Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Post-Transplant Lymphoproliferative Diseases in the Elderly after Cardiac Transplantation: The Diagnostic Role of [18f] FDG-PET With Co-Registered CT and the Effect of Sports Activity Rehabilitation Program

Antonello Sica
,
Maria Luisa de Rimini
,
Beniamino Casale
,
Caterina Sagnelli
* ORCID logo ,
Alessandro Spada
,
Alfonso Reginelli
,
Armando Calogero
,
Cristiano Amarelli
,
Ciro Maiello
,
Evangelista Sagnelli
,
Maria Paola Belfiore
,
Salvatore Cappabianca
Version 1 : Received: 28 December 2019 / Approved: 29 December 2019 / Online: 29 December 2019 (10:37:20 CET)

How to cite: Sica, A.; de Rimini, M.L.; Casale, B.; Sagnelli, C.; Spada, A.; Reginelli, A.; Calogero, A.; Amarelli, C.; Maiello, C.; Sagnelli, E.; Belfiore, M.P.; Cappabianca, S. Post-Transplant Lymphoproliferative Diseases in the Elderly after Cardiac Transplantation: The Diagnostic Role of [18f] FDG-PET With Co-Registered CT and the Effect of Sports Activity Rehabilitation Program. Preprints 2019, 2019120379. https://doi.org/10.20944/preprints201912.0379.v1 Sica, A.; de Rimini, M.L.; Casale, B.; Sagnelli, C.; Spada, A.; Reginelli, A.; Calogero, A.; Amarelli, C.; Maiello, C.; Sagnelli, E.; Belfiore, M.P.; Cappabianca, S. Post-Transplant Lymphoproliferative Diseases in the Elderly after Cardiac Transplantation: The Diagnostic Role of [18f] FDG-PET With Co-Registered CT and the Effect of Sports Activity Rehabilitation Program. Preprints 2019, 2019120379. https://doi.org/10.20944/preprints201912.0379.v1

Abstract

The incidence of cancer in organ transplant patients is higher than in the non-transplanted population. The incidence increases with increasing age. The use of Fludeoxyglucose positron emission tomography/CT (PET/CT) is sensitive and specific to detect PTLD LD compared with conventional CT imaging. We analyzed the medical data of 127 patients aged over 60 years, who underwent heart transplantation in the above period, who have been practicing early CT-PET for diagnostic purposes between February 2007 and October 2018. Of 127 consecutive patients who underwent CT-PET, SUVs up than 4, were found in 84 patients of which 20 were affected by PTLDs, seven patients were affected by chronic non neoplastic inflammatory diseases, the remainder were affected by other neoplasms. The favorable effect of physical activity programs on cardiorespiratory and psychomotor function occur in all patients. In conclusion, CT-PET at the first doubts about the possibility of the development of neoplasms has allowed a diagnosis and then a treatment more quickly. Education in behavioral norms that improve the patient's quality of life is necessary.

Keywords

post-transplant lymphoproliferative disorder; FDG-PET/CT; elder age; physical activity

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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