REVIEW
|
doi:10.20944/preprints202104.0016.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Immune checkpoint inhibitors; pediatric solid tumor; immune suppression
Online: 1 April 2021 (12:22:35 CEST)
REVIEW
|
doi:10.20944/preprints202009.0084.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
programmed cell death; inflammation; intestinal disease; cancer; inhibitors
Online: 4 September 2020 (07:21:17 CEST)
ARTICLE
|
doi:10.20944/preprints201911.0094.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
hPSCs; ROCK inhibitors; fasudil; cell survival; metabolism; differentiation
Online: 8 November 2019 (10:41:13 CET)
ARTICLE
|
doi:10.20944/preprints201810.0103.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Nipah Virus, outbreak, inhibitors, QSAR, database, prediction algorithm
Online: 5 October 2018 (15:04:23 CEST)
REVIEW
|
doi:10.20944/preprints201809.0435.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
Acute Myeloid Leukemia; FLT3; Tyrosine kinase inhibitors; resistance
Online: 21 September 2018 (10:28:34 CEST)
ARTICLE
|
doi:10.20944/preprints201807.0540.v1
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
3-hydroxy-3-methylglutaryl-coenzyme-A inhibitors; Sepsis
Online: 27 July 2018 (13:07:17 CEST)
REVIEW
|
doi:10.20944/preprints202304.0564.v1
Subject:
Medicine And Pharmacology,
Psychiatry And Mental Health
Keywords:
serotonin antagonist/reuptake inhibitors; comorbidity; psychiatric disorders; trazodone; neurobiology; emotion
Online: 19 April 2023 (07:52:17 CEST)
ARTICLE
|
doi:10.20944/preprints202307.1694.v1
Subject:
Medicine And Pharmacology,
Internal Medicine
Keywords:
Idiopathic Pulmonary Fibrosis; Lung Neoplasms; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Database
Online: 25 July 2023 (10:01:14 CEST)
ARTICLE
|
doi:10.20944/preprints201811.0221.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Fatty Acid Amide Hydrolase; cannabinoid; carboxamide inhibitors; 3D-QSAR; CoMSIA.
Online: 8 November 2018 (14:52:23 CET)
ARTICLE
|
doi:10.20944/preprints202310.1726.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
dacomitinib; EGFR inhibitor; overall survival; pharmacokinetics; progression-free survival; proton pump inhibitors
Online: 27 October 2023 (07:06:07 CEST)
REVIEW
|
doi:10.20944/preprints202302.0205.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
breast cancer; ovarian cancer; PARP inhibitors; Alu repeats; protein-protein interactions
Online: 13 February 2023 (07:54:35 CET)
ARTICLE
|
doi:10.20944/preprints202105.0772.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Immune checkpoint inhibitors; immune-related endocrine dysfunction; hypothyroidism; targeted therapy; malignancy
Online: 31 May 2021 (12:49:40 CEST)
ARTICLE
|
doi:10.20944/preprints201706.0022.v1
Subject:
Chemistry And Materials Science,
Theoretical Chemistry
Keywords:
HPPD inhibitors; pharmacophore model; molecule docking; HipHop model; virtual screening; ChemDiv
Online: 5 June 2017 (05:16:39 CEST)
REVIEW
|
doi:10.20944/preprints202304.1236.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
FLT3 mutations; resistant/relapsed acute myeloid leukemia; tyrosine kinase inhibitors; gilteritinib
Online: 29 April 2023 (10:55:21 CEST)
REVIEW
|
doi:10.20944/preprints202305.0041.v1
Subject:
Biology And Life Sciences,
Endocrinology And Metabolism
Keywords:
endothelial dysfunction; chronic kidney disease; heart failure; sodium-glucose cotransporter 2 inhibitors
Online: 2 May 2023 (02:18:51 CEST)
REVIEW
|
