Preprint Concept Paper Version 1 Preserved in Portico This version is not peer-reviewed

Epigenetic Programming of Cancer-Related Inflammation byncRNA Rheostat: Impact on Tumor Directed Immune Therapies

Version 1 : Received: 6 September 2021 / Approved: 8 September 2021 / Online: 8 September 2021 (12:07:58 CEST)

How to cite: Roy, R.; Sharma, U.; Yadav, R.; Rana, M.K.; Sharma, A.; Tanwar, P.; Jain, A.; Prakash, H. Epigenetic Programming of Cancer-Related Inflammation byncRNA Rheostat: Impact on Tumor Directed Immune Therapies. Preprints 2021, 2021090148 (doi: 10.20944/preprints202109.0148.v1). Roy, R.; Sharma, U.; Yadav, R.; Rana, M.K.; Sharma, A.; Tanwar, P.; Jain, A.; Prakash, H. Epigenetic Programming of Cancer-Related Inflammation byncRNA Rheostat: Impact on Tumor Directed Immune Therapies. Preprints 2021, 2021090148 (doi: 10.20944/preprints202109.0148.v1).

Abstract

Accumulating evidences demonstrate that the host genome's epigenetic modificationsare essential for living organisms to adapt extreme conditions.DNA methylation, covalent modifications of histone, andinter-association of non-coding RNAs facilitate the cellular manifestation ofepigenetic changes in the genome. Out of various factors involved in the epigenetic programming of the host, miRNA (microRNA) and LncRNA (Long non-coding RNA) are new generationnon-coding molecules that influence a variety of cellular processes like immunity, cellular differentiation, and tumor development. During tumor development, temporal changes in miRNA/LncRNA rheostat influence sterile inflammatory responses accompanied by the changes in the carcinogenic signalling in the host. At the cellular level, this is manifested by the up-regulation of Inflammasome and inflammatory pathways, which promotes cancer-related inflammation. In view of this, we discuss the potential of lncRNA and miRNA directed interventions in regulating inflammation and tumor development in the host.

Keywords

Cancer related Inflammation; miRNA; LncRNA; Epigenetics, immune polarization

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