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Preprint REVIEW | doi:10.20944/preprints202401.1654.v1

Chronic Fatigue Syndrome, Viruses and Related Conditions in Women: The Liver Link

Nuria Lorite-Ayán

Subject: Medicine And Pharmacology, Other Keywords: Chronic fatigue syndrome; Epstein Barr virus; Liver; Th1 - Th2; Women’ s Health

Online: 23 January 2024 (09:55:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0925.v1

Middle Meningeal Artery Embolization Reduces the Recurrence Rate of Chronic Subdural Hematoma

Ying Wang, Anwen Shao, Wei Wang, Qinghua Huang, Wei Yan, Meijuan Lan

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: chronic subdural hematoma; middle meningeal artery embolization; propensity score matching; burr hole craniostomy

Online: 15 November 2023 (02:06:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0551.v1

Chronic Kidney Disease in the Elderly Patient with Diabetes

Raja Ravender, Maria-Eleni Roumelioti, Darren W Schmidt, Mark L Unruh, Christos Argyropoulos

Subject: Medicine And Pharmacology, Other Keywords: Diabetes; Chronic Kidney Disease; Treatment; Elderly; Geriatric; Dialysis; SGLT2 inhibitors; GLP1 Receptor Agonists; Non-steroidal Mineralocorticoid Antagonists

Online: 9 October 2023 (16:56:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0134.v1

Chronic Pediatric Pain in Low and Middle Income Countries

Camila Walters, Matthew Kynes, Jenna Sobey, Tsitsi Chimhundu-Sithole, Kelly McQueen

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pediatric pain; low income country; middle income country; low and middle income country; pediatric palliative care.

Online: 8 June 2018 (12:45:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0087.v1

DPP-4/GLP-1 Axis as a Potential Therapeutic Target in Chronic Stress-related Vascular Aging and Atherosclerosis

Ying Wan, Limei Piao, Yongshan Nan, Xian-Wu Cehng

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Chronic stress; Vascular senescence; inflamamtion; atherosclerosis; dipeptidyl peptidase-4

Online: 9 January 2020 (13:05:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0686.v1

Is Chronic Kidney Disease due to Cadmium Exposure Inevitable and Can it be Reversed?

Soisungwan Satarug

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: albuminuria; β2-microglobulin; cadmium; chronic kidney disease; GFR; proteinuria; receptor-mediated endocytosis

Online: 12 February 2024 (13:51:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0373.v1

Improving Quality of Life in Chronic Fatigue Syndrome using Antioxidant Complex Twendee M®.

Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, Haruhiko Inufusa

Subject: Biology And Life Sciences, Life Sciences Keywords: oxidative stress; Twendee M®; antioxidant; chronic fatigue syndrome; ROS; mitochondria; inflammation

Online: 6 February 2024 (11:06:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1193.v1

The Influence of Emotional Intelligence in Quality of Life in Patients Undergoing Chronic Hemodialysis

Afra Masià-Plana, Miquel Sitjar-Suñer, Susana Mantas-Jiménez, Rosa Suñer-Soler

Subject: Public Health And Healthcare, Nursing Keywords: Chronic Kidney Disease; Hemodialysis; Emotional Intelligence; Quality of life; Sex differences; Nursing

Online: 16 January 2024 (06:22:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1228.v1

Varvara Aleksandrovna Ryabkova, Artemiy Vladimirovich Rubinskiy, Valeriy Nikolaevich Marchenko, Vasiliy Ivanovich Trofimov, Leonid Pavlovich Churilov

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: chronic fatigue syndrome; COVID-19; Post-COVID; heart rate variability; autonomic dysfunction

Online: 20 November 2023 (07:51:21 CET)

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Background There is a considerable overlap between clinical presentation of post-COVID-19 condition (PCC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) . Many of their common symptoms can be linked to dysregulation of the autonomic nervous system (dysautonomia). This study aimed to objectively assess autonomic function in patients with PCC and in patients with ME/CFS whose disease was not related to COVID-19. Methods Synchronous recordings of an electrocardiogram, continuous dynamics of blood pressure in the digital artery using the Penaz method and ultrasound pneumotachography with the spirography function were obtained with spiroarteriocardiorhythmography method in 34 patients diagnosed with ME/CFS, in whom the onset of the disease was not associated with COVID-19, 29 patients meeting PCC definition and 32 healthy controls. Heart rate variability (HRV), systolic and diastolic blood pressure variability (RV), respiration variability were assessed at rest and in tests with fixed respiratory rates. At rest, indicators of baroreflex regulation were additionally determined (baroreflex effectiveness index and baroreflex sensitivity). Results The total power, power of very low frequency, low-frequency and high-frequency of RR interval variability at rest as well as baroreflex effectiveness index in up-ramps of arterial blood pressure and baroreflex sensitivity were significantly lower both in PCC and ME/CFS patients compared to HC. Several diagnostic prediction models for ME/CFS were developed based on HRV parameters. During slow breathing HRV parameters return to normal in PCC, but not in ME/CFS. Correlation analysis revealed a close relationship of HRV, RV parameters and baroreflex sensitivity with fatigue, but not with HADS depressive/anxiety symptoms in ME/CFS and PCC. Conclusion A similar pattern of HRV and baroreflex failure with signs of a pathological acceleration of age-dependant dysautonomia was identified in ME/CFS and PCC. The clinical, diagnostic and therapeutic implications of these findings are discussed, in light of previously described relationship between inflammation, vascular pathology, atherosclerotic cardiovascular disease and autonomic dysfunction.

Preprint ARTICLE | doi:10.20944/preprints201907.0064.v1

Microcystins and Daily Sunlight: Predictors of Chronic Liver Disease and Cirrhosis Mortality

Rajesh Melaram

Subject: Environmental And Earth Sciences, Environmental Science Keywords: microcystins; climatic factors; chronic liver disease and cirrhosis; daily sunlight; enzyme-linked immunosorbent assay

Online: 3 July 2019 (11:46:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1522.v1

A Review and Meta-Analysis of the Effect of Atenolol on All-Cause Mortality Risk among Asians With Chronic Progressive Diseases

Abdullah Alkattan, Eman Alsalameen, Alaa Harmoush, Mhd Nour Farawati, Hind Alsharif, Nagla Mahmoud, Mhd Ali Farawati, Amjad Alfaleh, Mahmoud Kandeel, Nashwa Radwan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Atenolol; mortality; Asians; chronic progressive disease; cardiovascular disease

Online: 22 September 2023 (04:36:12 CEST)

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Working Paper ARTICLE

Effects of Chronic Lithium Treatment on Anxious Behaviors and Serotonergic Genes Expression in the Midbrain Raphe Nuclei of Defeated Male Mice

Dmitriy A. Smagin, Irina L Kovalenko, Anna G. Galyamina, Irina V Belozertseva, Nikolay V Tamkovich, Konstantin O Baranov, Natalia N. Kudryavtseva

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic social defeat stress; anxiety; lithium chloride; mice

Online: 3 June 2021 (11:41:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1348.v1

Examining the Impact of Infection Reactivation on Extracellular Vesicles purified from Patients with Chronic Chagas Disease

Rafael Pedro Madeira, Paula Meneghetti, Nicholy Lozano, Gislene M. Namiyama, Vera Lucia Pereira-Chioccola, Ana Claudia Torrecilhas

Subject: Biology And Life Sciences, Parasitology Keywords: Trypanosoma cruzi; extracellular vesicles; chronic Chagas Disease patients; immunosuppression; infection reactivation.

Online: 18 December 2023 (15:17:58 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202005.0035.v1

When Chronic Diseases Meet Infectious Diseases: A Proposal Toward Healthy Aging: Lessons from COVID-19 Outbreak

Juan Carlos Gómez-Verjan, Carmen García-Peña, Nadia A. Rivero-Segura

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; Chronic diseases; Aging; Immune response; Public health; Healthy Aging

Online: 3 May 2020 (08:15:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0198.v1

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Raimunda Sheyla Carneiro Dias, Dyego José de Araújo Brito, Cleodice Alves Martins, Elton Jonh Freitas Santos, Erika Cristina Ribeiro de Lima Carneiro, Elisangela Milhomen dos Santos, Denizar Vianna Araújo, Natalino Salgado Filho, Mario Bernardo Filho

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Magnesium deficiency; Body composition; Chronic kidney failure.