doi:10.20944/preprints202003.0378.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
China's COVID-19 Guide; Remdesivir; Xuebijing; Hydroxychloroquine; IL6 inhibitors; COVID-19
Online: 26 March 2020 (01:48:42 CET)
REVIEW
|
doi:10.20944/preprints202108.0037.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
ovarian cancer; checkpoint inhibitors; ICIs; immunotherapy; PARP; avelumab; pembrolizumab; nivolumab; bevacizumab; platinum
Online: 2 August 2021 (13:01:35 CEST)
REVIEW
|
doi:10.20944/preprints202306.1955.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
breast cancer; CDK4/6 inhibitors; estrogen receptor; therapeutic resistance
Online: 28 June 2023 (07:39:44 CEST)
REVIEW
|
doi:10.20944/preprints202306.1643.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
metastasis treatment; small molecules; tyrosine kinase inhibitors; integrins; siRNA
Online: 22 June 2023 (16:10:15 CEST)
REVIEW
|
doi:10.20944/preprints202305.1761.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
checkpoint inhibitors; colitis; immune-related adverse events; enterocolitis; diarrhea
Online: 25 May 2023 (08:03:37 CEST)
REVIEW
|
doi:10.20944/preprints202305.1317.v1
Subject:
Chemistry And Materials Science,
Food Chemistry
Keywords:
Starchy food; potato protease inhibitors; phytochemicals; antioxidants; cancer prevention
Online: 18 May 2023 (09:48:15 CEST)
REVIEW
|
doi:10.20944/preprints202204.0202.v1
Subject:
Medicine And Pharmacology,
Endocrinology And Metabolism
Keywords:
Metabolic syndrome; SGLT2 inhibitors; Dapagliflozin; Empagliflozin; Canagliflozin; Translational modeling
Online: 21 April 2022 (10:12:04 CEST)
ARTICLE
|
doi:10.20944/preprints202105.0251.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Vorinostat, histone deacetylase, HDAC inhibitors, dibenzodiazocines, hydroxamic acid, selectivity
Online: 11 May 2021 (15:35:00 CEST)
REVIEW
|
doi:10.20944/preprints202104.0667.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
breast cancer; CDK inhibitors; liquid biopsy; resistance mechanisms; therapy
Online: 26 April 2021 (12:57:01 CEST)
REVIEW
|
doi:10.20944/preprints202103.0063.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
breast cancer, CDK inhibitors, liquid biopsy, resistance mechanisms, therapy
Online: 2 March 2021 (09:53:38 CET)
REVIEW
|
doi:10.20944/preprints202009.0449.v1
Subject:
Biology And Life Sciences,
Agricultural Science And Agronomy
Keywords:
oleaginous microorganisms; microbial lipids; lignocellulose pretreatment; enzymatic hydrolysis; inhibitors
Online: 19 September 2020 (05:16:42 CEST)
ARTICLE
|
doi:10.20944/preprints202301.0325.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Immune checkpoint inhibitors; Anti-tumor immunity; Predictive biomarker; Malignant melanoma; NSCLC
Online: 18 January 2023 (08:39:18 CET)
REVIEW
|
doi:10.20944/preprints202012.0343.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
COVID-19; platelet activating factor; thrombosis; inflammation; Mediterranean diet; PAF-inhibitors
Online: 14 December 2020 (14:16:37 CET)
ARTICLE
|
doi:10.20944/preprints201810.0133.v2
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
aging; angiotensin-converting enzyme inhibitors; nutrient metabolism; genetic background; nutritional stress
Online: 29 October 2018 (10:33:59 CET)
REVIEW
|
doi:10.20944/preprints202004.0160.v2
Subject:
Biology And Life Sciences,
Virology
Keywords:
COVID-19; ACE; ACE2; Angiotensin II; Bradykinin; RAS inhibitors; ACE inhibitors; AT1 receptor blockers; Losartan; Bradykinin Antagonists; Ang II loading; Giapreza; Icatibant.
