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Preprint ARTICLE | doi:10.20944/preprints202001.0038.v1

Responses of Individual Plant Species, Functional Groups, α- and β-Diversity to Short-Term Grazing Exclusion under Severe Drought Episode in Long-Term Grazed Alfa-Steppes

Yacine Kouba, Saifi Merdes, Badreddine Saadali, Haroun Chenchouni

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Mediterranean steppes; drylands; alpha diversity; beta diversity; rangeland grazing; indicator species

Online: 5 January 2020 (15:22:33 CET)

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Grazing exclusion has been proved to be one of the main measures for rehabilitating degraded arid steppes. However, the effect of this management practice on plant species diversity and composition is ambiguous, specially under prolonged droughts. Concurrently considering the responses of individual plant species, diversity of functional groups, α-diversity, and β-diversity (and its components) may be crucial to the holistic understanding of grazing exclusion effects on plant communities under drought conditions. Here, we investigated the response of these diversity measures to short-term sheep exclusion under severe drought episode in arid steppes of Alfa-grass (Stipa tenacissima) with a long evolutionary history of livestock grazing. Individual species responses were tested based on species occurrence and abundance in either grazed or grazing-excluded steppes, in addition, we used indicator species analysis to assess the strength of the association between plant species and management type. Likewise, α-diversity, abundance- and incidence-based β-diversity, as well as the functional groups’ diversities were quantified using Hill Numbers and compared between the two management types. Sheep grazing exclusion enabled the recovery of various Alfa-steppe indicator species and improved the size of regional species pool, overall α-diversity, and the diversity of therophytes. This management practice decreased the abundance-based β-diversity and the nestedness-resultant fraction of the incidence-based β-diversity at the local scale, while at the landscape scale increased the abundance-based β-diversity and its balanced variation fraction and reduced the incidence-based β-diversity and its turnover component. Furthermore, protection from grazing altered β-diversities scaling patterns by maintaining higher balanced variation in species abundance at large spatial scale and greater abundance-gradient in species composition at the fine-scale. Our results suggest that the implementation of short-term grazing exclusion in degraded arid steppes would be the appropriate management practice for vegetation restoration and plant diversity conservation during prolonged drought periods.

Preprint ARTICLE | doi:10.20944/preprints202304.0308.v1

Effects of Different Feeding Patterns on the Rumen Bacterial Community of Tan Lambs, based on High-Throughput Sequencing of 16S rDNA Amplicons

Lili Zhang, Yanliang Bi, Jie Zhang, Zilin Fu, Xiaofeng Xu

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Alpha diversity; Beta diversity; Mutton quality; Pasture-fed; Pen-fed; Tan lambs

Online: 13 April 2023 (08:01:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0283.v1

Geomorphology and Altitude Effects on Diversity and Structure of Vanishing Montane Forest of Southern Ecuador

Omar Cabrera, Angel Benítez, Nixon Cumbicus, Carlos Naranjo, Pablo Ramón, Fani Tinitana, Adrián Escudero

Subject: Biology And Life Sciences, Forestry Keywords: alpha diversity; beta diversity; floristic arrangement; geological landscapes; geomorphology; Ecuador; mountain forests

Online: 15 October 2018 (06:19:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0385.v1

mySORT: A Web Framework by using Deconvolution Approach to Estimating Immune Cell Composition from Complex Tissues

Shu-Hwa Chen, Bo-Yi Yu, Wen-Yu Kuo, Ya-Bo Lin, Sheng-Yao Su, I-Hsuan Lu, Chung-Yen Lin

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Cancer; Immunotherapy; Deconvolution; Alpha diversity; Beta diversity; Precision medicine; Microenvironment; Single-cell RNA sequencing

Online: 13 November 2020 (14:18:40 CET)

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Cancer immunotherapy reaches a remarkable achievement in various cancer types and brings new possibilities to improve cancer patients’ long-term survival. However, outcomes vary from case to case, and the present protocol benefits a small fraction of patients. One notable factor is the tumor microenvironment, especially the immune cell components, that may reflect the immune response's status quo on site. Thus, understanding the content of infiltrating immune cells in tumors is not only for research interesting but also a crucial subject toward precision medicine. We implement an algorithm for resolving relative proportions of twenty-one immune cell subclasses from a human tissue profiled transcriptome by microarray technology to reach the goal above. By selecting gene features and then adopting ?-Support Vector Regression, we can construct a deconvolution model and resolve the immune cell context. The excellent consistency between the estimated values and the correct immune-cell composition further demonstrates this approach provides a more natural alternative to revealing samples' immune cell content and reliable results like recent single-cell technologies. Based on this algorithm, the web-based deconvolution tool implemented named mySORT provides a user-friendly interface for estimating the immune cell content by uploading gene expression profiling. We also present comprehensive visualization 2D/3D plots in mySORT so that users can easily make a comparison between different samples. Finally, we synthesized pseudo-bulk expression data from single-cell transcriptomic datasets of 17 melanoma and 16 head and neck cancer patients. The deconvolution results of microarray-based data in the previous study and synthetic pseudo-bulk data all proved the excellent performance of mySORT. We believe that mySORT can help researchers in all fields easily understand complex immune microenvironment. The website of mySORT is freely accessible on https://symbiosis.iis.sinica.edu.tw/mySORT/.

Preprint ARTICLE | doi:10.20944/preprints201909.0177.v1

Forest Diversity and Structure in the Amazonian Mountains Ranges of Southeastern Ecuador

Wilson Quizhpe, Angel Benítez, Jesus Muñoz, Klever Cuenca, Hernán Uvidia, Isau Huamantupa, Omar Cabrera

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: alpha diversity; canonical correspondence; NMDS; Sandstones Forests; Terra firme Forests

Online: 17 September 2019 (03:48:02 CEST)

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1) Background: We analyzed the size structure, richness and diversity in eight permanent forest plots in the upper limit of the great Amazon basin located in the Ecuadorian parts of Cordilleras del Cóndor and Cutucú. Our hypothesis was that not all the forests of the eastern mountain ranges are homogeneous in characteristics, but rather present differences in their structure, richness and floristic diversity. In order to test this, our main objective was to classify the types of forests based on characteristics in diametric structure and species composition of the Amazonian forests of the eastern cordilleras in southern Ecuador, and also to determine the influence of critical edaphic-environmental and geomorphological factors. 2) Methods: Eight one-hectare permanent plots were installed in homogeneous and well-conserved forest stands. Four plots were located in the province of Zamora Chinchipe and four in the province of Morona Santiago. We identified and measured all trees> 10 cm at diameter breast height. For each plot, soil samples were taken, along with environmental and slope data. The multidimensional non-metric adjusted scaling (NMDS) was used to evaluate changes in climatic and geomorphological gradients. The relationship between the composition of the species at the plot level and the edaphoclimatic variables was tested using a canonical correspondence analysis (CCA). Finally, we modeled the change in species diversity (Fisher's alpha) in relation to the climatic gradients, altitudinal and geomorphological using a GLMM. 3) Results: Overall, we identified 517 species belonging to 76 families. We determined the existence of two different types of forest, the first one named Terra Firme, characterized by the presence of a larger number of species and individuals per plot, compared to the second type of forest, called Tepuy or Sandstones forest. Species richness was negatively correlated with soil phosphorus content and pH, mean annual temperature, annual precipitation and altitude. The CCA analysis showed differences in the species composition between the Terra Firme and Sandstone forests. The climatic seasonality and the concentration of cations in the soil influence the diversity of the Amazon forest communities of the southeastern cordilleras. The forests of Terra Firme, which are settled in more stable and nutrient-rich climatic areas, were more diverse. Sandstone forests are poor in nutrients and develop in areas with stronger seasonality

Preprint ARTICLE | doi:10.20944/preprints202402.1605.v1

Autoprobiotics in the treatment of patients with colorectal cancer in the early postoperative period

Elena I Ermolenko, Natalia V Baryshnikova, Galina Alekhina, Alexander Zakharenko, Oleg Ten, Victor A Kashchenko, Nadezhda Lavrenova, Olga Gushchina, Timofey Ovchinnikov, Anastasia Morozova, Anastasia Ilina, Alena B. Karaseva, Anna Tsapieva, Nikita Gladyshev, Alexander V. Dmitriev, Alexander Suvorov

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: microbiome, autoprobiotics, Enterococcus spp., Parvomonas micra, alpha diversity, gut dysbiosis, interleukins

Online: 28 February 2024 (08:05:17 CET)

