Butranova, O.; Zyryanov, S.; Gorbacheva, A.; Asetskaya, I.; Polivanov, V. Drug-Induced Anaphylaxis: National Database Analysis. Pharmaceuticals2024, 17, 90.
Butranova, O.; Zyryanov, S.; Gorbacheva, A.; Asetskaya, I.; Polivanov, V. Drug-Induced Anaphylaxis: National Database Analysis. Pharmaceuticals 2024, 17, 90.
Butranova, O.; Zyryanov, S.; Gorbacheva, A.; Asetskaya, I.; Polivanov, V. Drug-Induced Anaphylaxis: National Database Analysis. Pharmaceuticals2024, 17, 90.
Butranova, O.; Zyryanov, S.; Gorbacheva, A.; Asetskaya, I.; Polivanov, V. Drug-Induced Anaphylaxis: National Database Analysis. Pharmaceuticals 2024, 17, 90.
Abstract
(1) Background: National health system databases represent one of the most obvious sources of information about epidemiology of adverse drug reactions including drug-induced allergy and anaphylaxis. (2) Methods: Retrospective analysis of data from national database of pharmacovigilance in the Russian Federation (analyzed period 02.04.2019 - 21.06.2023) was performed. The prevalence of anaphylactic reactions (ARs) was determined, the structure of drugs involved was estimated together with patients’ characteristics. (3) Results: ARs were reported in 8.3% of drug-induced allergic reactions (2304/27,727), mean age of patients was 48.2 ± 15.8 years, 53.2% were females. Main causative groups of drugs were antibiotics, ABs (44.62%), local anesthetics, (19.97%), and cyclooxygenase (COX)-inhibitors (10.07%). Fatal ARs was reported in 9.5% (218/2304), mean age 48.0 ± 16.7 years, 56.2% females. Pediatric population accounted for 5.8% (133/2304), mean age 11.8± 4.5 years, 51.9% females. Elderly population accounted for 2.8% (65/2304), mean age 73.0±5.3 years, 43.5% (27/65) females. ABs were the leading causative groups of ARs in the elderly (40%), children (42.86%), and among fatal cases (50%). (4) Conclusions: ARs accounted for 8.3% of all drug-induced allergic reactions, and ABs were the most common causative agents. Females predominated in all groups except elderly patients.
Keywords
drug-induced allergy; anaphylaxis; antibiotics; local anesthetics; cyclooxygenase (COX)-inhibitors
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
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