Online: 14 April 2020 (14:34:43 CEST)
ARTICLE
|
doi:10.20944/preprints202305.0742.v1
Subject:
Medicine And Pharmacology,
Urology And Nephrology
Keywords:
renal lithiasis; phytate; lower inositol phosphates; crystallization inhibitors; calcium oxalate; calcium phosphates
Online: 10 May 2023 (10:45:26 CEST)
REVIEW
|
doi:10.20944/preprints202311.0529.v1
Subject:
Public Health And Healthcare,
Primary Health Care
Keywords:
SARS-CoV-2; Papain-like protease; COVID-19; Molecular modelling; Molecular dynamics simulations; Drug discovery; Antiviral drugs; Inhibitors; Therapeutic agents; therapeutic targets; Irreversible inhibitors; Repurposing drugs
Online: 8 November 2023 (16:11:55 CET)
REVIEW
|
doi:10.20944/preprints201909.0140.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
hepatocellular carcinoma; immune checkpoint inhibitors; HCC; pembrolizumab; nivolumab; immune microenvironment; targeted therapies
Online: 14 September 2019 (18:37:29 CEST)
ARTICLE
|
doi:10.20944/preprints202205.0142.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
glioblastoma; immunotherapy; radiotherapy; brain cancers; radioimmunotherapy; immune checkpoint inhibitors; temozolomide; durvalumab; immunoradiotherapy.
Online: 10 May 2022 (13:22:16 CEST)
REVIEW
|
doi:10.20944/preprints202302.0380.v1
Subject:
Medicine And Pharmacology,
Psychiatry And Mental Health
Keywords:
serotonin antagonist/reuptake inhibitors; comorbidity; psychiatric disorders; neurological disorders; dementia; primary care
Online: 22 February 2023 (08:42:51 CET)
REVIEW
|
doi:10.20944/preprints202212.0026.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Advanced Hepatocellular carcinoma; Immune checkpoint inhibitors; Low middle-income countries; Financial Toxicity
Online: 1 December 2022 (10:33:14 CET)
ARTICLE
|
doi:10.20944/preprints202011.0395.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
TNBC; Ca2+-ATPase; SICE; HDAC inhibitors; EMT; WNT signaling; vorinostat; romidepsin; vimentin
Online: 13 November 2020 (20:50:48 CET)
REVIEW
|
doi:10.20944/preprints202401.2222.v1
Subject:
Medicine And Pharmacology,
Pediatrics, Perinatology And Child Health
Keywords:
gastroesophageal reflux disease; efficacy; safety; proton-pump inhibitors; pediatric patients; systematic review
Online: 31 January 2024 (14:59:40 CET)
CASE REPORT
|
doi:10.20944/preprints202307.0971.v1
Subject:
Medicine And Pharmacology,
Dermatology
Keywords:
atopic dermatitis; emollient plus cream; topical corticosteroids; topical calcineurin inhibitors; case report
Online: 14 July 2023 (09:18:55 CEST)
REVIEW
|
doi:10.20944/preprints202306.1788.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Meningioma; Cabozantinib; VEGF; Targeted treatment Cabozantinib; METs; VEGFR2; Inhibitors; Angiogen-esis; Oncology
Online: 26 June 2023 (10:57:00 CEST)
ARTICLE
|
doi:10.20944/preprints202011.0292.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Alzheimer's disease; BACE1; Molecular dynamics; MM/GBSA; Inhibitors; Drug likeness; Ligand efficiency, Kd.