Online: 13 July 2022 (09:27:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0645.v1

Can a single trial of a thoracolumbar myofascial release technique reduce pain and disability in chronic low back pain? Randomized balanced cross-over study

Luana Rocha Paulo, Ana Cristina Rodrigues Lacerda, Fábio Luiz Mendonça Martins, José Sebastião Cunha Fernandes, Leonardo Sette Vieira, Cristiano Queiroz Guimarães, Sílvia de Simoni Guedes Ballesteros, Marco Túlio Saldanha dos Anjos, Patrícia Aparecida Tavares, Sueli Ferreira da Fonseca, Murilo Xavier Oliveira, Mário Bernardo-Filho, Danúbia da Cunha de Sá-Caputo, Vanessa Amaral Mendonça, Redha Taiar

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: fascia; chronic low back pain; myofascial release

Online: 25 March 2021 (16:24:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0143.v1

Income Levels and Mortality Rates in Patients with Chronic Kidney Disease in South Korea: a Population-Based Cohort Study Using National Health Insurance Data

Young Choi

Subject: Public Health And Healthcare, Health Policy And Services Keywords: chronic kidney disease; low socioeconomic status; mortality

Online: 6 August 2020 (09:46:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2098.v1

Frailty in Older Patients with End-Stage Renal Disease and Undergoing Chronic Dialysis in Vietnam

Tan Van Nguyen, Thu Thi Xuan Pham, Mason Jenner Burns, Tu Ngoc Nguyen

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: chronic kidney disease; end-stage renal disease; dialysis; diabetes; frailty; elderly; Vietnam

Online: 29 June 2023 (10:16:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0645.v1

Best Administration Schedule for Optimal Efficacy and Safety of Arsenic Trioxide Treatment in Chronic Graft versus Host Disease

Dominique Rongvaux-Gaïda, Lieven Huysse, François Rieger, Carole Nicco

Subject: Medicine And Pharmacology, Hematology Keywords: Arsenic trioxide; Chronic Graft-versus-Host Disease; cGvHD; Corticosteroid; autoimmunity

Online: 11 March 2024 (15:18:01 CET)

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Chronic graft-versus-host disease (cGvHD) occurs in 20-50% of recipients following allogeneic haematopoietic stem cell transplantation (allo-HSCT). Corticosteroids (CS) remain the first line treatment but have suboptimal efficacy and carry the risk of long-term side effects. New agents with a better safety profile and higher efficacy, ideally combining immunomodulatory and antifibrotic properties, are urgently needed. From 2016 to 2020, we conducted a phase 2 clinical trial with ATO in chronic GvHD (ClinicalTrials.gov ID NCT02966301 - GMED16-001). This study aimed to evaluate the efficacy and safety of a first-line combination of arsenic trioxide (ATO) and CS in adult patients with cGvHD who require systemic therapy after a first allo-HSCT for a haematological disease. In this prospective, national, multicenter, single-arm, open-label phase II study, conducted in 5 university hospital centers in France, ATO was initiated within 10 days of starting CS at 1 mg/kg/day. Patients received 11 infusions of ATO per 4-week cycle, at a dose of 0.15 mg/kg per infusion. Patients received 1 or 2 cycles of treatment depending on the clinical response and the assessment of the treating physician. The results were published in July 2022 in a paper entitled "High Response Rate and Corticosteroid Sparing with ATO-Based First-Line Therapy in Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation". The GMED16-001 study demonstrated convincing efficacy and safety characteristics of the intravenous drug (Trisenox^®/Arscimed^®): the first-line use of ATO in addition to corticosteroids was associated with a high clinical response rate and correlated with rapid corticosteroid (CS) sparing in moderate to severe cGvHD after allo-HSCT. We performed a post-hoc analysis of the data to determine the best schedule for treating cGvHD patients with ATO. Our post-hoc analysis leads us to the conclusion that two cycles of ATO, at 0.15 mg/kg/day, 5 days per week for 4 weeks each, separated by a 4-week therapy-free interval, appears to be the most promising treatment schedule.

Preprint ARTICLE | doi:10.20944/preprints202005.0101.v1

Developing and Validating an Algorithm to Identify Incident Chronic Dialysis Patients Using Administrative Data

Dino Gibertoni, Claudio Voci, Marica Iommi, Benedetta D'Ercole, Marcora Mandreoli, Antonio Santoro, Elena Mancini

Subject: Computer Science And Mathematics, Information Systems Keywords: chronic dialysis; administrative data; hospital discharge records; ambulatory specialty visits; case definition; algorithm

Online: 6 May 2020 (15:26:06 CEST)

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Background: Administrative healthcare databases are widespread and are often standardized with regard to their content and data coding, thus they can be used also as data sources for surveillance and epidemiological research. Chronic dialysis requires patients to frequently access hospital and clinic services, causing a heavy burden to healthcare providers. This also means that these patients are routinely tracked on administrative databases, yet very few case definitions for their identification are currently available. The aim of this study was to develop two algorithms derived from administrative data for identifying incident chronic dialysis patients and test their validity compared to the reference standard of the regional dialysis registry. Methods: The algorithms are based on data retrieved from hospital discharge records (HDR) and ambulatory specialty visits (ASV) to identify incident chronic dialysis patients in an Italian region. Subjects are included if they have at least one event in the HDR or ASV databases based on the ICD9-CM dialysis-related diagnosis or procedure codes in the study period. Exclusion criteria comprise non-residents, prevalent cases, or patients undergoing temporary dialysis, and are evaluated only on ASV data by the first algorithm, on both ASV and HDR data by the second algorithm. We validated the algorithms against the Emilia-Romagna regional dialysis registry by searching for incident patients in 2014. Results: Algorithm 1 identified 680 patients and algorithm 2 identified 676 initiating dialysis in 2014, compared to 625 patients included in the regional dialysis registry. Sensitivity for the two algorithms was respectively 90.8% and 88.4%, positive predictive value 84.0% and 82.0%, and percentage agreement was 77.4% and 74.1%. Conclusions: These results suggest that administrative data have high sensitivity and positive predictive value for the identification of incident chronic dialysis patients. Algorithm 1, which showed the higher accuracy and has a simpler case definition, can be used in place of regional dialysis registries when they are not present or sufficiently developed in a region, or to improve the accuracy and timeliness of existing registries.

Preprint ARTICLE | doi:10.20944/preprints202312.1769.v1

Investigating the Efficacy of Kidney-Protective Lactobacillus Mixture-Containing pet Treats in Feline Chronic Kidney Disease and Its Possible Mechanism

Ching-Wen Tsai, Hsiao-Wen Huang, Ya-Jane Lee, Tsu-Cheng Hsu, Ming-Ju Chen

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: chronic kidney disease; gut microbiota; Lm pet treats; feline

Online: 25 December 2023 (11:19:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0168.v1

The Impact of Spiritual-Based Care Interventions on the Quality of Life of Children with Chronic Diseases: a Philosophical Perspective

Idyatul Hasanah, Moses Glorino Rumambo Pandin, Tita Rohita

Subject: Public Health And Healthcare, Nursing Keywords: Nursing; Spiritual care; Quality of life; Chronic disease; Children

Online: 13 June 2022 (05:17:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0303.v1

Analysis of the Dimensions of Physiotherapy Index of Ventilatory Workload in People with Chronic Obstructive Pulmonary Disease During Stability and Exacerbation in An Outpatient Setting

Rodrigo Muñoz Cofré, Mariano del Sol, Paul Medina González, Jorge Valenzuela Vásquez, Gerardo Molina Vergara, Ramón Pinochet Urzúa, Pablo A. Lizana, Máximo Escobar Cabello

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: ventilatory assessment; physiotherapy; chronic obstructive pulmonary disease

Online: 29 August 2019 (04:52:15 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202405.0204.v1

Endoscopic Picture in Chronic Rhinosinusitis Associated with Gerd

Kalamkas T. Sagandykova, Natalia M. Papulova, Talapbek M. Azhenov, Aliya Darbekova, Jerome R. Lechien

Subject: Otolaryngology, Medicine And Pharmacology Keywords: Chronic rhinosinusitis; Endoscopic picture; Gastroesophageal reflux disease; Laryngopharyngeal reflux; Rhinosinusitis; Nasopharyngeal reflux. The Reflux Symptom Index (RSI); The Reflux Symptom Score (RSS)

Online: 6 May 2024 (08:47:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.2007.v1

Immunological Patient Stratification in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Johanna Rohrhofer, Lisa Hauser, Lisa Lettenmaier, Lena Lutz, Larissa Koidl, Salvatore Alessio Gentile, Davide Ret, Michael Stingl, Eva Untersmayr

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: myalgic encephalomyelitis, chronic fatigue syndrome, immunology, immunodeficiencies, mucosal barrier function, patient stratification, post-viral fatigue, intestinal barrier leakage, debilitating disease

Online: 30 November 2023 (16:56:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0569.v1

Effects of Clinical Characteristics on Sleep Quality in Patients with Chronic Temporomandibular Disorders

Yeon-Hee Lee, Q-Schick Auh, Jung-Sub An, Tae Kim

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Sleep quality; Chronic pain; Temporomandibular disorder; Pittsburgh Sleep Quality Index; STOP-Bang; Epworth Sleepiness Scale

Online: 23 June 2021 (11:11:14 CEST)

