Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Micronutrients, Non-Nutrients and Mediterranean Diet: A Potential Protective Role Against COVID-19 through Modulation of PAF Actions and Metabolism

Version 1 : Received: 12 December 2020 / Approved: 14 December 2020 / Online: 14 December 2020 (14:16:37 CET)

How to cite: Detopoulou, P.; Demopoulos, C.; Antonopoulou, S. Micronutrients, Non-Nutrients and Mediterranean Diet: A Potential Protective Role Against COVID-19 through Modulation of PAF Actions and Metabolism. Preprints 2020, 2020120343 (doi: 10.20944/preprints202012.0343.v1). Detopoulou, P.; Demopoulos, C.; Antonopoulou, S. Micronutrients, Non-Nutrients and Mediterranean Diet: A Potential Protective Role Against COVID-19 through Modulation of PAF Actions and Metabolism. Preprints 2020, 2020120343 (doi: 10.20944/preprints202012.0343.v1).

Abstract

The new coronavirus disease 2019 (COVID-19) pandemic is an emerging situation with high rates of morbidity and mortality, in the pathophysiology of which inflammation and thrombosis are implicated. The disease is directly connected to the nutritional status of patients and a well-balanced diet is recommended by official sources. Recently, the role of platelet activating factor (PAF) was suggested in the pathogenesis of COVID-19. In the present review several micronutrients (vitamin A, vitamin C, vitamin E, vitamin D, selenium, omega-3 fatty acids, minerals), phytonutrients and Mediterranean diet compounds (olive oil, fish, honey, plant foods) with potential anti-COVID activity are presented. We further underline that the well-known anti-inflammatory and anti-thrombotic actions of the investigated nutrients and/ or holistic dietary schemes, such as the Mediterranean diet, are also mediated through PAF. In conclusion, although there is no single food to prevent coronavirus, the aim is to follow a healthy diet containing PAF inhibitors in order to target both inflammation and thrombosis and try to avoid or/and reduce the deleterious effects of the COVID-19 epidemic.

Subject Areas

COVID-19; platelet activating factor; thrombosis; inflammation; Mediterranean diet; PAF-inhibitors

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