Version 1
: Received: 19 July 2021 / Approved: 20 July 2021 / Online: 20 July 2021 (09:37:36 CEST)
How to cite:
Kim, H.; Jo, H.Y.; Kim, S.H. Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age. Preprints2021, 2021070434. https://doi.org/10.20944/preprints202107.0434.v1
Kim, H.; Jo, H.Y.; Kim, S.H. Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age. Preprints 2021, 2021070434. https://doi.org/10.20944/preprints202107.0434.v1
Kim, H.; Jo, H.Y.; Kim, S.H. Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age. Preprints2021, 2021070434. https://doi.org/10.20944/preprints202107.0434.v1
APA Style
Kim, H., Jo, H.Y., & Kim, S.H. (2021). Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age. Preprints. https://doi.org/10.20944/preprints202107.0434.v1
Chicago/Turabian Style
Kim, H., Ha Young Jo and Seong Heon Kim. 2021 "Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age" Preprints. https://doi.org/10.20944/preprints202107.0434.v1
Abstract
Background: Little information exists regarding the differences in the clinical and laboratory characteristics of Kikuchi-Fujimoto disease (KFD) according to age. Objective: To evaluate the clinical and laboratory characteristics of KFD according to age. Methods: We retrospectively evaluated patients diagnosed with KFD at Pusan National University Hospital between 2010 and 2020. Results: Eighty patients (46 children and 34 adults) with a mean age of 21.5 ± 11.8 years (range, 3–49 years) were included in the study. Among children, the male sex ratio was higher, in adults, the female sex ratio was higher. Fever, tenderness in the lymph node, and skin rashes were more common in children, while myalgia and weight loss were more common in adults. In children, the recurrence rate was significantly higher among boys than among girls (15.8% vs 0.0%, P=0.001). EBV and ANA positivity rates were higher in boys than in girls. In adults, the recurrence rate was significantly higher in women than in men (18.2% vs 0.0%, P=0.005). ANA positivity rates were higher in women than in men. Conclusion: The clinical features, laboratory findings, and recurrence of KFD may differ depending on age and sex. Clinicians should be aware of this.
Keywords
Kikuchi-Fujimoto disease; histiocytic necrotizing lymphadenitis; prognosis; children; age
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