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Objectives: This study aimed to investigate and compare sleep quality between patients with chronic temporomandibular disorder and healthy controls, and to analyze the association of sleep quality with disease characteristics, obstructive sleep apnea risk factors, and excessive daytime sleepiness. Methods: Chronic temporomandibular disorder patients (n=503) and 180 age- and sex-matched healthy controls were included, who completed well-organized clinical report and answered questions on sleep quality (Pittsburgh Sleep Quality Index), sleep apnea risk factors (STOP-Bang questionnaire), and excessive daytime sleepiness (Epworth sleepiness scale). Results: Mean global Pittsburgh Sleep Quality Index scores were significantly higher in the patients (6.25±2.77) than in healthy controls (6.25±2.77) (p<0.001). Poor sleep was significantly more prevalent in the patient group (56.9%) than in healthy controls (22.2%) (p<0.001). Compared with healthy controls, chronic temporomandibular disorder patients had a higher likelihood of obstructive sleep apnea. (STOP-Bang total score ≥3; 7.2% vs. 16.1%; p<0.01) and higher excessive daytime sleepiness (Epworth sleepiness scale score ≥10; 12.8% vs. 19.7%; p<0.05). Age (odds ratio=2.551; p<0.001), female sex (odds ratio=1.885; p=0.007), total Epworth sleepiness scale score (odds ratio=1.839; p=0.014), and headache attributed to temporomandibular disorder (odds ratio=1.519; p=0.049) were the most powerful predictors of poor sleep (global Pittsburgh Sleep Quality Index score ≥5) in chronic temporomandibular disorder patients. Conclusion: Chronic temporomandibular disorder patients had sleep quality impairment. Various factors, including peripheral and central factors, affect the patient's sleep quality. Therefore, in addition to sleep quality and sleep-related problems, the underlying central mechanism for poor sleep quality should be assessed when treating chronic temporomandibular disorder patients.

Preprint ARTICLE | doi:10.20944/preprints201806.0392.v1

Amani Zidan, Ahmed Awaisu, Maguy El-Hajj, Samya Al-Abdulla, Dianne Figueroa, Nadir Kheir

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Medication-related burden; Questionnaire; chronic disease conditions; adherence

Online: 25 June 2018 (14:35:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0142.v1

Employ of Anthocyanins in nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases

Ana C. Gonçalves, Amícal Falcão, Gilberto Alves, João A. Lopes, Luís R. Silva

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: bioactive compounds; anthocyanins; drug delivery system; nanoparticles; chronic diseases; health benefits

Online: 11 October 2022 (05:04:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0371.v2

Observational Pilot Study: A comparison of Amino Acids and Derangement of Intestinal Function between Healthy Ageing Subjects and Patients Affected by Chronic Kidney Disease in Conservative Management

Piergiorgio Bolasco, Roberto Aquilani, Roberto Maestri, Maria Paola Esposito, Maria Luisa Deiana, Mariella Cadeddu, Romina Secci, Barbara Casu, Antonella Serra, Paolo Iadarola, Maura D'Amato, Stefano Murtas

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Chronic Kidney Disease; aminoacids; Dysbiosis; metabolic disorders

Online: 27 January 2022 (15:48:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0432.v1

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Amir Alhaidari, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; myalgic encephalomyelitis; schizophrenia; neuroimmunomodulation; inflammation; biomarkers

Online: 29 March 2020 (10:52:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0262.v1

Chronic Fatigue and Fibromyalgia Symptoms are Key Components of Deficit Schizophrenia and are Strongly Associated with Activated Immune-Inflammatory Pathways

Abbas Almulla, Hussein Al-Hakeim, Mokhlad Abed, André Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Chronic fatigue syndrome, inflammation, neuro-immune, physio-somatic, schizophrenia, cytokines

Online: 23 July 2019 (11:49:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0934.v1

Exploration of Potential Breath Biomarkers of Chronic Kidney Disease through Thermal Desorption Gas Chromatography Mass Spectrometry

Si-Hyun Seong, Hyun Sik Kim, Yong-Moon Lee, Jae-Seok Kim, Sangwoo Park, Jieun Oh

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Chronic kidney disease; Hemodialysis; Uremic toxins; Breath markers; Volatile organic compounds; Mass spectrometry

Online: 13 June 2023 (11:40:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0123.v1

Falls Incidence and Associated Risk Factors among People with Chronic Obstructive Pulmonary Disease (COPD)

Mehrdad Davoudi, Seyyed Mohammadreza Shokouhyan, Mohsen Abedi, Mehdi Rezaei, Mohamad Parnianpour, Kinda Khalaf, Masood Mazaheri

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: chronic obstructive pulmonary disease; COPD; fall risk factor; gait; balance; cognition; daily activity; muscle dysfunction

Online: 8 September 2022 (10:35:01 CEST)

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Chronic obstructive pulmonary disease (COPD) is increasingly being recognized as a systemic disease rather than a mere disorder of the lungs. Central (respiratory) and peripheral (limb) muscle weakness are among the main pronounced systemic effects of COPD. While the disease primarily affects the lower limb muscles and contributes to gait impairment, COPD is also associated with an increasing risk of falls in patients (COPDp). Previous studies have reported higher rates of falls among COPDp (1.17 to 1.20 falls/person-year), amounting to four times higher than an age-matched healthy group. Potential fall risk factors include muscle weakness, impaired daily activities, cognitive dysfunction, and gait and balance impairment. Although COPDp often manifest many of these risk factors, there remains a gap in literature regarding falls during walking in this population. This study aimed to 1. analyze the literature to identify the risk factors of falling in COPDp, and 2. investigate the underlying mechanisms by which these risk factors can lead to increased prevalence of falling. The results suggest that in addition to the known risk factors of falling, low back pain and mental fatigue should also be considered as relevant risk factors in the treatment process of these patients. Moreover, respiratory problems, which are common in this population, have demonstrated pronounced effects on energy expenditure, gait, and other types of activities of daily living (ADLs), leading to reduced intensity, disrupted coordination of the trunk-pelvic structure with the lower limbs during gait, and altered motor control performance due to activation of muscles in an inefficient synergic manner. These problems potentially lead to the increased vulnerability of these patients to external disturbances and higher incidence risk of falls and injuries. Cognitive problems, which are typically due to reduced oxygen received by the brain, as well as general inflammation caused by COPD, also play a significant role in gait disruption and balance. Future research is warranted to determine the prevalence of falls in COPDp by examining the response of these patients to Medio-Lateral (ML) and Anterior-Posterior (AP) disturbances during gait in association with traditional and recommended fall risk factors.

Preprint REVIEW | doi:10.20944/preprints202310.0145.v1

Omega-3 Lipid Mediators: Modulation of the M1/M2 Macrophage Phenotype and its Protective Role in Chronic Liver Diseases

Luis A Videla, Rodrigo Valenzuela, Andrea Del Campo, Jessica Zuñiga-Hernandez

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic liver disease; specialized pro-resolving mediators; inflammation; macrophage polarization; inmunometabolism

Online: 3 October 2023 (11:11:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0173.v1

Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-based Study

Joaquim Oristrell, Joan C. Oliva, Isaac Subirana, Enrique Casado, Didier Dominguez, Andrea Toloba, Patricia Aguilera, Joan Esplugues, Pilar Fafian, Maria Grau

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: calcitriol; vitamin D; COVID-19; SARS-CoV2 infection; chronic kidney disease

Online: 6 April 2021 (11:50:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1240.v1

Advancements in Treatment Strategies for Chronic Mesenteric Ischemia: A Comprehensive Review

Genti Xhepa, Andrea Vanzulli, Lucilla Violetta Sciacqua, Agostino Inzerillo, Pierre Faerber, Anna Maria Ierardi, Gianpaolo Carrafiello, Filippo Del Grande, Alexis Ricoeur

Subject: Medicine And Pharmacology, Surgery Keywords: review; chronic mesenteric ischemia; superior mesenteric artery; revascularization; treatment; endovascular revascularization (ER); percutaneous transluminal angioplasty (PTA); primary stenting (PMAS)

Online: 19 October 2023 (10:14:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0483.v1

Causal Variables in the Association between Physical Well-Being and Chronic Pain: Results from a Cohort Study in Galicia (Northwest Spain)

Roya Karimi, Jesús Prego-Domínguez, Bahi Takkouche

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Chronic pain; confounding; interaction analysis; mediation analysis; physical well-being

Online: 8 May 2023 (08:50:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1870.v1

Polish Adaptation and Psychometric Validation of the PREM-C9 Questionnaire Dedicated for Patients with Chronic Obstructive Pulmonary Disease

Iwona Damps-Konstańska, Weronika Ciećko, Ewa Jassem, Tomasz Bandurski, Dominika Bosek, Marzena Olszewska-Karaban, Ewa Bandurska

Subject: Public Health And Healthcare, Health Policy And Services Keywords: chronic obstructive pulmonary disease (COPD); Patient Reported Outcome Measures; Health Care Surveys

Online: 29 August 2023 (03:31:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2147.v1

Effects of Chronic Heat Stress on Lung and Growth Performance in Cherry-Valley Ducks under Different Ambient Temperatures

Min Tang, Yi Liu, Dongyue Sun, Congcong Xu, Kongdong Li, Hantao Zhang, Jie Gu, Chaofan Shan, Shijia Ying

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: chronic heat stress; duck rearing; environmental temperature; next-generation sequencing; carcass traits

Online: 1 August 2023 (05:35:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1585.v1

A Proposed Explainable Artificial Intelligence-Based Machine Learning Model for Discriminative Metabolites for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Fatma Hilal Yagin, Abedalrhman Alkhateeb, Ali Raza, Nagwan Abdel Samee, Noha F. Mahmoud, Cemil Colak, Burak Yagin

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Explainable artificial intelligence; Myalgic encephalomyelitis/chronic fatigue syndrome; Metabolomics data; Clinical classification.