Online: 10 November 2020 (09:10:50 CET)
REVIEW
|
doi:10.20944/preprints202110.0298.v1
Subject:
Medicine And Pharmacology,
Orthopedics And Sports Medicine
Keywords:
Osteoarthritis; LithoLexal; Lithothamnion; Disease-modifying adjunctive therapy; Anti-inflammatory agents; Cytokine inhibitors
Online: 20 October 2021 (22:49:47 CEST)
ARTICLE
|
doi:10.20944/preprints202007.0221.v1
Subject:
Chemistry And Materials Science,
Food Chemistry
Keywords:
hCA IX and XII; dual inhibitors; molecular modeling studies; in vitro assays
Online: 11 July 2020 (02:30:03 CEST)
ARTICLE
|
doi:10.20944/preprints202311.1938.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
drug-induced allergy; anaphylaxis; antibiotics; local anesthetics; cyclooxygenase (COX)-inhibitors
Online: 30 November 2023 (04:21:45 CET)
ARTICLE
|
doi:10.20944/preprints202305.1103.v1
Subject:
Engineering,
Bioengineering
Keywords:
mutate HIV protease inhibitors; carboxamides; heteroarenes; mammalian cells essay; ADME
Online: 16 May 2023 (05:32:28 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0327.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Ovarian cancer; PARP inhibitors; epithelial to mesenchymal transition; drug response
Online: 13 April 2023 (14:30:07 CEST)
REVIEW
|
doi:10.20944/preprints202010.0338.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Urothelial carcinoma; immune checkpoint inhibitors; immunotherapy; tumor microenvironment; metabolic pathway
Online: 16 October 2020 (08:00:41 CEST)
REVIEW
|
doi:10.20944/preprints202004.0331.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
COVID-19; associated comorbidities; treatment; ACE2 inhibitors; Type 2 diabetes
Online: 19 April 2020 (05:42:22 CEST)
ARTICLE
|
doi:10.20944/preprints202004.0003.v2
Subject:
Biology And Life Sciences,
Virology
Keywords:
SARS-CoV-2; protease; virtual screening; pharmacophore; inhibitors; natural compounds
Online: 17 April 2020 (11:00:55 CEST)
REVIEW
|
doi:10.20944/preprints202105.0430.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
ethylene biosynthesis; ethylene inhibitors; in vitro culture; plant hormones; S-adenosylmethionine; stress responses
Online: 19 May 2021 (07:50:29 CEST)
REVIEW
|
doi:10.20944/preprints202306.0994.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
hepatocellular carcinoma (HCC); LOXL2; tumor microenvironment (TME); extracellular matrix (ECM); LOXL2 inhibitors; target therapy
Online: 14 June 2023 (07:18:34 CEST)
ARTICLE
|
doi:10.20944/preprints201805.0209.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Vezf1; angiogenesis; vascular biology; endothelial cells; MSS31, tube formation, small molecule inhibitors computational modeling.
Online: 15 May 2018 (08:08:15 CEST)
ARTICLE
|
doi:10.20944/preprints202307.0161.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Non-small cell lung cancer; Targeted Gene Therapy; Immune Checkpoint Inhibitors; Machine Learning
Online: 4 July 2023 (07:57:03 CEST)
REVIEW
|
doi:10.20944/preprints202309.1061.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
prodrugs; HIV; AIDS; Nucleoside Reverse Transcriptase Inhibitors (NRTI); co-drugs; new drugs; medicinal chemistry
Online: 18 September 2023 (05:47:07 CEST)
REVIEW
|
doi:10.20944/preprints201910.0255.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
antimicrobial resistance; biofilm; efflux pump inhibitors; antibiotic potentiation; eskapee pathogens; gram-negative bacteria
Online: 22 October 2019 (10:22:56 CEST)
ARTICLE
|
doi:10.20944/preprints201812.0362.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Antibiotic resistance, efflux pump inhibitors, Escherichia coli, efflux pumps, multidrug resistance, Staphylococcus aureus
Online: 31 December 2018 (09:55:32 CET)
ARTICLE
|
doi:10.20944/preprints202305.2226.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
