Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

A Comprehensive Review on Skin Pigmentation-Types, Causes, and Treatment

Version 1 : Received: 6 May 2023 / Approved: 10 May 2023 / Online: 10 May 2023 (11:32:48 CEST)

A peer-reviewed article of this Preprint also exists.

Thawabteh, A.M.; Jibreen, A.; Karaman, D.; Thawabteh, A.; Karaman, R. Skin Pigmentation Types, Causes and Treatment—A Review. Molecules 2023, 28, 4839. Thawabteh, A.M.; Jibreen, A.; Karaman, D.; Thawabteh, A.; Karaman, R. Skin Pigmentation Types, Causes and Treatment—A Review. Molecules 2023, 28, 4839.

Abstract

Humans have extremely variable skin pigmentation and melanin production influenced by genetics, UV exposure, and some medications. A significant number of skin illnesses that result in pigmentary abnormalities have an impact on patients’ physical appearance as well as their psychological and social well-being. Skin pigmentation can be divided into two basic categories: hyperpigmentation, where pigment appears to overflow, and hypopigmentation, where pigment is reduced. Albinism, melasma, vitiligo, Addison's disease, and post-inflammatory hyperpigmentation, which can be brought on by eczema, acne vulgaris, and drug interactions, are the most common skin pigmentation disorders in clinical practice. Anti-inflammatory medications, antioxidants, and medications that inhibit tyrosine, which prevents the production of melanin, are all possible treatments for pigmentation problems. Skin pigmentation can be treated orally and topically with medications, herbal remedies, and cosmetic products, but a doctor should always be consulted before beginning any new medicine or treatment plan. This review article explores the numerous types of pigmentation problems, their causes, and treatments, as well as the 25 plants, four marine species, and 17 topical and oral medications now on the market that have been clinically tested to treat skin diseases.

Keywords

Skin pigmentation; melanin; Tyrosinase inhibitors; hypopigmentation; hyperpigmentation; Vitiligo; skin-lightening; Depigmentation

Subject

Medicine and Pharmacology, Medicine and Pharmacology

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