Online: 25 July 2023 (04:33:22 CEST)

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Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating disease with a significant global prevalence of over 65 million individuals. It affects various systems, including the immune, neurological, gastrointestinal, and circulatory systems. Studies have shown abnormalities in immune cell types, increased inflammatory cytokines, and brain abnormalities. Further research is needed to identify consistent biomarkers and develop targeted therapies. A multidisciplinary approach is essential for diagnosing, treating, and managing this complex disease. The current study aims at employing explainable artificial intelligence (XAI) and machine learning (ML) techniques to identify discriminative metabolites for ME/CFS. Material and Methods: The present study used a metabolomics dataset of CFS patients and healthy controls, including 26 healthy controls and 26 ME/CFS patients aged 22-72. The dataset encapsulated 768 metabolites, classified into nine metabolic super-pathways: amino acids, carbohydrates, cofactors, vitamins, energy, lipids, nucleotides, peptides, and xenobiotics. Random forest-based feature selection and Bayesian Approach based-hyperparameter optimization were implemented on the target data. Four different ML algorithms [Gaussian Naive Bayes (GNB), Gradient Boosting Classifier (GBC), Logistic regression (LR) and Random Forest Classifier (RFC)] were used to classify individuals as ME/CFS patients and healthy individuals. XAI approaches were applied to clinically explain the prediction decisions of the optimum model. Performance evaluation was performed using the indices of accuracy, precision, recall, F1 score, Brier score, and AUC. Results: The metabolomics of C-glycosyltryptophan, oleoylcholine, cortisone, and 3-hydroxydecanoate were determined to be crucial for ME/CFS diagnosis. The RFC learning model outperformed GNB, GBC, and LR in ME/CFS prediction using the 1000 iteration bootstrapping method, achieving 98% accuracy, precision, recall, F1 score, 0.01 Brier score, and 99% AUC. Conclusion: RFC model proposed in this study correctly classified and evaluated ME/CFS patients through the selected biomarker candidate metabolites. The methodology combining ML and XAI can provide a clear interpretation of risk estimation for ME/CFS, helping physicians intuitively understand the impact of key metabolomics features in the model.

Preprint ARTICLE | doi:10.20944/preprints202401.1483.v1

Comparison of Disease Severity Classifications of Chronic Obstructive Pulmonary Disease: Gold vs. Star in Clinical Practice

Koichi Nishimura, Masaaki Kusunose, Ayumi Shibayama, Kazuhito Nakayasu

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: chronic obstructive pulmonary disease (COPD); disease severity; Global Initiative for Chronic Obstructive Lung Disease (GOLD); STaging of Airflow obstruction by Ratio (STAR); St. George’s Respiratory Questionnaire (SGRQ); COPD assessment test (CAT)

Online: 19 January 2024 (09:47:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0213.v1

High Sensitivity Cardiac Troponin T in Patients with Severe Chronic Kidney Disease and suspected Acute Coronary Syndrome

Brunilda Alushi, Fabian Jost-Brinkmann, Adnan Kastrati, Salvatore Cassese, Massimiliano Fusaro, Karl Stangl, Ulf Landmesser, Holger Thiele, Alexander Lauten

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: troponin; high-sensitivity; chronic kidney disease; renal insufficiency; myocardial infarction; acute coronary syndrome

Online: 10 August 2021 (08:45:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0488.v1

Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: Insights from a Low-Volume Centre and Comparative Analysis with Other Centres

Taida Ivanauskiene, Sigitas Cesna, Egle Grigoniene, Lina Gumbienė, Aurelija Daubaraite, Kaste Ivanauskaite

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: balloon pulmonary angioplasty; chronic thromboembolic pulmonary hypertension; treatment of inoperable CTEPH

Online: 8 February 2024 (10:21:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0254.v1

Solanum Fruit Juice as a Natural and Sustainable Source of Antioxidants for Patients with Chronic Hepatitis C under Antiviral Therapy

Chidiebere Uchenna Iheka, Justice Obinna Osuoha, Idongesit Ekong Archibong, Peter Uchenna Amadi, Oluwatoyin Taiwo Adeoti

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Solanum fruit juice; biochemical markers; chronic hepatitis C; oxidative stress; antioxidants

Online: 12 October 2018 (04:55:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0978.v1

Oncostatin M’s Involvement in the Pathogenesis of Chronic Rhinosinusitis: Focus on Type 1 and 2 Inflammation

Chie Ishikawa, Sachio Takeno, Yukako Okamoto, Tomohiro Kawasumi, Takashi Kakimoto, Kota Takemoto, Manabu Nishida, Takashi Ishino, Takao Hamamoto, Tsutomu Ueda, Akio Tanaka

Subject: Medicine And Pharmacology, Otolaryngology Keywords: paranasal sinus; chronic rhinosinusitis; CRS; epithelial cell; eosinophil; oncostatin M; OSM; OSM receptor; OSMR

Online: 17 October 2023 (08:05:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2135.v1

Vaccination against Influenza: Clinical and Cytokine Profile of Patients with Asthma and Chronic Obstructive Pulmonary Disease

Мikhail Petrovich Kostinov, Alexander Chuchalin, Anna Chebykina, Nelli Kimovna Akhmatova, Valentina Borisovna Polishchuk, Nadezhda Kryukova, Aristitsa M. Kostinova, Anna E Vlasenko, Alexander Petrovich Cherdantsev, Irina Leonidovna Solovieva, Marina Loktionova, Anna Dmitrievna Shmitko, Lilya Solomonovna Gladkova, Yvette Albahansa Mana

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Influenza vaccine; Grippol® Plus; asthma; chronic obstructive pulmonary disease; vaccine efficacy; cytokines; CRP

Online: 30 September 2023 (08:27:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0233.v1

Relationship Between ACE I/D Polymorphism and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease

Hendri Susilo, Budi Susetyo Pikir, Mochammad Thaha, Mochamad Yusuf Alsagaff, Satriyo Dwi Suryantoro, Citrawati Dyah Kencono Wungu, Ifan Ali Wafa, Cennikon Pakpahan, Delvac Oceandy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic kidney disease; gene polymorphism; angiotensin-converting enzyme; cardiovascular disease; cardiovascular mortality risk; genotype

Online: 26 April 2022 (10:05:25 CEST)

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Working Paper HYPOTHESIS

The Central Nervous System’s Adaptive Changes Make Chronic Diseases Incurable

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: incurable disease; chronic disease; cancer theory; central nervous system; state memory; mutation; tissue ecosystem; emotion; stress; exercise; baseline biochemical and cellular processes

Online: 24 November 2019 (14:50:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0253.v1

Links between Serotonin Levels and Stress: Cortisol, Candida A./Mycetes, Omega 3/6 Ratio and Dysbiosis (Skatole/Indoxyl Sulfate) Role in Chronic Fatigue Syndrome (CFS) and Depression

Daniele Orlandoni, Giuseppe Di Fede, Mauro Mantovani, Consuelo Rubina Nava, Marco Tomasi, Paola Fusi

Subject: Biology And Life Sciences, Other Keywords: stess; chronic fatigue syndrome; depression; dysbiosis; serotonin/cortisol

Online: 5 September 2023 (07:52:50 CEST)

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Intestinal microbiota attracts daily attention of a growing number of study which have attempted to link gut dysbiosIs with a variety of disease states: irritable bowel syndrome (IBS), inflamed bowel disease (IBD), Crohn's disease (CD), leaky gut syndrome (LGS), food intolerance, diabetes, metabolic syndrome, cancer, etc.. In our study we analyzed how intestinal dysbiosis may be related to chronic fatigue syndrome (CFS) and depression through the exchange of information through the gut-brain axis (GBA). We studied 33 subjects, 13 males and 20 females, who reported CFS or/and depression: we investigated their salivary cortisol levels, blood serotonin, omega 3/6 ratio, intestinal dysbiosis (calculated on the urinary levels of indoxyl sulfate and skatole), and we looked for the presence of Candida a. or mycetes in the stool; the data accumulated with this research show a correlation between the presence of Candida a./miceti, indoxyl sulfate urine values beyond the physiological and low serotonin levels. In addition, data analysis showed that the EPA/DHA values also show pro-inflammatory levels in case of dysbiosis and low serotonina levels. The relationship, however, with cortisol levels requires further research although this study showed a statistically significant positive correlation between these values, measured at specific times, and serotonin levels. Aims its connections with We investigated the relationship between stress (evaluated through the measurement of salivary cortisol levels) and gastrointestinal efficiency measured as a function of intestinal fermentative and putrefactive dysbiosis, evaluating the levels of urinary indoxyl sulfate in the first case (a possible correlation with the presence of Candida spp or Mycetes in the subjects feces was investigated), urinary skatole levels in the second one, in patients with chronic fatigue syndrome (SFC) and depression. In these patients we also have studied omega 3/6 ratio, and finally we have analized the impact that the alteration of these parameters can have on the serotonin levels. This research attemps to highlight the contact points, in some cases not so obvious, among these topics, contact points that, although they give us interesting indications, show the need to be further deepened by analyzing a larger amount of data.