melanoma; cutaneous melanoma; mucosal melanoma; uveal melanoma; immune-checkpoint inhibitors; metabolomics; tryptophan; kynurenine; spermine
Online: 31 May 2023 (10:45:46 CEST)
CASE REPORT
|
doi:10.20944/preprints202201.0298.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Checkpoint inhibitors; Immune related adverse events; Cholestasis; Severe ductopenia; Vanishing bile duct syndrome
Online: 20 January 2022 (11:07:21 CET)
ARTICLE
|
doi:10.20944/preprints202109.0375.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
HIV-protease inhibitors; pseudo-symmetric core; heteroaryl carboxyamides; synthesis; biological screening; molecular modeling
Online: 22 September 2021 (10:44:16 CEST)
ARTICLE
|
doi:10.20944/preprints202404.1746.v1
Subject:
Life Sciences,
Biology And Life Sciences
Keywords:
Retinoblastoma; Epigenetic Reprogramming; Cancer Therapy; Epigenetic Therapy; DNA methyltransferase (DNMT) inhibitors
Online: 26 April 2024 (12:19:15 CEST)
SHORT NOTE
|
doi:10.20944/preprints202312.0899.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
monoamine oxidase; inhibitors; 1,3-oxazole; benzenesulfonamide; drug research; Parkinson’s disease; MAO
Online: 12 December 2023 (14:22:48 CET)
REVIEW
|
doi:10.20944/preprints202311.0295.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
Atrial fibrillation, SGLT2 inhibitors, cardiovascular outcomes, hemodynamic effects, AF risk reduction
Online: 6 November 2023 (08:13:49 CET)
REVIEW
|
doi:10.20944/preprints202310.1318.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
advanced melanoma; immunotherapy; target therapy; lysine histone methyl transferase inhibitors; UNC0642
Online: 20 October 2023 (08:35:45 CEST)
REVIEW
|
doi:10.20944/preprints202305.0751.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Skin pigmentation; melanin; Tyrosinase inhibitors; hypopigmentation; hyperpigmentation; Vitiligo; skin-lightening; Depigmentation
Online: 10 May 2023 (11:32:48 CEST)
REVIEW
|
doi:10.20944/preprints202201.0468.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Flavivirus; NS2B-NS3; ZIKA Virus; Dengue Virus; West Nile Virus; Inhibitors
Online: 31 January 2022 (13:46:44 CET)
ARTICLE
|
doi:10.20944/preprints202106.0565.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
HIV-1 transcription; HIV-1 Tat; TAR RNA; small molecule inhibitors
Online: 23 June 2021 (11:04:21 CEST)
REVIEW
|
doi:10.20944/preprints202102.0150.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
CTLA-4; Treg cells: Immune checkpoint inhibitors; CD28; Antigen Presenting Cells
Online: 5 February 2021 (09:35:47 CET)
ARTICLE
|
doi:10.20944/preprints202310.0751.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Drosophila; male meiosis; cyclin B; Cyclin-dependent kinase 1; Cyclin-dependent kinase inhibitors
Online: 12 October 2023 (05:32:28 CEST)
REVIEW
|
doi:10.20944/preprints202311.1632.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
checkpoint inhibitors; esophageal cancer; gastric cancer; immunotherapy; PD-L1; HER2; clinical trials; history; disparities
Online: 28 November 2023 (01:45:08 CET)
ARTICLE
|
doi:10.20944/preprints202211.0516.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Antivirals; coronavirus; COVID-19; covalent drugs; dynamic light scattering; inhibitors; main protease; natural products
Online: 28 November 2022 (13:40:01 CET)
ARTICLE
|
doi:10.20944/preprints202103.0752.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Mixture toxicity; Neurotoxicity; Antagonism; Organophosphate; Acetylcholinesterase inhibitors; GABA; Behavior; Risk assessment; Spontaneous movement activity
Online: 31 March 2021 (07:52:05 CEST)
ARTICLE
|
doi:10.20944/preprints202102.0408.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
NhaP2-type cation-proton antiporter; Vibrio cholerae; Amiloride Analogs; Inhibitors against NhaP-type antiporters