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Introduction: Despite great advances in the treatment of oncological diseases, the development of medical technologies to prevent or reduce complications of therapy, in particular, those associated with surgery and the introduction of antibiotics remains relevant. The aim of the study: to evaluate the effectiveness of the use of autoprobiotics based on indigenous non-pathogenic strains of Enterococcus faecium and Enterococcus hirae in the complex therapy of colorectal cancer (CRC) in the early postoperative period. Materials and methods: A total of 36 patients diagnosed with CRC were enrolled in the study. The study group (Group A) comprised 24 CRC patients who received autoprobiotic therapy in the early postoperative period, while the control group (Group C) included 12 CRC patients without autoprobiotic therapy.Prior to surgery and between days 14-16 post-surgery, comprehensive evaluations were conducted on all patients, encompassing the following: stool and gastroenterological complains analysis. examination of the gut microbiota (bacteriological study, quantitative polymerase chain reaction, metagenome analysis), analysis of interleukins in serum. Results: The use of autoprobiotics led to decrease dyspeptic complaints after surgery, was associated with absence of postoperative complications, did not cause side effects, led to a decrease in the level of pro-inflammatory cytokines (IL-6 and IL-18) in the blood serum. The use of autoprobiotics led to positive changes in the structure of escherichia and enterococci populations, the elimination of Parvomonas micra, Fusobacterium nucleatum, decrease in the quantitative content of Clostridium perfringens, Akkermansia muciniphila. Metagenomic analysis (16S rRNA) revealed an increase in alpha diversity. Conclusion: The administration of autoprobiotics in the postoperative period is highly effective and safe in the comprehensive treatment of colorectal cancer patients. Future studies will allow the discovery of additional fine mechanisms of autoprobiotic therapy and its impact on the digestive, immune, endocrine and neural systems.

Preprint ARTICLE | doi:10.20944/preprints202402.1050.v1

Seasonal Variation in the Gut Microbiota of Athletes: A Comparative Study of Japanese Handball Players

Kazuya Toda, Shin Yoshimoto, Keisuke Yoshida, Eri Mitsuyama, Noriyuki Iwabuchi, Koji Hosomi, Takayuki Jujo Sanada, Miyuki Tanaka, Hinako Nanri, Jun Kunisawa, Toshitaka Odamaki, Motohiko Miyachi

Subject: Biology And Life Sciences, Life Sciences Keywords: Gut microbiota; athletes; longitudinal study; alpha-diversity; Japanese male handball players

Online: 20 February 2024 (04:36:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0771.v1

Collembola Communities Reflect Soil Recovery After Fire in Mediterranean Pinus pinaster Forests

María José Luciáñez, Alicia Serena

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Collembola; edaphic communities recovery; Alpha diversity indexes; burned forest; removal and burning of wood after fire

Online: 10 January 2024 (08:12:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0116.v1

Potent Natural Inhibitors of Alpha-Glucosidase and Alpha-Amylase against Hyperglycemia in Vitro and in Vivo

Jirawat Riyaphan, Chien-Hung Jhong, May-Jwan Tsai, Der-Nan Lee, Max K. Leong, Ching-Feng Weng

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: In vivo; Alpha-glucosidase; Alpha-amylase; hyperglycemia

Online: 16 March 2017 (09:35:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0420.v1

Acetylation and Phosphorylation in the Regulation of Hypoxia-Inducible Factors Activities: Additional Options to Modulate Adaptations to Changes in Oxygen Levels

Martina Minisini, Emanuele Cricchi, Claudio Brancolini

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Hypoxia; phosphorylation; HIF-1 alpha; HIF-2 alpha; HIF-3 alpha, acetylation; HDACs; KATs

Online: 7 December 2023 (06:16:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0734.v1

Novel Approach to Study Soft α-Open Sets and Its Applications via Fuzzy Soft Topologies

Islam Taha, Wafa Alqurashi

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: Fuzzy soft set; fuzzy soft topological space; r-fuzzy soft α -closed (α -open) set; fuzzy soft α -closure (α -interior) operator; fuzzy soft α -continuity; fuzzy soft almost (weakly) α -continuity; connectedness; compactness.

Online: 13 February 2024 (12:46:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0257.v2

Quantifying Transcriptome Diversity: A Review

Emma Jones, Anisha Haldar, Vishal Oza, Brittany Lasseigne

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gene expression; transcriptome diversity; transcriptional variation; transcript diversity; isoform-level diversity; gene-level diversity

Online: 13 April 2023 (03:07:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0171.v1

Bioactive Flavonoids from the Stem Bark of Cordia dichotoma Forst.: Identification, Docking and ADMET Studies

Nazim Hussain, Bibhuti Bhushan Kakoti, Mithun Rudrapal, Khomendra Kumar Sarwa, Ismail Celik, Emmanuel Ifeanyi Attah, Shubham Jagadish Khairnar, Soumya Bhattacharya, Ranjan Kumar Sahoo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: C. dichotoma; Flavonoids; Antidiabetic; alpha-glucosidase, alpha-amylase, Docking; ADMET

Online: 10 May 2021 (11:02:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0391.v1

Alpha-glucosidase and Alpha-amylase Inhibitory Activities, Molecular Docking and Antioxidant Capacities of Salvia Aurita Constituents

Ninon G.E.R Etsassala, Jelili A. Badmus, Jeanine L. Marnewick, Felix Nchu, Ahmed A. Hussein

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Diabetes mellitus; oxidative stress; alpha-glucosidase; alpha-amylase; Salvia aurita; abietane diterpenes

Online: 17 September 2020 (09:03:16 CEST)

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Diabetes mellitus (DM) is one of the most dangerous metabolic diseases with high rate of mortality worldwide. It is well known that insulin resistance and deficiency in insulin production from pancreatic β-cells are the main characteristic of DM. Due to the detrimental side effects of the current treatment, there is a considerable need to develop new effective antidiabetic drugs, especially alpha-glucosidase and alpha-amylase inhibitors with lesser adverse effects. These inhibitors are known to be directly involved in the delay of carbohydrate digestion, resulting in a reduction of glucose absorption rate and consequently reduce the post-prandial raise of plasma glucose, which can reduce the risk of long-term diabetes complications. Hence, natural products are well-known sources for the discovery of new scaffold for drugs discovery, including new antidiabetic drugs. The phytochemical investigation of Salvia aurita collected from Hogobach pass, Eastern Cape, South Africa (SA), yielded four known abietane diterpenes namely carnosol (1), rosmanol (2), 7-methoxyrosmanol (3), 12-methoxycarnosic acid (4) and one flavonoid named 4,7-dimethylapigenin (5). Structural characterization of these isolated compounds was conducted using 1 and 2D NMR, in comparison with reported spectroscopic data. These compounds are reported for the first time from S. aurita. The biological evaluation of the isolated compound against alpha-glucosidase exhibited strong inhibitory activities for 3 and 2 with IC50 values of 4.2 ± 0.7 and 16.4 ± 1.1 µg/mL respectively, while 4 and 1 demonstrated strong alpha-amylase inhibitory activity amongst the isolated compounds with IC50 of 16.2 ± 0.3 and 19.8 ± 1.4 µg/mL. Molecular docking analysis confirms strong inhibitory activity of 3 against alpha-glucosidase. Additionally, excellent antioxidant capacities were displayed by 2, 1 and 3 respectively as ORAC (25789.9 ± 10.5; 23961.8 ± 14.1; 23939.3 ± 2.4) µM TE/g; 1 and 2 as FRAP (3917.8 ± 2.1; 1522.3 ± 0.9) µM AAE/g; 5 and 2 as TEAC (3190.4 ± 2.8; 2055.0 ± 2.6) µM TE/g. The methanolic extract of S. aurita is a rich source of abietane diterpenes with excellent antioxidant and anti-diabetic activities that can be useful to modulate oxidative stress, and might possibly be excellent candidates for the management of diabetes. This is the first scientific report on the phytochemical isolation and biological evaluation of alpha-glucosidase and alpha-amylase inhibitory activities of Salvia aurita.

