Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cautionary Observations Concerning the Introduction of Psychophysiological Biomarkers into Neuropsychiatric Practice

Version 1 : Received: 11 March 2022 / Approved: 17 March 2022 / Online: 17 March 2022 (15:19:38 CET)

A peer-reviewed article of this Preprint also exists.

Rapp, P.E.; Cellucci, C.; Darmon, D.; Keyser, D. Cautionary Observations Concerning the Introduction of Psychophysiological Biomarkers into Neuropsychiatric Practice. Psychiatry Int. 2022, 3, 181-205. Rapp, P.E.; Cellucci, C.; Darmon, D.; Keyser, D. Cautionary Observations Concerning the Introduction of Psychophysiological Biomarkers into Neuropsychiatric Practice. Psychiatry Int. 2022, 3, 181-205.

Journal reference: Psychiatry Int. 2022, 3, 15
DOI: 10.3390/psychiatryint3020015

Abstract

The combination of statistical learning technologies with large databases of psychophysiological data has appropriately generated enthusiastic interest in future clinical applicability. It is argued here that this enthusiasm should be tempered with the understanding that significant obstacles must be overcome before the systematic introduction of psychophysiological measures into neuropsychiatric practice becomes possible. The nonspecificity of psychophysiological measures complicates their use in diagnosis. Low test-retest reliability complicates use in longitudinal assessment, and quantitative psychophysiological measures can normalize in response to placebo intervention. Ten cautionary observations are introduced and, in some instances, possible directions for remediation are suggested.

Keywords

biomarkers; electroencephalography; event related potentials; heart rate variability; diagnosis; sensitivity; specificity

Subject

MEDICINE & PHARMACOLOGY, Psychiatry & Mental Health studies

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