Roy, R., Sharma, U., Yadav, R., Rana, M.K., Sharma, A., Tanwar, P., Jain, A., & Prakash, H. (2021). Epigenetic Programming of Cancer-Related Inflammation byncRNA Rheostat: Impact on Tumor Directed Immune Therapies. Preprints. https://doi.org/10.20944/preprints202109.0148.v1
Roy, R., Aklank Jain and Hridayesh Prakash. 2021 "Epigenetic Programming of Cancer-Related Inflammation byncRNA Rheostat: Impact on Tumor Directed Immune Therapies" Preprints. https://doi.org/10.20944/preprints202109.0148.v1
Accumulating evidences demonstrate that the host genome's epigenetic modificationsare essential for living organisms to adapt extreme conditions.DNA methylation, covalent modifications of histone, andinter-association of non-coding RNAs facilitate the cellular manifestation ofepigenetic changes in the genome. Out of various factors involved in the epigenetic programming of the host, miRNA (microRNA) and LncRNA (Long non-coding RNA) are new generationnon-coding molecules that influence a variety of cellular processes like immunity, cellular differentiation, and tumor development. During tumor development, temporal changes in miRNA/LncRNA rheostat influence sterile inflammatory responses accompanied by the changes in the carcinogenic signalling in the host. At the cellular level, this is manifested by the up-regulation of Inflammasome and inflammatory pathways, which promotes cancer-related inflammation. In view of this, we discuss the potential of lncRNA and miRNA directed interventions in regulating inflammation and tumor development in the host.
Cancer related Inflammation; miRNA; LncRNA; Epigenetics, immune polarization
Biology and Life Sciences, Immunology and Microbiology
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