Preprint ARTICLE | doi:10.20944/preprints202302.0343.v1

Rapid EElution of ²²⁶Th from a Two-Column ²³⁰U/²²⁶Th Generator with Diluted and Buffer Solutions

Stanislav Ermolaev, Aino Skasyrskaya, Aleksandr Vasiliev

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: targeted alpha therapy; alpha-emitter; thorium-226; uranium-230; isotope generator; extraction chromatography

Online: 20 February 2023 (14:17:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0117.v1

HIF-alpha Activation Impacts Macrophage Function During Murine Leishmania major Infection

Manjunath Bettadapura, Hayden Roys, Anne Bowlin, Gopinath Venugopal, Charity L. Washam, Lucy Fry, Steven Murdock, Humphrey Wanjala, Stephanie D. Byrum, and Tiffany Weinkopff

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Leishmania; leishmaniasis; macrophages; HIF-alpha

Online: 7 October 2021 (11:00:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0015.v1

A Novel Device-Free Counting Method Based on Channel Status Information

Junhuai Li, Pengjia Tu, Huaijun Wang, Kan Wang, Lei Yu

Subject: Computer Science And Mathematics, Computer Science Keywords: wavelet transform; covariance matrix; spatial diversity; frequency diversity; robustness

Online: 1 August 2018 (10:10:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0123.v1

A Self-Emulsified Adjuvant System Containing Alpha-Tocopherol Induced Higher Neutralizing Antibody Responses than a Squalene Only Emulsion Against a Recombinant Cytomegalovirus (CMV) Pentamer Antigen

Rushit N Lodaya, Amey P Kanitkar, Asma Ashraf, Douty Bamba, Mansoor M. Amiji, Derek T. O'Hagan

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Adjuvants; emulsions; self-emulsification; alpha-tocopherol

Online: 7 November 2022 (12:18:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0195.v1

Random Fixed Point Theorems for Generalized Random α-ψ-contractive Mappings with Applications to Stochastic Differential Equation

Chayut Kongban, Poom Kumam, Juan Martinez-Moreno

Subject: Computer Science And Mathematics, Analysis Keywords: random fixed point, random $\alpha-$admissible with respect to $\eta$, generalized random $\alpha-\psi-$contractive mapping.

Online: 11 September 2018 (11:52:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0404.v1

Effects of Land Cover on Taxonomic and Functional Diversity of the Bird Communities in a Subtropical Mountain

Wenwen Zhang, Shengjun Zhao, Xiao Yang, Jing Tian, Ding Chen, Yuan Yu, Jie Shi, Peng Cui, Xue Wang, Chunlin Li

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Bird community; Functional diversity; Taxonomic diversity; Landscape pattern; Mountain city

Online: 4 January 2024 (11:28:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1956.v1

Building a Teleost Fish Traceability Program Based on Genetic Data from Pacific Panama Fish Markets

Edgardo Enrique Díaz-Ferguson, Magaly Sánchez De Chial, Maribel Arlene González Torres, Edgardo A. Muñoz T., Magister Olga Chen, Ovidio Durán, Angel Javier Vega, Carlos Ramos Delgado

Subject: Biology And Life Sciences, Aquatic Science Keywords: COI; teleostei; nucleotide diversity; haplotypic diversity; qPCR; demographic history; environmental DNA

Online: 28 June 2023 (07:37:41 CEST)

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Fish tissue samples from 203 adult individuals were collected in the main ports and markets of the Pacific coast of Panama. Molecular identification based on cytochrome oxidase I gene segment of all species was verified GENBANK reference sequences. 34 species from 14 families (Ariidae, Lutjanidae, Caranjidae, Scianidae, Centropomidae, Serranidae, Scombridae, Sphyraenidae, Haemulidae, Gerreidae, Stromotidae, Lobotidae, Malacanthidae, Mugilidae) were identified at species molecular level from 164 sequences. Also, three Caribbean species were molecularly identified among the analyzed samples (Mycteroperca xenarcha, Paralonchurus brasilensis and Lobotes surinamensis). Species diversity was slightly higher in the Gulf of Panama than in the Gulf of Chiriquí. For species with 5 or more individual sequences, genetic diversity and genetic connectivity parameters such as: total number of haplotypes (H), haplotype diversity (Hd), and nucleotide diversity (π) were calculated. Overall, pelagic-migratory species showed higher values of genetic diversity than coastal and estuarine species with some exceptions. Connectivity between Gulf areas was compared using values of genetic distances and genetic differentiation (Fst). High level of connectivity observed between Gulf of Chiriqui and Gulf of Montijo indicates the existence of a single stock in that area for the following species: Scomberomorus sierra, Caranx caninus and Lutjanus guttatus. Demographic history of the most common species was examined using Tajima’s D values suggesting population expansion for two snapper species, L. peru and L. argentiventris, having significant and higher values. Another important contribution from this research was the production of primers and dual labeled probes for environmental DNA detection using qPCR for the five most abundant species (spotted rose snapper, yellow snapper, green jack, Pacific crevalle jack and the Pacific sierra fish). These markers represent a new set of tools for environmental DNA (eDNA) detection and molecular traceability of three commercially important fish species along the supply chain including landing sites and markets of the main fishery areas.

Preprint ARTICLE | doi:10.20944/preprints202206.0328.v1

Assessing the Spatiotemporal Relationship between Coastal Habitats and Fish Assemblages at Two Neotropical Estuaries of the Mexican Pacific

Victor Muro, Felipe Amezcua, Georgina Ramírez-Ortiz, Francisco Flores-de-Santiago, Felipe Amezcua-Linares, Yareli Hernandez

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: mangrove forests; Marine Protected Areas; α-diversity; β-diversity; multivariate analyses

Online: 24 June 2022 (03:28:50 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202403.1396.v1

Occurrence of Clostridium perfringens in Wild Mammals in the Amazon Biome

Hanna Gabriela da Silva Oliveira, Ananda Iara de Jesus Sousa, Isabela Paduá Zanon, Cinthia Távora de Albuquerque Lopes, Rodrigo Otavio Silveira Silva, Sheyla Farhayldes Souza Domingues, Felipe Masiero Salvarani

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: alpha toxin; toxinotype A; wild mammals; diarrhoea

Online: 23 March 2024 (09:34:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1027.v1

TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis

Nathan K.P. Wong, Emma L. Solly, Richard Le, Victoria A. Nankivell, Jocelyne Mulangala, Peter J. Psaltis, Stephen J. Nicholls, Martin K.C. Ng, Christina A. Bursill, Joanne T.M. Tan

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Inflammation; Ischemia; Neovascularization; HIF-1α ; eNOS

Online: 19 February 2024 (08:33:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0569.v1

Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-inflammatory Cytokine Secretion in Keratinocytes

Thi Huyen Dang, Ji Yeong Kim, Hyun Jong Kim, Byung Joo Kim, Woo Kyung Kim, Joo Hyun Nam

Subject: Medicine And Pharmacology, Dermatology Keywords: Keratinocytes; alpha-mangostin; TRPV3; skin inflammation; dermatitis

Online: 8 August 2023 (03:42:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0061.v1

Epigenetics and Dysfunctional Energy Factors of Neurodegenerative Disease with Therapeutic Potential of H₂O₂ as Neuroprotective Agent

Sri Widyarti, Syahputra Wibowo, Akhmad Sabarudin, Intan Abhirama, Sutiman Bambang Sumitro

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: alpha-synuclein; energy; H2O2; mitochondria; neurodegenerative disease

Online: 2 August 2022 (10:13:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0268.v1

Catch Composition, Seasonality and Biological Aspects of Sharks Caught in the Ecuadorian Pacific

Jesús Briones-Mendoza, Diego Mejía, Pol Carrasco-Puig

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: diversity; abundance; cartilaginous fish

Online: 20 June 2022 (10:10:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0050.v1

Diversity and Reassortment Rate of Influenza a Viruses in Wild Ducks and Gulls

Yulia Postnikova, Anastasia Treshchalina, Elizaveta Boravleva, Alexandra Gambaryan, Aydar Ishmukhametov, Mikhail Matrosovich, Ron A.M. Fouchier, Galina Sadykova, Alexei Prilipov, Natalia Lomakina

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Avian influenza; Reassortment; Diversity

Online: 5 May 2021 (12:32:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0010.v1

Biological Hotspot of Ichthyoplankton in the Estuarine Environment Timbulsoko Village, Demak

Hanityo Adi Nugroho, Sutrisno Anggoro, Ita Widowati

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Diversity; Ecology; Fishes; Geoscience

Online: 2 December 2019 (10:38:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0346.v1

Biological Hotspot larva Ikan Diperairan Estuari Desa Timbulsoko, Demak

Hanityo Nugroho, Sutrisno Anggoro , Ita Widowati

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: diversity; ecology; fishes; geoscience

Online: 31 July 2019 (04:40:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0018.v2

Comparing Measures of Community Lineage Diversity across North American Forests

Kyle G. Dexter, Ricardo A. Segovia, Andy Griffiths

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: temperate forests; species richness; lineage diversity; phylogenetic diversity; United States; trees; TILD

Online: 13 February 2019 (10:15:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0963.v1

Fixed Point Results for $\alpha$-Type $F$-Suzuki Contraction and $\alpha$-Type $F$-Weak-Suzuki Contraction With Application to Non-linear Fractional Differential Equation in $b$-Metric Spaces

Yohannes Tesfaye Gher, Kidane Koyas Tola, Haider Ebrahim Yesuf

Subject: Computer Science And Mathematics, Analysis Keywords: Fixed points, $F$-Suzuki-contraction, $\alpha$-type $F$-Suzuki contraction, $\alpha$-type $F$-Weak-Suzuki contraction, $b$-metric space.

