Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Epigenetics and Dysfunctional Energy Factors of Neurodegenerative Disease with Therapeutic Potential of H2O2 as Neuroprotective Agent

Version 1 : Received: 31 July 2022 / Approved: 2 August 2022 / Online: 2 August 2022 (10:13:50 CEST)

How to cite: Widyarti, S.; Wibowo, S.; Sabarudin, A.; Abhirama, I.; Bambang Sumitro, S. Epigenetics and Dysfunctional Energy Factors of Neurodegenerative Disease with Therapeutic Potential of H2O2 as Neuroprotective Agent. Preprints 2022, 2022080061 (doi: 10.20944/preprints202208.0061.v1). Widyarti, S.; Wibowo, S.; Sabarudin, A.; Abhirama, I.; Bambang Sumitro, S. Epigenetics and Dysfunctional Energy Factors of Neurodegenerative Disease with Therapeutic Potential of H2O2 as Neuroprotective Agent. Preprints 2022, 2022080061 (doi: 10.20944/preprints202208.0061.v1).

Abstract

The number of people with neurodegenerative disease continues to increase every year. A new perspective is needed in overcoming this disease. In this review, researchers collected information about epigenetics and energy factors of neurodegenerative disease driven by mitochondria. Mitochondrial epigenetic dysregulation can cause damage to the neuron system. The increase in the amount and interaction of alpha-synuclein with SAMM50 in the mitochondria is one of the factors causing neurodegenerative disease. As an energy provider in the body, the existence of harmonization in the regulation of mitochondria specifically the mitochondrial outer membrane is important. Hydrogen peroxide (H2O2) has neuroprotective abilities to overcome the impairment function of mitochondria in neurodegenerative patients. Based on the computational simulation of this case, it can be used as the basic concept for the development of the role of H2O2 in neurodegenerative disease.

Keywords

alpha-synuclein; energy; H2O2; mitochondria; neurodegenerative disease

Subject

MEDICINE & PHARMACOLOGY, Clinical Neurology

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