Preprint ARTICLE | doi:10.20944/preprints202402.1018.v1

Management of Short Bowel Syndrome/Chronic Intestinal Failure – the Experience of a Single Portuguese Center

Marisa Domingues Santos, Vânia Magalhães, Luís Loureiro, Pedro Pina, Ana Castro, Paulina Aguiar, Ana Gomes, Diana Soares, Anabela Rocha

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Keywords; Short bowel Syndrome; Chronic Intestinal failure; Home Parenteral Nutrition; Teduglutide; Complications of Parenteral Support

Online: 19 February 2024 (16:24:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0018.v2

Effects of Excitatory Repetitive Transcranial Magnetic Stimulation of the P3 Point in Chronic Stroke Patients – Case Reports

Ronaldo Luis da Silva, Angela Maria Costa de Souza, Francielly Ferreira Santos, Sueli Toshie Inoue, Johanne Higgins , Victor Frak

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: intraparietal sulcus; stroke; rTMS; Fugl-Meyer Assessment; fast frequency TMS; motricity; sensibility; chronic patients

Online: 17 April 2018 (08:35:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1294.v1

The Mediating Effects of Social Networks and Wisdom on the Relationship between Lifestyle Habits and Healthy Aging in Older Adults with Chronic Diseases

Hee-Kyung Kim, Hye-Suk Oh, Cheol-Hee Park

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: elderly; healthy aging; lifestyle habits; social networks; wisdom; chronic disease

Online: 19 July 2023 (09:53:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0447.v1

Still Finding Ways to Augment the Existing Management of Acute and Chronic Kidney Diseases with Targeted Gene and Cell Therapies: Opportunities and Hurdles

Peter Corridon

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: acute kidney disease; chronic kidney disease; gene therapy; cell therapy

Online: 25 January 2023 (04:29:25 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.1664.v1

Limb Salvage and Survival in Chronic Limb-Threatening Ischemia: The Need for Fast-Track Team-Based Approach

Giorgio Ventoruzzo, Giulia Mazzitelli, Umberto Ruzzi, Francesco Liistro, Alessia Scatena, Eugenio Martelli

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: peripheral arterial disease; critical limb ischemia; chronic limb-threatening ischemia; survival; mortality; limb salvage

Online: 25 August 2023 (02:41:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0458.v2

Cost-sensitive Ensemble Feature Ranking and Automatic Threshold Selection for Chronic Kidney Disease Diagnosis

Syed Imran Ali, Bilal Ali, Jamil Hussain, Musarrat Hussain, Fahad Ahmed Satti, Gwang Hoon Park, Sungyoung Lee

Subject: Computer Science And Mathematics, Computer Science Keywords: Cost-sensitive feature selection; ensemble models; decision tree classifiers; chronic kidney disease; random forests; gradient boosted trees

Online: 6 July 2020 (09:56:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1715.v1

Percutaneous Deep Venous Arterialization for Limb Salvage of No Option Patients with Chronic Limb-Threatening Ischemia

Stavros Spiliopoulos, Efstathia Davoutis, Nikolaos-Achilleas Arkoudis, Kaji Sritharan, Symeon Lechareas

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic limb-threatening ischemia; peripheral arterial disease; endovascular treatment; tibial vessels; percutaneous deep venous arterialization

Online: 26 September 2023 (04:44:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0171.v1

The Effects of Chronic Stress on Neuroanatomy and Cognitive Function

Niki Viradia, Jesica Godinez Paredes, Syed Hassan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s; aging; amygdala; brain plasticity; CA1; CA3; chronic stress; cognition; GABA; HIF-1; hippocampus; hypoxia; neurogenesis; Parkinson’s; prefrontal cortex; PSA-NCAM; ROS; spatial learning

Online: 12 July 2022 (04:25:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0207.v1

Mild Chronic Kidney Disease Associated with Low Bone Formation and Decrease in Phosphate Transporters and Signaling Pathways Gene Expression

Evdokia Bogdanova, Airat Sadykov, Galina Ivanova, Irina Zubina, Olga Beresneva, Natalia Semenova, Olga Galkina, Marina Parastaeva, Vladimir Sharoyko, Vladimir Dobronravov

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Chronic kidney disease; bone remodeling; static bone histomorphometry; inorganic phosphate transporters; intracellular signaling

Online: 13 February 2023 (08:46:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0243.v1

Serum Agrin and Talin, Two Muscular Proteins, are Significantly Increased in Major Depression and Increased Agrin and Lowered Creatine Phosphokinase are Associated with Chronic Fatigue and Fibromyalgia Symptoms in Depression

Hussein Kadhem Al-Hakeim, Ameer Abdul Razzaq Al-Issa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depression; chronic fatigue; fibromyalgia; neuro-immune; inflammation

Online: 24 June 2019 (10:19:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1998.v1

Non-Thyroidal Illness in Chronic Renal Failure: Triiodothyronine Levels and Modulation of Extra-Cellular Superoxide Dismutase (ec-SOD)

Antonio Mancini, Andrea Silvestrini, Fabio Marcheggiani, Emmanuele Capobianco, Sonia Silvestri, Erminia Lembo, Patrick Orlando, Flavia Beccia, Nicola Nicolotti, Nicola Panocchia, Luca Tiano

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Oxidative stress; ec-SOD; Low T3 syndrome; total antioxidant capacity; hemodialysis; chronic kidney diseases

Online: 31 July 2023 (02:49:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0604.v1

People-Centeredness, Chronic Conditions and Diversity Sensitive eHealth: Exploring Emancipation of the ‘Health Care System’ and the ‘Patient’ in Health Informatics

Lars Botin, Pernille S. Bertelsen, Christian Nøhr

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: eHealth; end-user; chronic disease; participatory design; socio-technical; diversity in care

Online: 29 October 2020 (09:30:26 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202305.2264.v1

Chronic Fatigue Syndrome and Multiple Sclerosis have Reduced Craniospinal Compliance and Dilated Pressurized Bridging Cortical Veins: A Hypothesis Illustrated with Two Case Studies

Grant Bateman, Alexander Bateman

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Chronic fatigue syndrome; myalgic encephalomyelitis; multiple sclerosis; cortical vein; venous pressure

Online: 31 May 2023 (14:31:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1957.v1

A Single-Session Process-Based Cognitive-Behavioural Interven-Tion for Chronic Pain Associated with Emotional Disorders

Cristiana Manuela Cojocaru, Cosmin Octavian Popa, Alina Schenk, Zsolt Jakab, Bogdan Andrei Suciu, Peter Olah, Horațiu Valeriu Popoviciu, Simona Szasz

Subject: Social Sciences, Psychiatry And Mental Health Keywords: rheumatic conditions; chronic pain; anxiety; depression; psychological intervention; process-based cognitive-behavioural therapy; single-session intervention

Online: 28 December 2023 (02:23:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1984.v1

Urinary L-FABP, a Biomarker for Disease Progression, Dialysis and Overall Mortality in Chronic Kidney Disease

Nicos Mitsides, Vikram Mitra, Ananya Saha, Shelley Harris, Philip A. Kalra, Sandip Mitra

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; biomarkers; urinary liver type fatty acid binding protein; urinary protein to creatinine ratio

Online: 28 September 2023 (10:17:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2023.v1

Inhaled Corticosteroids and the Risk of Nontuberculous Mycobacterial Pulmonary Disease in Chronic Obstructive Pulmonary Disease: Findings from a Nationwide Population-Based Study

Iseul Yu, Se Hwa Hong, Min-Seok Chang, Seok Jeong Lee, Suk Joong Yong, Won-Yeon Lee, Sang-Ha Kim, Ji-Ho Lee

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: nontuberculous mycobacterial pulmonary disease; inhaled corticosteroid; chronic obstructive pulmonary disease; fluticasone; budesonide

Online: 30 May 2023 (02:34:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1234.v1

Perception of Complementary Medicine and Treatment Adherence as Predictors of Self-Efficacy in Individuals with Chronic Conditions in Mexico

Karina Isabel Casco-Gallardo, Nissa Yaing Torres-Soto, Claudia Nelly Orozco-González, Nancy Griselda Pérez-Briones, José Antonio Guerrero-Solano, Gabriela Maldonado-Muñiz, Claudia Atala Trejo-García, Benjamín López-Nolasco

Subject: Public Health And Healthcare, Nursing Keywords: Complementary therapies; treatment adherence; self-efficacy; chronic diseases; Diabetes Mellitus, Type 2; hypertension; obesity.