Online: 13 December 2023 (10:05:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0060.v1

Doubling the Accuracy of Indoor Location: Frequency Diversity

Berthold Horn

Subject: Engineering, Electrical And Electronic Engineering Keywords: indoor location; fine time measurement; round trip time; FTM; RTT; IEEE 802.11mc; IEEE 802.11-2016; time diversity; spatial diversity; bandwidth diversity; frequency diversity; Bayesian grid; observation model; transition model

Online: 8 January 2020 (04:18:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0103.v1

Microsatellite Sequence Polymorphisms Reveals Substantial Diversity in Caribbean Breadfruit [Artocarpus altilis (Parkinson) Fosberg] Germplasm

Oral O Daley, Angela T Alleyne, Laura B Roberts-Nkrumah, Lambert A Motilal

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Crop germplasm; genetic diversity; nucleotide diversity; nucleotide polymorphism; SSR markers; un-derutilized crop

Online: 2 February 2024 (04:54:00 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202404.0686.v1

Support Vector Machine-Based Formula for Detecting Suspected α Thalassemia Carriers: A Path Toward Universal Screening

Idit Lachover-Roth, Sari Peretz, Hiba Zoabi, Harel Eitam, Leonid Livshits, Dvora Filon, Carina Levin, Ariel Koren

Subject: Medicine And Pharmacology, Hematology Keywords: Alpha Thalassemia, Screening, Support Vector Machine, Mathematical Formulas

Online: 10 April 2024 (09:45:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0240.v1

An Investigative Analysis of Therapeutic Strategies in Hepatocellular Carcinoma: A Retrospective Examination of 23 Biopsy-Confirmed Cases Emphasizing the Significance of Histopathological Insights

Mugur Cristian Grasu, Radu Dumitru, Anca Zgura, Letitia Toma, Laura Iliescu, Cosmin Baciu

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: cancer; hepatocellular; biopsy; alpha-fetoprotein; immune checkpoint inhibitor

Online: 5 March 2024 (05:43:36 CET)

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Background: The Liver Imaging Reporting and Data System (LI-RADS) combines standardized terminology with a classification system for imaging findings in patients with HCC, therefore rendering diagnostic biopsy unnecessary in many cases. This retrospective study included 23 patients with a biopsy diagnosis of HCC, performed either before or after local interventional procedures, in order to evaluate the histopathologic changes induced by previous procedures and their potential influence on the response to immune therapy. Material and Methods: The study encompassed a cohort of patients diagnosed with Hepatocellular Carcinoma (HCC). Diagnosis was established through contrast-enhanced computer tomography or magnetic resonance imaging that identified LI-RADS-5 nodules in conjunction with historical liver disease and elevated alpha-fetoprotein (AFP) levels, or through histological examination confirming positivity for glypican3, heat shock protein70, and glutamine synthetase. The study detailed the liver disease etiology, LI-RADS scores, characteristics and dimensions of HCC nodules, serum AFP concentrations, Edmondson-Steiner grading, and the expression of programmed cell death ligand 1 (PD-L1) in the tumor cells. Results: Among the study's cohort of Hepatocellular Carcinoma (HCC) patients, a portion had not received any prior treatments, while the remainder experienced local HCC recurrence following trans-arterial chemoembolization or radiofrequency ablation. Observations indicated elevated alpha-fetoprotein (AFP) levels in those who had not undergone any previous interventions, showing statistical significance. The Edmondson-Steiner classification predominantly identified grade III differentiation across patients, irrespective of their treatment history. Furthermore, an increase in intra-tumoral programmed cell death ligand 1 (PD-L1) expression was noted in patients who had not been subjected to previous therapies. Conclusion: Liver biopsy offers valuable insights for patients with Hepatocellular Carcinoma (HCC), assisting in the tailoring of immune therapy strategies, particularly in cases of recurrence following prior local interventions.

Preprint ARTICLE | doi:10.20944/preprints202211.0532.v3

The DUX4-HIF1α Axis in Murine and Human Muscle Cells: A Link More Complex than Expected

Thuy-Hang Nguyen, Maelle Limpens, Sihame Bouhmidi, Lise Paprzycki, Alexandre Legrand, Anne-Emilie Declèves, Philipp Heher, Alexandra Belayew, Christopher R. S. Banerji, Peter S. Zammit, Alexandra Tassin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: FSHD; DUX4, HIF1α , myogenesis and skeletal muscle

Online: 29 January 2024 (04:15:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1457.v1

In Vitro and In Silico Analysis of Alpha-Amylase Inhibitory Activity of Ethanolic Extract of Adhatoda vasica Leaves

Chandrajeet Kumar Yadav, Sandhya KC, Shankar Thapa, Kamal Kandel, Laxmi Shrestha, Anjan Palikhey, Ashish Lamsal

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Anti-diabetic; Alpha amylase; Adhatoda vasica; Molecular docking

Online: 21 July 2023 (10:09:28 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.0435.v1

Do Not Fear When Menopause Is Near: The Importance of a Preparatory Time and Space to Face the Consequences before Reaching the Menopause

Manosha Perera, Irosha Perera

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Omega; Alpha; Menarche; Menopause; Reproductive Health; Preparatory Time

Online: 8 May 2023 (03:46:24 CEST)

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As a result of scientific technological advancements in medical diagnostics, treatment modalities of non-communicable and communicable diseases, and palliative care approaches, the life expectancy of women is soaring than men across the globe, due to the longer telomere length and other protective factors. The main symptoms of menopause broadly be divided into psychological somatovegetative and urogenital. Neglected menopausal symptoms can lead to debilitating comorbidities which may end up in mortalities. Fortunately, modern treatment and therapeutic formalities based on pharmaceutical preparations, as well as lifestyle- modifications have provided long-lasting relief for the pre-menopausal woman. This can be done as per her preference if she is knowledgeable, resourceful, and cheerful. Menarchae is the “ alpha” and menopause is the “omega” phase in the reproductive lifecycle of any woman. Reproductive health is essentially an integral part of women’s health. In this 4^th industial revolution era information technology and digital science go hand in hand to improve the quality of life of populations across the globe irrespective of their educational and professional status. Health literacy among disadvantageous sub populations increased. Positive attitudes, perception and evidence-informed knowledge on adolesecent girls about not only ‘period pains’ but menopausal symptoms as an inevitable phase in a woman’s reproductive health may make a better sense at the dawn of evidence based medicine even in a low middle income country like Sri Lanka. Hence, this timely communication strengthens by, Do not fear when menopause is near: The Importance of a Preparatory Time and Space to face the consequences of Menopaus. How to forget the fact that alpha and the omega are inevitable phases in woman’s reproductive health trajectory. Moreover, the importance of a preparatory time and space well in advance preferably in peri-menopausal time to prevent and control the inevitable health consequences. Moreover, to invest in menopause for a brighter future in the modern personalized medicine era based on global scientific evidence.

Preprint ARTICLE | doi:10.20944/preprints202303.0435.v1

Disease-Specific α-Synuclein Seeding and Structural Properties in Lewy Body Disease and Multiple System Atrophy are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain

Ain Kim, Ivan Martinez-Valbuena, Jun Li, Anthony E. Lang, Gabor Geza Kovacs

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: alpha-synuclein; protein extraction; FFPE; SAA; seeding behavior

Online: 27 March 2023 (03:23:29 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202206.0117.v1

Formation of Stable Gold Nanoparticles from Cannabis Indica Leaves

Anjul Khadria, Subhankar Paul

Subject: Engineering, Other Keywords: Gold nanoparticles; nanomaterials; alpha-lactalbumin protein; Cannabis indica

Online: 8 June 2022 (05:59:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0053.v1

Deciding on Optical Illusions: Reduced Alpha Power in Body Dysmorphic Disorder

Anastasios E. Giannopoulos, Ioanna Zioga, Konstantinos Kontoangelos, Panos Papageorgiou, Fotini Kapsali, Christos Ν. Capsalis, Charalabos Papageorgiou

Subject: Social Sciences, Behavior Sciences Keywords: body dysmorphic disorder; EEG; optical illusions; alpha oscillations

Online: 6 January 2022 (09:44:14 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202108.0117.v1

The α-Lipoic Acid Improves Hepatic Metabolic Dysfunctions in Acute Intermittent Porphyria: A Proof-of-Concept Study

Miriam Longo, Erika Paolini, Marica Meroni, Lorena Duca, Irene Motta, Anna L. Fracanzani, Elena Di Pierro, Paola Dongiovanni

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: AIP; PBGD; glucose metabolism; mitobiogenesis; alpha-lipoic acid

Online: 4 August 2021 (14:45:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0002.v1

The Catecholaldehyde Hypothesis for the Pathogenesis of Catecholaminergic Neurodegeneration: What We Know and What We Don’t Know