Online: 18 February 2021 (10:39:07 CET)
ARTICLE
|
doi:10.20944/preprints202305.2032.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Hep-G2 hepatocarcinoma cell; Deuterium-depleted water; Deuterium-enriched water; Cyclooxygenase inhibitors; MAPK pathway; Apoptosis
Online: 30 May 2023 (04:02:57 CEST)
ARTICLE
|
doi:10.20944/preprints202403.1433.v1
Subject:
Computer Science And Mathematics,
Artificial Intelligence And Machine Learning
Keywords:
FLT3 Inhibitors; Ligand-based Drug Design; Computer-Aided Drug Design; QSAR Modeling; AML Treatment
Online: 25 March 2024 (08:47:40 CET)
REVIEW
|
doi:10.20944/preprints202012.0167.v2
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Matrix metalloproteinase; MMPs; protease; TIMPs; exosite; small molecule inhibitors; monoclonal antibodies; proteomics; N-terminomics; TAILS
Online: 24 March 2021 (16:23:28 CET)
ARTICLE
|
doi:10.20944/preprints202403.1686.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
lung adenocarcinoma; drug-tolerant persister (DTP) cells; intrinsic resistance; tyrosine kinase inhibitors (TKIs); erlotinib; osimertinib; senescent cells; CD74
Online: 28 March 2024 (12:16:57 CET)
REVIEW
|
doi:10.20944/preprints202307.1557.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
vulnerable plaque; intravascular imaging; intravascular ultrasound; optical coherent tomography; computed tomography coronary angiography; PCSK9 inhibitors.
Online: 25 July 2023 (10:21:55 CEST)
REVIEW
|
doi:10.20944/preprints202401.0310.v1
Subject:
Medicine And Pharmacology,
Dentistry And Oral Surgery
Keywords:
inflammation; inflammasome; inhibitors of the inflammasome; nanomaterials; functionalized biomaterials; periodontitis; general pathology
Online: 4 January 2024 (09:25:17 CET)
HYPOTHESIS
|
doi:10.20944/preprints202309.0196.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Neurodegenerative disorders; schizophremia; PDK1 inhibitors; Lipid replacement therapy; Aryl hydrocarbon receptor antagonists
Online: 4 September 2023 (14:29:13 CEST)
ARTICLE
|
doi:10.20944/preprints202308.0458.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
polyamine analogs; monoamine oxidases; antiproliferative activity; inhibitors; docking studies; LN-229 cells
Online: 7 August 2023 (11:57:36 CEST)
REVIEW
|
doi:10.20944/preprints202308.0055.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
COVID-19; SARS-CoV-2 Mpro; protease inhibitors; coronavirus; peptidomimetics; Paxlovid; Nirmatrelvir
Online: 2 August 2023 (05:25:21 CEST)
ARTICLE
|
doi:10.20944/preprints202307.1905.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Colorectal cancer; pharmacovigilance; BRAF inhibitors; regorafenib; encorafenib; adverse drug reactions; renal disorders
Online: 28 July 2023 (02:34:59 CEST)
REVIEW
|
doi:10.20944/preprints202307.0979.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
breast cancer; microbiota; estrobolome; β-glucuronidase; dysbiosis; inhibitors; metabolomics; personalized medicine; review
Online: 14 July 2023 (07:08:34 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0530.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Poly (ADP-Ribose) Polymerase-1; PARP inhibitors; neoplasm; cancer; animal disease models
Online: 19 April 2023 (03:30:59 CEST)
ARTICLE
|
doi:10.20944/preprints202212.0170.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
SonoCloud; GL261 mouse model; ultrasound-mediated drug delivery; glioblastoma; immune checkpoint inhibitors
Online: 9 December 2022 (02:59:28 CET)
REVIEW
|
doi:10.20944/preprints202308.1547.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Main Protease Inhibitors; SARS-CoV-2; COVID-19; mutations; vaccines; therapeutics; drug repurposing; management strategies
Online: 22 August 2023 (09:31:05 CEST)
REVIEW
|