Online: 18 April 2024 (09:16:33 CEST)

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Chronic conditions like type 2 diabetes mellitus (T2DM), arterial hypertension (HTN), and obesity are major global health issues, causing significant morbidity and mortality. In Latin America, these conditions contribute to millions of premature deaths annually, posing challenges exacerbated by limited healthcare access and poor primary care quality, particularly in Mexico. Complementary medicine presents a potential solution, offering minimally invasive techniques to improve physical, mental, and spiritual well-being. Effective treatment adherence, crucial for positive outcomes, is influenced by self-efficacy, the ability to manage one's behavior in response to medical conditions. However, treatment adherence rates remain low, indicating a pressing public health concern. This study aimed to explore how perception of complementary medicine and treatment adherence predict self-efficacy among individuals with chronic conditions in Mexico. Analyzing data from 113 participants revealed significant correlations between variables, with treatment adherence positively associated with self-efficacy and perception of holistic medicine negatively correlated with self-efficacy. Regression analysis showed that incorporating perception of complementary medicine and treatment adherence significantly explained self-efficacy levels, suggesting the potential of complementary therapies in holistic healthcare approaches. However, collinearity between variables highlights the need for further research to better understand these relationships and their implications for improving healthcare outcomes in Mexico. Integrating complementary therapies with conventional treatments could enhance overall well-being and treatment adherence, offering promising avenues for addressing chronic conditions in the region. These findings underscore the importance of comprehensive healthcare approaches that integrate both conventional and complementary modalities to optimize health outcomes and quality of life for individuals with chronic conditions in Mexico and beyond.

Preprint BRIEF REPORT | doi:10.20944/preprints202401.1407.v1

B Cell Subsets and Immune Checkpoint Expression in Patients With Chronic Lymphocytic Leukaemia

Aviwe Ntsethe, Zekhethelo Alondwe Mkhwanazi, Phiwayinkosi Vusi Dludla, Bongani Brian Nkambule

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic lymphocytic leukaemia; immune checkpoints; B cell subsets; beta-2 microglobulin; programmed death protein 1; cytotoxic T-lymphocyte associated protein 4

Online: 19 January 2024 (04:36:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0362.v1

Intersections between Pneumonia, Lowered Oxygen Saturation Percentage and Immune Activation Mediate Depression, Anxiety and Chronic Fatigue Syndrome-like Symptoms due to COVID-19: A Nomothetic Network Approach

Hawraa Al-Jassas, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; depression; chronic fatigue syndrome; inflammation; neuro-immune; psychiatry

Online: 14 June 2021 (13:01:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0804.v1

Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Viral Hepatitis: The Interlink

Cornelius J Fernandez, Mohammed Alkhalifah, Hafsa Afzar, Joseph M Pappachan

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: metabolic dysfunction-associated fatty liver disease (MAFLD); chronic viral hepatitis; Hepatitis B virus (HBV); Hepatitis C virus; Hepatic Fibrosis; Cirrhosis; and Hepatocellular carcinoma

Online: 14 November 2023 (05:28:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0595.v1

Effects of Multidisciplinary Biopsychosocial Rehabilitation on Short-Term Pain and Disability in Chronic Low Back Pain: A Systematic Review with Network Meta-Analysis

Ivan Jurak, Kristina Delaš, Lana Erjavec, Janez Stare, Igor Locatelli

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: chronic low back pain; multidisciplinary biopsychosocial rehabilitation; exercise therapy; network meta-analysis

Online: 9 November 2023 (07:44:33 CET)

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Chronic Low Back Pain (CLBP), defined as pain persisting for at least 12 weeks, is a significant public health issue, with prevalence intensifying due to an ageing global population, amassing approximately 619 million cases in 2020 and projected to escalate to 843 million by 2050. Given the multitude of therapeutic modalities available for CLBP, this research sought to ascertain their respective efficacies in ameliorating pain and disability. We specifically scrutinized Multidisciplinary Biopsychosocial Rehabilitation (MBR) among adults enduring non-specific low back pain for over 12 weeks, excluding acute pain conditions and pre-study surgical interventions. MBR is an approach encompassing various modalities, including exercise, behavioral therapies, educational programs, and work conditioning aspects, necessitating a comprehensive Network Meta-Analysis (NMA) to fully grasp the extensive scope of its impact. The constructed network comprised diverse MBR modalities (behavioral, educational, and work conditioning) alongside exercise therapy (ET), minimal intervention, and usual care, serving as controls with pain and disability as outcomes. Through the analysis of 4,619 initially identified studies, 93 were included, encompassing a total of 8,059 participants. The NMA conducted substantiated that both ET and MBR modalities were notably effective in alleviating CLBP, with education-oriented MBR emerging as the most efficacious for pain mitigation and behavior-focused MBR for disability reduction. Nevertheless, the discerned differences amongst the treatments were minimal and uncertain, highlighting that no modality was definitively superior to the others. The analysis revealed low global and local inconsistency within the network, underscoring the reliability of the observed outcomes. Given the intricate nature of CLBP, embodying various facets, our findings advocate for a combined therapeutic approach to optimize treatment efficacy. Nonetheless, the presence of high study heterogeneity and potential biases necessitates cautious interpretation of the results, prompting future research.

Preprint REVIEW | doi:10.20944/preprints202305.0562.v1

Intra-Articular Facet Joint Injection of Normal Saline for Chronic Low Back Pain: A Systematic Review and Meta-Analysis

Areerat Suputtitada, Tanawin Nopsopon, Thanitsara Rittiphairoj, KRIT Pongpirul

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Facet joint injection; Chronic low back pain; Normal saline; Meta-analysis; Patient Reported Clinical Outcomes

Online: 9 May 2023 (04:22:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0234.v1

Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

Jesus Castro-Marrero, Maria-Cleofé Zaragozá, Irene López-Vílchez, José Luis Galmés, Joan Carles Domingo, Sara Maurel, José Alegre-Martin

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic fatigue syndrome; fatigue; myalgic encephalomyelitis; melatonin; quality of life; sleep quality; zinc

Online: 8 March 2021 (16:00:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0488.v1

Machine Learning Model for Diagnosing the Stage of Liver Fibrosis in Patients With Chronic Viral Hepatitis C

Valeriy Tsvetkov, Ivan Tokin, Dmitriy Lioznov

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Hepatitis C virus; Chronic viral hepatitis C; Liver fibrosis; Liver cirrhosis; Diagnosis of liver fibrosis; Machine learning

Online: 22 February 2021 (15:31:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0311.v1

Retrospective Cross-Sectional Study on Chronic Hepatitis C in Estonia, Latvia, Lithuania, and Ukraine: Virus, Patient, and Disease Characteristics in Patients under Care (RESPOND-C Study)

Ligita Jančorienė, Baiba Rozentāle, Ieva Tolmane, Agita Jēruma, Riina Salupere, Arida Buivydienė, Jonas Valantinas, Limas Kupčinskas, Jolanta Šumskienė, Eglė Čiupkevičienė, Arvydas Ambrozaitis, Olga Golubovska, Larysa Moroz, Robert Flisiak, Borys Bondar

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Baltic states; chronic hepatitis C; epidemiology; hepatitis C virus; genotype; Ukraine

Online: 5 July 2023 (12:30:04 CEST)

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Background and objectives: Since 2013, highly effective direct-acting (DAA) chronic hepatitis C (CHC) antiviral therapy became available, which has cure rates of over 95%. For choice of optimal CHC treatment, assessment of hepatitis C virus (HCV) genotype (GT) and liver fibrosis stage are necessary. Information about distribution of these parameters among CHC patients in Baltic states and especially in Ukraine is scarce. This study was performed to obtain epidemiological data regarding CHC GT and fibrosis stage distribution for better planning of resources and prioritization of patients for DAA drug treatment according to disease severity in high-income (Baltic states) and lower-middle income (Ukraine) countries. Materials and Methods: This was an epidemiological, retrospective, cross-sectional study that included 1451 CHC patients. Demographic and disease information from medical charts was collected for each patient during a single visit. Results: Most frequent suspected mode of viral transmission was blood transfusions (17.8%), followed by injection drug use (15.7%); however, in 50.9% of patients exact mode of transmission was not clarified. In Ukraine (18.4%) and Estonia (26%) transmission by the injection drug use was higher than in Lithuania (5%) and Latvia (5.3%). Distribution of HCV GT among patients with CHC was as follows: GT1 - 66.4%; GT3 - 28.1; and GT2 - 4.1%. The prevalence of GT1 was the highest in Latvia (84%), and the lowest in Ukraine (63%, p<0.001). Liver fibrosis stages were distributed as follows: F0 - 12.2%, F1 - 26.3%, F2 - 23.5%, F3 – 17.1% and F4 - 20.9%. Cirrhosis (F4) was more prevalent in Lithuanian patients (30.1%) than in Estonians (8.1%, p <0.001). Conclusions: This study contributes to the knowledge of epidemiological characteristics of HCV infection in the Baltic states and Ukraine. The data regarding the patterns of HCV GT and fibrosis stage distribution will be helpful for the development of national strategies to control HCV infection in the era of DAA therapy.