David S Goldstein

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Catecholaldehyde; DOPAL; Autotoxicity; Monoamine Oxidase; Dopamine; Alpha-Synuclein

Online: 3 May 2021 (09:08:57 CEST)

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3,4-dihydroxyphenylacetaldehyde (DOPAL) is the focus of the catecholaldehyde hypothesis for the pathogenesis of Parkinson disease and other Lewy body diseases. The catecholaldehyde is produced via oxidative deamination catalyzed by monoamine oxidase (MAO) acting on cytoplasmic dopamine. DOPAL is autotoxic, in that it can harm the same cells in which it is produced. Normally DOPAL is detoxified by aldehyde dehydrogenase (ALDH)-mediated conversion to 3,4-dihydroxyphenylacetic acid (DOPAC), which rapidly exits the neurons. Genetic, environmental, or drug-induced manipulations of ALDH that build up DOPAL promote catecholaminergic neurodegeneration. A concept derived from the catecholaldehyde hypothesis imputes deleterious interactions between DOPAL and the protein alpha-synuclein (S), a major component of Lewy bodies. DOPAL potently oligomerizes S, and S oligomers impede vesicular and mitochondrial functions, shifting the fate of cytoplasmic dopamine toward MAO-catalyzed formation of DOPAL—destabilizing vicious cycles. Direct and indirect effects of DOPAL and of DOPAL-induced misfolded proteins could “freeze” intra-neuronal reactions, plasticity of which is required for neuronal homeostasis. The extent to which DOPAL toxicity is mediated by interactions with S, and vice versa, are poorly understood. Because of numerous secondary effects such as augmented spontaneous oxidation of dopamine by MAO inhibition, there has been insufficient testing of the catecholaldehyde hypothesis in animal models. The clinical pathophysiological significance of genetics, emotional stress, environmental agents, and interactions with numerous proteins relevant to the catecholaldehyde hypothesis are matters for future research. The imposing complexity of intra-neuronal catecholamine metabolism seems to require a computational modeling approach to elucidate clinical pathogenetic mechanisms and devise pathophysiology-based, individualized treatments.

Preprint HYPOTHESIS | doi:10.20944/preprints202104.0606.v2

Role of a-Synuclein in Cell Biology: A Hypothesis and its Implications in Neurodegenerative Diseases

Renu Minda

Subject: Biology And Life Sciences, Biophysics Keywords: Parkinson’s disease; alpha-synuclein; Lewy bodies; phase transition; thermodynamics; and mitochondria

Online: 10 January 2022 (12:23:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0239.v1

Fundamental Constants in Time from the Big-Bang

Heikki Sipilä, Ari Lehto

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Fine structure constant; period doubling; alpha; natural constants

Online: 11 July 2020 (10:23:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0189.v1

The Janus Face of NKT Cell Function in Autoimmunity and Infectious Diseases

Alessandra Torina, Giuliana Guggino, Marco Pio La Manna, Guido Sireci

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: microbes; autoimmunity; glycolipids,alpha-GalactosylCeramide; sulfatide; CD1d; NKT.

Online: 20 January 2018 (13:59:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1730.v1

Genetic Diversity of Human Norovirus in Children Less Than 5 Years of Age With Acute Gastroenteritis in Rural Communities in the Gambia

Sheriffo Jagne, M. Jahangir Hossain, Martin Antoni, Abdul Karim Sesay, Muhammed Khalie Abdul, Nuredin I. Mohammed, Madikay Senghore, Alansana Darboe, Jarra Manneh, Abdoulie Kanteh, Dam Khan, Saikou Y Bah, Ndaw Sylvanus Peter, Osbourne Quaye, George Enyimah Armah

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Norovirus genetic diversity genogroups genotypes

Online: 24 January 2024 (10:15:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1390.v1

Evaluation of Wild Raspberry (Rubus idaeus L.) Ecotypes from Northeastern Türkiye

Gulce Ilhan

Subject: Biology And Life Sciences, Horticulture Keywords: Raspberry; underutilized fruits; characterization; diversity

Online: 19 January 2024 (03:12:32 CET)

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Located between Asia and Europe, Türkiye is very rich in terms of wild edible fruit diversity. One of the most important wild edible fruits in Türkiye is red raspberries and they widely found in cold to warm temperate regions in the country. The wild raspberries in general have red fruit color but yellow fruited genotypes are evident. A total of 11 wild grown red raspberry genotypes sampled in Northern Anatolia region was used in this study and their sensory, biochemical and antioxidant characteristics were determined. For sensory analysis aroma, taste and juiciness were used as the main criteria to compare ecotypes each other. Biochemical and antioxidant characteristics of ecotypes included SSC (Soluble Solid Content), vitamin C, organic acids, total anthocyanins (TA), total phenolic content, total flavonoid content and total antioxidant capacity. FRAP (Ferric Reducing Antioxidant Power) assay was used to determine antioxidant capacity. There were significant differences among ecotypes for most of the searched parameters even they found similar growing condition. The ecotypes had fruit weight between 1.04 g and 1.33 g, and fruit Chroma value between 26.11 and 33.70. Vitamin C content of ecotypes were quite variable and ranged from 29.3 mg/100 g to 41.4 mg/100 g. The total phenolic content, total anthocyanin content, total flavonoid content was between 164-362 mg gallic acid equivalent/100 g; 17.3-33.3 mg cyanidin-3-glucoside equivalent/100 g and 10.3-17.2 mg quercetin equivalent/100 g, respectively. Citric acid was the dominant organic acid for all genotypes and ranged from 10.3-14.6 g/100 g fresh weight base. According to the results V-4, V-8, V-3 and V-10 had attractive bigger fruits indicate their suitability for fresh consumption. V-3 and V-5 had sweeter fruits indicated their suitability for processing and V-6, V-7 and V-11 had richer for human health promoting compounds (higher total phenolic content and antioxidant capacity), making them suitable for future use as functional foods and as promising sources of natural antioxidants.

Preprint REVIEW | doi:10.20944/preprints202206.0284.v1

Building Consensus around the Assessment and Interpretation of Symbiodiniaceae Diversity

Sarah Davies, Matthew H. Gamache, Lauren I. Howe-Kerr, Nicola G. Kriefall, Andrew C. Baker, Anastazia T. Banaszak, Line K. Bay, Anthony J. Bellantuono, Debashish Bhattacharya, Cheong Xin Chan, Danielle C. Claar, Mary Alice Coffroth, Ross Cunning, Simon K. Davy, Javier del Campo, Erika M. Diaz-Almeyda, Jorg C. Frommlet, Lauren E. Fuess, Raul A. Gonzalez-Pech, Tamar L. Goulet, Kenneth D. Hoadley, Emily J. Howells, Benjamin C. C. Hume, Dustin W. Kemp, Carly, D. Kenkel, Sheila A. Kitchen, Todd C. LaJeunesse, Senjie Lin, Shelby McIlroy, Ryan McMinds, Matthew R. Nitschke, Clinton A. Oakley, Raquel S. Peixoto, Carlos Prada, Hollie M. Putnam, Kate Quigley, Hannah G. Reich, James Davis Reimer, Mauricio Rodriguez-Lanetty, Stephanie Rosalas, Osama S. Saad, Eugenia M. Sampayo, Scott Santos, Eiichi Shoguchi, Edward G. Smith, Michael Stat, Timothy G. Stephens, Marie E. Strader, David J. Suggett, Timothy D. Swain, Cawa Tran, Nikki Traylor-Knowles, Christian R. Voolstra, Mark E. Warner, Virginia M. Weis, Rachel Wright, Tingting Xiang, Hiroshi Yamashita, Maren Ziegler, Adrienne M.S. Correa, John Everett Parkinson

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Symbiodinaceae; genetic diversity; coral symbiosis

Online: 21 June 2022 (04:49:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0397.v1

Simple Method for Assessing Diversity and Dynamics of Microbial Community: Comparison of Dairy Phages from Industrial and Spontaneous Fermentation

Agnieszka Olejnik-Schmidt, Bernadeta Pietrzak, Iwona Kawacka, Klaudia Malak, Weronika Wawrzyniak, Marcin Schmidt

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: phage; dairy; Lactococcus; diversity; community

Online: 19 August 2021 (10:30:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0254.v1

Distribution of Insect in Protected Forest Area in Ambon City

fransina latumahina

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Insects; Diversity; ecosystem health; Ambon

Online: 9 March 2021 (10:03:23 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202008.0021.v1

Safe Fieldwork Strategies for At-Risk Individuals

Amelia-Juliette Demery, Monique Pipkin

Subject: Social Sciences, Safety Research Keywords: diversity; inclusion; equity; fieldwork; research

Online: 2 August 2020 (11:55:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0366.v1

Does Islam Practice Tolerance? Some Notes from Quranic Perspective

Abur Hamdi Usman

Subject: Social Sciences, Religion Keywords: Tolerance; Religion; Islam; Society; Diversity

Online: 19 July 2018 (15:43:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0179.v1

Economic Diversity and the Resource Curse: A Dynamic Panel Model

Fred Olayele, Kwok Soo

Subject: Business, Economics And Management, Economics Keywords: Diversity; resource curse; economic growth.