doi:10.20944/preprints202305.1239.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Hodgkin lymphoma; non-Hodgkin lymphoma; PD1 / PD-L1 checkpoint inhibitors; tumor mutational burden; predictive biomarkers
Online: 17 May 2023 (10:52:16 CEST)
ARTICLE
|
doi:10.20944/preprints202111.0125.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
artificial intelligence; de novo design; fragment-based drug discovery; HIV-1 inhibitors; pseudo natural products
Online: 8 November 2021 (09:23:49 CET)
ARTICLE
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
kinase inhibitors; pure drug nanoparticles; drug nanocrystals; bottom-up nanonization; nanoprecipitation; microfluidics; flow focusing technologies
Online: 2 March 2021 (11:29:18 CET)
REVIEW
|
doi:10.20944/preprints202306.1269.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
tumor microenvironment; extracellular matrix; proteoglycans; tumor-associated fibroblasts; tumor immunity; immune checkpoint inhibitors; tumor stroma; angiogenesis
Online: 19 June 2023 (03:16:16 CEST)
REVIEW
|
doi:10.20944/preprints202207.0256.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cancer; immunotherapy; adverse events; immune checkpoints inhibitors; chimeric antigen receptor therapy; bispecific antibodies; toxicity; renal; oncology
Online: 18 July 2022 (09:21:56 CEST)
ARTICLE
|
doi:10.20944/preprints201906.0074.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
agrobacterium tumefaciens-mediated transformation; citrus fruit; metal ion chelators; fruit-fungal interaction; transcription factor; virulence; protease inhibitors
Online: 10 June 2019 (09:56:16 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0539.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Antibiotic resistance; metallo-β-lactamases; metal-dependent enzymes; broad-spectrum inhibitors; inhibition assays; enzyme kinetics
Online: 31 March 2023 (03:35:02 CEST)
ARTICLE
|
doi:10.20944/preprints202307.1154.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Uterine fibroids; BRD9 inhibitors; Cell proliferation; Extracellular Matrix; Transcriptome; Epigenome; m6A regulators; Epitranscriptome
Online: 18 July 2023 (04:30:08 CEST)
SHORT NOTE
|
doi:10.20944/preprints202212.0230.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
monoamine oxidase; inhibitors; indole; 1,2,4-oxadiazole; drug research; neuroprotective drugs; Parkinson’s disease; MAO
Online: 13 December 2022 (07:12:01 CET)
ARTICLE
|
doi:10.20944/preprints202010.0032.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
Nanomedicine; human ferritin; gastrointestinal tumors; non-camptothecin topoisomerase I inhibitors; drug-delivery; CD71
Online: 2 October 2020 (09:21:53 CEST)
ARTICLE
|
doi:10.20944/preprints202004.0439.v1
Subject:
Biology And Life Sciences,
Biophysics
Keywords:
SARS-CoV-2; COVID-19; spike glycoprotein; variability; molecular docking; molecular dynamics; inhibitors
Online: 24 April 2020 (11:42:01 CEST)
ARTICLE
|
doi:10.20944/preprints202310.0830.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
ZST316; L-257; dimethylarginine dimethylaminohydrolase 1; DDAH1 inhibitors; triple negative breast cancer; pharmacokinetics; xenograft models; analytical chemistry
Online: 12 October 2023 (12:01:21 CEST)
REVIEW
|
doi:10.20944/preprints201809.0364.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
clear cell renal cell carcinoma; hypoxia inducible factors (HIFs); selenium; PD-L1; miRNA; VEGF; mTOR inhibitors
Online: 19 September 2018 (05:10:22 CEST)
REVIEW
|
doi:10.20944/preprints202403.1790.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
heart failure; reduced ejection fraction; SGLT2 inhibitors; vericiguat; CardioMEMS; Cardiac Contractility Modulation; Left bundle branch area pacing; Wearable cardioverter defibrillators; Ultrafiltration
Online: 28 March 2024 (17:15:23 CET)