Preprint REVIEW | doi:10.20944/preprints202305.0041.v1

A Significance of an Amelioration of Endothelial Dysfunction by Sodium-Glucose Cotransporter 2 Inhibitors for an Improvement of Heart Failure and Chronic Kidney Disease

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: endothelial dysfunction; chronic kidney disease; heart failure; sodium-glucose cotransporter 2 inhibitors

Online: 2 May 2023 (02:18:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1448.v2

Effectiveness of Low-Level Laser Therapy on the Wound Healing Process in Fibroblasts Isolated from Chronic Human Wounds

Minh-Hoang Phan, Bich-Phuong Nguyen-Thi, Van-Han Dinh, Thi-Huong Nguyen

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Chronic wounds; Dermal samples; Fibroblast cells; Low-Level Laser Therapy (LLLT); Migration; Proliferation; Therapeutic intervention; Wound healing; Wound margins; Wound tissue

Online: 30 August 2023 (02:33:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0178.v1

A Prospective Cohort Study: Erector Spinae Plane Block Decreases Chronic Postoperative Pain Severity in Patients Undergoing Coronary Artery Bypass Grafting

Marcin Wiech, Sławomir Żurek, Arkadiusz Kurowicki, Beata Horeczy, Mirosław Czczuwar, Paweł Piwowarczyk, Kazimierz Widenka, Michał Borys

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic postoperative pain; erector spinae plane block; coronary artery bypass grafting; Neuropathic Pain Symptom Inventory

Online: 13 September 2022 (11:24:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0045.v1

Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study

Michele Fabrazzo, Rosa Zampino, Martina Vitrone, Gaia Sampogna, Lucia Del Gaudio, Daniela Nunziata, Salvatore Agnese, Anna Santagata, Emanuele Durante-Mangoni, Andrea Fiorillo

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Chronic hepatitis C; Direct-acting antiviral agents; Hepatitis C virus; Consultation-liaison psychiatry; Depression; Anxiety

Online: 5 July 2020 (05:15:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0455.v1

Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

Hasan Smesam, Hasan Qazmooz, Sinan Khayoon, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: inflammation; neuro-immune; cytokines; major depression; chronic fatigue syndrome; affective disorders

Online: 27 September 2021 (16:30:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0138.v1

Danggui-Shaoyao-San, a Traditional Chinese Medicine, Relieved Depression and Cognitive Disorder Induced by Chronic Restraint Stress Involved in Regulating Dendritic Spines Remodeling

Kecheng Zhou, Junbin Yin, Huanghui Wu, Wei Hu, Zhen Gao, Fang Li, An'an Wu, Wen Wang, Junping Kou

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Danggui-Shaoyao-San, chronic restraint stress, learning and memory, anxiety/depression, structural plasticity

Online: 31 January 2017 (15:30:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0182.v1

In Schizophrenia, Chronic Fatigue Syndrome- and Fibromyalgia-Like Symptoms are Driven by Breakdown of the Paracellular Pathway with Increased Zonulin and Immune Activation-Associated Neurotoxicity

Michael Maes, Laura Andrés-Rodríguez, Aristo Vojdani, Sunee Sirivichayakul, Décio Barbosa, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic fatigue syndrome; Myalgic encephalomyelitis; oxidative stress; neuro-immune; inflammation; bacterial translocation

Online: 10 May 2021 (12:27:45 CEST)

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Working Paper ARTICLE

Randomized Clinical Trial Is Biased and Invalid In Studying Chronic Diseases, Compared with Multiple Factors Optimization Trial

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: clinical trial; statistical analysis; experimental error; chronic diseases; cancer; health optimization; hypothesis test; variance analysis; covariance; stratification; randomization

Online: 21 November 2019 (04:04:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1793.v1

The Antidepressant Activity Taurine Containing Derivative of 4-Phenylpyrrolidone-2 in a Model of Chronic Unpredictable Mild Stress

Denis A Borozdenko, Darya I. Gonchar, Vlada I. Bogorodova, Dmitri V. Tarasenko, Eugene P Kramarova, Svetlana S. Khovanova, Yaroslav V. Golubev, Nina M. Kiseleva, Tatiana Anatolievna Shmigol, Aiarpi A. Ezdoglian, Konstantin A. Sobyanin, Vadim V. Negrebetsky, Yuri. I. Baukov

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: fluoxetine 1; antidepressant activity 2; chronic unpredictable mild stress 3; 4-phenylpyrrolidinone-2 derivative 4; hormones 5

Online: 27 October 2023 (12:53:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0042.v1

Synergistic Effect of Dietary Acid Load Levels and Cigarette Smoking Status on the Risk of Chronic Obstructive Pulmonary Disease (COPD) in Middle-Aged Healthy Korean Men

Jihyun Park, Mi Ri Ha, Juhyun Song, Oh Yoen Kim

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: dietary acid load; net endogenous acid production; chronic obstructive pulmonary disease; KNHANES

Online: 1 September 2023 (10:11:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0358.v1

Prevalence, Location, and Interference with Daily Life of Chronic Pain in Long-Term Survivors after Discharge from a Tertiary Emergency Center

Naoya Hashimoto, Takeshi Unoki, Nozomi Nagano, Ryota Funamizu, Keigo Sawamoto

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: chronic pain; intensive care units; critical care; critical illness; post-intensive care syndrome; emergency medicine

Online: 20 December 2022 (07:45:51 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202301.0379.v1

Combined Invasive Peripheral Nerve Stimulation in the Management of Chronic Post-Intracranial Disorder Headache. A Case Report.

Athanasia Alexoudi, Eustathios Vlahakis, Stamatios Banos, Konstantinos Oikonomou, Panayiotis Patrikelis, Anastasia Verentzioti, Maria Stefanatou, Stylianos Gatzonis, Stefanos Korfias, Damianos Sakas

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Combined Peripheral Nerve Stimulation; occipital nerve stimulation; secondary headache disor-ders; chronic post-intracranial disorder headache and case report

Online: 23 January 2023 (00:57:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0166.v1

Development and Implementation of Reasonable Accommodation in Employment for Persons with Chronic Health Issues: An Exploratory Study in Slovenia

Aleksandra Tabaj, Dare S. Kovačič, Črtomir Bitenc, Valentina Brecelj

Subject: Social Sciences, Sociology Keywords: reasonable accommodation; employment; vocational/employment rehabilitation; persons with health issues; persons with disabilities; persons with chronic diseases

Online: 12 April 2018 (13:49:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0241.v2

Puerariae Lobatae Radix Ameliorates Chronic Kidney Disease by Reshaping Gut Microbiota and Down-Regulating Wnt / β-Catenin Signaling

Peng Wu, Jingwen Xue, Zhangrui Zhu, Yao Yu, Qi Sun, Ming Xie, Benlin Wang, Pengcheng Huang, Zhengyuan Feng, Jie Zhao

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Puerariae Lobatae Radix; High salt diet; Chronic kidney disease; Wnt / β -catenin pathway; Gut microbiota; Fecal microbiota transplantation

Online: 17 January 2024 (11:11:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0367.v1

Disparities by Sex in Relation with Emotional Pre-Occupation and Variations in Stress Scores during Chronic Hemodialysis Management

Saira Akhlaq, Candace Ayars, Lynda Konecney, Monica Mitchell, Mohammad Zeeshan Qamar

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: Coping; Stress; Hemodialysis; Emotional Preoccupation; Coping with Health Injuries and problems (CHIP); Chronic Kidney Disease Stress Inventory (CKDSI)

Online: 6 September 2023 (09:42:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0065.v1

Arginine, Transsulfuration, and Folic Acid Pathway Metabolomics in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

Angelo Zinellu, Arduino A Mangoni

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: folic acid; transsulfuration; oxidative stress; nitric oxide; biomarkers; chronic obstructive pulmonary disease; homocysteine; asymmetric dimethylarginine; symmetric dimethylarginine; ornithine

Online: 1 August 2023 (09:04:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1449.v1

Promoting self-management and independent living of elders with chronic diseases through technology: A study of self-reported needs, priorities, and preferences.