Online: 13 April 2018 (14:18:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0247.v1

Species Diversity of Oak Stands and Its Significance for Drought Resistance

Jan Kotlarz, Sylwia Nasiłowska, Karol Rotchimmel, Katarzyna Kubiak

Subject: Environmental And Earth Sciences, Environmental Science Keywords: drought; diversity; oaks; remote sensing

Online: 26 January 2018 (04:52:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0116.v1

Evaluation of Diversification Techniques for Legal Information Retrieval

Marios Koniaris, Ioannis Anagnostopoulos, Yannis Vassiliou

Subject: Computer Science And Mathematics, Information Systems Keywords: diversity; algorithms; legal information retrieval

Online: 23 November 2016 (09:50:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0627.v1

BIOFACQUIM: A Mexican Compound Database of Natural Products

B. Angélica Pilón-Jiménez, Fernanda I. Saldívar-González, Bárbara I. Díaz-Eufracio, José L. Medina-Franco

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: chemical space; chemical data set; chemoinformatics; consensus diversity plot; drug discovery; molecular diversity; visualization

Online: 30 November 2018 (10:06:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.0841.v1

Review of Taxonomic Knowledge of Dictyota (Phaeophyceae; Dictyotales); Two Centuries after its Description

María del Carmen Altamirano-Cerecedo, Francisco Omar López-Fuerte, Juan Manuel López-Vivas, Elisa Serviere-Zaragoza, Karla León-Cisneros

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: alpha taxonomy; beta taxonomy; gamma taxonomy; macroalgae; integrative taxonomy

Online: 12 April 2024 (10:08:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1853.v1

Evaluating the Antihyperalgesic Potential of Sildenafil-Metformin Combination and Its Impact on Biochemical Markers in Alloxan-Induced Diabetic Neuropathy in Rats

Ciprian Pușcașu, Cristina Elena Zbârcea, Anca Ungurianu, Emil Ștefănescu, Cornel Chiriță, Nicoleta Mirela Blebea, Simona Negreș

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: diabetic neuropathy; sildenafil; metformin; antihyperalgesic; IL-6; TNF-α

Online: 29 March 2024 (13:45:41 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1253.v1

Gas Gangrene in a Horse in the Amazon Biome Caused by Clostridium septicum

Loise Araújo de Sousa, Leandro Oliveira da Silva, Márcio Alan Oliveira Moura, Marcos Dutra Duarte, Valíria Duarte Cerqueira, Rodrigo Otávio Silveira Silva, Felipe Masiero Salvarani

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Clostridium septicum, alpha toxin, multiplex PCR, malignant edema, claudication.

Online: 21 March 2024 (10:46:02 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.0189.v1

Examining TNF-Alpha Inhibition Potential: Molecular Docking Study of Pharmaceuticals and Natural Compounds

Ivan Vito Ferrari

Subject: Public Health And Healthcare, Other Keywords: autodock vina; pyrx program; TNF-alpha; inflammation; docking studies

Online: 5 February 2024 (06:24:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1698.v2

Mapping of Alpha-Emitting Radionuclides in the Environment Using an Unmanned Aircraft System

Pablo Royo, Arturo Vargas, Tania Guillot, David Saiz, Jonathan Pichel, Daniel Rabago, María Amor Duch, Claudia Grossi, Maksym Luchkov, Volker Dangendorf, Faton Krasniqi

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: radiological detection; alpha-emitting radionuclides; UAS software architecture; UAS

Online: 21 December 2023 (16:02:51 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.1085.v1

TNF-α Inhibitors Rescue APS-Induced Dangerous Pregnancies by Reducing the Risk of Miscarriage: A Report of 7 Cases

Ran An, Xiaolei Wang, Ligui Xiong, Yanqi Yang, Peiling Li

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Antiphospholipid syndrome; TNF-α Inhibitors; Dangerous pregnancy; gestational weeks

Online: 14 December 2023 (12:15:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1933.v1

Utility of the Serum Protein Electrophoresis in the Opportunistic Screening for the Deficiency of Alpha-1 Antitrypsin

Beatriz Fernández-Gomez, Sebastian Menao-Guillén, Ayala Fernandez Gonzalez, Maria Arruebo Muñio, Monica Ramos Alvarez, Mercedes Inda Landaluce, Maria Angeles Castillo Arce, Miguel-Angel Torralba-Cabeza

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Alpha-1 Antitrypsin; Protein electrophoresis; SERPINA1; screening; genetic counseling

Online: 28 July 2023 (10:24:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2133.v1

Structural Evolution of Primate Glutamate Dehydrogenase 2 as Revealed by in Silico Predictions and Experimentally Determined Structures

Ionela Litso, Andreas Plaitakis, Vasiliki E. Fadouloglou, Mary Providaki, Michael Kokkinidis, Ioannis Zaganas

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: glutamate dehydrogenase; alpha fold; protein structure prediction; primate evolution

Online: 30 May 2023 (11:55:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0202.v1

Behavioural and Neurophysiological Assessment of Hearing Aid Benefits in an Adult Population with and without Hearing Loss

Shivali Appaiah-Konganda, Mridula Sharma, Ronny Ibrahim, Jessica J. M. Monaghan, John Newall, Joaquin Tomas Valderrama Valenzuela

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Alpha synchronisation; Working memory; Auditory processing; Modulation detection threshold

Online: 12 January 2023 (01:48:00 CET)

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Background: Despite hearing aids adequately compensate for hearing loss, a substantial proportion of the population leave their hearing difficulties untreated. Even though this is a well-known clinical issue, the optimal approach to address this issue during the hearing rehabilitation process is still unclear. Purpose: The present study aims to characterise behavioural and neurophysiological auditory and cognitive processing skills in experienced hearing aid users versus those with normal hearing, aimed at providing clinicians with the evidence required to adequately manage the expectations of their clients, thus indirectly reinforcing hearing-aid adoption within the adult population with hearing loss. Research design: Behavioural tests included auditory, cognitive, and speech-in-noise tasks; and neurophysiological testing included cortical auditory evoked potentials evoked by a /da/ stimulus presented at 65 dB SPL. The tests were selected based on previous literature supporting specific speech-understanding skills. Study sample: Ten participants (7 female, 21—68 years) with bilateral, mild-moderate to moderately-severe sensorineural hearing loss (HL), and 10 with clinically normal hearing (NH, 8 female, 19—62 years) participated in the study. Data collection and analysis: Behavioural data was analysed using multivariate analysis of variance (MANOVA) and neurophysiological analysis used measurements such as independent t-test, time-frequency analysis and inter-trial phase coherence. Results: The NH and HL groups presented similar scores in all the behavioural tasks. Time-frequency analysis revealed a statistically significantly reduction in alpha (8–12 Hz) synchronisation at the centro-frontal electrodes in the HL group – a brain activity pattern that has been associated with listening effort, inhibition and selective attention. Conclusions and significance: Results support the conclusion that hearing aids are effective in compensating for the audibility of their users, enabling them to perform at similar levels than their normal-hearing peers. However, the reduced alpha synchronisation observed in the HL population indicates that adequate audibility does not extend to improved neural responses. Future studies need to investigate the induced activity in speech understanding paradigms to explore the auditory processing differences at cortical level. The results are only from a small sample size but the findings have the potential to support clinicians in managing adequately the expectations of their clients in regards the benefits of hearing aid technologies.

Preprint ARTICLE | doi:10.20944/preprints202206.0274.v1

α-amylase Inhibition Activity of Phytoconstituents Present in the Roots Of Cyclea peltata-An in-silico and in-vitro Investigation

Gandhimathi R., Binoy Varghese Cheriyan, Deevan Paul A., Saravanakumar A., Lakshmanan G.

