Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Rapid EElution of 226Th from a Two-Column 230U/226Th Generator with Diluted and Buffer Solutions

Version 1 : Received: 17 February 2023 / Approved: 20 February 2023 / Online: 20 February 2023 (14:17:58 CET)

A peer-reviewed article of this Preprint also exists.

Ermolaev, S.V.; Skasyrskaya, A.K.; Vasiliev, A.N. Rapid Elution of 226Th from a Two-Column 230U/226Th Generator with Diluted and Buffer Solutions. Molecules 2023, 28, 3548, doi:10.3390/molecules28083548. Ermolaev, S.V.; Skasyrskaya, A.K.; Vasiliev, A.N. Rapid Elution of 226Th from a Two-Column 230U/226Th Generator with Diluted and Buffer Solutions. Molecules 2023, 28, 3548, doi:10.3390/molecules28083548.

Abstract

A unique two-column 230U/226Th generator has been developed. The focus was hold on obtaining 226Th of high purity in a solution amenable to further labeling. The first column of the proposed generator filled with TEVA Resin held 230U, from which 226Th was eluted with 7 M HCl solution. UTEVA Resin pretreated with nitric acid solution was used as a sorbent for the second column for thorium retention. 226Th was extracted with 0.01-0.05 M citric buffer solution. One cycle of generator milking took 5-7 minutes and produced > 90% of 226Th in 1.5 ml of eluate, pH 4.5-5.0. The proposed two-column 230U/226Th generator was tested over two months including a second loading of 230U additionally accumulated from 230Pa. The 230U impurity in 226Th eluate was less than 0.01% allowing to use it directly in synthesis of radiopharmaceutical compounds.

Keywords

targeted alpha therapy; alpha-emitter; thorium-226; uranium-230; isotope generator; extraction chromatography

Subject

Chemistry and Materials Science, Medicinal Chemistry

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