Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Version 1 : Received: 19 July 2021 / Approved: 20 July 2021 / Online: 20 July 2021 (09:37:36 CEST)

How to cite: Kim, H.; Jo, H.Y.; Kim, S.H. Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age. Preprints 2021, 2021070434 (doi: 10.20944/preprints202107.0434.v1). Kim, H.; Jo, H.Y.; Kim, S.H. Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age. Preprints 2021, 2021070434 (doi: 10.20944/preprints202107.0434.v1).

Abstract

Background: Little information exists regarding the differences in the clinical and laboratory characteristics of Kikuchi-Fujimoto disease (KFD) according to age. Objective: To evaluate the clinical and laboratory characteristics of KFD according to age. Methods: We retrospectively evaluated patients diagnosed with KFD at Pusan National University Hospital between 2010 and 2020. Results: Eighty patients (46 children and 34 adults) with a mean age of 21.5 ± 11.8 years (range, 3–49 years) were included in the study. Among children, the male sex ratio was higher, in adults, the female sex ratio was higher. Fever, tenderness in the lymph node, and skin rashes were more common in children, while myalgia and weight loss were more common in adults. In children, the recurrence rate was significantly higher among boys than among girls (15.8% vs 0.0%, P=0.001). EBV and ANA positivity rates were higher in boys than in girls. In adults, the recurrence rate was significantly higher in women than in men (18.2% vs 0.0%, P=0.005). ANA positivity rates were higher in women than in men. Conclusion: The clinical features, laboratory findings, and recurrence of KFD may differ depending on age and sex. Clinicians should be aware of this.

Keywords

Kikuchi-Fujimoto disease; histiocytic necrotizing lymphadenitis; prognosis; children; age

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