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Cyclea peltata; Diabetes Mellitus; Docking; Schrodinger; Alpha amylase; Inhibition

Online: 20 June 2022 (14:33:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0472.v1

Potential of Entomopathogenic Nematodes versus Alpha-cypermethrin Against Potato Tuber Moth, Phthorimaea operculella Zeller 1873 (Lep.: Gelechiidae) in Storage Conditions

Laleh Ebrahimi, Aziz Sheikhigarjan, Mehran Ghazavi

Subject: Biology And Life Sciences, Insect Science Keywords: EPNs; PTM; biological control; potato tuber; efficacy; alpha-cypermethrin

Online: 22 February 2021 (13:19:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0428.v1

On the Fourth Coefficient of the Inverse of a Starlike Function of Positive Order

Toshiyuki Sugawa, Li-Mei Wang

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: starlike function of order $\alpha$; inverse function; coefficient estimates

Online: 16 November 2020 (15:08:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0130.v1

Synthesis of novel Triazinoindole-Based-Thiourea Hybrid: α-Glucosidase Inhibitors and Their Molecular Docking Study

Muhammad Taha, Foziah J. Alshamrani, Fazal Rahim, Shawkat Hayat, Hayat Ullah, Khalid Zaman, Syahrul Imran

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Synthesis; triazinoindole; thiosemicarbazide; alpha-glucosidase; molecular docking study; SAR

Online: 13 September 2019 (10:54:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0324.v1

Associations between the Duration and Frequency of Sedentary Bouts and Adiposity in Elderly Community-Dwelling Women

Jana Pechová, Jana Pelclová, Aleš Gába, Izabela Zając-Gawlak, Lenka Tlučáková, Jan Dygrýn, Zuzana Svozilová, Hana Lepková

Subject: Social Sciences, Behavior Sciences Keywords: Adipose tissue, Adiposity, Sedentary bouts, Alpha sedentary, Elderly women

Online: 14 November 2018 (08:09:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0787.v1

A Highly Homogeneous Airborne Fungal Community Around a Copper Open-Pit Mine Reveals a Poor Contribution by the Local Aerosolization of Particles

Sebastián Fuentes-Alburquenque, Victoria Olivencia Suez, Omayra Aguilera, Blanca Águila, Luis Rojas Araya, Dinka Mandakovic

Subject: Environmental And Earth Sciences, Ecology Keywords: microbial community; diversity; air; fungi; bioaerosol

Online: 11 April 2024 (08:03:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1642.v1

Shrews (Soricidae) and Viruses Identified in Shrews

Huan-Yu Gong, Rui-Xu Chen, Su-Mei Tan, Xiu Wang, Ji-Ming Chen, Yuan-Long Zhang, Ming Liao

Subject: Biology And Life Sciences, Virology Keywords: shrew; virus; diversity; domestic animal; human

Online: 21 December 2023 (10:25:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0860.v1

Equity, Diversity, and Inclusion Strategies in Engineering and Computer Science

Adan Amer, Gaganpreet Sidhu, Maria Isabel Ramirez Alvarez, Juan Antonio Lopez Ramos, Seshasai Srinivasan

Subject: Computer Science And Mathematics, Software Keywords: Equity; Diversity; Inclusion; strategies; priority areas

Online: 12 December 2023 (10:23:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0945.v1

Metataxonomic Analysis of Bacterial Diversity in Pigeon Pea after Soaking in Water

Yuni Sine, Donny Widianto, Yekti Asih Purwestri, Byong H. Lee, Widodo Widodo

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: pigeon pea; bacterial diversity; metataxonomic analysis

Online: 16 October 2023 (13:15:21 CEST)

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: With the increase in demand for non-dairy starter cultures and probiotic bacteria as carriers, the use of legumes (also called pulses) as an alternative has gained momentum. In this study, we investigated the diversity of bacterial communities in samples of pigeon pea (Cajanus cajan L. Millsp.) soaked in water for 12 h and 24 h. We soaked 500 g of pigeon pea in sterile distilled water at room temperature (± 25 °C) for 12 h and 24 h; 10 mL of the soaking water was then collected to measure the bacterial diversity using a metataxonomic analysis. The V1–V9 regions on the 16S ribosomal RNA gene were amplified using 27F and 1492R primers under specific polymerase chain reaction conditions for the bacterial identification. Genomic DNA (130 ng) was sequenced on a R9.4 flow cell by Oxford Nanopore Technologies using a GridION sequencer. Library preparations were initiated using a Native Barcoding Kit 24 V14 (SQK-NBD114.24). Primary data were acquired using MinKNOW version 22.05.7. A total of 13 bacterial families and 89 genera were identified in the pigeon pea sample soaked for 12 h; 26 families and 90 genera were identified in the pigeon pea sample soaked for 24 h. Among the bacterial families identified, the five predominant families in both samples were Enterobacteriaceae, Erwiniaceae, Yersiniaceae, Pectobacteriaceae, and Lactobacillaceae. According to the relative abundance of the identified bacterial genera, the following nine genera were predominant in both samples: Enterobacter, Klebsiella, Citrobacter, Pantoea, Kosakonia, Pseudoenterobacter, Pluralibacter, Leclercia, and Kluyvera. At a genus level, a slight increase in the abundance of Klebsiella, Kosakonia, and Pluralibacter and a slight decrease in the abundance of Citrobacter were observed after prolonged incubation from 12 h to 24 h. The values of five diversity indices revealed that the sample soaked in water for 24 h had a richer bacterial abundance and diversity than the 12 h sample. Shannon and Simpson values revealed a higher bacterial diversity in the sample collected at 24 h than the sample collected at 12 h. Species observations and abundance-based coverage estimator (ACE) values demonstrated that the sample collected at 24 h harbored a higher bacterial richness than the sample collected at 12 h. These findings indicated that the bacterial diversity in the pigeon pea samples increased with the soaking time. The bacterial communities during the soaking of the pigeon pea samples were dominated by the Enterobacteriaceae family and Enterobacter genus. The presence of bacterial genera such as Lacticaseibacillus, Lentilactobacillus, and Secundilactobacillus was notable because of their importance as starter cultures for fermented plant-based milk products, including pigeon pea beverages for lactose-intolerant individuals or individuals with malnutrition.

Preprint ARTICLE | doi:10.20944/preprints202310.0419.v1

Enhancing Tree Health through Improved Microbial Biodiversity in Soil

Vinesh Prasad, Daniel Cole

Subject: Environmental And Earth Sciences, Soil Science Keywords: soil health; mirobilogy; diversity; tree health

Online: 8 October 2023 (04:33:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1064.v1

Culture, Gender, and Business

EMMANUEL ADEYEMI

Subject: Arts And Humanities, History Keywords: culture; gender; business; organization; religion; diversity

Online: 18 September 2023 (05:30:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0692.v1

Functional and Species Diversity across Disturbance Levels and Environmental Variables in Yayu Coffee Forest Biosphere Reserve, Southwest Ethiopia

Ferede Abuye Jeldu, Motuma Tolera Feyisa, Teshale Woldeamanuel

Subject: Biology And Life Sciences, Forestry Keywords: biosphere reserve; disturbance; functional diversity; zonation

Online: 11 July 2023 (10:55:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1425.v1

Anaemia in Preschool-Aged Children in DR. Congo: Finding from a Nationally Representative Survey

Ngianga II (Shadrack) Kandala

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Haemoglobin; Anaemia; Dietary, Diversity; Random-effect

Online: 19 May 2023 (10:06:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1234.v1

Butterflies of the Neotropical Seasonally Dry Forest of Montes de María (Sucre, Colombia): What do they Tell us about the Intermediate Disturbance Hypothesis?

Yarlenis L Mercado-Gómez, Jorge D Mercado-Gómez, Carlos E Giraldo-Sánchez

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: structure; diversity; anthropic disturbance; conservation; Lepidoptera

Online: 17 May 2023 (10:38:26 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.0879.v1

Glucosinolate Diversity Analysis in Choy sum (Brassica rapa subsp chinensis var parachinensis) Germplasms for Functional Foods Breeding

Seong-Hoon Kim, Parthiban Subramanian, Bum-Soo Hahn

Subject: Biology And Life Sciences, Food Science And Technology Keywords: glucosinolate; germplasm; breeding; anticancer; genebank; diversity

Online: 12 May 2023 (04:27:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0206.v1

Testing White’s Floristic Impoverishment Hypothesis in the Forest-Savanna Transition Zones of Africa

Mathew Rees, John L. Godlee, David J. Harris, Casey M. Ryan, Kyle G. Dexter

Subject: Environmental And Earth Sciences, Ecology Keywords: Africa; forest; savanna; phylogenetic; diversity; transition

Online: 4 May 2023 (06:04:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0056.v2

Women’s Participation in Leadership Roles in a Single Canadian Paramedic Service

Justin Mausz, Sarah Salvis, Dominique Arseneau-Bruneau, Elizabeth Donnelly

Subject: Social Sciences, Sociology Keywords: Emergency Medical Services; paramedics; gender; diversity

Online: 15 February 2023 (04:34:52 CET)

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Introduction: Like other public safety professions, paramedicine has historically been a male-dominated occupation, both in the demography of its workforce and in its organizational culture. Although women are increasingly choosing paramedicine as a career, participation in leadership roles remains limited. Drawing on data from a recent comprehensive mental health survey, we describe the proportion of women in leadership in a single, large, urban paramedic service in Ontario, Canada. Methods: We distributed an in-person, paper-based survey during the fall 2019 - winter 2020 Continuing Medical Education (CME) sessions. Participating paramedics completed a demographic questionnaire alongside a battery of mental health screening tools. We assessed the demography of the workforce and explored differences in employment classification, provider level (e.g., primary vs. advanced care), and participation in formal leadership roles along self-reported gender lines. Results: Out of 607 paramedics attending CME, we received 600 completed surveys, with 11 excluded for missing data, leaving 589 for analysis and a 97% response rate. Women comprised 40% of the active-duty paramedic workforce, with an average of 8 years of experience. Compared to men, women were more than twice as likely to have a university degree (Odds Ratio [OR] 2.02), but almost half as likely to practice at the Advanced Care Paramedic level (OR 0.61), and somewhat less likely to be employed full-time (OR 0.77). Women were nearly 70% less likely to hold a leadership role in the service compared to men (OR 0.36), occupying just 20% of leadership positions. Conclusion: Although paramedicine is witnessing an encouraging shift in the demography of its workforce with greater participation from women, there is still work to be done, particularly in leadership. Future research should focus on identifying and ameliorating barriers to career advancement among women and other historically underrepresented people.

