Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Telomere-related Genomic Instability in Papillary Thyroid Cancers: A Preliminary Study

Version 1 : Received: 27 November 2020 / Approved: 30 November 2020 / Online: 30 November 2020 (11:37:22 CET)

How to cite: Rangel-Pozzo, A.; Dettori, T.; Frau, D.V.; Gartner, J.; Fisher, G.; Vanni, R.; Mai, S.; Caria, P. Telomere-related Genomic Instability in Papillary Thyroid Cancers: A Preliminary Study. Preprints 2020, 2020110720 (doi: 10.20944/preprints202011.0720.v1). Rangel-Pozzo, A.; Dettori, T.; Frau, D.V.; Gartner, J.; Fisher, G.; Vanni, R.; Mai, S.; Caria, P. Telomere-related Genomic Instability in Papillary Thyroid Cancers: A Preliminary Study. Preprints 2020, 2020110720 (doi: 10.20944/preprints202011.0720.v1).

Abstract

Papillary thyroid carcinoma (PTC) has two main histologic variants: classical-PTC (CL-PTC) and follicular variant PTC (FV-PTC). Recently, due to its similar features to benign lesions, the encapsulated FV-PTC variant was reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Nonetheless, specific molecular signatures are not yet available. It is well known that telomere-related genome instability is caused by inappropriate DNA repair of dysfunctional telomeres and that mechanisms involved in the damaged telomere repair processing may led to detrimental outcomes, altering the 3D nuclear telomere and genome organization in cancer cells. This pilot study aimed to evaluate whether a specific nuclear telomere architecture might characterize NIFTP, potentially distinguishing it from other PTC histologic variants. Our findings demonstrate that 3D telomere profiles of CL-PTC and FV-PTC were different from NIFTP and that NIFTP more closely resembles follicular thyroid adenoma (FTA). NIFTP has longer telomeres than CL-PTC and FV-PTC samples and telomere length overlaps in NIFTP and FTA. There was no association between BRAF expression and telomere length in all tested samples. Our data showing that 3D nuclear telomere organization is altered differently in thyroid cancer variants, suggest that this parameter might guide clinical management of NIFTP. Although further investigations in a larger cohort of patients are necessary to corroborate our observations, telomere-related genomic instability might be of value in the diagnosis of NIFTP and allow for a more appropriate selection of the correct treatment.

Subject Areas

Papillary thyroid cancer; noninvasive follicular thyroid neoplasm with papillary-like nuclear features; follicular adenoma; telomere-related genomic instability

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