Incidence, Mortality, and Trends of Prostate Cancer in Mexico from 2000 to 2019: Results from the Global Burden of Disease Study 2019. Cancers 2022, 14, 3184.

DOI: 10.3390/cancers14133184

Abstract

In 2019, the Global Burden of Disease (GBD) estimated that prostate cancer (PC) was the 16th cause of death globally in males. In Mexico, PC epidemiology has been reported for a selected number of metrics and years, although without including the most up-to-date estimates. Herein, we describe and compare the burden and trends of PC in Mexico and its 32 states from 2000 to 2019. For this, we extracted online available data from the GBD 2019 to estimate the crude and age-standardized rate (ASR per 100,000 people) of incidence, mortality, and disability-adjusted life years (DALYs). In Mexico, PC caused 27.1 thousand (95% uncertainty intervals, 20.6-36.0 thousand) incident cases, 9.2 thousand (7.7-12.7 thousand) deaths, and 161.5 thousand (122.7-219.5 thousand) DALYs in males of all ages in 2019. Among states, Sinaloa had the greatest ASR of incidence and Guerrero the highest values of deaths and DALYs. The burden of PC showed an increasing trend, although the magnitude of change differed between metrics and locations. We found both an increasing national trend and subnational variation in the burden of PC. Our results confirm the need for updated and timely estimates to design effective diagnostic and treatment campaigns in locations where the burden of PC is the highest.

Keywords

Age-standardized rate; Burden of disease; Cancer epidemiology; Malign neoplasm; Sociodemographic index; Subnational heterogeneity

Subject

MEDICINE & PHARMACOLOGY, Oncology & Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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