Widyarti, S.; Wibowo, S.; Sabarudin, A.; Abhirama, I.; Sumitro, S.B. Dysfunctional Energy and Future Perspective of Low Dose H2O2 as Protective Agent in Neurodegenerative Disease. Heliyon 2023, 9, e18123, doi:10.1016/j.heliyon.2023.e18123.
Widyarti, S.; Wibowo, S.; Sabarudin, A.; Abhirama, I.; Sumitro, S.B. Dysfunctional Energy and Future Perspective of Low Dose H2O2 as Protective Agent in Neurodegenerative Disease. Heliyon 2023, 9, e18123, doi:10.1016/j.heliyon.2023.e18123.
Widyarti, S.; Wibowo, S.; Sabarudin, A.; Abhirama, I.; Sumitro, S.B. Dysfunctional Energy and Future Perspective of Low Dose H2O2 as Protective Agent in Neurodegenerative Disease. Heliyon 2023, 9, e18123, doi:10.1016/j.heliyon.2023.e18123.
Widyarti, S.; Wibowo, S.; Sabarudin, A.; Abhirama, I.; Sumitro, S.B. Dysfunctional Energy and Future Perspective of Low Dose H2O2 as Protective Agent in Neurodegenerative Disease. Heliyon 2023, 9, e18123, doi:10.1016/j.heliyon.2023.e18123.
Abstract
The number of people with neurodegenerative disease continues to increase every year. A new perspective is needed in overcoming this disease. In this review, researchers collected information about epigenetics and energy factors of neurodegenerative disease driven by mitochondria. Mitochondrial epigenetic dysregulation can cause damage to the neuron system. The increase in the amount and interaction of alpha-synuclein with SAMM50 in the mitochondria is one of the factors causing neurodegenerative disease. As an energy provider in the body, the existence of harmonization in the regulation of mitochondria specifically the mitochondrial outer membrane is important. Hydrogen peroxide (H2O2) has neuroprotective abilities to overcome the impairment function of mitochondria in neurodegenerative patients. Based on the computational simulation of this case, it can be used as the basic concept for the development of the role of H2O2 in neurodegenerative disease.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
