Version 1
: Received: 26 February 2021 / Approved: 2 March 2021 / Online: 2 March 2021 (09:53:38 CET)
How to cite:
González-Conde, M.; Yanez, C.; López-López, R.; Costa, C. Liquid Biopsy: New Tool to Overcome CDKi Resistance Mechanism in Luminal Metastatic Breast Cancer. Preprints2021, 2021030063. https://doi.org/10.20944/preprints202103.0063.v1
González-Conde, M.; Yanez, C.; López-López, R.; Costa, C. Liquid Biopsy: New Tool to Overcome CDKi Resistance Mechanism in Luminal Metastatic Breast Cancer. Preprints 2021, 2021030063. https://doi.org/10.20944/preprints202103.0063.v1
González-Conde, M.; Yanez, C.; López-López, R.; Costa, C. Liquid Biopsy: New Tool to Overcome CDKi Resistance Mechanism in Luminal Metastatic Breast Cancer. Preprints2021, 2021030063. https://doi.org/10.20944/preprints202103.0063.v1
APA Style
González-Conde, M., Yanez, C., López-López, R., & Costa, C. (2021). Liquid Biopsy: New Tool to Overcome CDKi Resistance Mechanism in Luminal Metastatic Breast Cancer. Preprints. https://doi.org/10.20944/preprints202103.0063.v1
Chicago/Turabian Style
González-Conde, M., Rafael López-López and Clotilde Costa. 2021 "Liquid Biopsy: New Tool to Overcome CDKi Resistance Mechanism in Luminal Metastatic Breast Cancer" Preprints. https://doi.org/10.20944/preprints202103.0063.v1
Abstract
Breast cancer is the most commonly diagnosed cancer in women worldwide. Approximately, 70 % of breast cancer patients express hormone receptors (HR) (Luminal subtype). Adjuvant endocrine treatments are the standard of care in HR+/HER2- breast cancer. Over time, about 50% of those patients develop endocrine resistance and metastatic breast cancer. Cyclin-dependent kinase inhibitors (CDKi) in combination with an aromatase inhibitor or fulvestrant have demonstrated superior efficacy increasing progression-free survival, with a safe toxicity profile, in HR+/HER2- metastatic breast cancer patients. CDKi blocks kinases 4/6 ATP-binding domain preventing G1/S cell cycle transition. Despite this, not all patients respond to CDKi and those who respond, finally develop resistance to combination therapy. Different studies, in tumour tissue or cell lines, have tried to elucidate the mechanisms underlying this progression, but there are still no conclusive data. In the last few years, liquid biopsy has contributed relevant information to this knowledge. Liquid biopsy can be performed in real-time, non-invasively and be repeated whenever needed. Circulating tumour material are potential prognostic markers in metastatic luminal breast cancer to determine patient prognosis, monitor disease and treatment selection. The objective of this review is to outline the different studies carried out in HR+ metastatic breast cancer patients treated with CDKi plus endocrine therapy using liquid biopsy approaches looking for possible resistance mechanisms.
Keywords
breast cancer, CDK inhibitors, liquid biopsy, resistance mechanisms, therapy
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