Preprint ARTICLE | doi:10.20944/preprints202204.0283.v1

The Functional Biogeography of eDNA Metacommunities in the Post-fire Landscape of the Angeles National Forest

Savanah Senn, Sharmodeep Bhattacharyya, Gerald Presley, Anne E. Taylor, Jillian Ford, Brandon Jasinski, Yekaterina Badalova

Subject: Environmental And Earth Sciences, Environmental Science Keywords: molecular ecology; functional diversity; DNA sequencing

Online: 28 April 2022 (10:31:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0414.v1

Genotypic and Epidemiologic Profiles of Giardia duodenalis in Four Brazilian Biogeographic Regions

Deiviane Calegar, Beatriz Nunes, Kerla Monteiro, Polyanna Bacelar, Brenda Evangelista, Mayron Moraes, Jurecir Silva, Jéssica Santos, Márcio Bóia, Lauren Jaeger, Filipe Anibal Carvalho-Costa

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Giardia duodenalis; Assemblages; Epidemiology; Genetic diversity

Online: 27 January 2022 (11:18:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0560.v1

Microbial Diversity Based on Multifractal Analysis of Metagenomes

Xianhua Xie, Yuanlin Ma, Zuguo Yu, Guosheng Han

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: diversity index; multifractal; metagenome; gut mtagenome

Online: 26 July 2021 (10:04:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0349.v1

Genetic Diversity of Bemisia tabaci (Gennadius) (Hemiptera:Aleyrodidae) Colonizing Sweet Potato and Cassava in South Sudan

Beatrice Clarence Misaka, Everlyne N. Wosula, Philip W. Marchelo-d'Ragga, Trine Hvoslef-Eide, James Peter Legg

Subject: Biology And Life Sciences, Forestry Keywords: Bemisia tabaci; genetic diversity; distribution; haplotype

Online: 28 November 2019 (03:24:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0249.v1

The Yeast Atlas of Appalachia: Species and Phenotypic Diversity of Herbicide Resistance in Wild Yeast

Jordan B. Barney, Matthew J. Winans, Catherine B. Blackwood, Amaruy Pupo, Jennifer E. G. Gallagher

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Fungal diversity; Saccharomyces; genetic diversity; glyphosate-based herbicides; copper-based fungicides; RoundUp Ready™ corn; phylogenetics

Online: 17 February 2020 (15:37:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1004.v1

Depletion of Endothelial-Derived 2-AG Reduces Blood-Endothelial Barrier Integrity via Alteration of VE-Cadherin and the Phospho-Proteome

Aidan A Levine, Erika Liktor-Busa, Shreya Balasubramanian, Seph M Palomino, Anya M Burtman, Sarah A Couture, Austin A Lipinski, Paul R Langlais, Tally M Largent-Milnes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: endocannabinoid; blood-brain barrier; 2-AG, DAGLα ; VE-cadherin

Online: 14 December 2023 (04:52:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1168.v1

Exploring Polygonal Number Sieves through Computational Triangulation

Sergei Abramovich

Subject: Computer Science And Mathematics, Mathematics Keywords: computation; number theory; triangulation; polygonal numbers; spreadsheet; Wolfram Alpha; Maple

Online: 20 November 2023 (07:51:53 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.1555.v1

Overview of the Biotransformation of Limonene and α-Pinene from Wood and Citrus Residues by Microorganisms

Adama Ndao, Kokou Adjallé

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: limonene; alpha-pinene; biotransformation; terpene; flavouring agent; solid-state fermentation

Online: 23 August 2023 (02:49:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0743.v1

Applications of PERALS-Alpha Spectrometry for the Investigation of Radionuclides in Water Samples

Markus Raymond Zehringer, Franziska Kammerer, Anja Pregler

Subject: Physical Sciences, Acoustics Keywords: PERALS; alpha spectrometry; Polonium; Radon; Radium; Radiostrontium; Thorium; Uranium; Actinides

Online: 31 May 2021 (11:16:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0085.v3

Vertex Domination in Fuzzy Graphs

Mohammadesmail Nikfar

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: fuzzy graph; fuzzy bridge; fuzzy tree; $\alpha$-strong arc; vertex domination

Online: 5 May 2019 (12:20:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0391.v1

Wheat ATI CM3, CM16 and 0.28 Allergens Produced in Pichia Pastoris Display a Different Eliciting Potential in Food Allergy to Wheat

Silvio Tundo, Roberta Lupi, Mickael Lafond, Thierry Giardina, Colette Larré, Sandra Denery-Papini, Martine Morisset, Raviraj Kalunke, Francesco Sestili, Stefania Masci

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: wheat; alpha-amylase/trypsin inhibitor; heterologous expression; Pichia pastoris; allergy

Online: 17 October 2018 (17:15:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1032.v1

Agronomic and Economic Evaluation of Tree Species in Agroforestry Systems with Cocoa (Theobroma cacao L.) in Amazonas

Nixon Huaman Haro, Jerry Bryan Lopezhaya Mendoza, Angel James Medina Medina, Jhon Antony Zabaleta Santisteban, Daniel Tineo Flores, Lily Juarez-Contreras, Malluri Goñas, Manuel Oliva-Cruz

Subject: Biology And Life Sciences, Forestry Keywords: Peru; cocoa; diversity; agroforestry systems; economic analysis

Online: 18 March 2024 (16:12:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1144.v1

Linking Wetland Ecosystem Services to Fish Genetic Resources with Special Reference to Hilsa Shad (Tenualosa ilisha): A Novel Study from Northeastern Bangladesh

Atiqur Rahman Sunny, Md. Arifur Rahman, Md. Nazmul Hasan, Jeba Faizah Rahman, Sharif Ahmed Sazzad, Md. Faruque Miah, Md. Ashrafuzzaman, Shamsul Haque Prodhan

Subject: Biology And Life Sciences, Aquatic Science Keywords: Wetland; Ecosystem services; Genetic diversity; Hilsa; Bangladesh

Online: 20 February 2024 (12:44:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0127.v1

The Family Fabaceae in northeastern Mexico (Subfamily Caesalpinioideae, Mimosoideae Clade, Tribes Mimoseae, Acacieae, and Ingeae)

Eduardo Estrada-Castillón, José Ángel Villarreal-Quintanilla, Gerardo Cuéllar-Rodríguez, Juan Antonio Encina-Domínguez, José Guadalupe Martínez-Ávalos, Arturo Mora-Olivo, Jaime Sánchez-Salas

Subject: Biology And Life Sciences, Plant Sciences Keywords: Leguminosae; Clade Mimosoideae; taxonomy; diversity; northeastern Mexico

Online: 3 January 2024 (03:54:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0029.v1

Genomics of Re-emergent Aeromonas salmonicida in Atlantic Salmon Outbreaks

Marcos Godoy, Marco Montes de Oca, Rudy Suarez, Alexis Martinez, Juan Pablo Pontigo, Diego Caro, Karina Kusch, Harry Bohle, Molly Kibenge, Frederick Kibenge, Sion Bayliss

Subject: Biology And Life Sciences, Aquatic Science Keywords: furunculosis; Aeromonas salmonicida; Salmo salar; genomic diversity

Online: 1 December 2023 (05:31:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1261.v1

Fungal Diversity and Distribution in the Biodiversity Hotspots of the Western Himalayas

Neelesh Yadav, Shrey Rakholia, Naseem Ali, Reuven Yosef

Subject: Biology And Life Sciences, Life Sciences Keywords: Fungi; Diversity; Western Himalayan region; PCA; ANOVA

Online: 19 September 2023 (08:28:18 CEST)

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