Argyroula Kalaitzaki, Michael Rovithis, Alexios Dimitropoulos, Sofia Koukouli, Manolis Linardakis, Elli Katsiri, Nikos Rikos, George Vasilopoulos, George Tsolas, Aikaterini Papachristou, Anastasia Dimitrantzou, Dimitrios Katsiris, Areti Stavropoulou

Subject: Public Health And Healthcare, Other Keywords: chronic non-communicable diseases; disease management; digital health technologies; technology-based applications; mHealth; mobile apps

Online: 20 June 2023 (14:25:24 CEST)

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Background and Objectives: Elders’ needs are rarely examined beforehand, and thus, although technology-based tools can enhance self-management, acceptability rates are still low. This study aimed to examine and compare self-reported needs, priorities, and preferences of elders with heart failure (HF), diabetes mellitus (DM), and chronic obstructive pulmonary disease (COPD) toward technology use to enhance self-management. Materials and Methods: A convenience sample of 473 participants over 60s (60.5% females), diagnosed with HF (N=156), DM (N=164), or COPD (N=153) was recruited. They were administered a questionnaire about the usefulness of technology in general and in specific areas of disease management. Results: Most participants (84.7%) admitted that technology is needed for better disease management. This was equally recognized across the three groups both for the overall and specific areas of disease management (in order of priority: ‘Information’, ‘Communication with Physicians & Caregivers’, and ‘Quality of Life & Wellbeing’). Sociodemographic differences were found. Cell phones and PCs were the devices of preference. The four common features prioritized by all three groups were related to ‘information about disease management’ (i.e., monitoring symptoms, reminders for medication intake, management and prevention of complications), whereas the fifth one was related to ‘communication with physicians and caregivers (i.e., in case of abnormal or critical signs). The top disease-specific feature was also monitoring systems (of respiratory rate or blood sugar or blood pressure, oxygen), whereas other disease-specific features followed (i.e., maintaining normal weight for HF patients, adjusting insulin dose for DM patients, and training on breathing exercises for COPD patients). Conclusions: Elders in these three samples seem receptive to technology in disease management. mHealth tools, incorporating both common and disease-specific features and addressing different chronic patients, and being personalized at the same time, could be cost-saving and useful adjuncts in routine clinical care to improve self-management.

Preprint ARTICLE | doi:10.20944/preprints201709.0119.v1

Lp16-PSP, A Member of YjgF/YER057c/UK114 Protein Family Induces Apoptosis and p21WAF1/CIP1 Mediated G1 Cell Cycle Arrest in Human Acute Promyelocytic Leukemia (APL) HL-60 Cells

Thomson Patrick Joseph, Warren Chanda, Abdullah Faqeer Mohammad, Sadia Kanwal, Samana Batool, MeiShan Zhang, MinTao Zhong, Min Huang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: lentinula edodes; Lp16-PSP; acute promyeloid leukemia; extrinsic and lntrinsic apoptotic pathway; G1 phase cell cycle arrest

Online: 25 September 2017 (08:53:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0421.v1

Enhancing Post-Surgical Rehabilitation Outcomes in Patients with Chronic Ankle Instability: Impact of Subtalar Joint Axis Balance Exercises Following Arthroscopic Modified Broström Operation

Ji Myeong Park, Sang Ho Han, Byeong Chae Cho, Se Min Lee, Mal Soon Shin, Jae Ho Yu, Ho Jin Kim, Hyun Dong Noh, Min Suk Cho, Myung Ki Kim

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Anterior talofibular ligament; arthroscopic modified Broström operation; chronic ankle instability; subtalar joint axis balance exercises

Online: 4 January 2024 (14:30:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0103.v1

Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan Following Adverse Childhood Experiences

Rodney R. Dietert, Janice M. Dietert

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: microbiome; adverse childhood experiences (ACEs); gerobiotics, microimmunosome; healthspan; circadian rhythms; sleep disorders; noncommunicable diseases and conditions (NCDs); chronic disorders; early life programming

Online: 7 December 2021 (12:48:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0401.v1

Influence of Comorbidities on Chronic Obstructive Pulmonary Disease (COPD) Outcomes: Risk Prediction of Acute Exacerbations Using the Cumulative Illness Rating Scale (Cirs)

Domenico Di Raimondo, Edoardo Pirera, Chiara Pintus, Riccardo De Rosa, Martina Profita, Gaia Musiari, Gherardo Siscaro, Antonino Tuttolomondo

Subject: Biology And Life Sciences, Aging Keywords: Comorbidity; Multimorbidity; Chronic Obstructive Pulmonary Disease; COPD; Cumulative Illness Rating Scale; acute exacerbation of COPD (AECOPD)

Online: 7 November 2023 (10:33:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0622.v1

Short-term Effects of Manual Therapy Plus Capacitive and Resistive Electric Transfer Therapy in Individuals with Chronic Non-specific Low Back Pain: A Randomized Clinical Trial Study

Konstantinos Kasimis, Paris Iakovidis, Dimitrios Lytras, Georgios Koutras, Ioanna P. Chatziprodromidou, Antonis Fetlis, Stefania Rafailia Ntinou, Natalia-Maria Keklikoglou, Antigoni Samiotaki, Georgios Chasapis, Georgia Tarfali, Thomas Apostolou

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Keywords: Chronic Low back pain; Manual therapy; Capacitive and Resistive Electric Transfer Therapy

Online: 8 June 2023 (10:13:14 CEST)

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Background: Chronic non-specific low back pain (CNSLBP) is defined as back pain that lasts longer than 12 weeks. Objectives: To investigate the efficacy of manual therapy (MT) program combined with Capacitive and Resistive Electric Transfer (TECAR) therapy in individuals with CNSLBP. Method: Sixty adults with CNSLBP were randomly equally divided into three groups. The first group followed an MT protocol in the lumbar region (MT group), the second group followed the same MT protocol combined with TECAR therapy (MT + TECAR group) using a conventional capacitive electrode as well as a special resistive electrode bracelet and the third group (Control group) received no treatment. Both intervention programs included six treatments over two weeks. Pain in the last 24 hours with the Numeric Pain Rating Scale (NPRS), functional ability with the Roland-Morris Disability Questionnaire (RMDQ), Pressure Pain Threshold (PPT) in the lumbar region with pressure algometry, and mobility of the lumbo-pelvic region through fingertip-to-floor distance (FFD) test were evaluated before and after the intervention period with a one-month follow-up. Analysis of variance with repeated measures was applied. Results: In the NPRS score, both intervention groups showed statistically significant differences compared to the control group both in the second week as well as in the one-month follow-up (p < .001). Between-groups differences were also noticed between the two intervention groups in the second week (p < .05). Differences in the RMDQ score in the second week and on the one-month follow-up were detected between the intervention groups and the control group (p < .001), while differences between the two intervention groups were only detected in the one-month follow-up (p < .001). Regarding the PPT values, differences were found mainly between the MT + TECAR and the control group and between the MT + TECAR and the MT group (p < .05), with the MT + TECAR group in most cases showing the greatest improvement compared to the other two groups, which remained statistically significant in the one-month follow-up (p < .05). Finally, both intervention groups improved the mobility of the lumbo-pelvic region in both time points compared to the control group without, however, statistically significant differences between them (p> .05). Conclusion: The application of an MT protocol with TECAR therapy appeared more effective than conventional MT as well as compared to the control group in reducing pain and disability and improving PPT in individuals with CNSLBP. No further improvement was noted in mobility of the lumbo-pelvic region by adding TECAR to the MT intervention.

Preprint ARTICLE | doi:10.20944/preprints202309.0113.v1

Chronic Fatigue and Dis-Autonomy following COVID-19 Vaccination is Distinguished from Normal Vaccination Response by Altered Blood Markers

Amelie Semmler, Anna Katharina Mundorf, Anna Sabrina Kuechler, Karin Schulze-Bosse, Harald Heidecke, Kai Schulze-Forster, Matthias Schott, Markus Uhrberg, Sandra Weinhold, Karl J. Lackner, Marc Pawlitzki, Sven Guenther Meuth, Fritz Boege, Jana Ruhrländer

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Post-Acute COVID-19 Vaccination Syndrome; PACVS, G-protein-coupled receptor; receptor antibody; interleukin-6; dis-autonomy; chronic fatigue.

Online: 4 September 2023 (07:14:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0336.v1

In End-Stage Renal Disease, the Effects of Hemodialysis on Chronic Fatigue Syndrome- and Fibromyalgia-Like Symptoms are Mediated via Inflammatory Biomarkers, Copper and Wnt/Catenin Pathway Proteins

Halah Asad, Hussein Al-Hakeim, Shatha Moustafa, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Myalgic Encephalomyelitis/chronic fatigue syndrome; Wnt pathway; inflammation; neuro-immune; oxidative stress; biomarkers

Online: 12 March 2021 (08:46:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0276.v1

Elevated Expression of HSP72 in the Prefrontal Cortex and Hippocampus of Rats Subjected to Chronic Mild Stress and Treated with Imipramine

Adam Bielawski, Agnieszka Zelek-Molik, Katarzyna Rafa-Zabłocka, Marta Kowalska, Piotr Gruca, Mariusz Papp, Irena Nalepa

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: chronic mild stress; depression; imipramine; heat shock protein; HSP90; inducible HSP90A; constitutive HSP90B; HSP70; inducible HSP72; constitutive HSC70

Online: 6 November 2023 (11:35:13 CET)

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